The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. AI Expert Says: Humans Are Just Mystical Meat Robots

    13H AGO

    AI Expert Says: Humans Are Just Mystical Meat Robots

    What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences.  Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity.  You'll Learn:  Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit How your mitochondria pre-process sensory reality before your auditory cortex even fires Why emotions like anger, love, and remorse are computational tools evolution built into your reward function How low energy and blood sugar directly degrade your decision-making at a hardware level What "resource rationality" means and how to use it to make better decisions under constraint Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head How neuroplasticity can eliminate the inner critic and reshape your mental operating system Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence   Thank you to our sponsors!   -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -Quantum Upgrade | Try it free for 15 days — no credit card required — at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data. -Go to timeline.com/dave and save 20% with code DAVE20   Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By  Resources:    • Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 – Intro 00:50 - Tom's Background & Chronic Fatigue  10:22 – Mathematics of Mind  12:43 – Memory and Emotion  15:29 – Decision Making Under Constraints  21:10 – Computational Problems of Consciousness  24:18 – Reality Pre-Processing  26:14 – Meat Robots vs Stochastic Parrots  29:21 – Emotions: Game Theory  35:39 – Dual Systems: Model-Based vs Model-Free  39:22 – Mitochondria and Consciousness  50:00 – Testing AI Like Humans  52:11 – Choosing AI Models  57:14 – AI Research Questions  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    58 min
  2. How I Finally FIXED My Terrible Sleep After 18 Years

    2D AGO

    How I Finally FIXED My Terrible Sleep After 18 Years

    Block toxic light with these glasses: https://truedark.com/discount/DAVETUBE Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it. Thank you to our sponsors!  -Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface. Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com   Chapters: 0:00 – Introduction 0:38 – The Real Reason You're Still Tired 0:59 – How Light Controls Your Sleep Quality 1:36 – Circadian Rhythm Explained (NASA-Approved) 2:51 – The Secret Sleep Trigger 5:29 – Blue Light: The Silent Sleep Killer 6:12 – How to Hack Your Evening Light 7:52 – Screen Time vs. Sleep Time 8:12 – Social Jet Lag: The Weekend Mistake See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    10 min
  3. WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements

    4D AGO

    WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements

    This week’s stories:  Healthy Diets That Offset "Bad Genes"  A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol.  • Sources:  -https://www.science.org/doi/10.1126/sciadv.ads7559  -https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179  -https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity  Micro-Habits in Sleep, Activity, and Diet That Extend Life  Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation.  • Sources:  -https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424  -https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502  -https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life  Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure  New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too  • Sources:  -https://elifesciences.org/reviewed-preprints/108825v2  -https://www.nature.com/articles/s42255-025-01297-8  -https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review  Tyrosine and Lifespan: What the Data Says for Men  A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically   • Sources:  -https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx  -https://www.eurekalert.org/news-releases/1105915  -https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men  War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator  Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking.  • Sources:  -https://www.sciencedaily.com/releases/2024/07/240718124709.htm  -https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds  -https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers  -https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387  All source links are provided for direct access to the original reporting and research.  This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026  Thank you to our sponsors!   -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. -BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  0:00 - Introduction  0:18 - Story #1: Diet vs. Genetics  2:14 - Story #2: 1% Better Every Day  4:26 - Story #3: Sulfur Amino Acids & Fat Loss  5:55 - Story #4: Tyrosine & Longevity  7:58 - Story #5: Doomscrolling & Aging  10:00 - Weekly Roundup  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    12 min
  4. Your Brain Is 0.5% Plastic (Here’s How to Flush It)

    5D AGO

    Your Brain Is 0.5% Plastic (Here’s How to Flush It)

    Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  -Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout  Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging.  Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization.  This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.   You'll Learn:  Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine  Thank you to our sponsors!    The One Device | Use code DAVE for $10 off at http://theonedevice.com/daveHeartMath | Go to https://www.heartmath.com/dave to save 15% off.Igniton | Go to Igniton.com and use code DAVE to save 15% off.Puori | Go to http://Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding  Resources:    • Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Introduction  03:00 – Microplastics in the Brain  08:40 – Olyxir Tea Strip Solution  10:10 – Health Impacts & Weight Gain  11:05 – Environmental Solutions  14:29 – The Teabag Problem  18:57 – How to Remove Microplastics  22:04 – Olive Leaf Benefits  28:26 – Josephine's Scientific Background  33:00 – Guarana & Lymphatic Support  34:22 – Skincare & Microplastics  36:38 – Sauna Protocol  44:19 – Household Exposure Sources  47:18 – Workout Clothing Risk  48:59 – Leather vs Synthetic Fashion  50:54 – Pregnancy & Fertility  54:20 – Closing & Discount Code  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    56 min
  5. Why Are Hackers Microdosing “Sex Drugs” Now?

    MAR 3

    Why Are Hackers Microdosing “Sex Drugs” Now?

    Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice.  Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise.  This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.    You'll Learn:  Why precision medicine outperforms population-based health strategies for human performance How to layer genomics, transcriptomics, and proteomics into one complete biological picture Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits The real story on metformin, peptides, and which supplements actually move the needle How AI can help you understand your own biology and act on it faster Why biohacking precision beats random stacking every time  Thank you to our sponsors!    • Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order.  • BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off  https://beyondconference.com  • Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.  • Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs  Resources:    • Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 – Trailer  00:53 – Intro to Precision Medicine  01:58 – Dr. Bajnath's Holistic Health Journey  05:03 – Pharmaceuticals vs. Supplements  07:58 – Peptides and Longevity Molecules  10:34 – Sexual Health and Vitality  13:56 – Vascular Health and Blood Flow  15:14 – Multi-Omics Approach  19:03 – DNA and Genomics  22:17 – Transcriptomics and RNA  24:24 – Proteomics and Inflammation Markers  32:00 – The Human Exposome  34:55 – Key Health Biomarkers  36:58 – Cell Membrane Dynamics  40:28 – Biological Investment Strategy  41:53 – Life Extension Possibilities  48:52 – Bioenergetics and Mitochondria  49:47 – Quantum Medicine and the Future  51:33 – Vagal Nerve Stimulation  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    53 min
  6. A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free)

    MAR 1

    A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free)

    What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young? Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age. The twist? You can activate it in just 10 minutes a day, no prescription required. Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you... Thank you to our sponsors!  -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com   0:00 – Introduction 0:46 – Lobsters and Human Longevity Connection 1:14 – Understanding Telomeres and Aging 2:26 – How Lobsters Defy Aging 3:32 – Rethinking Aging Biology 4:53 – The Telomerase Challenge 6:43 – Natural Ways to Protect Telomeres 9:33 – Meditation's Role in Anti-Aging 11:04 – Different Meditation Techniques 13:19 – Benefits and Long-Term Effects See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    15 min
  7. Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026

    FEB 27

    Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026

    This week’s stories:  Sinclair’s This Is the Test: Are we about to see age reversal in humans?  At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.    • Sources:  – World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026    – NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair      AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine  Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.    • Sources:  – Nature: https://www.nature.com/articles/d41586-026-00365-7    – Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier    Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness  After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.    • Sources:  – New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/    – Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954    – Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM      The disease we thought was dead: measles comes roaring back  Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.    • Sources:  – AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026    – ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078    – CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections      DC vs your health: Trump’s State of the Union health reset  President Donald Trump’s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.    • Sources:  – Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup    – Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/    – This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/    All source links are provided for direct access to the original reporting and research.    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.    New episodes every Tuesday, Thursday, Friday, and Sunday.    Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update    Thank you to our sponsors!   -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  0:00 - Introduction  0:30 - Story #1: David Sinclair 2026  2:13 - Story #2: Google Drug Discovery  3:48 - Story #3: El Mencho Biohacking 5:30 - Story #4: Measles Outbreak  6:51 - Story #5: Trump State of the Union  8:00 - Weekly Roundup  9:10 - Closing  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    9 min
  8. The Secret to Staying DANGEROUS After 50

    FEB 26

    The Secret to Staying DANGEROUS After 50

    Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  -Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/  Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies.  They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You’ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting.  Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects.  Then the conversation turns into what’s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing.  You’ll Learn:  • What peptides are, explained without jargon  • Why delivery matters and why pens beat mixing vials all day  • How PK curves change real results and dosing schedules  • What elamipretide means for mitochondria and longevity  • Why MOTS-c can feel like a fast energy shift for some people  • How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support  • Why MK-677 sounds easy but can bring unwanted effects  • What Jay claims FLGR 242 does for myostatin, muscle, and fat loss  • Why Klotho shows up in longevity research and why dose matters  Thank you to our sponsors!    • 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Generation Lab | Go to https://www.generationlab.com/ and use code Dave20 for $20 off to see what your body is really doing beneath the surface.  • Pique | Establish a powerful foundation for sustained wellness at https://www.piquelife.com/DAVE and unlock 20% off.  • Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection  Resources:    • Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  0:00 – Trailer  1:22 – Introduction to Peptides  7:52 – Peptide Delivery Systems & Pens  14:22 – Safety & Regulation of Peptides  19:22 – SS-31 & Mitochondrial Health  26:22 – Blending Peptides & Cross-Linking  38:22 – Growth Hormone Peptides  44:22 – FLGR-242: The New Myostatin Inhibitor  54:22 – Melanin & Consciousness  57:22 – Klotho: The Longevity Peptide  59:25 – Regulatory Landscape & Future of Peptides  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1h 1m
4.6
out of 5
6,937 Ratings

About

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

More From Integrity Network

You Might Also Like