X-Health.show - meet the future of healthcare Alex Jani: interviewing visionaries of healthcare innovation

How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients?
In this episode, you’ll hear about
how are blood cells producedacute myeloid leukemiahematopoietic stem cell transplantation or bone marrow transplant procedurehow to replace chemotherapy in the conditioning stageATLyphe is a Swiss Startup, a spin-off from the ETH Zurich and the University of Zurich. They developed a T cell engager and activator for safer, precise conditioning before hematopoietic stem cell transplantation in leukemia.

My guest today is Dr. Danielle Villars, the CEO of ATLYphe, a biologist who completed her PhD in cancer biology. She already proved she is a high achiever – before committing to science-backed entrepreneurship and bringing this new process to patients, she broke four national records as an Olympic swimmer for Switzerland.
Here’s more about ATLyphe:
https://www.atlyphe.com/

Please note, the treatment is not yet available for patients.


If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

A specific strain of bacteria might help prevent and even treat colorectal cancer. The studies in animals show potential in treating other cancers, too.
You’ll hear about
how many bacteria inhabit a human and how much do they weigh (I bet you underestimate their weight)what is a dysbiotic gut microbiomethe gut microbiome and its influence on colorectal cancerstudies of specific strains of bacteria that show reducing cancer in micewhat is the potential of life biotherapeutic productsMy guest today is Dr. Ana Montalban-Arques, the CEO of Recolony. Trained in molecular biology and biotechnology she researched host-microbe interactions in the gut.
Recolony is a Swiss startup, a spin-off from the University of Zurich. They aim to develop a bacteria-based oral therapy to treat and prevent colorectal cancer. No chemotherapy, no side effects – oral administration at home. Please note, their treatment is in the pre-clinical phase and it means it is not yet available for patients.

You may find out more about them at
https://www.recolony.ch/



If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Out of 16 000 livers donated in the US, 7 000 are discarded. 14 000 patients are on the waiting list for a transplant. What if we could recondition the 7 000? What if we could treat these livers outside of a human body and transplant to the patients that need them?
You’ll hear
what’s the ideal liver graft and why there’s a shortage of themhow to keep a liver alive outside of a human bodythe possible future of growing organsand more
My guest today is Dr. Waldemar Hoffmann, the CEO of Apersys. A bioengineer and biomedical engineer, with years of experience in medtech. Also, with years of experience in waiting with his father for a kidney transplant.
Apersys is a Swiss startup that developed a perfusion machine able to preserve and recover human organs outside of the human body. What it means is, putting a discarded liver onto a machine, treating it, regenerating it, and transplanting into a patient.
You may find them at https://apersys.com/


If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

What is your optimal breathing rhythm for relaxing? How to make sure it is exactly for you? How does the sensor know when you drift off and how you breathe?

Today you’ll hear about
sleep trackingbreathing exercises for anxiety, stress, panic attacksHRV or heart rate variabilityand ECG in a T-shirtsmart textilesand Alex’s experience using OxaOxa is a wearable to help you relax and fall asleep by not only tracking your heart rate but also breathing. The sensor allows live biofeedback and you only have to put a T-shirt a bra or a strap on.
My guest, Dr. Vincent Martinez is the CEO of Nanoleq. An engineer who created an unbreakable cable during his PhD in biosensors and bioelectronics. This was the basis to create, with neuroscientists on board, Oxa.
Find out more about Oxa at
https://oxalife.com/


If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Take a plastic chip,
a bunch of cells,
add some real complex engineering and cellular biology science
and you'll have a lung-on-chip that can breathe as if in a human body.
You're ready to test drugs, as if on people, instead of mice

In this episode, you’ll hear about
the biology of breathing, down to the cellular level,how to better predict drug responses in humans,the difference between organoids and organs-on-chip,how does a lung-on-chip work and can you trust it,the wonderland of alveoli biology,the future with less animal testing.
My guest today is Dr. Nina Hobi the CEO of AlveoliX. A molecular biologist with over a decade of research in organs-on-chip and an awesome talent for putting complicated biological processes in simple words. A compelling intuitive leader, she inspires her team and partners to keep the ball rolling. No wonder, after hours she’s a volleyball referee.

AlveoliX is a Swiss startup that developed organ-on-chip technologies to make pre-clinical drug testing safer, better, and personalized while reducing animal testing. Their lung-on-chip enables human alveoli cells breathe just like they do in the human body.

Find out more about AlveoliX at
https://www.alveolix.com


If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

You cannot underestimate the emotion when you can feel the warmth of someone’s hand in the hand you do not have.
Or cold in the fingers you have not had for years.
In this episode, you’ll hear about
how people with an amputated hand, can feel the temperature in their phantom handwhy you don’t really feel wet or can be tricked into feeling wet when there’s no wetnesshow do you feel the temperatureand surely
bionic handsrobotic handsneuroprosthesesMy guest, Dr. Solaiman Shokur is a neuroengineer and a scientist, a co-founder of a neurotech company working on 'nerve machine interfaces’. He worked on some real cool stuff: brain-computer interfaces – he worked in the same lab with Neuralink CTO and co-founders and he was involved in the mind-controlled robotic exoskeleton featured during the 2014 World Cup. Dr. Shokur moved then into restoring sensory-motor functions, haptics, 
and now, with an international team, he works on new bionic technology called MiniTouch. There are three centers involved: Translation Neural Engineering Lab at EPFL led by Prof. Silvestro Micera, Switzerland, Scuola Superiore Sant’Anna subsidiary in Pisa, INAIL institute in Bologna. MiniTouch allows a person with an amputated hand to feel hot and cold in their phantom hand.
You may learn more about the lab here:
https://neuro-x.epfl.ch/en/


If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.

The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.