Gear, Growth, and Gains Hosted by Type-IIx

Type-IIx

Anabolic steroid and peptide chemistry and bodybuilding training discussions with expert guests

  1. SEP 4

    Ep. 010: The Expanding World of PEDs, Emerging Compounds SLU-PP-332, Semaglutide, Tirzepatide, Retatrutide; and SARMs

    Title Gear, Growth, and Gains: Ep. 010: The expanding world of PEDs; Emerging compounds in bodybuilding: SLU-PP-332, GLP-1, GIP, and glucagon incretin peptides (semaglutide, Ozempic; tirzepatide, Mounjaro; tirzepatide); Selective Androgen Receptor Modulators (SARMs); Comparative analysis: New PEDs. vs. traditional drugs; Legal and safety considerations for cutting-edge PEDs; Future trends in performance enhancement Runtime 21 min, 15 sec Synopsis SLU-PP-332 ("Sloop"), GLP-1, Ozempic, semaglutide, dual GLP-1 and GIP agonists, Mounjaro, tirzepatide, tripe GLP-1, GIP, and glucagon agonists, retatrutide, SARMs, Ostarine, Enbosarm, RAD140, MK677, Ibutamoren, Growth Hormone, GH, Bolus Features Type-IIx Topics peptides, SLU-PP-332 ("Sloop"), GLP-1, Ozempic, semaglutide, dual GLP-1 and GIP agonists, Mounjaro, tirzepatide, tripe GLP-1, GIP, and glucagon agonists, retatrutide, SARMs, Ostarine, Enbosarm, RAD140, MK677, Ibutamoren, Growth Hormone, GH, Bolus, bodybuilding,  enhanced bodybuilding, supplements, training, weight training, exercise References Get a Free Sneak Peek into Bolus – the ONLY GH book you'll EVER need! Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Book a Meeting with Type-IIx Today! Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

  2. AUG 30

    Exploring the Dangers and Benefits of Gregg Valentino’s “Get the Bucket” Leg Press Routine

    Title Exploring the Dangers and Benefits of Gregg Valentino’s “Get the Bucket” Leg Press Routine Summary In this episode of the "Gear Growth and Gains" podcast, host Type-IIx critically examines Gregg Valentino’s “Get the Bucket” leg press program, highlighting its high risk for muscle damage and rhabdomyolysis. The episode also presents a case study on chemical enhancement in elite strongman athletes, detailing performance outcomes and side effects of various anabolic regimens. Finally, the host compares berberine, metformin, and GLP-1 agonists for blood glucose management, discussing their mechanisms, effects on muscle growth, and practical recommendations for enhanced athletes. The episode emphasizes evidence-based harm reduction in bodybuilding. Timestamps Podcast Introduction and Disclaimers (00:00:30) Host introduces the podcast, gives medical disclaimers, and promotes newsletter and community platforms. Premium Content and Symposium Announcement (00:01:41) Details about the Type-IIx Insider program, premium content, symposiums, and subscriber instructions. Symposium Topics Overview (00:02:55) Breakdown of upcoming symposium topics: Estrogen management for men and advanced PED periodization for women. Episode Structure and Topics Preview (00:04:20) Overview of the three main sections: Gregg Valentino’s program, strongman case study, and blood glucose management. Gregg Valentino’s Introduction (00:05:08) Gregg Valentino introduces his "Get the Bucket" leg press program with characteristic hype. Get the Bucket Program Explained (00:05:20) Detailed explanation of the four-set leg press routine, including reps, weights, and tempo. Host’s Critique of Get the Bucket (00:09:37) Host recaps and critiques the program, warning of excessive muscle damage and risks like rhabdomyolysis. Risks and Muscle Damage Discussion (00:10:19) Further analysis of the dangers, including muscle damage, rhabdo, and long-term negative effects. Section Two Introduction: Strongman Case Study (00:12:33) Transition to the next section, introducing a case study on chemical enhancement in elite strongman. Strongman Athlete Profile and Stack (00:13:41) Details on the strongman’s stats, training, and anabolic steroid regimen leading up to competition. Performance Results and Side Effects (00:15:00) Discussion of the results, side effects, and health impacts of the strongman’s drug protocol. Blood Work Sponsor Ad (00:15:47) Promotion for Fitomics blood work services, including discount code and benefits. Section Three Introduction: Blood Glucose Management (00:16:38) Introduction to the third section: comparing berberine, metformin, and GLP-1s for blood glucose control. Mechanisms and Effects of Berberine and Metformin (00:17:42) Explanation of how berberine and metformin work, their effects on muscle, and insulin sensitivity. Comparing Berberine, Metformin, and GLP-1s (00:19:06) Comparison of the three agents, their unique benefits, side effects, and practical recommendations. Summary and Decision Factors (00:21:51) Host summarizes key points and encourages listeners to weigh options based on personal needs. Meso-Rx Community Promotion (00:21:51) Promotion of the Meso-Rx community for unfiltered reviews and harm reduction. Book Advertisement: "Bolus" Guide (00:22:16) Ad for the "Bolus" guide on GH and related compounds, highlighting its practical value and research-based protocols. Keywords Gear Growth and Gains, Type-IIx, bodybuilding, enhanced bodybuilding, chemical enhancement, health topics, newsletter, premium content, symposiums, Get the Bucket program, leg press program, muscle damage, rhabdomyolysis, hypertrophy, eccentric tempo, training volume, chemical enhancement protocol, elite strongman, testosterone, Dianabol, Anadrol, Trenbolone, Halotestin, blood glucose management, Berberine, Metformin, GLP-1 Agonists, insulin sensitivity, nutritional supplement, hepatoprotective, AMPK activation, appetite suppression, muscle hypertrophy, performance optimization, risk management, evidence-based approaches, Fitomics, bloodwork, harm reduction   References GET THE BUCKET - IT'S LEG DAY!!!...GREGG VALENTINO'S LEG VIDEO Emerging Data About Combining GLP-1 Agonists with Myostatin Inhibitors | Article | Cormac Mannion (Type-IIx) | Substack & Ampouletude Bolus HGH Book | Cormac Mannion (Type-IIx) | Amazon & Ampouletude Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-

    23 min

  3. JUL 29

    Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths

    Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, COURAGE trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroids, dyslipidemia, hypertrophy, training volume, mechanical tension, anabolic steroids, effective reps, bloodwork, ACE-083, IGF1-LR3, recovery, strength gains, peptide myths, clinical trials, muscle growth, fitness podcast, bodybuilding community, health and fitness, performance enhancement References Emerging Data About Combining GLP-1 Agonists with Myostatin Inhibitors | Article | Cormac Mannion (Type-IIx) | Substack & Ampouletude Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    27 min

  4. APR 8

    Ep. 013: Managing Blood Viscosity, Why Do Some People Build Strength but Not Muscle, and Navigating the Peptide Landscape: What Women Should Know in 2025

    Title Managing Blood Viscosity, Why Do Some People Build Strength but Not Muscle, and Navigating the Peptide Landscape: What Women Should Know in 2025 Runtime 32 min 03 sec Synopsis Podcast Episode Summary: Gear Growth and Gains - Episode 13 In this episode of "Gear Growth and Gains," hosted by Type-IIx and presented by Meso-Rx, the focus is on three critical topics in enhanced bodybuilding: blood viscosity management, strength without muscle gain, and peptide use for women in 2025. Blood Viscosity Management: Type-IIx discusses managing elevated hematocrit and hemoglobin levels due to androgen use. Strategies include using milk thistle (silymarin), aspirin, and phlebotomy to mitigate risks like thromboembolic events. Strength Without Muscle Gain: The episode explores how individuals can achieve significant strength through neural adaptations and specific training methods, without substantial muscle hypertrophy. Peptide Landscape for Women: Insights are provided on peptides like GHK-Cu for skin enhancement and anti-aging, emphasizing informed and safe usage. Listeners are encouraged to prioritize education, safety, and long-term health in their bodybuilding journey. Features Type-IIx Topics Type-IIx, Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, blood viscosity management, hematocrit, hemoglobin, erythrocytosis, androgen use, thromboembolic events, deep vein thrombosis, DVT, testosterone replacement therapy, TRT, silymarin, milk thistle, iron chelator, aspirin, phlebotomy, muscle hypertrophy, strength training, neural adaptations, training methods, muscle fiber recruitment, genetic factors, nutritional considerations, peptide landscape, GHK-Cu, angiogenesis, wound healing, collagen synthesis, skin regeneration, BPC-157, Body Protective Compound-157, TB-500, Thymosin Beta-4, tissue repair, inflammation management, recovery, fitness enthusiasts, performance optimization, harm reduction, blood work, healthcare professionals, training goals. References Events | Symposium IV (The 4th Symposium): Growth Hormone (GH) vs. GH Secretagogues: Why? When? How? | Apr 12 2025 | Archives | Substack The Meaning of "Genetics" for Bodybuilding | Article | Cormac Mannion (Type-IIx) | Substack Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    32 min

  5. MAR 11

    Ep. 012: Case Study of Ben Pollack (IFBB Pro) - 3 Contest Prep Cycle Designs - General Approach, John Meadows, Justin Harris

    Title Analysis Across Three-Dimensions of the Wisdom of Top Bodybuilding Cycle Designs Runtime 13:50 Synopsis In the 12th episode of "Gear Growth and Gains," host Type-IIx analyzes 3 contest prep cycle designs for IFBB Pro Ben Pollack that were designed by his coaches, John Meadows and Justin Harris, as well as the "General Consensus Approach," that he defaults to at other times. Features Type-IIx Topics Ben Pollack, IFBB pro bodybuilder, powerlifting, steroid cycle strategies, John Meadows, Justin Harris, TLMT cycle, Testosterone, Masteron, Trenbolone, Anavar, Winstrol, growth hormone, anti-estrogenic effects, gynecomastia, Primobolan, Halotestin, insulin, muscle protein synthesis, caloric deficit, performance-enhancing substances, bodybuilding, personalized approaches, cycle design mistakes. References utben's USAs Writeup/AMA in r/bodybuilding Unique Per-Anabolic Androgenic Steroid Characteristics | Meso-Rx Article Series | Cormac Mannion (Type-IIx) Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    14 min

  6. MAR 2

    Ep. 011: Sleep Meds and Bodybuilding, Genetics and Bodybuilding, Cardarine (GW501516): Is the Risk (Cancer?) worth the Reward? Secrets of Russian Weightlifting

    Title Gear, Growth, and Gains: Ep. 011: Sleep Medications (Magnesium, Melatonin, NyQuil, ZzzQuil, Trazodone, Mirtazapine, the Z-Drugs, Ambien, etc.) and Effects on Body Composition and Performance; Genetics and Enhanced Bodybuilding: Specific Genetic Markers, like ACE, ACTN3, PPARGC1A, AR, and GH-R; Cardarine (GW501516) and Cancer: Are the Risks Overblown? Is it Still of Benefit if Not? What are Russian Weightlifters Doing Behind the Scenes? Well... Dexamethasone! Runtime 36 min 43 sec Synopsis In Episode 011, we tackle three major topics that serious bodybuilders need to know about. First up, we break down the truth about sleep medications - from basic supplements like magnesium and melatonin to prescription options like trazodone and Z-drugs like Ambien®. Learn which ones actually help muscle recovery and which ones might sabotage your gains. Next, we dive into how genetics shape bodybuilding success, revealing key markers like ACE and ACTN3 that influence muscle growth and training response. Using real research from Russian sports scientists, we explain why some lifters need just 5% of the volume to make the same gains as others. The show wraps with an insider’s look at Russian weightlifting methods, including their controversial use of dexamethasone for recovery. Plus, don’t miss our announcement of Symposium IV covering growth hormone vs. secretagogues, and a preview of next week’s special guest - a veteran homebrewer from Meso-Rx sharing the ins and outs of steroid brewing. Features Type-IIx Topics Sleeping medications Bodybuilding Magnesium Melatonin NyQuil (doxylamine succinate) Mirtazapine (Remeron) Trazodone Z-drugs (Zaleplon, Zolpidem, Zopiclone) Genetics Enhanced bodybuilding ACE gene (rs4646994) ACTN3 gene (rs1815739) PPARGC1A gene (rs8192678) Cardarine (GW501516) PPAR delta agonist Cancer risk Russian weightlifters Dexamethasone Recovery techniques Anabolic steroids References The Meaning of "Genetics" for Bodybuilding Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    37 min

  7. 12/12/2024

    Ep. 009: Why DHB (1-Testosterone) Raises E1 & DHT; Restorative Methods: Soft Tissue Flexibility, ART, Graston techniques, Body Tempering, Voodoo Floss, etc., and RhGH and Hyperplasia

    Title Type-IIx's Gear, Growth, and Gains: Ep. 009: Why DHB (1-Testosterone) Raises E1 & DHT; Restorative Methods: Soft Tissue Flexibility, ART, Graston techniques, Body Tempering, Voodoo Floss, etc., and RhGH and Hyperplasia Runtime 20 min Synopsis Hypothesis for DHB (1-Test's) increasing DHT & E1 (estrone) and decreasing E2 [discussed at length in forthcoming article from Unique Effects of AAS Series; Coach's Corner: Beyond Drugs – restorative methods for soft tissue flexibility, injury prevention, and performance , comparing Active Release Techniques [ART], Voodoo Floss, myofascial release, Body Tempering, cupping therapy, sauna; Growth Hormone (rhGH) and skeletal muscle hyperplasia – how it works Features Type-IIx Topics anabolic steroids, steroids, AAS, DHB, dihydroboldenone, 1-testosterone, estradiol, estrone, 17B-HSD1 inhibitor, MesoRx, ART, active release techniques, body tempering, Graston technique, Voodoo Floss, foam rolling, massage, cupping, sauna, growth hormone, hyperplasia, bodybuilding,  enhanced bodybuilding, supplements, training, weight training, exercise References Order Bolus – the ONLY GH book you'll EVER need, or Get a Free Preview Recovery Methods for Bodybuilding – Part One: Introduction | Substack Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    15 min

  8. 11/06/2024

    Ep. 008: AI Comparison between Aromasin vs. Arimidex; Masteron (Mast) vs. Primobolan (Primo); Coach's Corner: Feeling and Using the Back in Exercises

    Title Type-IIx's Gear, Growth, and Gains: Ep. 008: AI Comparison between Aromasin (Asin) vs. Arimidex (Adex); Masteron (Mast) vs. Primobolan (Primo); Coach's Corner: Cues and Modifications to Emphasize Different Back Muscles Runtime 23 min Synopsis Type-IIx discusses the clear winner (Aromasin) between the AIs Aromasin and Arimidex, including a concise explanation of what suicide inhibition means, and why Aromasin is best. Then, in the next section, Masteron (Mast) is compared to Primobolan (Primo; Rimobolan; Rimos), and it too is the clear winner here. Tangentially, the AI atamestane is discussed, albeit merely to point out its total irrelevance to the topic since it is not any sort of metabolite of either drug despite claims to the contrary! Finally, cues and modifications for back exercises like rows, pulldowns, pull-ups, shrugs, et cetera are discussed. A YouTube video will follow demonstrating different shrug variations for maximally growing the trapezius (upper, middle, and lower segments). Features Type-IIx Topics anabolic steroids, steroids, AI, AAS, Primo, Primobolan, Rimobolan, Rimos, Mast, EQ, atamestane, Arimidex, anastrozole, suicide inhibition, suicide inhibitors, Aromasin, exemestane, bodybuilding, training cues, enhanced bodybuilding, supplements, training, weight training, exercise References Labcorp Research Insider Quest Research Insider Check out the actual sheet listing biomarkers and pricing Kurt Havens, Ph.D. candidate's claim that atamestane is a potential intermediate metabolite to explain antiestrogenic effects in Primo v.s. Mast "Advanced Discussion" Newsletter Subscribe to Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter Type-IIx's Gear, Growth, and Gains Insider Substack Newsletter | Archives Communities Communities ❯ Telegram › Gear, Growth, and Gains | Team Ampouletude | Type-IIx

    22 min
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Anabolic steroid and peptide chemistry and bodybuilding training discussions with expert guests

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