This episode is brought to you by Solaray Solaray, is an eight-product longevity supplement system created to support cellular energy, muscle health, healthy ageing*. 👉 Save 30% on Unlimit -Targeted formulas to support cellular energy, muscle health, and healthy ageing* Click the link https://solaray.com/FOSTER and use code FOSTER *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. If you purchase using this link or discount code I may receive a small commission. Dr. Kien Vuu and I talk about cellular energy, estrogen, NAD+ and spermidine in midlife, and how to build more energy today while staying strong and sharp at 80. Physician and Thrive State author Dr. Kien Vuu breaks down the three parts of one energy system behind midlife fatigue: mitochondria, insulin sensitivity and metabolic flexibility. He explains why falling estrogen hits mitochondrial efficiency, glucose metabolism, muscle and bone at the same moment life demand peaks, why fasting glucose and HbA1c move late, and how he sorts longevity compounds into mapped, emerging and frontier science before deciding whether glutathione, NAD or spermidine earn a place on top of the foundations. WHAT YOU'LL LEARN - Why the felt sense of low energy shows up long before fasting glucose or HbA1c move - What falling estrogen does to mitochondrial efficiency, glucose metabolism and muscle mass at the exact moment life demand peaks - How to sort any longevity compound into mapped, emerging or frontier science before you spend a penny - The four questions Dr. Vuu asks before adding a supplement, and why he says you have to earn it first WHAT YOU'LL LEARN - Why the felt sense of low energy shows up long before fasting glucose or HbA1c move - What falling estrogen does to mitochondrial efficiency, glucose metabolism and muscle mass at the exact moment life demand peaks - How to sort any longevity compound into mapped, emerging or frontier science before you spend a penny - The four questions Dr. Vuu asks before adding a supplement, and why he says you have to earn it first TIMESTAMPS 00:00 - Intro: Why Your Energy Drops in Midlife Before Anything Shows on a Blood Test 10:02 - Perimenopause, Estrogen and What Changes at the Cellular Level After 40 16:25 - Epigenetics, the Five Foundations, and How to Judge a Longevity Supplement 25:51 - Glutathione, NAD, NADH and NMN for Oxidative Stress and Cellular Energy 35:09 - Spermidine, Autophagy and the Senescent Cell Frontier 43:04 - Where a Busy Woman in Midlife Should Actually Start VALUABLE RESOURCES Dr. Kien Vuu’s website https://kienvuu.com/ Thrive State (Dr. Kien's book), free PDF: https://thrivestatestarter.com Follow Dr. Kien Vuu on Instagram: https://www.instagram.com/doctorvmd Listen to Dr. Kien Vuu’s Podcast: https://podcasts.apple.com/ph/podcast/thrive-state-podcast/id1548233524 ABOUT THE GUEST Dr. Kien Vuu is a physician, human performance and longevity expert, and the author of Thrive State. He hosts the Thrive State podcast and is a brand partner and advisor to Solaray. A former chief of interventional radiology, he burnt out in his mid-30s and developed type 2 diabetes and high blood pressure. That experience drives his mission to help people build energy and longevity through five pillars of health: physical, mental, emotional, social and spiritual.