The Pod of Inquiry The Podcast For Human Optimization And Understanding

Dr. Stephen L. Barrett
  • 4.8 (21)
  • MEDICINE
  • UPDATED WEEKLY

The Podcast For Human Optimization And Understanding - The Pod Of Inquiry is designed to empower you with knowledge. What happens from there is up to you. Your host, Dr. Stephen Barrett, has designed this show to take you down some very deep rabbit holes hopefully bringing you back out again, relatively unscathed, but cerebrally wicked enabling a better understanding of all things worthy of inquiry. Past topics on the podcast include: Podiatry; Adhesive Arachnoiditis; Alzheimers; Antioxidants; Autoimmunity; Bioidentical Hormone Replacement Therapy; Biomechanics; Charcot Neuroarthropathy; Diabetes; Diabetic Foot Ulcers; Diabetic Neuropathy; Diagnostic Ultrasound; Direct pay medical care; Drop Foot; Functional Medicine; hallux limitus; Hallux Valgus Surgery; Hashimoto's Disease; Heel Pain; Holistic Medicine; Inflammation; Iodine; Ketamine; Melatonin; Metabolism; Mortons Entrapment; Nitric Oxide; Ozone Therapy; Pain; Palmitoylethanolamide; Peptides; Peripheral Nerve Surgery; Peripheral Neuropathy; Plantar Fasciitis; PRP; Pulsed Electromagnetic Field Therapy (PEMF); Regenerative Medicine; Remy; Restless Leg Syndrome; Stem Cells; Sub clinical nerve entrapment; Tarsal Tunnel; The Phoenix Sign; Thyroid; Triglycerides; and more.

  1. 3D AGO

    Awake Liposuction vs Implants | Dr. Daniel Suissa | S8 - E8

    ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com ✅Valasta Astaxanthin : https://valasta.net/  (Checkout with code POI5 for 5% discount) ✅Marodyne LiV: www.marodyne.us (Vibration Therapy Device) (Checkout with code SB200 for $200 discount) What if some of the most advanced plastic surgery today is performed while patients are completely awake—and it's actually safer? In this episode of Pod of Inquiry, we sit down with Dr. Daniel Suissa to explore the evolution of awake liposuction, fat transfer, and modern body sculpting—and why many surgeons are rethinking traditional implant-based approaches. From the science of tumescent anesthesia to the psychology of cosmetic surgery, this conversation pulls back the curtain on what patients should really know. 💉 In this episode, we discuss: ➡️Why some surgeons are moving away from breast implants and the growing conversation around Breast Implant Illness (BII) ➡️How awake liposuction avoids general anesthesia—and why that can improve safety and precision ➡️The neuroscience of pain control, including how vibration leverages Gate Control Theory ➡️When cosmetic surgery won't fix the underlying issue—and how responsible surgeons screen for unrealistic expectations ➡️The rise of social media–driven procedures in younger patients ➡️Real-world complications, risk management, and surgical transparency Dr. Suissa shares insights from his training at the University of Toronto and Yale University, along with his experience practicing across North America—from Montreal to Beverly Hills to Miami. Whether you're considering cosmetic procedures, interested in regenerative aesthetics, or simply curious about how neuroscience intersects with surgical innovation, this episode delivers a thoughtful, evidence-informed perspective. 🎧 Watch now to understand the real risks, benefits, and breakthroughs in modern body sculpting. If you value in-depth conversations with leading experts in medicine and human optimization, consider subscribing and leaving a review—it helps more people discover the show. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction   01:49 Dr. Suissa's Background   03:20 Training & Career Path   04:52 Miami & Cosmetic Surgery Culture   05:48 Social Media Influence   06:30 Canada vs US Market   08:02 Surgical Philosophy   09:36 Managing Expectations   11:35 When Surgery Is Appropriate   12:34 Younger Cosmetic Trends   14:10 Patient Red Flags   15:31 Body Dysmorphic Disorder   16:45 Surgery & Quality of Life   20:00 Function vs Form   21:01 Psychology of Scars   23:05 Minimizing Scars   25:00 Facelift Techniques   25:36 Breast Surgery Scars   26:55 Endoscopic Approaches   27:38 Fat Transfer vs Implants   28:51 Implant Removal Trend   29:01 Implant Types & Evolution   30:00 Implant Ruptures   31:42 Breast Implant Illness   32:42 BII & Explant Decisions   33:07 Benefits of Fat Transfer   34:06 Patient Selection   35:04 Implant Litigation History   36:06 Body Sculpting Innovation   36:59 Liposuction Evolution   37:27 History of Liposuction   38:28 Tumescent Breakthrough   39:07 Tumescent Solution Components   40:52 How Tumescent Works   41:21 Lidocaine Safety   42:26 Technique Refinements   43:40 Vibratory Cannula Innovation   45:06 Gate Control Theory   48:08 Vibration vs Ultrasound   48:37 Skin Tightening Claims   -- Hashtags -- #AwakeLiposuction #FatTransfer #BreastImplantIllness #BodySculpting #PlasticSurgery #AestheticMedicine #SurgicalInnovation

    54 min
  2. You Might Also Like: Las Culturistas with Matt Rogers and Bowen Yang

    3D AGO · BONUS

    You Might Also Like: Las Culturistas with Matt Rogers and Bowen Yang

    Introducing "The Mayor" (w/ Laura Dern) from Las Culturistas with Matt Rogers and Bowen Yang. Follow the show: Las Culturistas with Matt Rogers and Bowen Yang Um, is this thing on? Because a pink corduroy-clad Laura Dern bursts like the sun into the Las Cultch studio to speak with Matt & Bowen at length and... that's OUR world! That's the world that WE're livin' in. Dern whips out a Reese impression, discusses channeling anger better than anyone in the biz, talks creating Amy Jellicoe alongside Mike White in Enlightened, and gets into both the comedic and dramatic brutality of Big Little Lies. Also, defining wonder whilst looking up at CGI Brachiosaurii, starring as Ellen's gay love interest in The Puppy Episode of her sitcom, and even more on Jeff Goldblum's chest, if you can believe it. All this, growing up in Hollywood in a different era, reflections on the current status of the entertainment industry, going punk rock at 12 years old, David Lynch as niche yet mainstream culture, and Laura's real life interaction with a Real Housewife. See one of Laura's thousands of current projects (Is This Thing On?, Jay Kelly, Palm Royale on Apple TV+), as well as her millions of indelible ones you probably already love. I SAID THANK YOU! See omnystudio.com/listener for privacy information. DISCLAIMER: Please note, this is an independent podcast episode not affiliated with, endorsed by, or produced in conjunction with the host podcast feed or any of its media entities. The views and opinions expressed in this episode are solely those of the creators and guests. For any concerns, please reach out to team@podroll.fm.

  3. FEB 9

    Reversing POTS with Functional Neurology | Dr. George Michalopoulos | S8 - E7

    ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com ✅Valasta Astaxanthin : https://valasta.net/  (Checkout with code POI5 for 5% discount) ✅Marodyne LiV: www.marodyne.us (Vibration Therapy Device) (Checkout with code SB200 for $200 discount) If you or someone you know struggles with POTS (Postural Orthostatic Tachycardia Syndrome)—dizziness, brain fog, fatigue, or rapid heart rate upon standing—this episode offers a radically different way to understand what's happening and how recovery may be possible. In this conversation, we are joined by Dr. George Michalopoulos, a Chicago-based functional neurologist, to explore why POTS is not a "broken heart" or a permanently damaged body—but a nervous system that has lost confidence in its predictions. Rather than symptom suppression, this episode dives into root-cause neurology, neuroplasticity, and objective clinical outcomes. 🧠 In this episode, you'll learn: ➡️Why beta blockers often mask symptoms without correcting the underlying dysfunction ➡️How viral infections and inflammation disrupt sensory integration and autonomic control ➡️The neuroplasticity-based approach showing measurable improvements in as little as 12 days ➡️Why dietary triggers (especially gluten and dairy) can interfere with nervous system recovery ➡️Real patient outcomes, including balance scores improving from 20% to 95% in 10 days ➡️Why POTS disproportionately affects women (75–80% of cases) and why cases are rising Dr. Michalopoulos shares what he's seeing clinically, how progress is objectively measured, and why restoring nervous system trust—not forcing the body—is key to improvement. If you're frustrated with conventional explanations or looking for actionable, evidence-based insights into autonomic dysfunction, this episode goes far beyond standard care models. 🎧 Watch now to rethink POTS, neuroplasticity, and what recovery can look like. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction to POTS   01:19 Journey into Functional Neurology   03:09 Daughter's Tics & Turning Point   04:25 What Is POTS & Dysautonomia   04:45 Brain Prediction Errors in POTS   14:48 Limits of Beta Blockers   19:21 Dystonia Case Study   21:11 Nerve Surgery & Brain Adaptation   22:53 Cerebellum & Balance Pathways   26:03 Why POTS Develops   26:28 Inflammation & Diet   28:53 Fasting & Immune Triggers   35:44 Treating POTS: Art & Science   39:28 Why Results Appear Fast   39:34 Using Objective Metrics   41:26 Vagal Nerve Stimulation   43:50 Hope for POTS Patients   45:02 Metrics Build Confidence   45:57 Balance Training Results   47:53 Gender Differences in Neurology   48:55 Contact Information   49:51 Closing Remarks -- Hashtags -- #POTS #Dysautonomia #FunctionalNeurology #Neuroplasticity #AutonomicNervousSystem #BrainHealth #IntegrativeMedicine

    53 min

  4. FEB 2

    Vibration Therapy for Bone Health | Ian Cutts & Dr. Clinton Rubin | S8 - E6

    ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com ✅Valasta Astaxanthin : https://valasta.net/  (Checkout with code POI5 for 5% discount) What if improving bone density, muscle mass, and mitochondrial health didn't require intense workouts—or even breaking a sweat? In this episode, I sit down with Dr. Clinton Rubin, SUNY stem cell biologist and pioneer in vibration therapy research, and Ian Cutts, CEO of Marodyne, to break down the real science behind low-magnitude vibration therapy—and why most vibration platforms are being used incorrectly and dangerously. Backed by decades of peer-reviewed research and FDA-approved technology, this conversation separates legitimate clinical science from fitness-industry gimmicks. 🧬 In this episode, you'll learn: ➡️Why 30 Hz at 0.4g is the Goldilocks zone for bone and muscle health ➡️How high-intensity gym vibration plates may damage the brain and nervous system ➡️How vibration therapy stimulates mitochondria and mechanotransduction without raising heart rate ➡️Why bisphosphonates address only 1/3 of osteoporosis physiology ➡️Clinical evidence showing benefits in children with muscular dystrophy and elderly adults at risk of fractures ➡️How vibration signals influence stem cells, bone remodeling, and telomere protection This is not pseudoscience. Dr. Rubin's work has shaped how we understand mechanical signaling, skeletal health, and longevity, with real-world clinical applications already in use. Whether you're a clinician, researcher, longevity enthusiast, or simply curious about safer alternatives to traditional exercise, this episode offers a deep, evidence-based look into the future of bone health. 🎧 Listen now and rethink how stillness can be therapeutic. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction   01:16 Guest Introductions   02:44 Exogen Bone Stimulator Origins   05:00 Vibration as a Biological Signal   08:24 Exercise as Mechanical Medicine   10:00 Shockwave Therapy & Bone Healing   12:19 Systemic Effects of Bone Signals   15:00 Clinical Trial Populations   15:37 History of Vibration Therapy   16:56 Sponsor: Stem Regen   20:00 Return of Physical Medicine   21:37 When Vibration Becomes Dangerous   23:57 High-Intensity Vibration & Brain Injury   25:00 Proper Vibration Dosage   26:56 Why 30 Hz at 0.4g   30:00 Mitochondrial Activation   35:00 Longevity & Fracture Prevention   38:29 Balance & Fracture Reduction Study   40:00 Bisphosphonates: Limits & Compliance   43:27 Aging in Place Strategy   46:29 Daily Mechanical Signals   47:43 Endothelial Health Benefits   49:10 Mechanotransduction Explained   49:50 Device Access & Clinical Use -- Hashtags -- #VibrationTherapy #BoneHealth #LongevityScience #RegenerativeMedicine #MedicalInnovation #OsteoporosisPrevention #Mechanotransduction

    54 min

  5. JAN 26

    2x Better and Faster Nerve Repair | Dr. Isaac Clements | S8 - E5

    ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com ✅Valasta Astaxanthin : https://valasta.net/  (Checkout with code POI5 for 5% discount) 🧠 What if peripheral nerve repair didn't require delicate microsutures—and worked better? In this episode, we talk with Dr. Isaac Clements, the inventor of NerveTape, a sutureless nerve repair device that's changing how surgeons reconnect damaged nerves. Originally discovered by accident during neural interface research, NerveTape uses shape-memory nitinol (the same material used in heart stents) to align and stabilize nerve ends—making repairs faster, more consistent, and potentially more successful than traditional microsurgical techniques. ⚠️ Even in expert hands, traditional nerve repair achieves good recovery less than 50% of the time. NerveTape aims to raise that bar. 🧬 In this episode, you'll learn: ✅ How NerveTape works and why no sutures are needed ✅ Why alignment matters more than stitching in nerve regeneration ✅ How the device reduces surgical time and technical difficulty ✅ The role of shape-memory alloys in medical devices ✅ How this tech may reduce neuroma risk and improve outcomes ✅ What this means for trauma, hand surgery, and nerve injuries Whether you're a surgeon, medical student, bioengineer, or just into cutting-edge medical tech, this conversation offers a rare look at how real innovation happens—and how it can change patient outcomes. 🎧 Don't miss this deep dive into the future of nerve repair and regenerative surgery. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 – NerveTape Overview   01:27 – Dr. Clements' Background   07:40 – What Is NerveTape?   12:36 – Limits of Sutures   18:00 – How NerveTape Works   25:00 – Why Nitinol   29:02 – Repair Technique   31:00 – Clinical Results   35:00 – Key Benefits   40:00 – Future Updates   45:00 – Device Design   50:00 – Surgeon Adoption   54:00 – FDA & Market   57:00 – Final Takeaways   62:00 – Outro -- Hashtags -- #NerveRepair #MedicalInnovation #PeripheralNerves #SurgicalTechnology #RegenerativeMedicine #Neuroscience #FutureOfSurgery

    1h 2m

  6. JAN 19

    Astaxanthin and Cancer Recovery (Part: 2) | Samuel Shepherd | S8 - E4

    In this video: Astaxanthin and Cancer Recovery (Part: 2) | Samuel Shepherd ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com ✅Valasta : https://valasta.net/  (Checkout with code POI5 for 5% discount) What if chronic inflammation is the common thread behind many of today's most serious diseases—and what if reducing it at the cellular level could change how we think about prevention and treatment? In this episode, Dr. Barrett continues his conversation with biochemical engineer Samuel Shepherd, who began studying oxidative stress and inflammation after facing a serious health diagnosis of his own. What followed was years of research into reactive oxygen species, protein damage, and mitochondrial stress—and how compounds like astaxanthin may influence these processes. This is a deep, science-focused discussion on how inflammation develops, how cells get damaged, and why aging increases disease risk—not a typical supplement talk. In this episode, we discuss: ➡️How oxidative stress and free radicals damage proteins, DNA, and mitochondria ➡️Why antioxidant defenses decline with age ➡️The role of protein folding in insulin function and metabolic health ➡️New ways researchers are thinking about neurodegenerative disease mechanisms ➡️How inflammation and cellular stress may contribute to heart and brain disorders ⚠️ Important: This episode is for educational purposes only. It does not provide medical advice or claim to diagnose, treat, or cure any disease. Always consult qualified healthcare professionals for medical conditions. If you're interested in biochemistry, inflammation, aging, and the future of disease prevention research, this episode will challenge how you think about health at the cellular level. 🔔 Subscribe for more long-form conversations on emerging health science and medical research. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction & Episode Overview 01:21 The "Trojan Horse" Glucose Mechanism 02:19 How Glucose Improves Absorption 02:24 Cancer Cell Targeting Explained 07:05 Cancer Marker Spike Phenomenon 07:46 Dosing Protocol & hsCRP Testing 08:01 Additional Inflammation Markers 08:16 The "Tree" Model of Disease 10:57 Antioxidant Power Comparison 13:09 Why Baseline Testing Matters 13:26 Cholesterol vs Inflammation 16:44 Samuel's Cardiac Case 21:11 His Wife's Heart Results 21:22 Genetics Joke Moment 21:46 Cardiologist's Response 22:24 Brain vs Heart Cholesterol Paradox 23:35 Inflammation Behind Disease Deaths 23:59 Legal Challenges Explained 24:08 Oncologist's Call About Hospice Patients 26:28 Oncologist Rejects Chemo for Family 26:34 Prostate Cancer Case Results 26:28 Limits of Medical Imaging 27:17 Biopsy Risks 29:20 Upstream Intervention Strategy 29:20 Parkinson's Case Discovery 31:29 Parkinson's Mechanism Revealed 32:03 Dopamine and Hydroxyl Reaction 34:53 Why Standard Parkinson's Treatment Fails 34:53 Estrogen and Breast Cancer Mechanism 34:53 Testosterone and Prostate Cancer Parallel 35:16 Why Young People Are Protected 36:20 Infertility Crisis Discussion 37:42 Genetic Evidence Discussion 42:58 Synthetic Organism Example 42:58 mRNA Persistence Concerns 43:41 Molten Aluminum Burn Story 46:17 Healing and Pain Modulation 47:21 Free Radical Balance Equation 48:19 Serendipity of the Discovery 49:05 Global Impact of ValAsta 49:41 Future Book Plans 50:00 Contact Information 50:43 Closing Thoughts -- Hashtags -- #InflammationScience #Astaxanthin #CellularHealth #LongevityResearch #OxidativeStress #HealthPodcast #Biochemistry

    55 min

  7. JAN 12

    Astaxanthin and Cancer Recovery | Samuel Shepherd | S8 - E3

    In this video: Astaxanthin and Cancer Recovery | Samuel Shepherd ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com What would you do if you were told you had anywhere from 10 minutes to 10 years to live? In this episode, Dr. Barrett sit down with Samuel Shepherd, biochemical engineer, who shares his personal journey after being diagnosed with polycythemia vera, a rare blood disorder, and how that diagnosis led him to investigate the role of oxidative stress, free radicals, and cellular damage in chronic disease. His research led him to study astaxanthin, a powerful carotenoid found in nature, and how it may influence inflammation, mitochondrial health, and oxidative balance at the cellular level. This is not a typical supplement conversation. It's a deep dive into biochemistry, reactive oxygen species (ROS), protein misfolding, and immune signaling—and how these processes may be involved in conditions like cancer, diabetes, and neurodegenerative disease. In this episode, we discuss: ➡️How oxidative stress and free radicals damage DNA and proteins ➡️The role of mitochondria and inflammation in chronic disease ➡️Why antioxidant defenses decline with age ➡️How protein misfolding may contribute to insulin resistance ➡️Why astaxanthin has become a major focus of his research ⚠️ Important: This episode is for educational discussion only and does not replace medical care. Cancer and chronic disease require professional diagnosis and treatment. Always consult qualified healthcare providers before making medical decisions. If you're interested in biochemistry, longevity research, inflammation, and cellular health, this conversation will give you a new way to think about why disease develops—and what future research may reveal. 🔔 Subscribe for more conversations on cutting-edge health science and emerging medical ideas. Follow Pod of Inquiry 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction & Episode Overview 01:48 Sam's Medical Crisis Begins 02:43 Diagnosis: Polycythemia Vera 04:46 Treatment and Prognosis 06:30 The Question That Changed Everything 08:21 Discovery of a Common Thread 09:25 What Is Astaxanthin? 10:21 Algae Cultivation Technique 12:04 First Dosing Experiments 13:19 Dose Escalation Results 15:00 Mathematical Dose Projection 16:56 Effects at High Dose 17:04 Understanding the Mechanism 20:50 The Hydroxyl Free Radical 21:35 How Mutations Occur 22:51 Inflammation Marker Discovery 24:07 Glutathione and Aging Study 25:00 Antioxidant Decline After 50 27:07 Neutralizing Free Radicals 28:01 Commercial Production Begins 29:01 First Cancer Patient Case 29:52 High-Risk Treatment Decision 31:06 Dramatic Recovery 32:03 MD Anderson Findings 33:41 Blood Marker Discovery 35:00 Pathologist Confrontation 36:01 Expanding Treatment Cases 37:00 Glioblastoma Outcomes 37:48 Washington DC Presentation 38:57 NIH Research Funding 39:35 Diseases Linked to ROS 40:00 Protein Misfolding Mechanism 40:55 Insulin Resistance Explained 42:39 Type 2 Diabetes Effects 45:00 Alzheimer's Disease Mechanism 46:39 MIT Light Therapy Study 47:45 Non-Invasive Light Therapy 48:53 Two-Pronged Alzheimer's Strategy 49:53 The Role of ROS Balance -- Hashtags -- #Astaxanthin #OxidativeStress #CellularHealth #LongevityScience #InflammationResearch #HealthPodcast #Biochemistry

    53 min

  8. JAN 5

    HRV and Immune Function | Andrew J. Holman, M.D. | S8 - E2

    ✅StemRegen: http://www.stemregen.co/drstephen  (Special Offer: Save 15% Using Code "SBPOD" At Checkout) ✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF (A Trusted Source for Natural & Synthetic Bioregulators) ✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz  Your 10% discount code is POI10  ( Photonic EMF Protection + Bio Tuning ) ✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/ (Non-licensed patients can use code "sbarrett" for a 10% discount.) Please register your patients at - www.tremorstudy.com What if a 5-minute test could predict—with 90% accuracy—whether a $50,000 medication will actually work for you? In this episode, Dr. Barrett sits down with Dr. Andrew Holman, rheumatologist and CEO of Inmedix, to explore the hidden biology of stress and how it directly controls your immune system—millisecond by millisecond—through heart rate variability (HRV). This isn't another generic "manage your stress" talk. We dive into measurable, clinical-grade HRV and how it's changing the way doctors predict treatment response in rheumatoid arthritis, autoimmune disease, and chronic pain. In this episode, you'll learn: ➡️Why wearables like Oura Ring and Whoop don't tell the full clinical story ➡️The surprising link between sleep apnea and rheumatoid arthritis (even without snoring) ➡️How stress biologically regulates immune function in real time ➡️How an FDA-cleared HRV test measures both branches of the autonomic nervous system ➡️Why this technology could save $34 billion in healthcare costs over the next decade The big takeaway: Stress isn't psychological—it's measurable physiology that may be sabotaging your treatment outcomes. If you care about precision medicine, HRV, immune health, autoimmune disease, or longevity, this is a must-watch. 🔔 Subscribe for more deep dives into cutting-edge health science. Follow Pod of Inquiry: 📘 Facebook: https://www.facebook.com/podofinquiry 📸 Instagram: https://www.instagram.com/podofinquiry 🐦 X (Twitter): https://www.x.com/podofinquiry 🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/ Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information. Timestamps:  00:00 Introduction & Episode Overview 01:38 Interview Begins 03:26 What Is Heart Rate Variability (HRV)? 04:02 HRV and the Autonomic Nervous System 05:00 Why HRV Matters Clinically 06:01 Consumer Wearables vs Medical-Grade HRV 08:18 Development of Cloud HRV Technology 09:33 Technical Requirements for Accurate HRV 10:00 Inside the Cloud HRV System 11:00 Measuring Both Sympathetic & Parasympathetic Systems 11:41 Interpreting Autonomic Measurements 13:09 Why HRV Matters in Medicine 14:27 Better Tools for Measuring Stress 14:41 Mainstream Recognition of Stress Biology 16:11 Vagus Nerve Stimulation & Immune Control 16:19 Medical School vs Modern Science 20:57 Clinical Applications & Treatment Strategy 22:39 Sleep Apnea and Rheumatoid Arthritis 23:07 Sleep Heart Health Study 23:31 Japanese RA Sleep Apnea Study 24:01 Effects of Treating Sleep Apnea 25:00 Key Lessons for Rheumatologists 25:45 The Future of Autonomic Medicine 27:19 Prevention & Risk Assessment 28:12 Predicting Rheumatoid Arthritis Risk 28:58 Restoring Physiologic Balance 29:09 Adoption of HRV in Clinical Practice 30:00 Availability & Insurance Coverage 31:34 Patient Perspectives on Stress 32:27 Future of Rheumatology Practice 33:08 Patient Demand & Treatment Limits 33:23 HRV as a Missing Vital Sign 34:10 Follow-Up Testing Strategies 34:44 Predicting Biologic Drug Response 36:27 Combination Therapy Study 38:58 East Meets West Medicine 39:08 Need for Objective Measurement 39:38 Restless Leg Syndrome & Nerve Entrapment 41:39 The Phoenix Sign Explained 42:14 Importance of Diagnostics 42:52 Atypical Disease Presentations 44:37 Economic Impact of Immuno-Autonomics 46:40 Autonomics Across Medicine 48:04 Stress, Strain, and Duress 48:40 Addressing Suffering in Medicine 50:00 About InMedix 51:01 Company Timeline & Funding 51:38 InMedix Mission 52:01 Business Development & Growth 53:35 Vision for the Future 53:56 Closing Remarks -- Hashtags -- #HRV #StressScience #AutoimmuneHealth #RheumatoidArthritis #PrecisionMedicine #ImmuneSystem #LongevityScience

    56 min
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4.8
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21 Ratings

About

The Podcast For Human Optimization And Understanding - The Pod Of Inquiry is designed to empower you with knowledge. What happens from there is up to you. Your host, Dr. Stephen Barrett, has designed this show to take you down some very deep rabbit holes hopefully bringing you back out again, relatively unscathed, but cerebrally wicked enabling a better understanding of all things worthy of inquiry. Past topics on the podcast include: Podiatry; Adhesive Arachnoiditis; Alzheimers; Antioxidants; Autoimmunity; Bioidentical Hormone Replacement Therapy; Biomechanics; Charcot Neuroarthropathy; Diabetes; Diabetic Foot Ulcers; Diabetic Neuropathy; Diagnostic Ultrasound; Direct pay medical care; Drop Foot; Functional Medicine; hallux limitus; Hallux Valgus Surgery; Hashimoto's Disease; Heel Pain; Holistic Medicine; Inflammation; Iodine; Ketamine; Melatonin; Metabolism; Mortons Entrapment; Nitric Oxide; Ozone Therapy; Pain; Palmitoylethanolamide; Peptides; Peripheral Nerve Surgery; Peripheral Neuropathy; Plantar Fasciitis; PRP; Pulsed Electromagnetic Field Therapy (PEMF); Regenerative Medicine; Remy; Restless Leg Syndrome; Stem Cells; Sub clinical nerve entrapment; Tarsal Tunnel; The Phoenix Sign; Thyroid; Triglycerides; and more.

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