11 episodes

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including aging, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician and medical school professor focusing on the applied science of health and longevity through lifestyle and other tools.

Health Longevity Secrets Robert Lufkin MD

    • Health & Fitness
    • 5.0 • 1 Rating

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including aging, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe and get ready to change your life. HLS is hosted by Robert Lufkin MD, a physician and medical school professor focusing on the applied science of health and longevity through lifestyle and other tools.

    Gordan Lauc PhD: Glycans- The Next Biological Longevity Clock?

    Gordan Lauc PhD: Glycans- The Next Biological Longevity Clock?

    #011-Glycans are being hailed as possibly the next great biological longevity clock. Today we speak with the leading expert on the subject.  

    Gordan Lauc PhD, is Professor of Biochemistry and Molecular biology at the University of Zagreb and Co-Founder and Chief Scientific Officer at GlycanAge. He graduated from the University of Zagreb Faculty of Science in 1992, and obtained PhD in Biochemistry and the University of Zagreb.
    Take home points:
    Glycans– the third revolution in evolution
    Nuclei acids - 4 building blocks [linear]
    Proteins -  20 amino acids [linear]
    Glycoproteins- 2000+ [nonlinear]
    Examples -Blood groups ABO are glycans
    Post translational-make protein 
    Glycans modifications of proteins lipids and even DNA by sugar
    Nonlinear branching oligosaccharide 
        Glucose-monosaccharide-
    Post translational modifications-
         Phosphorylation
         Glycosylation
    AGE- advanced glycation end products——reaction glucose and proteins- not the same as glycosylation.
    Immunoglobulins- older get more pro inflammatory glycans-
    Igg glycosylation suppress inflammation
    Human glycan project
    Health Longevity Secrets show listeners who wish to try The Glyconage longevity clock on themselves can receive a 20% discount enter the code ROBERTLUFKIN at the glycanage.com website.
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    *** SPONSORSHIPS & BRANDS ***
    We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact​
    NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. 
    ------------------------------------------------------------------------
    #longevity #wellness #antiaging #MR #lifestylemedicine #younger #glycans #biohacking #RobertLufkinMD #genetics #glycosylation #gordonlauc

    • 50 min
    Elizabeth Parrish: Gene Therapy for Longevity

    Elizabeth Parrish: Gene Therapy for Longevity

    #010-Today we take a look at gene therapy and the possibilities for longevity with someone who is not only an expert in the field but who has also tested the longevity gene therapy on herself. 
    Elizabeth Parrish is an entrepreneur and founder and CEO of Bio-Viva Sciences. She is a graduate of the University of Washington. 

    Preprint: Telomerase reverse transcriptase (TERT) and follistatin (FST). 
    Mouse cytomegalovirus (MCMV) carrying exogenous TERT or FST (MCMVTERT or MCMVFST) extended median lifespan by 41.4% and 32.5%, respectively. First report of CMV being used successfully as both an intranasal and injectable gene therapy system to extend longevity. Jaijyan, Dabbu Kumar, Anca Selariu, Ruth Cruz-Cosme, Mingming Tong, Shaomin Yang, George Church, David Kekich, et al. “New Intranasal and Injectable Gene Therapy for Healthy Life Extension.” Preprint. Cell Biology, June 26, 2021. https://doi.org/10.1101/2021.06.26.449305.
    https://www.biorxiv.org/content/10.1101/2021.06.26.449305v1.full.pdf 

    https://bioviva-science.com/

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    *** SPONSORSHIPS & BRANDS ***
    We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact​

    NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.

    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. ------------------------------------------------------------------------

    #longevity #wellness #antiaging #MR #lifestylemedicine #younger #artificial intelligence #biohacking #RobertLufkinMD

    • 45 min
    Stephen Sideroff PhD: Resilience for Health and Longevity

    Stephen Sideroff PhD: Resilience for Health and Longevity

    #009-Stress is now known to affect everything from gray hair to epigenetic age among other things in our health.  Dr Stephen Sideroff beautifully outlines the 9 pillars of resiliency that allow us to handle the inevitable chronic stress in our lives.
    Please join Dr Stephen Sideroff for this masterclass in human stress management through building lasting resilience.
     
    Take away points: 
    -Stress can be both positive and negative. Chronic stress tends to be harmful.
     -Stress can affect telomeres and other markers for aging
    -Early childhood experiences can strongly influence how we deal with stress as adults
     
    03:38 Steve's early career in brain research
    06:04 Failure of longterm results in stress management from single workshop
    08:24 Early childhood experiences and the primitive gestalt effect on stress
    14:23 Enhancing neuroplasticity
    18:00 The path: mastering the nine pillars of resilience
    24:12 Stress effect on telomeres and markers for aging
    30:15 Concept of eustress for positive stress from Hans Selye
    37:23 Key pillars of resilience
    40:45 Relationship with ourselves, others, and something greater
    41:52  John M. Gottman ratio of positive to negative couples interactions
    45:03 Stress as sympathetic nervous system activator
    48:21 Personal lifestyle choices
    http://drstephensideroff.com/  


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    NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.
    Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel.
    To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. 
    ------------------------------------------------------------------------
    #longevity  #wellness #antiaging #biologicalage #lifestylemedicine #younger #epigenetics #biohacking  #RobertLufkinMD #resilience #stephensideroff

    • 53 min
    Alan Green MD: Rapamycin for Longevity in Clinical Practice

    Alan Green MD: Rapamycin for Longevity in Clinical Practice

    #008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.

    Take away points: 
    -Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.
    -In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice. 
    -It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.
    -The drug requires a prescription and should only be used under supervision of a physician
    -Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]


    02:45 Blagosklonny papers (Blagosklonny 2019)
    05:23 Jane Mannick rapalogue paper (Mannick 2014)
    08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy
    09:14 Elevated mTOR as common factor- Inflammation, fibrosis, 
    12:03 Rapamycin role to decrease mTOR overview common pathway 
    14:23 mTOR is essentially command and control of the cell for the last 2 billion years
    15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects
    16:05 Increased mTOR causes increased innate immune system/inflammation 
    17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging
    19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy 
    23:00 Alzheimer disease as a disease of senescent cells
    26:00 importance of dose timing for Rapamycin
    27:00 Anti aging effects on mTOR1 and other effects on mTOR2
    32:00 Rapamycin as off patent drug
    37:00 Dosing considerations and subjective effects
    40:00 Tracking HOMA-IR  (Homeostatic Model Assessment for Insulin Resistance) score 
    42:00 Improvement in exercise related to maximum cardiac output
    45:00 Age associated cardiomyopathy
    49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.
    57:00 Personal lifestyle choices

    https://rapamycintherapy.com/ 


    Blagosklonny, Mikhail V. “Rapamycin for Longevity: Opinion Article.” Aging 11, no. 19 (October 4, 2019): 8048–67. https://doi.org/10.18632/aging.102355.

    Harrison, David E., Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, et al. “Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice.” Nature 460, no. 7253 (July 2009): 392–95. https://doi.org/10.1038/nature08221.

    Mannick, J. B., G. Del Giudice, M. Lattanzi, N. M. Valiante, J. Praestgaard, B. Huang, M. A. Lonetto, et al. “MTOR Inhibition Improves Immune Function in the Elderly.” Science Translational Medicine 6, no. 268 (December 24, 2014): 268ra179-268ra179. https://doi.org/10.1126/scitranslmed.3009892.

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    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. 
    ------------------------------------------------------------------------
    #longevity  #wellness #antiaging #biologicalage #lifestylemedicine #younger #epigenetics #biohacking  #Rapamycin #RobertLufkinMD

    • 1 hr 2 min
    Wiro Niessen PhD: Artificial Intelligence Meets Dementia

    Wiro Niessen PhD: Artificial Intelligence Meets Dementia

    #007-Magnetic resonance or MR  imaging is one of the most powerful noninvasive medical testing tools- and when we combine it with with the emerging power of artificial intelligence great things are possible. Today we are looking specifically at applying this technology to the brain  in order to help understand dementia from one of the leaders in the field. 
    Wiro Niessen is a professor at both Erasmus MC, University Medical Center Rotterdam and Delft University of Technology. He is founder and scientific lead of Quantib, an AI company in medical imaging. He received a master's degree in Physics and a PhD in Medical Imaging from Utrecht University.
    —2012 ImageNET competition revolutionized machine learning with deep convolutional neural networks
    -Data science approach to medical imaging
    -How risk factors [Genetic and lifestyle] are associated with outcome
    -Rotterdam study for population imaging
    -Increased deep white matter changes associated with increased stroke and dementia
    -DTI- diffusion tensor imaging allows white matter tracts to be seen- AI can automate processing to save orders of magnitude in processing time
    -Automated biomarker extraction from 15,000 Brain MRI
    -Hippocampal volume- associated with risk for later developing Alzheimer disease. 
    -MICCAI Society- Medical Image Computing and Computer Assisted Interventions
    -ESR- European Society of Radiology
    -FAIR- Finable, Accessible, Interoperable, Reusable Data
    https://www.erasmusmc.nl/en/research/researchers/niessen-wiro


    https://www.quantib.com/about/team/wiro-niessen


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    *** SPONSORSHIPS & BRANDS *** 
    We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact​ 
    NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. ------------------------------------------------------------------------
    #longevity #wellness #antiaging #MR #lifestylemedicine #younger #artificial intelligence #biohacking #RobertLufkinMD

    • 29 min
    Judith Finlayson: You Are What Your Grandparents Ate

    Judith Finlayson: You Are What Your Grandparents Ate

    #006-Epigenetic change is now recognized as the cumulative effect of our life experiences in controlling gene expression. What is less well known is that this epigenetic influence on our gene expression can extend back to our parents’ and even our grandparents’ life experiences. Let's dive into this fascinating topic with todays guest expert.
    Judith Finlayson is a best-selling author who has written books on a variety of subjects, from personal well-being and women’s history to food and nutrition. Her most recent book ‘You Are What Your Grandparents Ate’ is a revealing take on transgenerational epigenetics and has been translated into German, French, Spanish, Slovenian and Japanese. 
    Key points:
    -Current understanding - genomic information is transferred but epigenetic information is wiped clean each generation-but not quite so simple. 
    -For example, studies have shown that both the children and grandchildren of women who survived the Dutch famine of 1944-45 were found to have increased glucose intolerance in adulthood.
    -Other researchers have found that the descendants of Holocaust survivors have lower levels of the hormone cortisol, which helps your body bounce back after trauma.
    -Mechanisms for transgenerational epigenetics
    -David Barker- hypothesis
    -dietary and lifestyle choices she prioritizes to support optimal genetic expression. 


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    *** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact
    *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact 
    NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.
    Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel.
    To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regardless of the accuracy or completeness of any such content.
    Disclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. 
    ------------------------------------------------------------------------
    #longevity  #wellness #antiaging #biologicalage #lifestylemedicine #Finlayson #epigenetics #biohacking  #RobertLufkinMD

    • 49 min

Customer Reviews

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dao8881234 ,

Health longevity secrets

Very useful information about how I can improve my health and longevity by lifestyle choices informed by science for myself and my family. I highly recommend it!

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