The Loop Podcast: Peptides, Longevity & Women’s Wellness

Stephanie Gambetta

A podcast exploring peptides, women's health, longevity strategies, and modern wellness—through real conversations and lived experience. Hosted by Stephanie Gambetta, The Loop Podcast breaks down what’s actually working when it comes to feeling better, aging well, and taking ownership of your health.

  1. 3d ago

    Ep 75: GLP-1s, Macros & Why Eating Less Isn't Always Better | Megan Kohrs

    Certified nutrition and macro coach Megan Kohrs joins Stephanie Gambetta to talk about building a healthier relationship with food, understanding macronutrients, and why eating less isn't always the answer when you're trying to lose fat or build muscle. Megan shares her personal experience with eating disorders, body dysmorphia, gut health issues, and food sensitivities, and how learning to properly fuel her body changed her approach to nutrition. She also shares how her journey eventually led her to become part of the Loop Health coaching team. Stephanie and Megan break down what macros actually are, why protein is especially important for women in midlife, and how to build balanced meals without obsessing over every calorie. They discuss the challenges of eating enough while taking GLP-1 medications, maintaining muscle during weight loss, and why strength training and proper nutrition need to work together. Megan also opens up about her experience with mast cell activation syndrome (MCAS), histamine reactions, and her personal experience using peptides as part of her wellness journey. Beyond nutrition, they explore the emotional side of food, from overcoming restrictive eating patterns and letting go of food guilt to enjoying vacations, restaurants, and everyday life without constantly worrying about weight gain. They also discuss motherhood, finding purpose outside of raising children, and why building confidence and a supportive community can be just as important as the food on your plate. The goal isn't another restrictive diet. It's learning how to fuel your body, build strength, and create a healthy lifestyle you can actually enjoy. This episode is for educational purposes only and does not constitute medical or nutritional advice. Consult a qualified healthcare professional for individualized guidance, particularly regarding eating disorders, GLP-1 medications, and peptides. Peptides & Compounds Discussed GLP-1 medications, including tirzepatide; KPV; BPC-157 (the transcript appears to reference it, but the wording is garbled); MOTS-c; and Selank/Semax in the closing discussion. Want to book a nutrition coaching session with Meg?  Find her at www.megkohrswellness.com Follow her on instagram @megkohrswellness - Join the Loop Health Community: https://loop.health - Signup for Loop Beauty Launch Updates: www.loop-beauty.com  Book a 1:1 coaching call with Stephanie for 30% off: https://calendly.com/stephanie-theloopway/steph-45-minute-q-a-with-peptide-coach-clone

  2. Oct 8

    EP 74: Stop People-Pleasing & Reclaim Your Power | Christine Hassler

    Master life coach and spiritual psychologist Christine Hassler joins Stephanie Gambetta for a conversation about personal growth, emotional healing, and what it really means to trust yourself. With over 20 years of coaching experience, Christine shares why so many women struggle with people-pleasing, perfectionism, and the need for outside validation, and how reconnecting with your inner authority can change the way you approach relationships, career, motherhood, and everyday life. Stephanie also opens up about her own experience working with Christine, including navigating uncertainty, surrendering control, and learning to approach difficult emotions with more compassion. Together, they explore breathwork, emotional release, old survival patterns, jealousy, comparison, and why personal growth doesn't mean you'll never struggle with the same things again. They also discuss finding confidence as women get older, the changing coaching industry, the importance of finding your own answers, and how to recognize when you're giving too much power to other people's opinions. Christine also shares stories about meeting Joe Rogan, finding love, and learning to embrace desire without turning it into suffering. They wrap up with a conversation about postpartum inflammation, peptides, and what Christine hopes to pass on to the next generation. Whether you're navigating a major life transition, feeling stuck in old patterns, or simply ready to reconnect with yourself, this episode is about learning to trust who you are instead of constantly searching for answers outside yourself. This episode is for educational purposes only and should not be considered medical or mental health advice. - Join the Loop Health Community: https://loop.health - Signup for Loop Beauty Launch Updates: www.loop-beauty.com  - Book a 1:1 coaching call with Stephanie for 30% off: https://calendly.com/stephanie-theloopway/steph-45-minute-q-a-with-peptide-coach-clone

  3. Oct 1

    EP 73: DEXA Scans, GLP-1s & The Truth About Muscle Loss | Aabid Farukhi

    Stephanie Gambetta starts this episode with a solo update on what’s happening with Loop Health, her current peptide routine, the upcoming Loop Beauty line, and some of the changes she’s making in her own health at 51. She talks about building muscle in midlife, improving her sleep during menopause, prioritizing recovery, monitoring her blood work, and the mitochondrial stack she’s currently using. She also gets personal about the realities of building Loop Health, navigating life without Instagram, experimenting with TikTok, and making more time for friendships, travel, and the things that actually fill her back up.  Then Stephanie sits down with Aabid Farukhi, a board-certified musculoskeletal radiologist, to break down DEXA scans and why the number on your bathroom scale doesn’t tell the whole story. They explain how a DEXA scan measures muscle mass, body fat, visceral fat, bone density, and even muscle symmetry between different sides of your body. Stephanie also walks through her own DEXA results, including gaining a pound of muscle while microdosing a GLP-1, and shares why she uses these scans to see whether her training, nutrition, peptides, and lifestyle are actually changing her body composition.  Stephanie and Aabid also dig into one of the biggest concerns surrounding GLP-1s: losing muscle and bone mass while losing weight. They discuss resistance training, protein, visceral fat, bone health during perimenopause and menopause, and why tracking body composition can give you a much clearer picture of your progress than obsessing over weight alone. Whether you’re using GLP-1s and peptides or simply trying to build muscle, lose fat, and stay strong as you age, this episode is about understanding what’s actually happening inside your body.  This episode is for educational purposes only and should not be considered medical advice. Always consult qualified healthcare professionals before beginning or changing medications, peptides, supplements, hormones, or other treatments. Peptides & Compounds Discussed SS-31MOTS-c5-Amino-1MQNAD+Thymosin Alpha-1KPVGLP-1 receptor agonistsGlutathioneGHK-CuProgesteroneMagnesiumCreatine LOOPHEALTH20 to get 20% off a dexascan with Dexafit OC (https://www.oc.dexafit.com/)

  4. Sep 24

    EP 72: Midlife Crisis or Midlife Awakening? The Psychology of Starting Over After 40 | Dr. Sarah Sarkis

    Psychologist Dr. Sarah Sarkis returns to The Loop Podcast to talk about the psychology of midlife and why the changes that happen in your 40s and 50s can feel so uncomfortable. Stephanie and Sarah break down the idea of a “midlife crisis” and look at what’s actually happening when your identity, relationships, career, family life, hormones, and priorities all begin shifting at the same time. Sarah explains why discomfort doesn’t necessarily mean something is wrong, how the things that worked earlier in life may need to be upgraded, and why the whispers telling you something needs to change can eventually become impossible to ignore.  Stephanie also shares what this has looked like in her own life, from divorce and rebuilding her identity to the recent challenges with Instagram, postponing her Loop event, and unexpectedly finding a new creative outlet on TikTok. They talk about what happens when your growth makes the people around you uncomfortable, why progress includes plateaus and even periods of regression, dealing with comparison and rejection, grieving an old version of your life, and learning to keep moving when you have no idea exactly where you're headed. Sarah also shares a different way to think about whether a major life change is “working”: sometimes constantly measuring your progress is perfectionism disguised as excellence. Stephanie and Sarah also preview the upcoming Aspen retreat, where Sarah will help women explore the stories they’re carrying into midlife, decide which ones still serve them, and become more intentional about what they want the next chapter of their lives to look like. Join Steph & Dr. Sarkis at the Loop retreat ( http://www.theloopway.com/events/aspen ), $500 off exclusively for podcast listeners available here:  https://buy.stripe.com/8x27sKfz30JKb1S7jo3gk01

  5. Sep 17

    EP 71: HRT, Peptides & GLP-1s: What Women Need to Know About Menopause | Karen Martel |

    Karen Martel, CEO of Midlife Solutions, joins Stephanie Gambetta for a candid conversation about perimenopause, menopause, hormone replacement therapy, peptides, GLP-1s, and what actually changes in a woman’s body during midlife. Karen shares how her own experience being pushed into early menopause at 42 changed the direction of her career, despite already working as a nutritionist and doing everything she thought was “right.” She and Stephanie break down the early signs of perimenopause, progesterone and estrogen loss, stubborn midlife weight gain, brain fog, mood changes, and why you can’t always diet, exercise, or biohack your way out of hormonal changes. Stephanie also opens up about her own HRT journey at 51, including progesterone, estrogen, testosterone pellets, and the changes she’s currently navigating. Together, she and Karen discuss why HRT and peptides can work together rather than compete, combining GLP-1s with optimized hormones, microdosing, food noise, preserving muscle, thyroid health, and why some women plateau on GLP-1s even at higher doses. They also get into starting HRT later in life, overdoing biohacking, wearable data, DEXA scans, peptide safety, and why women need individualized protocols instead of copying whatever someone else is taking online. Karen and Stephanie also challenge the idea that suffering through menopause deserves a badge of honor. The goal isn’t perfection or doing every wellness trend imaginable. It’s understanding your body, finding the right tools, and building a sustainable approach that helps you feel strong, confident, and healthy through the second half of life. Use code LOOP10 for 10% off at Midlife Solutions. Shop Midlife Solutions This episode is for educational purposes only and should not be considered medical advice. Always consult qualified healthcare professionals before beginning or changing hormones, medications, peptides, supplements, or other treatments. Peptides, Hormones & Compounds Discussed Hormone Replacement Therapy (HRT)EstrogenProgesteroneTestosteroneGLP-1 receptor agonistsRetatrutideGHK-CuTB-500BPC-157MOTS-cTesamorelinThyroid medication

  6. Sep 10

    EP 70: GLP-1s, Peptides & Why Doing Everything Right Isn’t Working | Sienna Olson

    Sienna Olson, founder of SLO Rx, joins The Loop Podcast for a conversation about what happens when you’re doing everything “right” but your body still isn’t responding. Sienna holds a Doctorate in Chiropractic and a Master’s in Sports Medicine, and her own journey from ski racing and bodybuilding to gaining 50 pounds in five months changed the way she thinks about metabolism, body composition, and women’s health. Today, she works with women who are juggling careers, families, and packed schedules but still wondering why their energy is low and their hard work isn’t showing up in the mirror. Her philosophy is simple: more isn’t better, right is. Stephanie and Sienna break down GLP-1s, peptides, protein, resistance training, body composition, and why simply increasing a dose or adding another wellness tool isn’t always the answer. They discuss tirzepatide versus retatrutide, microdosing, BPC-157, why Sienna takes a conservative approach to peptides, and how the scale can completely distort your perception of progress when you’re building muscle. They also get into comparison, consistency, sleep, finding a sustainable routine, and giving women permission to want to feel healthy, strong, confident, and hot without apologizing for it. It’s a conversation about getting away from quick fixes and finding the tools that actually fit your body and your life.  Peptides & Compounds Discussed TirzepatideRetatrutideGLP-1 receptor agonistsBPC-157SelankSemaxMicrodosing GLP-1s / peptide protocols This episode is for educational purposes only and should not be considered medical advice. Always consult qualified healthcare professionals before beginning or changing medications, peptides, supplements, training, or other treatments.

  7. Sep 3

    EP 69: Facelifts, Peptides & What Actually Works After 40 | Dr. Jonathan Zelken

    Plastic surgeon Dr. Jonathan Zelken returns to The Loop Podcast for a candid conversation about plastic surgery, peptides, aging, and the treatments that are actually worth your time and money. Stephanie opens up publicly about getting a deep plane facelift at 48, why she chose to do it before she felt like she “needed” one, and what the recovery was really like. Together, Stephanie and Dr. Zelken break down deep plane versus SMAS facelifts, fat transfer versus filler, Botox, buccal fat removal, rhinoplasty, breast augmentation, skin resurfacing, body contouring after weight loss, and why subtle results often require more work than social media makes it seem. Then they flip the script and put Stephanie in the expert seat for a rapid-fire round on peptides, GLP-1s, HRT, muscle building, sleep, libido, recovery, and injectable versus oral peptide therapy. Stephanie also challenges Dr. Zelken to try a new peptide and body-composition protocol before returning to the podcast later this year. It’s an honest, funny conversation about looking better, feeling better, and making informed choices without pretending there’s one right way to age. This episode is for educational purposes only and should not be considered medical advice. Always consult qualified medical professionals before undergoing surgery or beginning or changing medications, peptides, hormones, supplements, or other treatments. Peptides & Compounds DiscussedBPC-157TB-500CJC-1295IpamorelinGHK-CuGLP-1 receptor agonistsRetatrutideTesamorelinPT-141Thymosin Alpha-1EpitalonDSIPHGH / growth hormoneHormone Replacement Therapy (HRT)

  8. Aug 27

    EP 68: The Future of Peptides: FDA Changes, Safety & What’s Coming Next | Trevor Kruder |

    Peptide expert and manufacturer Trevor Kruder returns to The Loop Podcast for an inside look at what’s happening behind the scenes in the rapidly changing world of peptides. Trevor joins Stephanie Gambetta to break down the recent FDA hearings, what they actually mean for compounded peptides, why manufacturing quality and sterility matter, and how to tell the difference between legitimate products and questionable sources. They also explore some of the most exciting developments Trevor is working on, including Klotho research, longer-lasting peptides, oral peptide technology, new applications for women’s health, regenerative medicine, and even peptide therapies for pets. Trevor also shares an incredible personal update involving fertility after believing for decades that he couldn’t have children, while Stephanie opens up about her own experiences with peptide reactions, GLP-1 microdosing, muscle gain, and finding the right tools for her body. This episode is a deep dive into where peptide science is headed and why education, testing, quality, and responsible use matter more than ever. This episode is for educational purposes only and should not be considered medical advice. Always consult a qualified healthcare professional before starting or changing medications, peptides, supplements, or other treatments. Peptides & Compounds Discussed KlothoBPC-157TB-500CJC-1295IpamorelinTesamorelinGHK-CuGLP-1 receptor agonistsPT-1415-Amino-1MQP21NAD+GlutathioneMK-677, which Trevor specifically notes is not a peptideGrowth hormone / growth-hormone-related therapies

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A podcast exploring peptides, women's health, longevity strategies, and modern wellness—through real conversations and lived experience. Hosted by Stephanie Gambetta, The Loop Podcast breaks down what’s actually working when it comes to feeling better, aging well, and taking ownership of your health.

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