FitgenesUSA

FitgenesPodcast
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Join Dr. Sam Shay, DC, FMCP, and co-host Mikayla Wachsmann, MS, CNS, as they decode complex genetics into practical, actionable strategies for health, performance, and longevity. Each episode bridges the gap between clinical data and real-world results, breaking down the specific genes and pathways that actually matter—without the hype or technical noise. Whether you are working to shift your own health trajectory or you're a practitioner seeking clearer communication and better clinical outcomes, this show gives you the frameworks to make DNA truly usable. Stop guessing. Start decoding.

  1. 6d ago

    The “Sugar Sensor Gene”: Why Does Your Brain Keep Asking for More Sugar?

    Ever wonder why one cookie is never enough? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his “Frenchie”. Some people’s brains don’t “see” the sugar that’s already in their bloodstream. So they keep eating more of it to get the same “I’m satisfied” signal other people get from a few bites. Dr. Sam explains the gene behind this sugar-sensing glitch and why our ancestors were wired to hunt for sweetness. He also covers the five most common reasons people overeat sugar, and only one of them is genetic. You’ll also learn about “metabolic barbed wire.” These are hidden gut, metabolic, and energy problems that keep you from getting the full benefit of your genetic blueprint. Functional testing helps clear them so your DNA-based diet and lifestyle plan can actually work. Key topics covered in this episode:• GLUT2 (rs5400) and Sugar Sensing: How this gene works as the brain’s glucose sensor and moves sugar into cells. Certain variations may make it harder to detect circulating blood sugar, which can drive you to eat more.• Why We’re Wired for Sweet: Sugar was once rare and could keep you alive, so sweetness signaled safe, energy-dense food. Bitter taste did the opposite job and warned of poison.• Reason #1 - Emotional Eating: Using sugar to “numb out” from stress or trauma.• Reason #2 - Underlying Metabolic Dysfunction: How a misfiring metabolism or poor blood sugar regulation can leave the body craving more fuel.• Reason #3 - Gut Infections: How overgrowths like Candida may compete for your calories and fuel cravings for quick energy.• Reason #4 - Mineral and Nutrient Deficiencies: Your body may crave sweets when it’s really looking for the vitamins and minerals that sugar-rich whole foods like fruit used to supply.• Reason #5 - Mitochondrial Damage: Damaged mitochondria (the cell’s energy factories) make far less ATP from the same fuel, up to an 18-fold energy gap. The body then demands more sugar to make up the difference.• “Metabolic Barbed Wire”: How finding and “defanging” these hidden roadblocks through functional testing can make genetic-based recommendations far more effective. Loved learning why your cravings might not be about willpower at all? Don’t leave your health to guesswork - subscribe and drop us a review to help others decode their DNA Connect with Dr. Sam:• IG: https://www.instagram.com/fitgenesusa/• W: https://www.fitgenesusa.com Are you a health practitioner ready to decode your clients’ genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS0:00 - Intro & Hosts1:29 - GLUT2 Gene & Brain Sugar Sensor4:49 - Evolution of Sweetness12:20 - 5 Non-Genetic Craving Causes15:26 - Key Functional Diagnostic Lab Tests17:32 - Human Eye & Fruit Tree Evolution22:38 - Mitochondria Damage & ATP Loss27:50 - Metabolic Barbed Wire Explained34:12 - Control Environment, Not Willpower DISCLAIMERThe information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References:• Eny, K. M., et al. (2008)• Sun B, et al. (2023)

  2. Oct 20

    The "Sweet Tooth Gene": Why Do Some People Crave Sugar More Than Others?

    Is your DNA the reason you can't say no to sweets? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". Discover why some people need more sugar just to taste the same sweetness - and how that can quietly drive cravings for sweets, alcohol, and processed foods. Dr. Sam and Mikayla unpack the genetics of sweet taste, why our environment makes sugar so hard to resist, and an honest personal story of breaking free from sugar addiction. Plus, practical tools to curb cravings, from smarter sweet swaps to supportive nutrients and steady blood sugar, so you can work with your genetics instead of fighting them with willpower alone. KEY TOPICS COVERED: TAS1R2, TAS1R3, and Sweet Taste: How genetics raise your sweetness threshold and drive cravingsEnvironment Over Willpower: Why grocery placement and marketing beat willpowerA Personal Story of Sugar Addiction: Breaking free from a 15-year sugar addictionThe Problem With Artificial Sweeteners: Health concerns with aspartame and case studiesGlycine as a Sweet Swap: A naturally sweet amino acid that supports detoxHerbs and Nutrients for Cravings: How Gymnema, chromium, zinc, and magnesium helpSteady Blood Sugar, Fewer Cravings: Using protein, healthy fats, and fiber to stabilize energy Loved learning why sugar has such a hold on you? Don't leave your cravings to guesswork - subscribe and drop us a review to help others decode their DNA. CONNECT WITH DR. SAM: Instagram: https://www.instagram.com/fitgenesusa/Website: https://www.fitgenesusa.com Are you a health practitioner ready to decode your clients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIMESTAMPS: 0:00 - Introduction1:24 - Cravings vs. Sweet Detection5:52 - TAS1R2 & TAS1R3 Genes7:27 - Addiction & Emotional Coping9:32 - 9 Signs of Addiction10:43 - Commercials & Food Marketing13:30 - Cereal Branding Evolution16:50 - Fitgenes Practice Focus18:17 - SNPs & Enzyme Shape21:24 - Sweet Sensitivity & Alcohol22:56 - History of Aspartame26:55 - Clinical Case Study31:11 - Genetic Carb Tolerance32:19 - Evolutionary View on Sugar35:35 - The Forager Advantage38:10 - Environment vs. Willpower39:45 - Restaurant Psychology40:57 - Alternative Sweeteners & Glycine42:52 - Diet Adjustments for Cravings43:55 - Gymnema Sylvestre Effect44:19 - Overcoming Addiction47:48 - Glucose Metabolism Nutrients48:53 - Carbs Spectrum & Sugar50:08 - Outro & Directory DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. REFERENCES: Bachmanov, A. A., Bosak, N. P., Floriano, W. B., Inoue, M., Li, X., Lin, C., . . . Beauchamp, G. K. (2011). Genetics of sweet taste preferences. Flavour Fragr J, 26(4), 286-294.Dias, A. G., Eny, K. M., Cockburn, M., Chiu, W., Nielsen, D. E., Duizer, L., & El-Sohemy, A. (2015). Variation in the TAS1R2 Gene, Sweet Taste Perception and Intake of Sugars. J Nutrigenet Nutrigenomics, 8(2), 81-90.Mainland, J. D., & Matsunami, H. (2009). Taste perception: how sweet it is (to be transcribed by you). Curr Biol, 19(15), R655-656.

  3. Oct 13

    Born to Hate Broccoli or Built to Love It? The Genetics of Bitter Taste

    Is your DNA the reason you can't stand broccoli? Join host Dr. Sam Shay, DC, FMCP (Genetics Expert & Fitgenes Educator) with co-host Mikayla Wachsmann, MS, CNS, and Lily his "Frenchie". Discover how genes decide bitter sensitivity and shape diet, fullness, and weight. Dr. Sam explains evolutionary bitter detection, "super tasters" vs. "non-tasters," gut/lung receptors, and cooking tricks for vegetables. Key topics covered: Evolution of Bitter Taste: Toxicity avoidance & gag safety mechanism.Bitter Foods & Digestion: Vagus nerve, stomach acid & enzyme activation.TAS2R38 Gene: Super tasters vs. non-tasters.Evolutionary Trade-Offs: Plant protection vs. missing nutrients.Non-Genetic Factors: Age, gender, emotions & sweet crop breeding.Receptors Outside Tongue: Lung & gut immune/satiety roles.Taste Genetics & Weight: Fullness signals & obesity links.Cooking Hacks: Fat, salt, spices & aromatics to cut bitterness. SUBSCRIBE:Loved learning why bitter foods taste different to you? Don't leave your nutrition to guesswork - subscribe and drop us a review to help others decode their DNA. CONNECT: IG: https://www.instagram.com/fitgenesusa/W: https://www.fitgenesusa.com Are you a health practitioner ready to decode your clients' genetics and offer truly personalized, root-cause care? Elevate your practice by heading over to https://FitgenesUSA.com today to become a certified practitioner and gain access to our advanced genetic testing and clinical support. TIME STAMPS00:00 - Introduction00:54 - Welcome: Bitter Taste & Genetics01:21 - 5 Flavor Profiles & Evolution02:35 - Bitter Reflexes & Safety03:20 - Vagus Nerve & Enzymes04:41 - Stomach Acid Triggering05:10 - Using Bitters Before Meals06:03 - Lung & Gut Receptors07:22 - TAS2R38 Genes & RSIDs08:32 - Super Tasters vs Non-Tasters09:12 - Sensitivities in Children10:05 - Genetic Risk-Reward Strategy14:58 - Sponsor: Fitgenes USA16:24 - Vegetables & Overconsumption17:43 - Why Super Tasters Enjoy Greens18:31 - Age, Gender & Pregnancy20:02 - Sweeter Agriculture Trends21:39 - 4 Cooking Hacks for Bitters24:20 - Sugar, Alcohol & Non-Tasters26:12 - Carnivore vs Plant Diets29:13 - Sponsor: Fitgenes Practitioners30:20 - Key Provider Takeaways32:06 - Lung Immune & Gut Satiety33:37 - Gastric Emptying & Appetite35:15 - Reduced Satiety & Obesity Risk36:47 - Closing Remarks DISCLAIMER:The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. REFERENCES: • Behrens, M., Gunn, H. C., Ramos, P. C., Meyerhof, W., & Wooding, S. P. (2013) • Ortega, F. J., Aguera, Z., Sabater, M., Moreno- Navarrete, J. M., Alonso-Ledesma, I., Xifra, G., . . . Fernandez-Real, J. M. (2016). • Pawellek, I., Grote, V., Rzehak, P., Xhonneux, A., Verduci, E., Stolarczyk, A., . . . Koletzko, B. (2016). • Sandell, M., Hoppu, U., Mikkila, V., Mononen, N., Kahonen, M., Mannisto, S., . . . Raitakari, O. T. (2014). • Tepper, B. J., Koelliker, Y., Zhao, L., Ullrich, N. V., Lanzara, C., d'Adamo, P., . . . Gasparini, P. (2008). • Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. L. (2018). • Tonic water:https://www.medicinenet.com/side_effects_of_quinine_in_tonic_water/article.htm accessed June 16, 2026 9:58 am

  4. Oct 6

    The "Walking Habit": Why Your Body Was Built to Move, and What Happens When It Doesn't?

    Could the world's simplest exercise be the most powerful tool for lowering inflammation and living longer? Join host Genetics Experts & Int'l Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, co-host Mikayla Wachsmann, MS, CNS, and Lily (his Frenchie). From evolutionary survival to modern health, Dr. Sam traces why walking upright was our greatest adaptation - and how science shows it lowers chronic inflammation today. Discover the truth about realistic step targets and simple daily habits to bridge the gap between ancient movement and modern living. Key topics covered: • Inflammation Markers at Rest: How regular walking lowers resting levels of IL-1, 6, 8, 18, TNF-alpha, and CRP - key markers tied to chronic disease. • The Bipedalism Story: 4 evolutionary hypotheses (Thermoregulatory, Provisioning, Postural Feeding, Endurance Running) and anatomical traits that made long travel possible. • Modern Sedentarism by the Numbers: Today's average 1.5 miles/day vs. the 7-10 miles walked by hunter-gatherer populations. • Rethinking the 10,000-Step Rule: Why a 1965 marketing slogan became the standard - and why health benefits actually plateau around 6,000-8,000 steps. • Small Steps, Big Habit: Building up by adding +33 steps a day, plus habit-stacking like hourly 5-minute breaks and under-desk treadmills. • The Power of the Post-Dinner Walk: How an evening walk supports digestion, blood sugar control, circadian rhythm, and neighborhood connection. • Walk Like You Mean It: Why the arm backswing engages the posterior deltoid, supports shoulder health, and naturally lengthens your stride. Loved this episode? Subscribe & leave a review! Are you a health practitioner ready to decode your clients' genetics? Elevate your practice at FitgenesUSA.com to become a certified practitioner and gain access to advanced genetic testing and clinical support. Connect with Dr. Sam: IG:@fitgenesusa | W: fitgenesusa.com TIME STAMPS 00:00 - Intro 00:53 - Why Walking on Genetics Show? 02:00 - Lowering Inflammation 03:26 - Bipedalism Evolution 04:52 - Thermoregulatory Hypothesis 06:18 - Provisioning & Feeding 08:11 - Endurance Running 09:53 - Fitgenes USA 11:42 - Brain Stimulation 14:50 - Mating & Trade-Offs 17:35 - 10,000 Steps Slogan 18:33 - Hunter-Gatherer vs Modern 22:35 - Math of Walking 27:13 - Steps & Longevity 30:03 - Hit 7,500 Steps 33:22 - Fitgenes Blueprint 34:35 - Arm Backswing Mechanics 36:52 - Post-Dinner Walks 38:46 - Habit Stacking 40:22 - 33-Step Strategy 41:30 - Community Walking 43:30 - Outro DISCLAIMER The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References 1. Harvard Health (2019) 2. Lee I-M. JAMA (2019) 3. Paluch AE. Lancet (2022) 4. Banach M. Eur J Prev (2023) 5. Lancet Meta-Analysis (2025) 6. MoTrPAC. Cell (2020) 7. Pedersen BK. Phys Rev (2008) 8. Exercise & Cytokines (2021) 9. Activity & CRP. JACC (2005) 10. Aerobic & Inflam (2019) 11. Resistance & TNF (2018) 12. IL-6/IL-10. PLOS (2010) 13. Exercise & IL-10 (2010) 14. COX-2 Inhibitor (2014) 15. Chinsomboon J. PNAS (2009) 16. Genetics & Endurance (2021) 17. MacArthur. ESSR (2007) 18. Bramble. Nature (2004) 19. Wheeler. J Hum Evol (1991) 20. Ruxton. PNAS (2011) 21. Lovejoy. Science (1981) 22. Hunt. S Afr J Sci (1996) 23. Sockol. PNAS (2007) 24. Univ of Arizona (2007) 25. Bravata. JAMA (2007) 26. Patel. Ann Int Med (2016)

  5. Sep 29

    The "Oxygen Genes": Is Your DNA Fueling or Limiting Your VO2 Max?

    Could your DNA be the reason you're gasping for air while your training partner cruises right past you? Join host Dr. Sam Shay, DC, FMCP (Genetics Expert), co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". Discover the genetics behind VO2 max - one of the most powerful indicators of longevity, measuring how efficiently your body takes in, transports, and uses oxygen. Dr. Sam and Mikayla break down why oxygen is the fuel your mitochondria need to produce energy, what happens when your body can't keep up with that demand, and how four specific genes shape your engine's efficiency.If you enjoyed discovering whether you're built for sprint or endurance in our muscle fiber type episode, this one goes a layer deeper: it's not just which fibers you have, but how well your body actually fuels them with oxygen. Key topics covered in this episode: VO2 Max & Mitochondria: What VO2 max measures, oxygen for ATP production, and anaerobic pathways.Mitochondria as "Guests": Symbiotic organisms with their own DNA powering our cells.AMPD1: Recycles ATP in skeletal muscle; variations affect endurance vs. cardiac protection.VEGFA: Regulates angiogenesis and new capillary creation for oxygen delivery.HIF1A: Low-oxygen emergency sensor & Goldilocks effect.ACSL1: Helps mobilize fatty acids to make ATP for aerobic capacity.Evolutionary Trade-Offs: Variations reflect adaptation, not "broken" genes.The "Non-Responders": Why 40% don't improve VO2 max from Zone 2 alone, and HIIT.Training Smarter: Recovery, biomechanics, and progress by recovery speed from deep muscle burn. Loved learning what your genes reveal about your engine's oxygen efficiency? Don't leave your training to guesswork - subscribe and drop us a review to help others decode their DNA. Connect with Dr. Sam:IG: @fitgenesusa | W: fitgenesusa.com Health Practitioners: Ready to offer personalized, root-cause care? Visit FitgenesUSA to get certified & access testing TIME STAMPS:00:00 - Intro 01:26 - What is VO2 Max? 02:20 - VO2 Max & Longevity 04:31 - Oxygen & Mitochondria 07:02 - 4 Key VO2 Max Genes 08:14 - AMPD1: ATP Recycling 16:02 - VEGFA: Capillaries & Oxygen 21:54 - HIF1A: Hypoxia Sensor 26:24 - ACSL1: Fatty Acids & ATP 31:22 - Increasing VO2 Max Safely 33:50 - Why 40% Don't Respond to Zone 2 34:28 - HIIT vs Zone 2 44:23 - Measuring Recovery Speed 47:40 - Outro References (22 Studies): 1. Bouchard et al. (1999) - HERITAGE Family Study2. Bouchard et al. (2011) - Genomic predictors of O2 uptake3. Ginevičienė et al. - AMPD1 & athletic performance4. AMPD1 Deficiency Overview5. Rannou et al. (2017) - AMPD1 mutation insights6. Smolenski et al. (2014) - AMPD1 & Heart Disease7. Boidin et al. (2022) - VEGFA & training adaptation8. Ahmetov et al. - HIF1A in elite endurance athletes9. Genetic Polymorphisms & Endurance Meta-Analysis10. Beall et al. (2010) - EPAS1 in Tibetan highlanders11. Lorenzo et al. - EPAS1 & High-Altitude Hypoxia12. Simonson et al. - Tibetans & hypoxia response13. Yvert et al. (2012) - ACSL1 & elite endurance status14. ACSL polymorphism among runners15. Bailey et al. (2013) - Nitrate supplementation & exercise16. HFE gene H63D polymorphism & endurance17. Vitamin C & Oxygen Sensing in vivo18. Gerling et al. (2019) - Omega-3s & mitochondrial membranes19. Herbst et al. - Omega-3s & mitochondrial respiration20. Hypoxia Training at High Altitudes21. HIIT vs MICT on mitochondrial dynamics22. HIIT vs MICT on VO2 max & blood pressureDISCLAIMER:This podcast is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Neither Dr. Sam nor the publisher assumes liability for actions taken based on this content. Always consult a qualified healthcare provider before making changes to your diet, supplements, or health plan. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and CarbChoice Advanced

  6. Sep 22

    The "Recovery Genes": Is Your DNA Setting You Up for Chronic Inflammation and Slow Healing?

    Is your workout helping you heal - or keeping you stuck in a cycle of inflammation? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie" Discover why some bodies bounce back from a hard workout within a day, while others stay sore, swollen, or sidelined for a week - and how a handful of genes tied to inflammation and bone strength may be the reason. Dr. Sam breaks down how exercise-induced micro-damage is actually the first step toward getting stronger, what happens when the body never gets the chance to fully repair, and how to tell whether your training style matches your genetic recovery capacity Key topics covered in this episode: Inflammation 101: Why exercise micro-damage happens - and how it turns chronic when repair fails, leading to fluid retention and lost muscle tone.VDR1 & VDR2: How Vitamin D Receptor gene variations raise bone fracture risk and drive stronger inflammatory responses.IL-6 & TNF-alpha ("Hub Genes"): Why cytokine hub variations prolong the repair response, causing chronic inflammation, oxidative stress, and soreness.Movement vs. Exercise: Why reframing "exercise" as "movement" and "training" improves consistency for those triggered by the word "exercise."Recovery Is Not Optional: Why sleep, anti-inflammatory nutrition, saunas, cold exposure, and light swimming matter as much as the workout.Smarter HIIT: Capping HIIT at 2-3 sessions per week with 45-60 sec bursts of deep muscle burn and keeping total session time under 30 minutes.The Pedometer Advantage: Why step counters are one of the most effective tools for building consistent, low-inflammation movement. Loved learning what your genes reveal about injury and recovery? Don't leave your training to guesswork - subscribe and drop us a review to help others decode their DNA Connect with Dr. Sam:• IG: @fitgenesusa• Web: FitgenesUSA.com Health practitioners: Head to FitgenesUSA.com to become a certified practitioner and access advanced genetic testing and clinical support. TIME STAMPS:00:00 - Intro & Overview00:48 - Host Introductions01:14 - Exercise-Induced Inflammation Genetics02:08 - Case Study: Over-Exercising & Fluid Retention04:17 - Scaffolding Analogy of Inflammation07:03 - Reversing Hyper-Inflammation08:06 - Hyper-Inflamers & The Muffin Test11:42 - Key Inflammatory Genes (IL-6, TNF-Alpha, VDR)13:28 - DNA Decoded Program15:32 - VDR Genes & Bone Micro-Fractures18:21 - TNF-Alpha: Inflammatory Smoke Alarm19:24 - Personalizing Workout Frequency22:15 - Effective Recovery Strategies23:00 - Movement vs. Training vs. Recovery32:00 - Strains, Sprains & Injury Anatomy36:40 - Fit Genes USA Practitioner Info37:54 - Safe Training for High-Risk Genotypes40:08 - 45-to-60-Second HIIT Protocol44:26 - Tracking Recovery & Lactate Threshold49:14 - Modifying Overtraining in CrossFit51:02 - Outro & Resources DISCLAIMER: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: Genetic variation and exercise-induced muscle damageVitamin D receptor gene polymorphisms and injuriesVitamin D receptor protein and IL-6 in skeletal muscleExercise-induced VDR and AR mediate inhibition of IL-6VDR gene polymorphisms and fracture healing

  7. Sep 15

    The "Speed Gene": Are You Genetically Built to Sprint, Go the Distance, or Both?

    Are you training against your genetics without even knowing it? Join your host, Genetics Expert and International Fitgenes Educator & Trainer Dr. Sam Shay, DC, FMCP, alongside co-host Mikayla Wachsmann, MS, CNS, and Lily-his "Frenchie". Discover how a single gene (called ACTN3)-nicknamed the "speed gene"-can reveal whether your body is naturally wired for explosive power, endurance, or a mix of both. Dr. Sam breaks down muscle fiber types, evolutionary history, and injury prevention strategies. Key topics covered in this episode:• ACTN3 Genotypes: RR (power), XX (endurance), and RX (blended) profiles.• Sprint vs. Endurance Genetics: Fast-twitch explosive power vs. slow-twitch aerobic performance.• Evolutionary History: How migration, foraging, and cold survival shaped genetic variants.• Injury Prevention: Training and recovery strategies based on your genetic profile.• Beyond Genetics: The roles of diet, hormones, and mindset in performance. Loved learning the code behind your muscle fibers? Subscribe and drop us a review to help others decode their DNA! Connect with Dr. Sam:IG: @fitgenesusaW: fitgenesusa.com Are you a health practitioner ready to decode your clients' genetics? Elevate your practice today at FitgenesUSA.com to become a certified practitioner. DISCLAIMERThe information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced. References: • Baltazar-Martins G, Gutiérrez-Hellín J, Aguilar-Navarro M, et al. Effect of ACTN3 Genotype on Sports Performance, Exercise-Induced Muscle Damage, and Injury Epidemiology. Sports (Basel). 2020;8(7):99. Published 2020 Jul 13. doi:10.3390/sports8070099. • Eynon N, Hanson ED, Lucia A, et al. Genes for elite power and sprint performance: ACTN3 leads the way. Sports Med. 2013;43(9):803-817. doi:10.1007/s40279-013-0059-4.• Yang N, MacArthur DG, Gulbin JP, et al. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet. 2003;73(3):627-631. doi:10.1086/377590. Alpha-actinin-3 • Alpha-actinin is an actin-binding protein with multiple roles in different cell types. This gene expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments.[7]• Fast versus slow twitch muscle fibers • Skeletal muscle is composed of long cylindrical cells called muscle fibers. There are two types of muscle fibers, slow twitch or muscle contraction (type I) and fast twitch (type II). Slow twitch fibers are more efficient in using oxygen to generate energy, while fast twitch fibers are less efficient. However, fast twitch fibers fire more rapidly, allowing them to generate more power than slow twitch (type I) fibers. Fast twitch fibers and slow twitch fibers are also called white muscle fibers and red muscles fibers, respectively. The alpha-actinin-3 protein is found in type II muscle fibers. • It has been speculated that variations in this gene evolved to accommodate the energy expenditure requirements of people in various parts of the world. 8]: 155–156  Over 75% of the persons have one or two copies of ACTN3 577R and have alpha-actinin-3. Homozygous individuals (ACTN3 577XX) have no alpha-actinin-3 (16%-20% of the population), [11][12 but they have a high level of alpha-actinin-2.

  8. Sep 8

    Decoding Collagen Genetics: Hypermobility, Injury Prevention, and Soft Tissue Recovery

    Is collagen marketing hiding the truth about your joint, skin, and soft tissue health?Join Dr. Sam Shay, DC, FMCP, co-host Mikayla Wachsmann, MS, CNS, and Lily - his "Frenchie". Discover how COL1A1 and COL5A1 genetic variations influence collagen structure, joint hypermobility, and risks for EDS, disc herniations, and hernias. Learn why overuse and chronic inflammation - not age - drive tissue breakdown, plus strategies for safe training, managing histamine, and recovery.Key topics covered in this episode:• Hypermobility: COL5A1 & COL1A1 variants increase risks for EDS and soft tissue injuries.• Overuse vs. Aging: Joint wear-and-tear is driven by cumulative strain and inflammation.• Training & Recovery: Dangers of cold static stretching, dynamic warm-ups, and HIIT recovery.• Nutrition: Support collagen with Vitamin C, Creatine, Inositol; manage histamine.• Movement: Low-impact activities (walking, Qigong) maintain mobility without joint overload.Subscribe and drop us a review to help others decode their DNA!TIME STAMPS00:00 - Intro00:53 - Collagen Integrity01:41 - Collagen Protein & Tryptophan02:18 - Genetics of Collagen03:49 - Hypermobility & EDS04:13 - Age vs. Overuse06:44 - COL5A1 & COL1A107:18 - Injury Prevention09:50 - Hernias & Osteoporosis11:04 - Fit Genes USA12:42 - Collagen Health Variables14:04 - Static Stretching vs. Warm-ups15:23 - Post-Exercise Recovery16:13 - Overtraining & Inflammation17:29 - Safe HIIT21:35 - Collagen on Plant-Based Diet24:29 - Managing Histamine26:55 - Genetic Reality28:51 - Dog Rescuing Benefits29:16 - Staying Active29:45 - OutroConnect with Dr. Sam:IG: @fitgenesusaWebsite: fitgenesusa.comHealth practitioners: Ready to offer personalized, root-cause care? Elevate your practice at FitgenesUSA.com to become a certified practitioner.DISCLAIMERThe information provided in this podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, cures or treatment. Neither Dr. Sam nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. Always consult with a qualified healthcare provider before making any changes to your diet, supplement routine, or overall health plan based on genetic information or podcast discussions. Dr. Sam Shay, DC, FMCP is the founder of and has a direct financial interest in FitgenesUSA testing, the Fitgenes Genetic Blueprint, and the CarbChoice Advanced.REFERENCES• Beck KL, et al. Micronutrients and athletic performance. Food Chem Toxicol. 2021;158:112618. doi:10.1016/j.fct.2021.112618.• de la Puente Yagüe M, et al. Role of Vitamin D in Athletes. Nutrients. 2020;12(2):579. doi:10.3390/nu12020579.• Kaufman MW, et al. Impact of Supplements on Sports Performance. Curr Sports Med Rep. 2022;21(7):232-238. doi:10.1249/JSR.0000000000000972.• Leońska-Duniec A, et al. Genetic variants influencing exercise training programmes. Biol Sport. 2016;33(3):207-214. doi:10.5604/20831862.1201052.• Maffulli N, et al. Genetics of sports injuries. Muscles Ligaments Tendons J. 2013;3(3):173-189.• Petersen AM, Pedersen BK. Role of IL-6 in mediating anti-inflammatory effects of exercise. J Physiol Pharmacol. 2006;57 Suppl 10:43-51.• Type I Collagen• Collagen Alpha 1• Type V Collagen• Collagen Type V Alpha 1

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About

Join Dr. Sam Shay, DC, FMCP, and co-host Mikayla Wachsmann, MS, CNS, as they decode complex genetics into practical, actionable strategies for health, performance, and longevity. Each episode bridges the gap between clinical data and real-world results, breaking down the specific genes and pathways that actually matter—without the hype or technical noise. Whether you are working to shift your own health trajectory or you're a practitioner seeking clearer communication and better clinical outcomes, this show gives you the frameworks to make DNA truly usable. Stop guessing. Start decoding.

Information

  • Creator
    FitgenesPodcast
  • Years Active
    2026
  • Episodes
    20
  • Rating
    Clean
  • Copyright
    © FitgenesPodcast
  • Show Website
    FitgenesUSA

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