On The Pen GLP-1 News

Dave Knapp GLP-1 Industry Insider
  • 4.8 (9)
  • Medicine

On The Pen is the leading GLP-1 news podcast and platform covering obesity medicine, FDA actions, drug shortages, access policy, and the business of NuSH therapies. The podcast is in the top 1% of all podcasts globally, and On The Pen is a top Substack best-seller.

  1. Retatrutide, Multi Agonist Obesity Drugs, and the PBM Access War

    4d ago

    Retatrutide, Multi Agonist Obesity Drugs, and the PBM Access War

    https://linktr.ee/manonthemounjaro

    31 min
  2. Lilly Bets $8B on Weight Loss Future

    May 19

    Lilly Bets $8B on Weight Loss Future

    https://linktr.ee/manonthemounjaro

    23 min

  3. May 12

    The Next Two Weeks in GLP1 Are Huge, Here's Why

    http://www.otplinks.com

    1h 7m
  4. He Took Retatrutide 40mg and Proved a Point

    May 5

    He Took Retatrutide 40mg and Proved a Point

    This episode examines a serious case involving retatrutide, where an individual experienced an overdose due to improper medication administration. We discuss the critical importance of medication safety and patient safety, especially concerning prescription drugs.The discussion also touches upon a recent report of liver failure following the Foundayo launch, emphasizing the need for vigilant drug safety and thorough error analysis to prevent future incidents. https://www.otplinks.com 1. 🚨 The 40mg Retatrutide Overdose Case — 0:00:02A 32-year-old self-administered gray market Retatrutide, forgot he'd dosed, injected again — hitting 40mg. The setup for the whole episode. 2. 🏥 What Actually Happened to Him (ER Visit & Why It Matters) — 0:05:02Deep dive into the published medical case: severe diarrhea, dehydration, kidney danger, and the frightening ease with which it happened. 3. ⚠️ Gray Market GLP-1s: The Real Risk Nobody's Talking About — 0:07:20How buying unregulated research peptides means guessing on purity, dose, and contents — and why that's terrifying at scale. 4. 💊 Orforglipron (Fondayo) & the Liver Failure Report — 0:13:00 (approx.)One month after Fonda's launch, a liver failure report emerges. The FDA's concerns, elevated liver enzymes in trials, and why Lilly scaled back from 45mg to 36mg in Phase 3. 5. 🔗 How These Two Stories Connect: Clinical Trials vs. the Real World — 0:16:31The through-line of the episode: drugs behave differently outside controlled settings. Peptide influencers hawking research-grade OrforglprIon pills mid-fast is the canary in the coal mine. 6. 🚪 Compounding Access Is Being Squeezed — State Boards, Lawsuits & the Gray Market Funnel — 0:19:06State medical boards in CA, RI, and KY pressuring doctors. As regulated access tightens, patients don't stop — they just shift to riskier sources. 7. 📱 Introducing the Pivot App: A GLP-1 Tracking Tool for Patients — 0:21:55Interview with Shed's Chief Product Officer Kyler Ockey about the Pivot app — dose logging, daily habit tracking, weekly check-ins, and why patient self-tracking is critical to safe GLP-1 use.

    37 min
  5. Eli Lilly Earnings Call Recap: Q1 2026

    Apr 30

    Eli Lilly Earnings Call Recap: Q1 2026

    We just got done listening to the quarter one, 2026 Eli Lilly earnings call. There was a lot of information to get into, whether you're interested in retatrutide, eloralintide, or Foundayo, and all of the numbers that were so incredible to hear. This video analyzes Eli Lilly's Q1 2026 earnings call, discussing key products like eloralintide, brenipatide, and retatrutide, providing essential finance news and stock market news for those tracking pharmaceutical companies. The presenter highlights the strong start of Foundayo's U.S. launch and reviews the Lilly Select Pipeline, touching upon the U.S. Incretin Analogs Market and broader healthcare industry trends. WAYS TO SUPPORT MY WORK ⬇️http://www.otplinks.com💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS: BPC-157 // Can’t Weight // TB4-FRAG // KPVSign up here and use code “OTP10” to save 10%https://integrativepeptides.com/OTPWHY I TRUST INTEGRATIVE PEPTIDES:🇺🇸 Made in the USA📋 CGMP Compliant (FDA oversight of their products)🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA📕 GET MY BOOK! Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapphttps://amzn.to/4gAXrz4

    25 min
  6. SURVODUTIDE Phase 3 Data: Why Weight Loss Isn't The Whole Story

    Apr 28

    SURVODUTIDE Phase 3 Data: Why Weight Loss Isn't The Whole Story

    https://www.otplinks.com A new GLP-1 and glucagon agonist dropped data that was supposed to rival retatrutide, just without the GIP, and on the surface the results look solid. But that is not the real story. Even when people successfully lose weight, a large percentage gain it back, and for years that has been framed as a failure of discipline or willpower. This episode breaks down new research that helps explain why that happens. A study published in EMBO Reports shows that obesity can leave lasting changes at the cellular level through epigenetics, where gene activity is altered without changing the DNA itself. Researchers found that immune cells remained in a pro inflammatory, metabolically altered state even after weight loss, with some of these changes potentially lasting for years. In practical terms, this means the body does not simply return to a neutral baseline after weight loss. It can continue to operate as if it is still in an obese state, which helps explain why so many people feel like their body is working against them. This shifts the conversation away from personal responsibility and toward biology, reinforcing the idea that obesity is a chronic, relapsing metabolic disease. That distinction matters because it changes how treatment should be approached. If the underlying biology does not fully reset, then short term solutions are unlikely to be effective long term. These medications may not just be tools for losing weight, but part of ongoing management for a system that retains a memory of obesity and requires continued intervention.

    19 min
  7. BPI STOPS TIRZEPATIDE Production, Second Major Pharmacy Out!

    Apr 23

    BPI STOPS TIRZEPATIDE Production, Second Major Pharmacy Out!

    Major disruption hits the GLP-1 landscape as another large 503B compounding pharmacy halts production of semaglutide and tirzepatide. In this episode, we unpack what’s driving the FDA’s increased enforcement and why these shutdowns could signal a broader shift in the compounded medication market. Joined by Sabina Hemmi from glpwinner.com, we break down the key differences between 503A and 503B pharmacies, what these changes mean for supply and patient access, and why delays in prescriptions may be on the horizon. We also dive into the growing legal battles between pharma companies and telehealth providers and what that could mean for the future of affordable GLP-1 options. If you’re using or considering compounded GLP-1s, this episode covers what you need to know right now and what could be coming next.

    41 min
  8. Retatrutide Could Change Everything… But Who Actually Gets It?

    Apr 21

    Retatrutide Could Change Everything… But Who Actually Gets It?

    ON THE PEN RESOURCES AND LINKS: HTTPS://WWW.OTPLINKS.COM What if the most powerful obesity drug ever created ends up being the one you can’t get? That’s the real conversation around retatrutide right now. In this video, I break down what Eli Lilly is doing behind the scenes, and why this isn’t just about whether retatrutide is better than tirzepatide. This is about strategy. This is about access. And this is about who gets left behind. We’re talking about:• The push to classify retatrutide as a biologic• Why that could mean pricing in the $7,000/month range• How LillyDirect is changing access to tirzepatide• The “two lane” system that could define obesity treatment going forward• And what this means for patients already struggling to stay on GLP-1 therapies If you’ve ever fought insurance, dealt with compounding disappearing, or felt like the system decides what you’re allowed to have… this one is for you. 👇 Let’s talk about itHave you ever felt stuck between “this is working” and “this isn’t enough”… with no clear path forward?

    30 min
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Ratings & Reviews

4.8
out of 5
9 Ratings

About

On The Pen is the leading GLP-1 news podcast and platform covering obesity medicine, FDA actions, drug shortages, access policy, and the business of NuSH therapies. The podcast is in the top 1% of all podcasts globally, and On The Pen is a top Substack best-seller.

Information

  • Creator
    Dave Knapp GLP-1 Industry Insider
  • Years Active
    2K
  • Episodes
    192
  • Rating
    Explicit
  • Copyright
    © Dave Knapp GLP-1 Industry Insider
  • Show Website
    On The Pen GLP-1 News

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