Peptide of The Week

JD Denham and Will Haas

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.

  1. 19H AGO

    Peptide of the Week: Retatrutide (GLP-3) – Fat Loss, Brain Boost & Total Control

    Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas return with the first full drop of 2026 and it's a fan-favorite: Retatrutide. Also known as GLP-3, this triple agonist is quickly becoming the most powerful fat loss compound in the peptide world. Whether you're just getting started or you're a seasoned gym rat trying to chisel that last layer of fat, this episode explains exactly why Retatrutide is dominating and how to use it strategically. We cover: 🔥 Retatrutide (GLP-3) Breakdown – Triple action: GLP-1, GIP, and Glucagon receptor agonist – Suppresses appetite, increases insulin sensitivity, and boosts metabolic rate – Torches visceral fat, especially in the midsection – Major brain and focus benefits no more “hanger,” no mental fog – Minimal to no nausea compared to semaglutide or tirzepatide – Adaptable for both weight loss and lean bulking it’s all about dosage ⚙️ Real Dosing Strategies for Different Goals – JD’s experience: 0.5mg 3x/week got him ultra-lean in just 2 weeks – Beginners: Start at 1mg 3x/week and assess after 2 weeks – Fat loss protocols: ramp up slowly to 5–6mg/week max – Lean bulk protocol: pair with MK-677 or CJC/Ipamorelin for nutrient partitioning 💊 Stacking for Results For Fat Loss: – Retatrutide + Tesamorelin (for visceral fat) – + 5-Amino 1MQ (fat cell breakdown) – + L-Carnitine (fuel fat over sugar) – + Sloof (exercise mimetic) For Lean Bulking: – Retatrutide + MK-677 (hunger + growth hormone boost) – + IGF-1 LR3 (nutrient partitioning and local muscle growth) – + Testosterone (non-negotiable for serious gains) ⚖️ Why Retatrutide Works for Nearly Everyone – Gym rats = get chiseled without extreme dieting – High-fat dieters = see double the burn from keto-style eating – Busy parents & business pros = regain control of food, energy, and cravings – Women should use extreme caution — not recommended for low-BMI users 🧠 Mindset Matters – Retatrutide isn’t a shortcut it’s a tool to help retrain habits – Discipline is a muscle: cutting sugar, eating clean, and saying NO becomes easier – From JD’s carnivore hacks to Will’s own transformation this peptide builds more than bodies 📌 Final Recap: – Retatrutide is a scientific breakthrough for fat loss, metabolism, and clarity – It burns fat like butter, kills cravings without killing your appetite, and protects your muscle – Get your blood work, understand your dose, and build the stack that fits your goals 💬 Got questions? Drop them in the comments stacks, doses, use cases, we’ll answer them all in the next Q&A. 📺 Subscribe now — Q&A episode drops Thursday and we’re just getting started for 2026.

    44 min

  2. 5D AGO

    Peptide Q&A #23 – Tendonitis Healing, RETA Storage, Estrogen Control & Long-Term Peptide Use

    Welcome back, warriors! In this episode of Peptide Q&A, JD Denham and William T. Haas dive into real-world questions on healing injuries, hormone balance, hair restoration, peptide storage, fat loss, longevity, and stacking intelligently over the long term. No fluff. No scripts. Just straight talk from experience. We cover: 💇 Hair Loss & GHK-Cu: Hair transplants vs peptides, why GHK-Cu supports thicker, darker regrowth, and real-world results seen in men and women 🦴 Tendonitis Healing: Why BPC-157 is the gold standard for tendons, direct vs near-tendon injections, and why cortisone only masks pain ⚡ Wolverine Stack: High-dose BPC-157 + TB-500 protocols, dosing ranges, and why pain increasing then centralizing is a sign of healing 💉 Injecting Injured Areas: Needle choice, safety tips, vein avoidance, and when local injections make sense 🧊 GLP Peptide Storage: Long-term storage best practices, unmixed shelf life (up to ~2 years), fridge vs freezer, and avoiding condensation 🧠 Peptide Desensitization: Tolerance vs permanent receptor damage, why cycling matters, and how breaks restore sensitivity ⚠️ Future Peptide Availability: RETA access, FDA approval timelines, and why cost may rise even if supply doesn’t disappear 🔥 RETA vs Tirzepatide: Appetite differences, fat-burning efficiency, patience during transition, and why RETA shines on stubborn belly fat 🧬 GHK-Cu & NAD+: Dosing ranges, copper considerations, NAD titration strategies, and long-term energy and longevity benefits ⚖️ Estrogen Control on Hormone Protocols: High estradiol symptoms, when to use an AI, myths around anastrozole, and finding your sweet spot 💪 Body Recomp & Leaning Out: RETA, AOD-9604, Tesamorelin/Tessa-IPA, SLU-PP-332, and stacking for fat loss without muscle loss 🧠 Cancer History Considerations: Growth hormone caution, fasting as a tool, safer alternatives, and long-term mindset 👵 Loose Skin After Weight Loss: GHK-Cu, SNAP-8 (injectable vs topical), realistic expectations, and when surgery is the only fix 🏋️ Older Athletes & HGH: Why low-dose long-term HGH preserves muscle, supports metabolism, and improves recovery without “getting big” 📚 Peptide Education Hub: Why protocols can’t live on social media, plans for a private platform, and future tools for organized learning 💡 Peptides are tools not shortcuts. Stack them with training, protein, sleep, discipline, and patience for results that stick. 👉 Drop your questions below for next week’s Q&A. 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You’re a warrior. Act like one.

    1h 8m

  3. JAN 5

    Peptide of the Week: BPC-157 + DSIP – Recovery Meets Rest

    Welcome back, warriors! In this first Peptide of the Week episode of 2026, JD Denham and William T. Haas break down two powerhouse peptides that work in tandem BPC-157 for total-body repair, and DSIP for deep, hormone-boosting sleep. Whether you’re training through pain, recovering post-surgery, or just struggling to wind down at night this episode lays out the game plan for healing hard and sleeping deeper. We cover: 💥 BPC-157 - The tendon and tissue fixer – Origin story: extracted from gut mucus, proven to heal at superhuman speed – Pills vs. injections what works best and why location matters – Injuries, tendonitis, post-op recovery, and long-term maintenance strategies – Why it’s Will’s #1 pick after 15+ surgeries and how JD used it in Cabo for a near tear – Dosing tips: acute vs. maintenance, injection site vs. systemic use – Pairing BPC with TB-500 for next-level repair (aka The Wolverine Stack) – Real-world stories: JD’s dad, Will’s grandmother, even direct tendon injections for advanced recovery 😴 DSIP (Delta Sleep-Inducing Peptide) – Recovery while you sleep – Not a sedative works by calming brain activity and deepening sleep quality – Boosts GABA, suppresses excitatory pathways, lowers cortisol, and regulates circadian rhythm – Why this is critical for muscle growth, fat loss, memory retention, and hormonal health – Best taken 1–2 hours before bed to optimize deep-wave (delta) sleep – Perfect for high-performers who sleep light, scroll late, or wake up exhausted – Stack benefits: DSIP + BPC = muscle repair and hormonal reset in one protocol 📌 Pro tip: If you’re prepping for surgery, stack BPC-157 + TB-500 daily 3 weeks prior and post-op to speed up recovery and reduce scar tissue formation. 💬 Have questions? Want to know what to stack next? Drop them in the comments and stay tuned for next week’s peptide deep dive. 📺 Subscribe now for weekly breakdowns of the best healing and performance tools on the planet.

    43 min

  4. JAN 1

    Peptide Q&A #22 – Post-Pregnancy Fat Loss, Liver Health, RETA Hunger & Long-Term Stacking

    Welcome back, warriors! In this episode of Peptide Q&A, JD Denham and William T. Haas break down hormone timing, fat-loss plateaus, longevity planning, and real-world stacking questions as we head into the new year. No fluff. No scripts. Just straight talk from experience. We cover: 💉 HGH + Tesamorelin Together: How somatostatin works, when GH can blunt Tessa, and why morning HGH + night Tessa-IPA still makes sense 🔥 Post-Pregnancy Fat Loss: Why the “baby belly” is last to go, adding AOD + Tesamorelin, and staying patient after big progress 🧠 Liver Health on Fat Loss Stacks: ALT/AST increases, glutathione, NAC, TUDCA, NAD+, and mitochondrial support during rapid fat loss ⚡ Peptides for POTS: Symptom-based support using NAD, MOTS-C, SS-31, TA-1, BPC-157, and inflammation control 💪 Female Muscle-Building Stack: Tesamorelin vs Tessa-IPA, IGF-1 LR3, carbs for growth, nutrient partitioning, and realistic expectations in your 40s ⏱️ Fasted vs Fed Peptides: Which peptides matter fasted (fat loss, GH, mitochondria) and which don’t (injury, skin, healing) 👣 Wolverine Stack for Plantar Fasciitis: Why not to inject the foot, where to inject instead, and how healing peptides travel systemically 👶 Pregnancy & Peptides: When to pause peptides, tapering GLPs safely, and maintaining habits without rebound weight gain 📉 RETA Hunger After GLP-1s: Why appetite comes back after stronger suppressors, why upping RETA isn’t the answer, and staying the course 🧪 Adding Cagrilintide: How it may help appetite noise when paired with RETA ⚠️ SLU-PP-332 & Cancer Claims: Breaking down rodent data, dose context, real-world risk, and why lifestyle matters more 🧠 Foundational Priorities: Why diet, sleep, training, fasting, and discipline still beat chasing more compounds 💡 Peptides are tools not shortcuts. Stack them with training, protein, sleep, and discipline for results that stick. 👉 Drop your questions below for next week’s Q&A. 📌 Subscribe now for weekly, no-fluff protocols, dosing guidance, and real-world results. You’re a warrior. Act like one.

    58 min

  5. 12/29/2025

    Peptide of the Week: Year-End Recap Growth, Gratitude & What’s Coming in 2026

    Welcome back, warriors! In this final Peptide of the Week episode of 2025, JD Denham and William T. Haas hit pause on peptide breakdowns to reflect on how far this podcast has come, what they’ve learned, and what’s in store for the year ahead. From Cabo beach reflections to podcast studio goals, this episode dives into the real story behind how Peptide of the Week started, why it blew up, and how you the listener are part of it. We cover: 🎙 How it all started – From recording in a backyard and a Vegas hotel to building a full studio – Why Will was hesitant at first and how the podcast became real talk between friends – No scripts, no hype just passion, experience, and lifelong curiosity for health optimization 🔥 Why this show works – Peptides changed our lives — and now they’re changing yours – Our conversations are the same ones we’ve had for years you’re just in the room now – Real questions. Real answers. No shortcuts. Just truth from trial, error, and deep dives 💬 Our favorite part of 2025 – Seeing lights come on in people’s lives – Hearing DMs from around the world parents, athletes, veterans saying, “This changed me” – Q&A episodes that reveal how curious and committed this community really is 🎯 Looking ahead to 2026 – Monthly expert guest episodes (doctors, researchers, specialists) coming soon – A fully optimized studio setup so the guys can just hit record and go – No fame-chasing just smarter systems, better quality, and more education for the community 💡 “Peptides are just the gateway.” – That’s the truth JD & Will return to because this show isn’t about one compound – It’s about helping people fall in love with health, performance, and a life they actually want – The deeper we go, the more we all learn together 🙏 Final message of the year: Gratitude – Life’s not about perfect routines or peptide stacks it’s about perspective – Be grateful for your body. For your journey. For every step forward you’ve taken – And if you’re just getting started? You’re in the right place 📌 Thank you for riding with us this year. We’re just getting started. 💬 Drop your goals for 2026 in the comments and tell us what episodes or peptides you want to see first next year. 📺 Subscribe now so you don’t miss what’s coming. It’s gonna be big.

    32 min

  6. 12/25/2025

    Peptide Q&A #21 – Women’s Hormones, AOD Reconstitution, RETA Dosing, & PT-141 Nasal Spray

    Welcome back, warriors! In this episode of Peptide Q&A, JD Denham and William T. Haas dig into real-world hormone optimization, peptide troubleshooting, longevity planning, and honest answers to listener questions. No fluff. No scripts. Just straight talk from experience. We cover: 💉 Women’s Hormones (HCG vs Testosterone): Optimal non-clinical ranges, total vs free testosterone, and when HCG makes sense vs direct TRT 📊 Female Testosterone Ranges: Why “normal labs” don’t mean optimal and how women find their personal sweet spot 💧 AOD-9604 Reconstitution: Why AOD is hydrophobic, proper acidic/glycerol water ratios, dosing math, and avoiding gelling 🧪 SLU-PP-332 Side Effects: Addressing bruising and skin issues, elimination testing, and when to discontinue 🌙 Tesamorelin Timing: Night dosing with shift work, starting doses, titration, and managing water retention 🔥 RETA Dosing Strategy: Starting low, adapting to tolerance, and when higher weekly totals are actually required 🧬 Follistatin Reality Check: Why real-world results don’t match the hype, cost vs benefit, and better alternatives ⚖️ RETA Not “Working”: Understanding tolerance, metabolism, muscle mass, and why some need higher doses 🧠 Longevity Reset Protocols: LL-37, FOXO4-DRI, Epitalon, fasting, autophagy, and cellular cleanup strategies ❄️ Fasting & Autophagy: Why 16-hour fasts trigger cleanup and how extended fasts reduce long-term disease risk 💗 PT-141 Nasal Spray Blend: PT-141 + oxytocin + Selank effects, microdosing vs acute use, and avoiding side effects 💉 Peptide Reconstitution Tips: Tesamorelin gelling issues, water temperature, and storage fixes 🩸 TRT Acne & Estrogen Control: Why lowering testosterone isn’t the answer, AI dosing, and real-world lab feedback 🧬 NAD+ vs Epitalon: Longevity roles, reset vs energy support, and why both have a place 🗣️ Convincing Others to Try Peptides: Why attraction beats promotion and leading by example actually works 📈 Future Peptides: What’s coming next, upcoming guests, doctors, and deeper health conversations in 2026 💡 Whether you’re dialing in hormones, troubleshooting peptides, or building a long-term longevity plan, this Q&A is packed with straight answers to help you make informed decisions. ⚠️ Reminder: Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline. 👉 Got a peptide question for JD and Will? Drop it in the comments for next week’s Q&A. 📌 Subscribe now for weekly deep dives, protocols, and no-fluff education. You’re a warrior. Act like one.

    54 min

  7. 12/22/2025

    Peptide of the Week: Industry Update – Retatrutide, GLP-1s & FDA Moves Explained

    Welcome back, warriors! In this week’s special episode of Peptide of the Week, JD Denham and William T. Haas are joined by peptide researcher and clinical expert Paul Bakhtiar to break down the biggest developments shaking up the entire peptide industry. From FDA crackdowns to the future of GLP-1s like Retatrutide, this episode gives you the real insider breakdown of what’s happening, why it matters, and what you should do right now if you’re using or selling peptides. We cover: ⚠️ Retatrutide: What’s changing & when – Big Pharma is moving fast to monopolize Retatrutide via FDA approval – Once approved, it will no longer be available through research-use sites – Access will be limited to prescription only via 503A/503B pharmacies & telehealth – Expect price increases of 50–100% compared to current availability 💉 What does this mean for GLP-1 users? – Stock up NOW if you’re using Retatrutide (powder can last 2+ years unreconstituted) – Semaglutide & Tirzepatide may still be available for a time, but not forever – New rules are expected by Q1 2026, if not sooner – Telehealth will become the main legal route for GLP-1s and other “controlled” peptides 📉 What about other peptides (BPC-157, TB-500, MOTC, etc.)? – The FDA is quietly reclassifying peptides as “biologics” to open them up for patents – 25–40 peptides are expected to become FDA approved in the next 12–18 months – Research-use availability will continue for now, but eventually move to doctor-prescribed only 💣 Why this proves peptides are the real deal – Peptides work that’s why Big Pharma is jumping in – The move to medicalize & retailize peptides is proof they’re not fringe they’re the future – Good news: this also removes bad actors & fake COAs from the market 📌 Whether you’re a casual user or deep in the industry this episode is a must-listen for truth over headlines and clarity over fear. 💬 Got questions? Drop them in the comments and we’ll keep unpacking this in future episodes. 📺 Subscribe for weekly deep dives into the truth about performance, healing, and longevity. No fluff. No fear. Just facts. Stay Connected & Follow Us! JD's Instagram: https://www.instagram.com/jd_denham_fit JD's Facebook: https://www.facebook.com/people/JD-Denham/61563578940850/ Wills Instagram: https://www.instagram.com/williamthaas/ Paul Bakhtiar's Instagram: https://www.instagram.com/paulbakhtiar/

    23 min

  8. 12/18/2025

    Peptide Q&A #20 – Bikini Prep Stacks, 2026 Peptide Restrictions, TRT Cycles & Long-Term Peptide Use

    Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas break down real-world protocols, competition prep, hormone optimization, longevity stacks, and what may be coming next for the peptide industry. No fluff. No scripts. Just straight talk from experience. We cover: 💪 Bikini Competitor Fat Loss: RETA dosing, Tesamorelin, SLU-PP-332, NAD+, glutathione, and how to tighten up without steroids 🩸 PCOS & Cycle Changes: Why RETA may help restore menstrual cycles and improve skin quality in female athletes 🔥 Getting Leaner on Prep: When to increase RETA, add 5-Amino-1-MQ, L-Carnitine alternatives, and why AOD matters ⚠️ 2026 Peptide Restrictions: What may change with GLPs and peptides, why prices may rise, and why stocking now could matter 🏋️ TRT + Cycle Planning: Deca vs NPP, cutter compounds, growth hormone dosing, and why long-term low-dose HGH wins 🧠 Sub-Q vs IM Testosterone: Aromatization, injection frequency, and real-world pros and cons 🧬 Bioregulators Explained: How bioregulators differ from peptides, gene signaling vs stimulation, and examples like Epitalon 👵 56-Year-Old Longevity Stack: RETA titration, MOTS-C, SS-31, NAD+, inflammation control, and safe fat-loss additions ⚖️ Cancer History & Peptides: What to avoid, what’s safer, and how to approach healing without over-stimulation 🏃 Athlete Recovery & Energy: Wolverine stack, secretagogues, HGH, and staying mobile past 40 🔥 RETA Cycling: How long to run it, tapering vs stopping cold turkey, and when it “works again” after a break 🥗 Plateaus After GLP-1/2: Why GLP-3 may be the answer when hunger never shuts off and fat loss stalls 🧠 Mental Clarity Stacks: MOTS-C, SS-31, NAD+, C-Lanx, C-Max, and energy for high-output professionals 🦠 Chronic UTIs & Sepsis: Thymosin Alpha-1, BPC-157, TB-500, KPV, gut repair, and immune balance 🔁 Long-Term Peptide Use: Can you stay on peptides forever, when to cycle, and avoiding diminishing returns 💡 Peptides are tools not shortcuts. Stack them with training, protein, sleep, and discipline for results that stick. 👉 Drop your questions below for next week’s Q&A. 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You’re a warrior. Act like one.

    1h 6m
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4.7
out of 5
64 Ratings

About

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.

Information

  • Creator
    JD Denham and Will Haas
  • Years Active
    2025 - 2026
  • Episodes
    60
  • Rating
    Clean
  • Copyright
    © JD Denham and Will Haas
  • Show Website
    Peptide of The Week

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