Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

Kent Holtorf, MD
  • 4.6 (19)
  • HEALTH & FITNESS
  • UPDATED WEEKLY

Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

  1. 4D AGO

    How Hydrogen Gas Affects Peptides

    Can drinking hydrogen water really restore your gut, boost your mitochondria, and slow aging? In this episode of Peptides & Longevity, Dr. Paul Barattiero joins us to explain the history of hydrogen water, its medical applications, and current research. We discuss how molecular hydrogen functions as a selective antioxidant and impacts pathways, telomerase, and mitochondria.  Dr. Barattiero emphasizes the importance of gut terrain: after antibiotics and environmental chemicals, restoring the gut’s electrical potential and microbial balance is essential, and dissolved hydrogen may support this process. He suggests mimicking natural gut fermentation by drinking hydrogen water several times per day. He also touches on spacing hydrogen from ozone therapy, field experiences ranging from energy and sleep to vision and reflux anecdotes, and briefly outlines his team’s electromagnetic field solution that depolarizes radiation and lowers signal strength in a defined area. Dr. Paul Barattiero is a leading voice in the field of molecular hydrogen and the founder of Echo Water. His journey began nearly two decades ago when his wife’s chronic illnesses weren’t improving with conventional medicine. After discovering the power of dissolved hydrogen in water, he dove deep into the research and witnessed firsthand the profound impact it had on her health. Inspired by her transformation, he dedicated his career to advancing hydrogen technology and making it accessible for both patients and practitioners. Today, he develops innovative solutions that support gut health, reduce oxidative stress, and even protect against electromagnetic fields. ----- Dr. Paul Barattiero Website: https://echowater.com/ Instagram: https://www.instagram.com/echohydrogen/?hl=en LinkedIn: https://www.linkedin.com/company/echohydrogen/ Facebook: https://www.facebook.com/echohydrogen ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    53 min

  2. AUG 27

    Creating a New You: The Use of Peptides, Hormones, and Regenerative Medicine Techniques to Look Your Best for Life Without Surgery

    Want to look younger, feel stronger, and live longer? Start with these six foundations. In this episode of Peptides & Longevity, Dr. Michael Meighen explores the six foundations of true vitality—sleep, nutrition, movement, stress balance, and hormone health—as the cornerstones of longevity and aesthetics. He also shares the latest regenerative therapies, peptides, and biohacking tools that help patients heal, look younger, and extend their healthspan. Peptides, stem cells, and hormone optimization are powerful—but only if the foundations are solid. In this episode of Peptides & Longevity, Dr. Michael Meighen joins us to bring a holistic and evidence-based approach to anti-aging, musculoskeletal health, and aesthetics. He stresses the importance of “lower-hanging fruit” like restorative sleep, proper nutrition, stress management, and movement, noting that no therapy works unless these foundations are in place. He also explains how balancing cortisol, optimizing diet to control blood sugar and insulin, and embracing lifestyle practices like time in nature and intentional exercise are key to healing and longevity. Dr. Meighen also introduces regenerative and functional interventions that extend beyond traditional medicine. He highlights the benefits of prolotherapy, platelet-rich plasma, stem cells, and certain peptides for joint repair, aesthetics, and recovery. The conversation expands into hormone optimization for mood, brain health, and vitality, as well as biohacking tools like hyperbaric oxygen therapy, infrared sauna, and cold immersion. He emphasizes symmetry, functional movement, and personalized testing as markers of true vitality—helping patients not just live longer, but thrive with confidence and energy. Dr. Michael Meighen is a physician, author, and health optimization specialist focused on regenerative medicine, aesthetics, and total body transformation. Board-certified in physical medicine, rehabilitation, and pain medicine, he brings over two decades of experience helping patients restore mobility, reduce pain, and extend vitality through conservative, non-operative treatments. Dr. Meighen is the bestselling author of A New You: Using the Body’s Regenerative and Restorative Powers to Optimize Orthopedic, Hormonal, and Sexual Health Function and a contributing author to The Codes of Longevity. He integrates advanced regenerative therapies—including platelet-rich plasma, stem cells, and peptide protocols—with hormone optimization, fitness strategies, and biohacking tools to help his patients achieve peak performance and aesthetic confidence. His mission is to empower people to live longer, stronger, and healthier lives by addressing root causes and unleashing the body’s innate healing power. Michael Meighen LinkedIn: https://www.linkedin.com/in/michael-meighen-6a882316b/ ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    59 min

  3. AUG 20

    Using Peptides to Help Master Love, Sex & Intimacy

    Your libido isn’t gone—it’s just waiting for the right support. In this episode of Peptides & Longevity, Dr. Nick Delgado joins us to dive into the science and practice of creating a fulfilling sex life that lasts well into later years. From communication and intimacy strategies to hormone optimization and peptide therapy, he shares practical ways to boost vitality, intimacy, and longevity. In this episode of Peptides & Longevity, Dr. Nick Delgado challenges cultural myths and common misunderstandings about sexual health, intimacy, and performance. He explains that while 95% of men believe they are great lovers, the majority of women report not experiencing orgasm in their relationships—a disconnect rooted in lack of communication, inadequate foreplay, and male insecurity. Drawing on decades of research and clinical practice, Dr. Delgado emphasizes that true intimacy depends on dialogue, patience, and understanding women’s unique physiology. Beyond the bedroom, he explores how lifestyle and science intersect to extend both sexual vitality and life itself. He outlines the importance of hormone optimization, detoxification of harmful estrogens, plant-based nutrition, adrenal support, and the use of certain peptides. These tools, he argues, not only enhance sexual performance but also improve longevity, immune function, and quality of life. The conversation is both entertaining and deeply educational, offering actionable strategies for couples and individuals seeking to feel younger, healthier, and more connected. Website: https://nickdelgado.com/ Instagram: https://www.instagram.com/dr.nickdelgado/ Facebook: https://www.facebook.com/theagedoc YouTube: https://www.youtube.com/@DelgadoProtocol ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    1h 23m

  4. AUG 13

    The Ultimate Peptide Cheat Sheet: Everything You Need to Know to Master Your Health

    Want to use peptides safely and effectively? In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith joins us to distill decades of clinical experience into a discussion on peptides for pain relief, fascia health, brain injury recovery, immune balance, and performance optimization. She shares real-world cases, practical protocols, and her philosophy on starting safely and effectively with these powerful tools. In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith gives us a masterclass on the diverse applications of peptides in clinical practice. Drawing from her background in internal medicine, functional medicine, regenerative therapies, and athletic coaching, she explains how specific peptides can be matched to the type of injury or dysfunction—whether that’s joint degeneration, fascia restriction, immune imbalance, or neurotrauma. She emphasizes the importance of fascia as an interconnected signaling network and outlines how combining physical manipulation with targeted injections or intravenous therapy can produce rapid, lasting results. Dr. O’Neil-Smith also details her personal experience using peptides to restore her son’s health after a severe traumatic brain injury, walking through the specific compounds, timing, and combinations she used for inflammation control, nerve regeneration, and whole-body recovery. The conversation expands into immune system assessment, gut-brain connections, mitochondrial health, performance optimization for elite athletes, and strategies for healthy aging. Throughout, she underscores that the key to success is starting somewhere with safe, foundational peptides and adapting as the patient’s needs evolve. Dr. Kathleen O’Neil-Smith is a physician, lecturer, and researcher specializing in peptides, regenerative medicine, and functional health. A magna cum laude graduate of Boston University School of Medicine, she completed postgraduate training in pathology at Harvard/Mass General and internal medicine at Brigham and Women’s Hospital. With additional certifications in stem cell therapies, traumatic brain injury treatment, and exercise physiology, she has served as founder of the International Peptide Society and Clinical Peptide Society, and as a senior lecturer at leading medical conferences worldwide. Known for her innovative, compassionate approach, Dr. O’Neil Smith integrates advanced peptide protocols, medicinal signaling therapies, and performance strategies to help patients—from elite athletes to complex chronic cases—achieve optimal health and recovery. ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    1h 3m

  5. AUG 6

    Combatting the Effects of Stress and Intense Physical Activity: How Peptides Can Help Keep Your Body in Peak Condition

    Meet the bioregulators: the small but mighty peptides rewriting the science of aging. In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explore the fascinating world of peptide bioregulators, their origins, and their profound impact on health and aging. He explains how these small yet powerful molecules can support immune function, hormone balance, and organ health while offering remarkable safety and adaptability. In this episode of Peptides & Longevity, Jean-François Tremblay joins us to explain peptide bioregulators—small chains of amino acids with the potential to revolutionize modern medicine. He shares the surprising history of their discovery during the Cold War and how early studies revealed their ability to influence longevity, immune function, and organ repair. Tremblay explains that while over 25 peptide bioregulators are currently well-studied, discoveries continue to expand our understanding of their therapeutic promise. He highlights certain peptides that have shown benefits for anti-aging, hormonal health, fertility, and joint support. Tremblay emphasizes their unique ability to adapt to the body’s state, working like “intelligent molecules” that restore balance without forcing unwanted effects. This episode offers a compelling look at why peptides could shape the future of preventive and regenerative medicine. Jean-François Tremblay is a biochemist and pharmacology expert with over two decades of experience in peptide research and application. He completed his undergraduate studies in biochemistry, mechanical engineering, and kinesiology before earning a master’s degree in pharmacology. He has consulted on peptides for anti-aging, sports performance, and overall health, and founded his own company specializing in the synthesis of peptides. Tremblay is widely respected for making complex science approachable, combining a wealth of knowledge with a passion for helping people live healthier, longer lives. ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    36 min

  6. JUL 30

    When It Sucks To Be A Woman: The Treatment Of Pelvic Problems, Incontinence, And Other Taboo Topics

    Why is no one talking about pelvic health? In this episode of Peptides & Longevity, Dr. Betsy Greenleaf sheds light on the often-overlooked world of pelvic health. She discusses the root causes of incontinence, pelvic pain, and chronic infections—revealing certain peptides that offer safe, effective, and holistic options for healing and prevention. Dr. Betsy Greenleaf is a urogynecologist, entrepreneur, and women’s health advocate with over two decades of experience specializing in pelvic medicine and reconstructive surgery. She made history as the first female in the United States to become board-certified in urogynecology, and she continues to lead the field with a holistic, patient-centered approach to care. Dr. Greenleaf is also the CEO of The Pelvic Floor Store, an online marketplace dedicated to providing reliable products for pelvic health. She also hosts Some of Your Parts Podcast, where she explores the mind-body-spirit connection in women’s wellness. Recognized as a Distinguished Fellow of the American College of Osteopathic Obstetrics and Gynecology, she is a sought-after speaker, educator, and media contributor, dedicated to breaking the silence around pelvic health and empowering women with innovative, effective solutions. Dr. Betsy Greenleaf ://pelvicfloorstore.com/ LinkedIn: http://linkedin.com/in/drbetsygreenleaf/ Instagram: https://www.instagram.com/drbetsygreenleaf/ Facebook: https://www.facebook.com/dr.betsy.greenleaf YouTube: https://www.youtube.com/@dr.betsygreenleaf7401 TikTok: https://www.tiktok.com/@drbetsygreenleaf ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    51 min

  7. JUL 23

    Microbiome, Mycology, and More!

    Discover how your gut’s microbial balance affects everything from stress to drug absorption. In this episode of Peptides & Longevity, Afif Ghannoum joins us to unpack the science of the gut microbiome and reveals how imbalances in this ecosystem can disrupt digestion, drug effectiveness, stress response, and immunity. In this episode of Peptides & Longevity, Afif Ghannoum, a biotechnology entrepreneur, breaks down the emerging science of the total microbiome—including bacteria, fungi, and viruses—and its massive impact on digestion, disease, drug response, and overall health. He shares insights from his father, Dr. Mahmoud Ghannoum, who coined the term ‘mycobiome’ and has led groundbreaking research into how fungi and bacteria form biofilms in the gut, driving inflammation and digestive disorders. Together, they developed BIOHM Health to bring this research to consumers with innovative testing and probiotic solutions. Afif also reveals surprising truths—like how stress, over-exercise, and restrictive diets can damage the microbiome, and how fungi aren’t inherently bad but vital to gut balance. He explains why prebiotics (dietary fibers that nourish good microbes) may be more important than probiotics alone, and how proper microbial balance affects pain, stress response, immunity, and even medication effectiveness. This is a powerful conversation for anyone who’s struggled with gut issues, chronic symptoms, or confusion about which ‘health rules’ to follow. Afif Ghannoum Website: https://www.biohmhealth.com/ LinkedIn: https://www.linkedin.com/in/afifghannoum/ Instagram: https://www.instagram.com/biohmhealth/ ----- ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    44 min

  8. JUL 16

    Can Peptides Be Utilized to Combat Viruses?

    Could balancing this overlooked system be the key to recovering from COVID-19? In this episode of Peptides & Longevity, Dr. Leo Galland joins us to unpack the critical role of the angiotensin pathway and peptides in addressing inflammatory bowel disease and even complications from COVID-19. He also shares insights into balancing the body’s natural systems to prevent infection, heal inflammation, and restore health. In this episode of Peptides & Longevity, Dr. Leo Galland dives deep into the science behind the angiotensin pathway and how its imbalance plays a major role in the severity of infections from COVID-19. He explains how the angiotensin pathway protects the heart, brain, and blood vessels, and how the virus hijacks this system to wreak havoc. He explores how blocking furin with peptides could prevent the virus from replicating at its first point of entry, the nose. Dr. Galland also highlights his pioneering work with certain peptides for treating inflammatory bowel disease and other gut conditions. He shares practical, individualized strategies that go far beyond one-size-fits-all medicine, emphasizing the importance of the gut microbiome, the viral biome, and how these emerging tools can help patients heal when mainstream treatments fail. This is a must-watch for anyone curious about the future of peptides, immune health, and personalized healing. Dr. Leo Galland is a board-certified internist and recognized leader in integrative and functional medicine, specializing in the evaluation and treatment of patients of all ages with complex chronic disorders. A graduate of Harvard University and the New York University School of Medicine, he has pioneered the study of the gut microbiome and intestinal permeability decades before they became mainstream, transforming how we understand the links between digestive health, inflammation, and immune resilience. Known for developing innovative nutritional therapies for autoimmune, inflammatory, allergic, infectious, and gastrointestinal conditions, Dr. Galland views the doctor-patient relationship as a true partnership, empowering people to take control of their own healing journey. His groundbreaking work has earned him multiple awards, including the Linus Pauling Award from the Institute for Functional Medicine and the Albert Nelson Marquis Lifetime Achievement Award. He serves on the medical advisory board of The Global Lyme Alliance and the Long Covid Advisory Group of the World Health Network, continuing to push the boundaries of what’s possible in personalized medicine. Website: https://www.drgalland.com/ Facebook: https://www.facebook.com/leogallandmd/  Instagram: https://www.instagram.com/dr.leogalland/ ----- Integrative Peptides Website: https://integrativepeptides.com/ Facebook: https://www.facebook.com/integrativepeptidesofficial/ Instagram: https://www.instagram.com/integrativepeptides/ ---- Holtorf Medical Group Website: https://holtorfmed.com/ Facebook: https://www.facebook.com/holtorfmed/ Instagram: https://www.instagram.com/holtorfmedicalgroup/ ---- Kent Holtorf, MD YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A ---- Produced by DrTalks  https://drtalks.com/podcast-service/

    58 min
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4.6
out of 5
19 Ratings

About

Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

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