Health Longevity Secrets

Robert Lufkin MD
  • 4.5 (22)
  • MEDICINE
  • UPDATED WEEKLY

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician/medical school professor and New York Times Bestselling author focusing on the applied science of health and longevity through lifestyle and other tools in order to cultivate consciousness, and live life to the fullest .'Envision a world of love, abundance, and generosity'.

  1. 1D AGO

    Are Mitochondria The Real Secret to Aging?

    What if the root cause of our most devastating chronic diseases—from Alzheimer's and cardiovascular disease to diabetes and cancer—could be traced back to the same cellular structures? And what if these tiny organelles hold the key to understanding how we age and potentially extending our healthspan? Dr. Hemal Patel, Professor in the Department of Anesthesiology at UC San Diego School of Medicine, takes us on a fascinating journey into the world of mitochondria. Far from being mere "powerhouses of the cell" as we learned in school, these ancient bacterial descendants play sophisticated roles as gatekeepers of cellular life and death, potential drivers of cell differentiation, and central players in understanding chronic disease. When functioning properly, mitochondria form interconnected communities within our cells—appearing like strings of pearls in heart cells, which devote a remarkable 30% of their volume to these energy-generating structures. But when these connections break down, disease follows. Dr. Patel explains how every chronic condition can be viewed through the lens of energy imbalance, with mitochondria at the center of this critical equation. Perhaps most exciting is the breakthrough technology Dr. Patel's team has developed: a simple blood test called MeScreen that can assess mitochondrial function without invasive biopsies. Using just a few drops of blood, this revolutionary approach reveals each person's unique mitochondrial signature, offering personalized insights that could transform how we approach health optimization and disease prevention. Whether you're curious about the fundamental biology of life, seeking to understand chronic disease, or interested in cutting-edge approaches to longevity, this conversation will forever change how you think about the trillions of tiny organelles powering every aspect of your existence. Discover why supporting these ancient symbionts might be the missing link in our pursuit of longer, healthier lives. https://mescreen.com/cart/47561239626013:1?discount=&ref=emssndtq (Use the code MITOHEALTH100 for $100 off) Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    21 min

  2. DEC 16

    How to Avoid a Fatal Fracture

    Unlock the secrets to a longer, healthier life with our special guest, Kevin Ellis, the Bone Coach. This episode dives deep into the critical importance of bone health, far beyond just keeping you upright. From blood cell production to immune system support and mineral storage, Kevin explains how your bones play a vital role in your overall well-being. Learn why early bone density scans (DEXA scans) are crucial and how conditions like osteoporosis and osteopenia can silently impact your life quality without proactive monitoring. Explore the hidden connections between inflammation, aging, and chronic diseases and discover how everyday factors like gluten, seed oils, and insulin resistance can erode your skeletal strength. Kevin shares actionable advice on diet, physical activity, and nutrient intake, emphasizing the power of weight-bearing exercises and resistance training. Especially important for older women, these strategies can dramatically enhance bone density and quality, making a significant difference in your health as you age. Finally, Kevin debunks common myths about osteoporosis treatment, advocating for a holistic approach over traditional medications like calcium and vitamin D supplements. From gut health to personalized exercise plans, he unveils a comprehensive blueprint for preventing bone loss and improving bone quality naturally. Plus, don't miss out on Kevin’s Stronger Bones programs and a free masterclass offering invaluable resources to start your journey toward stronger, healthier bones. Join us and take the first step towards a resilient, active future! https://bonecoach.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    39 min

  3. DEC 9

    What Is Next After the Apple Watch?

    What if you could see your inflammation—and your pace of aging—from your kitchen table? We sit down with Bob Messerschmidt, an optical engineer turned Apple platform architect who helped seed Apple Health and the Apple Watch, then left to build a simple at-home device that measures ESR, a century‑old inflammation marker with fresh relevance for longevity. We unpack why chronic inflammation drives heart disease, stroke, neurodegeneration, and metabolic dysfunction, and why a single, trackable number can change behavior more than any abstract advice. You’ll hear a clear breakdown of ESR vs CRP: how CRP reacts fast to single-protein changes while ESR integrates multiple inflammatory pathways over several days, often acting like a steadier signal for lifestyle experiments. We explore compelling evidence that ESR rises with age in Western populations—functioning as a biological clock—yet flattens in agrarian cohorts, underscoring how environment and habits accelerate “inflammaging.” Beyond theory, we get practical. Our guest shares what actually lowers ESR: meaningful weight loss, GLP‑1 therapies, omega‑3 rich fish, better sleep, daily movement, strength training, stress control, and even tart cherry juice. We talk about the design constraints that make wrist sensors tricky, why Apple prioritizes validation over speed, and how bringing blood-based testing into the home removes friction that once sidelined ESR in centralized lab workflows. With more than ten thousand tests across a diverse user base, the team is preparing anonymized insights and research in underserved communities to show which interventions move the needle in the real world. If you want a reliable, weekly feedback loop that ties your choices to measurable change, this conversation maps the path. Subscribe, share with a friend who cares about longevity, and leave a review to help more people discover smarter ways to measure and lower inflammation. https://corhealth.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    49 min

  4. DEC 2

    The Cookbook That Saved My Life

    What if everything you've been taught about nutrition is not just wrong, but actively harming your health? Cary Kelly's story might make you question your most basic assumptions about food and wellness. Cary grew up in a household religiously following conventional dietary guidelines—low-fat everything, margarine instead of butter, minimal red meat, and plenty of "heart-healthy" grains. Yet by his late 40s, his health was deteriorating rapidly. Chronic inflammation ravaged his body, extra weight accumulated around his middle, and simple activities became painful ordeals. When his arm suddenly went numb during a walk, Cary feared the worst. That frightening episode became his turning point. Desperate for solutions after being told he would simply have to "live with" his conditions, Cary reluctantly tried a new diet that seemed to contradict everything he'd been taught about nutrition. The results were nothing short of miraculous—within just three days, the inflammation that had plagued him for years began to subside. As Cary describes it, "It's like it had been raining inside my body every day for a decade and then, all of a sudden, the sun came out." Now, Cary has distilled his culinary expertise (from 28 years in the restaurant industry) into Carnicopia, a cookbook featuring simple, accessible meat-based recipes anyone can prepare. His approach isn't about perfection—it's about finding what works for your body and challenging the nutritional dogma that may be keeping you sick. Whether you're struggling with chronic inflammation, carrying extra weight that won't budge, or simply curious about why meat-based diets are transforming thousands of lives, Cary's story offers both inspiration and practical guidance.  https://healthrecoverywithcarykelly.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    49 min

  5. NOV 25

    How to Survive The Holiday Air Travel

    Holiday flights don’t have to flatten your energy or your immune system. Dr. Robert Lufkin breaks down what actually happens to your body at altitude—lower oxygen, desert-dry cabins, stalled circulation—and shares a clear plan to stay sharp before, during, and after you fly. Instead of white-knuckling through recycled air and jet lag, you’ll learn how to turn the cabin into a controllable environment and land clear, not crushed. We start with the physiology: why pressurization strains mitochondria, how dehydration slows immunity and brain function, and why hours of sitting leave lymph stuck. From there, we build a preflight foundation with real food, strategic fasting for domestic routes, and clean snacks for long-haul trips. You’ll hear a practical mindset shift that reframes travel as rare, uninterrupted time for deep work, reading, or calm recovery—because the nervous system follows your plan. On board, we get tactical. Sip water every 15 to 20 minutes, stand and move each hour, and use nasal breathing to pump lymph. Block harsh blue cabin light to protect circadian rhythm, and skip alcohol to prevent immune drag and sleep disruption. After landing, lock in recovery with 10 minutes of outdoor light, legs up to drain swelling, a short movement session to clear inflammation, and continued hydration with electrolytes. We finish with a one-trip challenge that proves how fast these fundamentals work, plus invites to our quarterly three-day water fast, weekly newsletter, and trusted tools for proactive health. Ready to test the protocol and feel the difference on your next trip? Subscribe, share this with a frequent flyer you care about, and leave a quick review to help others land clear too. FASTING CHALLENGE: https://tinyurl.com/3feksfda  Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    11 min

  6. NOV 18

    What If Sugar Wasn't Sweet?

    Cravings aren’t just about weak will; they’re biology doing exactly what billions of food dollars engineered them to do. We sit down with Sander Brus to unpack how sweetness hijacks reward circuits, why kids are showing up with adult metabolic diseases, and what happens when you flip the switch on sweet taste itself. Sander takes us from his diagnostics background into the heart of metabolic health, explaining how sweet taste receptors (T1R2/T1R3) live on the tongue and in the gut, where they act as glucose sensors. You’ll hear how plant compounds like gymnemic acids can temporarily block those receptors, making soda taste like “nothing,” softening the dopamine surge, and even reducing post-meal glucose and insulin in some studies. We compare the behavioral punch of reducing perceived sweetness to the pharmacology of GLP‑1 agonists, and we dig into CGM experiments that show real-world spikes shrinking when sweetness is inhibited. We also zoom out to the food environment: why sugar is uniquely craved compared to seed oils or grains, how high fructose corn syrup supercharges palatability, and why noncaloric sweeteners may still nudge insulin through cephalic responses. Sander shares practical playbooks for using a mouth rinse to tame dessert triggers or a capsule 30 minutes before carb-heavy meals to blunt spikes. Along the way, we talk palate reset in 10–14 days, metabolic flexibility, insulin’s role in aging pathways like mTOR, and the hope of nudging an industry to build foods that support healthspan rather than erode it. If you’ve ever wanted fewer cravings, steadier energy, and data-backed ways to quiet the glucose roller coaster, this conversation offers both science and tactics you can try today. Listen, share with someone navigating sugar struggles, and tell us your biggest craving scenario so we can tackle it in a future episode. And if you’re finding value here, subscribe, leave a review, and help more people discover metabolic tools that actually work. https://nosuhealth.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    45 min

  7. NOV 11

    Keto for Cancer?

    What if the real action in cancer isn’t in the genome, but upstream in the mitochondria and the metabolic “terrain” that shapes every signal your cells send and receive? We sit down with Dr Nasha Winters to rethink cancer as an ecologic disease and explore how shifting the terrain can change outcomes without rejecting standard care. We dig into why ketones are more than fuel. Nasha explains how a therapeutic ketotic state—reached through fasting, carb restriction, or exogenous support—can lower inflammatory cytokines, dial down insulin and IGF-1, reduce angiogenic drive, and directly influence the vagus nerve to move the body into a healing state. You’ll hear practical ways to pair ketosis with radiation, hyperbaric oxygen, and hyperthermia to both enhance efficacy and protect healthy tissue, plus real markers to track progress, from GKI and CRP to LDH and organic acids. Skeptical about “alternative” claims? So is Nasha—until the data line up. We talk pharmacogenomics, validated drug-sensitivity testing, and the smart use of repurposed meds like metformin, low-dose naltrexone, and mebendazole when the biology says they fit. We also connect longevity and cancer prevention through mitochondrial health: strategic fasting, urolithin A, melatonin, vitamin D, circadian repair, and toxin reduction all play a role in building metabolic flexibility. To close, Nasha unveils her vision for a residential, integrative hospital and research institute on a regenerative farm, where tumor experts and terrain experts co-manage under one roof—data first, dogma last. If this conversation expanded your map of what’s possible in oncology and longevity, follow the show, share it with someone who needs options, and leave a review with the biggest insight you’re taking into your own care. https://drnasha.com/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    48 min

  8. NOV 4

    DMT: Death By Astonishment with Andrew Gallimore

    Imagine your brain as a world-building engine that never shows you the thing-in-itself, only a model tuned for survival. Now imagine a molecule that doesn’t just bend that model but switches it to a fully formed, hyper-detailed reality populated by entities that seem to think, act, and sometimes deny you entry. That’s the claim at the heart of our conversation with computational neurobiologist and DMT researcher Andrew Gallimore, author of Death by Astonishment. We start by laying the groundwork: predictive brains, interface theory, and why ordinary dreams and hallucinations reuse what the brain already knows. From there we compare classic psychedelics—LSD, psilocybin, mescaline—with DMT. The former loosen constraints; the latter appears to replace the entire world model. Reports converge on crystalline clarity, higher-dimensional geometry, and interactive beings that feel autonomous. Andrew introduces the “lockout” effect, where access can be refused, and argues that orthodox neuroscience struggles to explain structured, agent-like phenomena arising so quickly and coherently. The breakthrough comes with extended-state DMT using target-controlled infusion—a medical technique borrowed from anesthesia—to hold explorers in the space for 30 to 90 minutes or longer. Early pilots suggest the state stabilizes, enabling intentional interaction and systematic observation. We explore a research roadmap: send in mathematicians to probe topology, linguists to parse symbolism, anthropologists to map social rules, artists to render lawful structure. Instead of asking entities to prove themselves, we let experts recognize operations that exceed typical human cognition, like effortless four-color theorem tilings or impossible geometric transforms performed in real time. We also talk safety, differences between DMT, ayahuasca, and 5-MeO, and emerging retreat-and-research models that combine medical oversight with rigorous protocols. Whether DMT reveals autonomous minds, emergent intelligence, or a yet-unknown information source, extended-state studies could convert private revelation into public evidence. Subscribe, share with a curious friend, and leave a review with the question you’d ask if you had an hour in the DMT space. What test would convince you that contact is real? https://noonautics.org/ Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/ Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/ Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin At home blood testing (20% off) https://siphoxhealth.com/lufkin Web: https://robertlufkinmd.com/ X: https://x.com/robertlufkinmd Youtube: https://www.youtube.com/robertLufkinmd Instagram: https://www.instagram.com/robertlufkinmd/ LinkedIn: https://www.linkedin.com/in/robertlufkinmd/ TikTok: https://www.tiktok.com/@robertlufkin Threads: https://www.threads.net/@robertlufkinmd Facebook: https://www.facebook.com/robertlufkinmd Bluesky: ...

    53 min
See All (238)

4.5
out of 5
22 Ratings

About

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician/medical school professor and New York Times Bestselling author focusing on the applied science of health and longevity through lifestyle and other tools in order to cultivate consciousness, and live life to the fullest .'Envision a world of love, abundance, and generosity'.

Information

  • Creator
    Robert Lufkin MD
  • Years Active
    2021 - 2025
  • Episodes
    238
  • Rating
    Clean
  • Copyright
    © 2025 Health Longevity Secrets
  • Show Website
    Health Longevity Secrets

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