DoctorPodcasts || Cykiert Files

Robert Cykiert, M.D. - Physician creator, writer, producer, director and host.
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DoctorPodcasts: The leading physician-hosted video podcasts that inform, inspire, & build trust in health and medicine. Created, written, directed, produced & hosted by physician, Robert Cykiert, M.D.

  1. Sep 27

    New FDA-Approved BEQALZI Cancer Pill For Mantle Cell Lymphoma. Watch oncologist from MD Anderson Hospital in Houston Texas.

    New FDA-Accelerated approval for BEQALZI pill to treat Mantle Cell Lymphoma cancers that are resistant to or recur with older treatments. Watch video podcast with expert, Michael Wang, M.D. , who explains the disease and BEQALZI made by BeOne Medicines.DoctorPodcasts EPISODE 170 Timeline/ Chapters: - Introduction & Welcome - Meet Dr. Michael Wang (MD Anderson Cancer Center) - What Is Lymphoma? (Liquid Cancers vs. Solid Tumors) - What Makes Mantle Cell Lymphoma Unique & Difficult to Treat? - Who Gets Mantle Cell Lymphoma? (Demographics & Risk Factors) - Symptoms of Mantle Cell Lymphoma - How MCL Is Diagnosed: Biopsies, Markers & Flow Cytometry - The Evolution of Treatment: Moving Beyond Chemotherapy - Targeted Therapies: BTK Inhibitors & CAR T-Cell Therapy - Understanding BCL-2 Inhibitors in Cancer Mitochondria - BEQALZI (Sonrotoclax): Breakthrough BCL-2 Inhibitor - What Is FDA Accelerated Approval? - BEQALZI Clinical Trial Results & Response Rates - Dosing & Treatment Duration (Once-Daily Pill) - Availability & Sonrotoclax vs. Venetoclax - BeOne Medicines & Global Collaboration - Conclusion & Closing Remarks

    New FDA-Approved BEQALZI Cancer Pill For Mantle Cell Lymphoma. Watch oncologist from MD Anderson Hospital in Houston Texas.

  2. Sep 19

    New FDA-Approved Gastro-Esophageal Cancer Breakthrough: How ZIIHERA Works; Oncologist Explains

    What is ZIIHERA, and how is this newly FDA-approved targeted therapy transforming the treatment of advanced HER2-positive gastroesophageal cancer? In this episode 168 of DoctorPodcasts: Cykiert Files, host Dr. Robert Cykiert is joined by two world-renowned oncology experts: • Dr. Geoffrey Ku – Associate Attending Physician, Gastrointestinal Oncology Service at Memorial Sloan Kettering Cancer Center (MSKCC) & Phase 3 trial investigator. • Dr. Robert Iannone – Executive Vice President, Global Head of R&D, and Chief Medical Officer at Jazz Pharmaceuticals. Together, they break down the groundbreaking science behind ZIIHERA, the landmark HORIZON-GEA-01 Phase 3 trial results, managing treatment side effects (including diarrhea prophylaxis), biomarker testing (HER2 & PD-L1), and what this means for patients with metastatic and locally advanced esophageal, GE junction, and gastric adenocarcinoma cancers. 📌 In This Episode, You’ll Learn: • What gastroesophageal adenocarcinoma (GEJ cancer) is and key risk factors (acid reflux, Barrett’s esophagus, H. pylori). • How ZIIHERA’s unique bispecific HER2 antibody mechanism differs from standard therapies like Herceptin (trastuzumab). • Key survival and progression-free survival findings from the HORIZON-GEA-01 Phase 3 study. • Why ZIIHERA combined with immunotherapy benefits patients regardless of PD-L1 status. • Essential clinical guidance on managing and preventing GI side effects. • Why comprehensive biomarker and HER2 testing is vital for every patient. ⏱️ TIMELINE / CHAPTERS: 00:00 - Introduction to Gastroesophageal Cancer & ZIIHERA 00:43 - Introducing Dr. Geoffrey Ku (MSKCC) & Dr. Robert Iannone (Jazz Pharmaceuticals) 02:16 - What is Gastroesophageal Adenocarcinoma (GE Junction & Stomach Cancer)? 03:27 - Risk Factors: Acid Reflux, Barrett’s Esophagus, Obesity & H. Pylori 06:43 - Why Esophageal and Stomach Cancers Are Often Diagnosed Late 09:17 - Understanding HER2-Positive Cancer & Key Biomarkers (PD-L1, MMR, Claudin 18.2) 12:25 - Evolution of 1st-Line Treatment: Chemo, Trastuzumab & Immunotherapy 14:06 - How ZIIHERA (Zanidatamab) Was Developed & Mechanism of Action 17:03 - Biliary Tract Cancer Approval to Gastroesophageal Phase 3 Trials 19:30 - HORIZON-GEA-01 Phase 3 Trial Design & FDA Approval Indications 20:56 - Efficacy Across PD-L1 Positive and Negative Patients 22:20 - Metastatic vs. Locally Advanced Disease & Potential Curative Setting 26:13 - Safety Profile & Managing Side Effects (Diarrhea Prophylaxis Protocols) 31:08 - Cardiac Monitoring & Drug Tolerability 31:47 - Dosing, Administration Route & Treatment Duration 33:28 - Overall Survival & Progression-Free Survival Data Breakdown 39:16 - Patient Quality of Life During Treatment 40:17 - Encouragement for Patients & Families Considering Targeted Therapy 44:06 - Nationwide Availability & Global Regulatory Status (Project Orbis) 46:11 - The Critical Importance of Routine HER2 Biomarker Testing 48:11 - Future Applications of ZIIHERA & Jazz Pharmaceuticals Oncology Pipeline 51:09 - Concluding Remarks & Summary 🔔 Please subscribe to DoctorPodcasts: Cykiert Files for expert discussions on medical breakthroughs, clinical trials, and healthcare innovations. Disclaimer: This video podcast is for educational and informational purposes only and does not constitute personalized medical advice. Please consult your physician or qualified healthcare provider regarding specific medical conditions or treatments. #EsophagealCancer #ZIIHERA #StomachCancer #Oncology #CancerResearch #HER2Positive #Immunotherapy #CancerBreakthrough #MedicalPodcast #JazzPharmaceuticals #Cykiert #DoctorPodcasts

    New FDA-Approved Gastro-Esophageal Cancer Breakthrough: How ZIIHERA Works; Oncologist Explains

  3. Sep 11

    Sanofi FDA-Approved Breakthrough Cancer Treatment Technology Is Transforming Multiple Myeloma Care

    In this episode 167 of DoctorPodcasts: Cykiert Files, we explore the groundbreaking advancements in cancer therapy and how Sanofi’s new FDA-approved treatment Sarclisa Escena via a CirCLIQ On‑Body Injector https://pro.campus.sanofi/us/products/sarclisa is revolutionizing multiple myeloma patient care and improving patients' quality of life. It's also benefiting physician and healthcare provider efficiencies while reducing healthcare costs.Learn how this targeted therapy works from Mayo Clinic Multiple Myeloma expert, Sikander Ailawadhi, M.D., https://www.mayoclinic.org/biographies/ailawadhi-sikander-m-d/bio-20087330, the clinical data behind its approval, and what this means for patients, oncologists, and the future of oncology treatments.⏱️ TIMESTAMPS / CHAPTERS00:00 - Introduction to Multiple Myeloma & Recent Breakthroughs03:15 - What is Multiple Myeloma? (Disease Overview)07:45 - The Science Behind Sanofi’s FDA-Approved Treatment12:30 - Key Clinical Trial Results & Patient Outcomes18:10 - How This Treatment Compares to Standard of Care23:40 - Future Outlook for Multiple Myeloma Therapies28:10 - Final Thoughts & Summary💬 JOIN THE CONVERSATIONHave questions about this new FDA approval or current cancer treatment advances? Drop your thoughts or questions in the comments below!👍 Like this video if you found it informative, and Subscribe to DoctorPodcasts: Cykiert Files for in-depth medical discussions, expert interviews, and healthcare breakthroughs.🔔 DISCLAIMERThe information provided in this video podcast is for educational and informational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional regarding any medical condition or treatment.🏷️ HASHTAGS#MultipleMyeloma #CancerResearch #Oncology #FDAApproval #CancerTreatment #MedicalBreakthrough #DoctorPodcasts #CirCLIQ #On-Body Injector#Sanofi #Sarclisa #Sarclisa Escena #Cykiert

    Sanofi FDA-Approved Breakthrough Cancer Treatment Technology Is Transforming Multiple Myeloma Care

  4. Sep 11

    Colon Cancer Screening: At-Home Cologuard Plus & FDA-approved SimpleScreen CRC Blood Test Save Lives

    Colon-rectal cancer is one of the leading causes of cancer-related deaths, yet it is highly treatable and preventable when detected early. Three world-renowned experts discuss the latest breakthroughs in non-invasive colon cancer screening, including at-home @Cologuard stool DNA tests and newly FDA-approved @Freenome blood tests.00:00 - Introduction: The Power of Non-Invasive Screening 02:36 - Welcome & Meet the Expert Panel 06:31 - Colorectal Cancer Trends & The Rise in Under-50 Cases 08:30 - Early Warning Signs vs. Asymptomatic Colon Cancer 09:09 - Why Screening Guidelines Lowered the Age to 45 10:40 - Why Do People Delay or Avoid Colonoscopies? 12:45 - What Is Cologuard & Multi-Target Stool DNA Testing? 15:10 - Who Is Eligible for Non-Invasive Screening? 16:04 - Step-by-Step: The At-Home Cologuard Experience 17:36 - Do At-Home Tests Replace a Colonoscopy? 18:47 - Accuracy & Clinical Data 20:23 - Patient Adherence Rates & Common Misconceptions 22:58 - Riley Ennis & The Story Behind Freenome 24:05 - How SimpleScreen CRC Uses Multiomics & AI 25:34 - SimpleScreen CRC Accuracy & PREEMPT CRC Trial Data 27:02 - Where Blood Tests Fit in the Screening Cascade 28:24 - Overview of New FDA-Approved Non-Invasive Options 29:07 - Cologuard vs. Cologuard Plus: What Changed? 30:05 - Can Stool and Blood Tests Be Combined? 31:22 - Awareness Campaigns & Educating the Public 33:06 - The Future of Colonoscopies & Early Detection 34:43 - Beyond CRC: Multi-Cancer Early Detection (Lung & Pancreas) 36:26 - Insurance & Medicare Coverage Explained 38:52 - Final Takeaways & Advice for Patients

    Colon Cancer Screening: At-Home Cologuard Plus & FDA-approved SimpleScreen CRC Blood Test Save Lives

  5. Aug 30

    Ozempic Face, Skin & Body; Breast Implants, Explants, Exchanges ; Plastic Surgery for Men: Top Plastic Surgeon Reveals the Truth About Plastic Surgery

    In this episode 165 of the DoctorPodcasts show, host Dr. Robert Cykiert video interviews board-certified plastic surgeon Dr. Nirmal Nathan, founder of the Nathan Clinic in Miami, Florida to break down the massive cultural and medical shifts defining modern cosmetic surgery. From the rapid rise of GLP-1 weight loss drugs like Ozempic, Wegovy, Mounjaro, and Zepbound to the reality behind "Ozempic Face, Skin and Body," Dr. Nathan pulls back the curtain on how plastic surgeons address sagging skin without causing the dreaded "wind tunnel" look. They also dive into why millions of men are turning to cosmetic surgery in the post-COVID "Zoom Boom," the truth about secret $100K celebrity procedures, and the real life-threatening dangers of low-regulated medical tourism overseas. Whether you’re curious about deep plane facelifts, the evolution of social media beauty standards, or how conditions like diabetes impact surgical safety, this deep-dive interview provides expert clinical insights you won't find anywhere else. Subscribe to DoctorPodcasts for more exclusive medical interviews, health trends, and expert insights:⏳ TIMESTAMPS 0:00 - Introduction & Meet Top Plastic Surgeon Dr. Nurmal Nathan2:48 - The Family Legacy: Growing Up Watching Facial Reconstruction5:01 - Inside the Training of a Top Plastic Surgeon (UCSF & Miami Volume)7:05 - From Nip/Tuck to the Kardashians: What is Driving the Plastic Surgery Boom?8:14 - The COVID "Zoom Boom" & The Massive Rise of Men's Plastic Surgery9:34 - Celebrity Plastic Surgery vs. Social Media Influence: What Sets the Trends?11:05 - The Truth About $100k "Secret" Procedures & Plastic Surgery Arbitrage12:48 - The Real Dangers of Medical Tourism (Botched Work Overseas)15:28 - The GLP-1 Weight Loss Revolution (Ozempic, Wegovy, Mounjaro)17:03 - Understanding "Ozempic Face" & Advanced Facial Aging18:26 - How Deep Plane Facelifts Tighten Sagging Skin Safely (Avoiding the Wind Tunnel Look)19:03 - The "Goldilocks Sweet Spot": When Is It Safe to Get Surgery After Weight Loss?21:13 - Medical Optimization: Why a Hemoglobin A1C Under 7 Matters for Healing

    Ozempic Face, Skin & Body; Breast Implants, Explants, Exchanges ; Plastic Surgery for Men: Top Plastic Surgeon Reveals the Truth About Plastic Surgery

  6. Aug 29

    High Triglycerides 500+ and Pancreatitis: Tryngolza with Dr. Brian Bergmark

    High triglycerides over 500 can trigger life-threatening acute pancreatitis. Harvard and Brigham cardiologist Dr. Brian Bergmark explains severe hypertriglyceridemia, familial chylomicronemia syndrome, and the FDA-expanded use of Tryngolza from Ionis. In the trials, triglycerides fell about 50–70% and acute pancreatitis dropped 85%. We cover how triglycerides differ from LDL cholesterol, who needs fasting labs, why statins barely move very high TGs, how ApoC3 antisense works, and who is a candidate for treatment. Video Timestamps 00:00 - What causes high triglycerides? Genetics vs. lifestyle 01:44 - Introduction: Dr. Robert Cykiert welcomes Harvard Cardiologist Dr. Brian Bergmark 04:05 - What are triglycerides and why does the body need them?04:38 - High triglycerides vs. cholesterol: The "Amazon Truck" analogy 06:28 - Severe health risks: Cardiovascular disease and acute pancreatitis 08:57 - How to test your triglycerides: Routine blood panels and fasting rules 09:48 - What is a normal triglyceride level vs. the danger zone? 10:37 - How high triglycerides cause pancreatitis, brain fog, and abdominal pain 12:59 - The relationship between triglycerides below 500 mg/dL and stroke risk 14:44 - Why very high triglycerides can actually lead to lower LDL cholesterol 16:31 - How the new drug Tryngolza works to break down fats in the blood 17:48 - FDA approval timeline and clinical trial results: 85% risk reduction 20:35 - Who is a good candidate for a once-monthly Tryngolza injection? 21:38 - Potential side effects: Skin reactions, HbA1c changes, and liver fat monitoring 24:22 - Lifestyle modifications and diet changes vs. immediate prescription medication Host: Dr. Robert #Cykiert | Guest: Dr. Brian BergmarkFollow #DoctorPodcasts | Episode 164 #triglycerides #cardiology #Tryngolza #cholesterol #heart

    High Triglycerides 500+ and Pancreatitis: Tryngolza with Dr. Brian Bergmark

  7. Aug 19

    Musk’s SpaceX Delivers First Space-Bioprinted Organs to Earth. Exclusive with Anthony Atala, M.D.

    First kidney and liver tissues ever bioprinted in space — and they just returned to Earth on a SpaceX Dragon capsule in June 2026.In this exclusive Episode 163 of the DoctorPodcasts Show, world-leading regenerative medicine pioneer Anthony Atala, M.D. (Director, Wake Forest Institute for Regenerative Medicine) reveals how microgravity on the International Space Station produces healthier, better-organized tissues than on Earth — and how SpaceX’s frequent, reusable cargo flights have transformed the field from rare opportunities into something “almost like booking an airline trip” says Robert Cykiert, M.D. of #DoctorPodcasts.Watch the full video podcast interview to learn:• Why growing tissues in space solves major Earth-based bioprinting challenges• How astronauts use Auxilium’s onboard bioprinter to create the first-ever space-printed kidney & liver tissues• The role of patient-specific cells (no rejection risk)• The path from small tissue samples to future transplantable organs• Radiation protection strategies and organ “avatars” for deep-space travel• How these breakthroughs are already accelerating regenerative medicine for patients on EarthTimestamps:0:00 – SpaceX Dragon returns the samples & why frequent cargo flights matter1:14 – Episode intro & organ shortage crisis2:10 – Meet Dr. Anthony Atala3:39 – What is regenerative medicine?4:16 – From lab-grown bladders to 3D bioprinting5:33 – Why bioprinting is a game-changer (scalability, reproducibility, cost)6:20 – The toughest hurdles for solid organs (kidney & liver)7:14 – Sending bioprinted tissues to the ISS8:44 – How bioprinting actually works (simple explanation)10:35 – Why microgravity is better for growing tissues12:09 – Who cares for the tissues in space?13:14 – Stem cells vs donor cells14:00 – “Diet” for cells in space15:07 – Printing blood vessels with kidney tissue16:00 – Do we need a whole kidney… or just “refill the tank”?17:39 – Historic first: kidney & liver tissues printed in space19:21 – SpaceX’s game-changing frequent returns20:35 – Working with NASA, Axiom, Auxilium, CASIS & the full team22:13 – When will we have transplantable space-grown organs?23:41 – Patient’s own cells = no rejection24:22 – Brain organoids, lungs & more26:18 – Protecting tissues from space radiation28:10 – What excites Dr. Atala most + message to the publicDr. Anthony Atala is a true pioneer: 18 technologies already used in patients, 900+ peer-reviewed papers, 300+ patents, National Academy of Medicine member, and twice named to TIME’s Top 10 Medical Breakthroughs.Subscribe for more exclusive interviews with the world’s leading physicians and scientists advancing healthcare.👍 Like • 💬 Comment • 🔁 Share if this gives you hope for the future of organ transplants#SpaceX #Bioprinting #RegenerativeMedicine #AnthonyAtala #SpaceMedicine #3DBioprinting #Kidney #Liver #ISS #NASA #AxiomSpace #OrganTransplant #Microgravity #WakeForest #Cykiert #SpaceXDragon #FirstInSpace #FutureOfMedicine #TissueEngineering

    Musk’s SpaceX Delivers First Space-Bioprinted Organs to Earth. Exclusive with Anthony Atala, M.D.

  8. Aug 17

    Is Coffee Good for Your Heart? Top Cardiologist Explains New, Surprising American Heart Association Statement.

    Is coffee good for your heart, brain and body — or should you cut back on caffeine ? In this DoctorPodcasts episode 162 we talk with top cardiologist, Gregory Marcus, M.D. (UCSF), the lead author of the brand-new American Heart Association (AHA) scientific statement on caffeine and cardiovascular disease. Dr. Marcus breaks down the latest evidence on coffee, caffeine, energy drinks, AFib, heart attacks, stroke, heart failure, diabetes, and more. You’ll learn:• How many cups of coffee are considered safe for most adults• Why moderate coffee drinking may actually lower risk of certain heart conditions• The big difference between coffee and high-dose energy drinks• What the science says about caffeine and atrial fibrillation• Practical takeaways for everyday coffee drinkers Clear, evidence-based answers from the doctor who led the AHA review. Watch or listen now and decide for yourself how your daily cup(s) fit into a heart-healthy life.

    Is Coffee Good for Your Heart? Top Cardiologist Explains New, Surprising American Heart Association Statement.
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About

DoctorPodcasts: The leading physician-hosted video podcasts that inform, inspire, & build trust in health and medicine. Created, written, directed, produced & hosted by physician, Robert Cykiert, M.D.

Information

  • Creator
    Robert Cykiert, M.D. - Physician creator, writer, producer, director and host.
  • Years Active
    2023 - 2026
  • Episodes
    169
  • Rating
    Clean
  • Copyright
    © Robert Cykiert, M.D. - Physician creator, writer, producer, director and host.
  • Show Website
    DoctorPodcasts || Cykiert Files

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