unPAUSED with Dr. Mary Claire Haver

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Welcome to unPAUSED, the podcast where bold, unfiltered conversations take place about what it really takes for women to thrive in the second half of life. Every week, Dr. Mary Claire Haver, a board-certified Obstetrician-Gynecologist, Certified Menopause Practitioner, and #1 New York Times best-selling author, tackles the conversations women actually need to hear. Dr. Haver sits down with a variety of medical experts, CEOs, and risk-takers to discuss everything that matters, from hormones and identity to financial power, relationships, and the tools needed to build the life you want. unPAUSED is about reclaiming your healthspan—not just the number of years you live, but the number of years you live well. Tune in every Tuesday for new episodes of unPAUSED. Subscribe now so you don't miss it.

  1. 1D AGO

    Female Libido in Menopause: Desire Loss, Biology & Solutions with Cindy Eckert

    This week on unPaused, Dr. Mary Claire Haver sits down with Cindy Eckert, founder and CEO of Sprout Pharmaceuticals and creator of Addyi, the first FDA approved treatment for low libido in women. Cindy is a pharmaceutical entrepreneur who began her career at Merck before founding her first company in 2007, focusing on undermarketed FDA approved products. After successfully building and selling a male sexual health company, she became the only woman running a sexual health company and witnessed firsthand the stark contrast between how medicine treats male versus female sexual dysfunction. Her journey to bring Addyi to market became a cultural battle about whether women's sexual desire matters, leading to two FDA rejections, public hearings, and ultimately a historic approval in 2015 after a six year fight. In this conversation, Dr. Haver and Cindy explore how Addyi works differently from Viagra, targeting brain chemistry and desire rather than blood flow and arousal. Cindy explains that Addyi is a mood drug originally developed for depression that showed an unexpected effect on female libido during clinical trials. The medication works on neurotransmitters in the brain, building over approximately eight weeks to restore spontaneous thoughts, fantasies, and desire in women with hypoactive sexual desire disorder or HSDD. She walks through the massive clinical trial requirements, including 13,000 patients compared to Viagra's 4,000, and the three things they had to prove with statistical significance versus placebo: increased interest in sex, more satisfying sexual experiences, and decreased distress from the condition. ADDYI, flibanserin, is for women 65 with low sexual desire disorder who have not had problems with low sexual desire in the past, and who have low sexual desire that is troubling to them no matter the type of sexual activity, situation, or sexual partner. The low sexual desire is not due to a medical or mental health problem, problems in the relationship or medicine or other drug use. ADDYI is not for men or to enhance sexual performance. Your risk of severe low blood pressure and fainting is increased if you drink 1-2 standard alcoholic drinks close in time to your ADDYI dose. Wait at least 2 hours after one to two drinks before taking ADDYI at bedtime and skip your dose if you drink three or more drinks that evening. If you take certain prescription, OTC or herbal medications, or have liver problems, the risk of low blood pressure and fainting increases and you should not take ADDYI.   Do not take if you are allergic to any of ADDYI’s ingredients. Sometimes serious sleepiness can occur. Common side effects include dizziness, nausea, tiredness, difficulty falling asleep or staying asleep and dry mouth. See PI and Boxed Warning at addyi.com/piGuest links: Cindy Eckert  Cindy Eckert (Instagram) Recommended Books: “Mars and Venus in the Bedroom: A Guide to Lasting Romance and Passion,” by John Gray Articles: Women with hypoactive sexual desire disorder compared to normal females: a functional magnetic resonance imaging study (Neuroscience) Sexual Dysfunction Induced by Antidepressants—A Pharmacovigilance Study Using Data from VigiBaseTM (Pharmaceuticals) Enhancing Sexual Health for Cancer Survivors (Symptom Science And Palliative Care) Flibanserin Approval: Facts or Feelings? (Sexual Medicine) Clinical trial evidence supporting FDA approval of novel therapeutic agents, 2005-2012 (JAMA) Other Resources: Addyi What is Patient-Focused Drug Development? International Society for the Study of Women's Sexual Health (ISSWSH) FDA Expands Approval of Flibanserin for Postmenopausal Women’s Sexual Health (Drug Topics) A Pill for Sexual Desire Reaches a New Group of Women (TIME Magazine)Drug Trials Snapshots Summary Report 2024 (FDA) To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    1h 7m

  2. FEB 3

    Understanding Your Brain Through Perimenopause and Menopause with Dr. Louisa Nicola

    An estimated 7.2 million Americans age 65 and older are currently living with Alzheimer's dementia. The part that should alarm every woman listening is this: almost two thirds of them are women. In this episode, Dr. Mary Claire Haver sits down with neurophysiologist and Alzheimer's researcher Dr. Louisa Nicola to unpack what's really happening to women's brains during perimenopause and menopause and what we can do about it. Louisa Nicola is a neurophysiologist, human performance coach, and founder of Neuro Athletics, a consulting firm that works with elite athletes and high-level professionals to optimize brain health and performance. A former world class triathlete, she transitioned into neuroscience and earned her Master of Medicine in neurophysiology from the University of Sydney. Dr. Nicola is currently pursuing her doctorate studying the effects of resistance exercise on brain health. She focuses on optimizing brain function and longevity, particularly in women, through sleep, nutrition, and exercise interventions. Dr. Nicola reveals how Alzheimer's disease doesn't suddenly appear at 70 but starts quietly in our thirties and forties, building up over a 30-year progression. She explains what's happening in the brain as amyloid beta proteins and tau tangles accumulate, why the hippocampus is the first area to go, and the critical role that sleep plays in clearing these proteins through the glymphatic system. The conversation explores why women are more predisposed to tau protein accumulation than men and how estrogen, progesterone, and prolactin inhibit the enzyme that causes tau proteins to become hyperphosphorylated and toxic. Dr. Nicola explains the connection between declining estrogen during perimenopause and increased Alzheimer's risk, including how estrogen helps mediate glucose metabolism in the brain, supports synaptic connections, and why the loss of this hormonal scaffolding leaves women vulnerable to cognitive decline. Guest links: Louisa Nicola (Instagram) Louisa Nicola (Facebook) Louisa Nicola, MMed, PhD(c) (LinkedIn) Louisa Nicola (YouTube) Louisa Nicola (X) Neuro Athletics The Neuro Experience Podcast (Apple Podcasts) The Brain Code Books “Joyspan,” by Dr. Kerry Burnight To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    1h 20m

  3. JAN 27

    Menopause, Hormones and Women’s Sexual Health with Dr. Rachel Rubin

    In this episode Dr. Mary Claire Haver is joined by Dr. Rachel Rubin, a board-certified urologist and nationally recognized expert in sexual medicine, fellowship trained in both female and male sexual health. As assistant clinical professor of urology at Georgetown University and former education chair of the International Society for the Study of Women's Sexual Health, she brings unique insight into the stark disparities in how sexual dysfunction is treated across genders. Dr. Rubin founded the Sexual Medicine Research Team, and her advocacy work has been instrumental in changing FDA labeling on hormone therapy and advancing the American Urological Association Guidelines on genital urinary syndrome of menopause. During the conversation, Dr. Haver and Dr. Rubin explore the intersection of menopause, hormones and women's sexual health, revealing why most doctors, including OB-GYNs, receive virtually no training in sexual health despite sexual dysfunction affecting millions of women. Dr. Rubin explains how men's sexual health benefits from 27 fellowship programs while women's sexual health has only three, and why erectile dysfunction research receives billions while female orgasm research gets nothing from the NIH. She breaks down the complete anatomy of the clitoris that most medical professionals never learned, explaining why understanding this matters for surgical outcomes, pleasure, and treating conditions like vulvar vestibule pain that affects penetration, tampon use, and pelvic exams. Dr. Rubin discusses how the vulvar vestibule, the hormone sensitive tissue surrounding the urethra, becomes a source of pain for many women during perimenopause, on birth control pills, or postpartum due to low estrogen and testosterone. Guest links: Dr. Rachel Rubin (Instagram) Dr. Rachel Rubin (YouTube) Dr. Rachel Rubin (Website) Dr. Rachel Rubin (LinkedIn) Dr. Rachel Rubin (Facebook) Dr. Rachel Rubin (X) Books “Vagina Obscura: An Anatomical Voyage Hardcover,” by Rachel E. Gross Articles Sexual function after hysterectomy according to surgical indication: a prospective cohort study (Sexual Health) The human cervix: Comprehensive review of innervation and clinical significance (Clinical Anatomy) Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves (Brain Research) The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe? (Biomolecules) Effect of Saw Palmetto Extract on Erectile Dysfunction and Libido in Patients with Lower Urinary Tract Symptoms Because of Benign Prostatic Obstruction (International Journal of Applied Research on Medicinal Plants) “Not feeling like myself” in perimenopause — what does it mean? Observations from the Women Living Better survey (Menopause) Updates on Therapeutic Alternatives for Genitourinary Syndrome of Menopause: Hormonal and Non-Hormonal Managements (Journal of Menopausal Medicine) Menopausal Hormone Therapy and Cardiovascular Diseases in Women With Vasomotor Symptoms: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials (JAMA Internal Medicine) To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    1h 47m

  4. JAN 22

    Strong Bones, Strong Body, Stronger Second Half with Dr Jocelyn Wittstein - Part 2

    In this continuation of their conversation, Dr. Jocelyn Wittstein and Dr. Mary Claire Haver shift from understanding why menopause affects bones and joints to what actually works for building stronger bones and preventing fractures. If you've been told your bone density is declining, or you're worried about falls and fractures, this episode delivers the practical protocols you need. Dr. Wittstein is a practicing orthopedic surgeon, researcher, and associate professor at Duke University specializing in sports medicine and the female athlete across the lifespan. She's also a former collegiate gymnast and mother of five. Her research focuses on frozen shoulder, ACL injuries in female athletes, and the musculoskeletal syndrome of menopause. As president of the Forum for Women in Sports Medicine, Dr. Wittstein is changing how we understand the intersection of hormones, movement, and independence in women's bodies. They tackle the questions women ask most. How much exercise is enough? What types build bone? Is jumping necessary? They discuss the LIFT More trial and EFOPS trial, research showing women in structured exercise programs had fifty percent reduction in fracture risk, even as bone density eventually declined. This reveals something crucial: preventing fractures goes beyond bone density numbers alone. Guest links: Jocelyn Ross Wittstein, MD (Duke Health) Jocelyn Wittstein, MD (Instagram) Duke Female Athlete Program Milken Institute Women’s Health Initiative Books:“The Complete Bone and Joint Health Plan: Help Prevent and Treat Osteoporosis and Arthritis,” by Dr. Jocelyn Wittstein and Sydney Nitzkorski, MS, RD To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    44 min

  5. JAN 20

    Menopause, Frozen Shoulder and the Joint Pain Wake Up Call with Dr. Jocelyn Wittstein - Part 1

    If you've ever struggled to put on a bra, reach behind your back, or lift your arm without searing pain in your shoulder, you're not alone. Frozen shoulder strikes women in midlife at alarming rates, yet for decades, medicine dismissed it as a mystery condition with no known cause. Orthopedic surgeon Dr. Jocelyn Wittstein saw what others missed: her patients with frozen shoulder were almost all women between forty and sixty, experiencing hot flashes, night sweats, and other symptoms of perimenopause and menopause. What she discovered is changing how we understand the impact of declining estrogen on women's joints, bones, and muscles. Dr. Wittstein is a practicing orthopedic surgeon, researcher, and associate professor at Duke University, specializing in sports medicine and the female athlete across the lifespan. She's also a former collegiate gymnast and mother of five. Her research focuses on frozen shoulder, ACL injuries in female athletes, and the musculoskeletal syndrome of menopause. As president of the Forum for Women in Sports Medicine, Dr. Wittstein is changing how we understand the intersection of hormones, movement, and independence in women's bodies. In this conversation, Dr. Mary Claire Haver and Dr. Wittstein explore how declining estrogen during perimenopause and menopause impacts joints, bones, muscles, and connective tissue. They discuss why frozen shoulder disproportionately affects women in midlife, with some Asian cultures having their own term for it that translates to fifty year shoulder. Dr. Wittstein explains the critical window for treatment, why early intervention can be transformative, and how hormone replacement therapy may prevent it, with preliminary data suggesting women using systemic estradiol have half the risk of developing frozen shoulder. She shares why physical therapy during the inflammatory phase can worsen it and how to recognize the early warning signs. Guest links: Jocelyn Ross Wittstein, MD (Duke Health) Jocelyn Wittstein, MD (Instagram) Duke Female Athlete Program Milken Institute Women’s Health Initiative Books“The Complete Bone and Joint Health Plan: Help Prevent and Treat Osteoporosis and Arthritis,” by Dr. Jocelyn Wittstein and Sydney Nitzkorski, MS, RD To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    1 hr

  6. JAN 17

    Sally Wainwright on Riot Women, Identity Theft of Menopause, and Writing Real Female Characters

    Award-winning British television creator Sally Wainwright joins Dr. Mary Claire Haver to discuss her groundbreaking new BBC series Riot Women, a drama about five midlife women who form a punk rock band while navigating menopause, aging parents, and the complexities of life after 50. Sally, the creative force behind acclaimed series including Happy Valley, Gentlemen Jack, and Last Tango in Halifax, shares how her own experience with perimenopause and menopause inspired the show and why she calls this life stage "identity theft." The conversation explores Sally's journey from bus driver to one of British television's most celebrated showrunners, her commitment to portraying authentic female characters who carry grief, desire, sexuality, rage, and resilience in bodies that reflect actual lived experience, and how brain fog, joylessness, and depression led her to finally try hormone replacement therapy after initially believing outdated myths about breast cancer risk, and how that decision transformed her wellbeing. Dr. Haver and Sally discuss the critical importance of naming menopause symptoms, from the devastating loss of motivation and confidence that can accompany hormonal changes to the sandwich generation pressures of dementia care for aging parents while raising teenagers. The episode examines why female stories, particularly those featuring women over 50, face funding challenges in entertainment, how male writers have historically constructed female characters through the male gaze, and why Sally believes women are more heroic and emotionally articulate than men. They explore the revolutionary aspects of Riot Women, including its honest portrayal of sexual health, libido changes, medical gaslighting, and the transformative power of HRT, rarely if ever depicted on screen with such nuance and optimism. Sally discusses audience response to the series, including an unprecedented volume of thank-you letters to the BBC from viewers who felt seen for the first time, men's surprising embrace of the show despite its focus on female experience, and a handful of critics who complained about the absence of "nice men" despite the show's ensemble of complex, flawed characters of all genders. This conversation offers validation for anyone navigating the physical and emotional challenges of perimenopause and menopause, inspiration for creative midlife reinvention, and hope that entertainment is finally beginning to tell the truth about women's lives with the honesty, ferocity, humor, tenderness, and rage they deserve. Guest links: Sally Wainwright (Instagram) Sally Wainwright (IMDB) Articles Menopausal Hormone Therapy and the Breast: A Review of Clinical Studies (Breast Care) Anhedonia: A Concept Analysis (Archives of Psychiatric Nursing) Other Resources Primary Ovarian Insufficiency in Adolescents and Young Women (American College of Obstetricians and Gynecologists) Riot Women (BBC) Clips from Riot Women: 251105_RiotWomen_Ep1_Clip_Satisfaction_Bug.mp4 251105_RiotWomen_Ep1_Clip_WithAttitude_Bug.mp4 251105_RiotWomen_Ep1_Clip_RiotWomen_Bug.mp4 251105_RiotWomen_Ep1_Clip_OneMenopausalWomanToAnother_Bug.mp4 251105_RiotWomen_Ep1_Clip_ForTheRefugees_Bug.mp4 To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    53 min

  7. JAN 13

    From Hysteria to Medical Gaslighting and the Path Forward with Dr. Elizabeth Comen

    Dr. Elizabeth Comen is a board certified oncologist at NYU Langone Health, co-director of the Mignoni Women's Health Collaborative, and author of the groundbreaking book “All In Her Head: The Truth and Lies Early Medicine Taught Us About Women’s Bodies and Why It Matters Today”. In this powerful conversation about medical gaslighting and women's healthcare, she and Dr. Mary Claire Haver trace the deep roots of medical misogyny and reveal why the healthcare system still dismisses women's symptoms today. Dr. Comen shares the story of a breast cancer patient on her deathbed who, hours from death, apologized for sweating during a hug. It's a moment that captures what nearly every woman experiences in a doctor's office, the reflexive apology for being in a normal human body. Whether it's apologizing for leg hair in stirrups or hiding underwear during an exam, women have internalized tremendous shame about their bodies. Dr. Comen explains this isn't random. It's the legacy of a medical system built by men who dismissed women's pain and symptoms as hysteria, neurosis, or anxiety. Through meticulous research into medical history, Dr. Comen reveals how this medical gaslighting became embedded in healthcare. She discusses William Osler, one of cardiology's founding fathers, who described women's chest pain as "neurotic angina" and wrote that "these women do not die." Yet heart disease is the number one killer of women. She explains how women are twice as likely to call an ambulance for their husband's heart attack than for themselves, and when they do seek help for chest pain, they're far more likely to be misdiagnosed with a panic attack instead of receiving proper cardiac care. Dr. Haver and Dr. Comen discuss the systemic healthcare gaps across medical specialties: why 80% of autoimmune diseases affect women yet it's not considered a women's health field, why female specific surgeries are reimbursed at significantly lower rates than comparable male procedures, why Alzheimer's disease is twice as common in women but received almost no research funding, and how the legacy of dismissing women's sexual health continues in breast cancer and oncology care today. They explore bizarre historical medical fears like "bicycle face," the myth that women would become ugly and infertile from exercise, and how plastic surgery evolved to make women "marriage material" rather than serve their actual health needs. Despite the sobering history of medical misogyny, this conversation ends with hope. Dr. Comen shares why she's optimistic about the cultural shift happening in women's healthcare now, the importance of women advocating for themselves in medical settings, and how the next generation doesn't have to wait for menopause to stop apologizing and start demanding better healthcare. Guest links: Dr. Elizabeth Comen Dr. Elizabeth Comen (Instagram) Dr. Elizabeth Comen (LinkedIn) Dr. Elizabeth Comen, MD (NYU) Books “All in Her Head: The Truth and Lies Early Medicine Taught Us About Women’s Bodies and Why It Matters Today,” by Dr. Elizabeth Comen “The New Menopause,” by Dr. Mary Claire Haver“The New Perimenopause: An Evidence-Based Guide to Surviving the Zone of Chaos and Feeling Like Yourself Again,” by Dr. Mary Claire Haver To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    1h 12m

  8. JAN 6

    Menopause Masterclass: Hormones, Brain Fog, Weight & Mental Health with Dr. Mary Claire Haver

    Dr. Mary Claire Haver breaks down everything you need to know about perimenopause, menopause, and postmenopause in this solo episode, answering critical questions about hormones, symptoms, and treatment with the medical expertise and personal experience that's made her a trusted voice for millions of women. Most women don't realize perimenopause can begin at 35-36 years old, a full seven to ten years before periods stop. Dr. Haver explains why the first signs are often brain-related: fog, anxiety, feeling like "something's not right," rather than physical changes. Menopause itself is just one day (one year after your last period), but postmenopause represents 30-50 years of life without ovarian hormones. Understanding these three phases changes everything about how women can navigate this transition. In this episode, Dr. Haver answers questions like: What is menopause and when does it really start? Why am I gaining weight around my middle even though my diet hasn't changed? Why am I suddenly experiencing anxiety and depression? What changes happen to the vagina and bladder? What are my hormone therapy options? And what about testosterone, do I need it? With estrogen receptors mapped throughout the body, Dr. Haver reveals how declining hormones affect nearly every system. She lists over 40 potential symptoms beyond hot flashes: frozen shoulder, elevated cholesterol, insulin resistance, joint pain, kidney stones, even heightened hearing. Understanding the biology of how your hypothalamus frantically signals ovaries that can't respond explains why menopause impacts so much more than your cycle. She also explains why visceral belly fat triples during this transition regardless of diet and exercise changes, and what that means for long-term health. Dr. Haver shares a revealing statistic: only 8% of OB-GYN residents feel competent treating menopause, and 77% receive zero menopause training. She explains what doctors should know but often don't: hormone therapy as first-line treatment for mental health changes in perimenopause, prophylactic vaginal estrogen for all perimenopausal women (considered safe even for many breast cancer patients), no mandatory stop date for hormone therapy when benefits outweigh risks, and affordable bioidentical options that exist beyond expensive pellets. This episode arms you with knowledge to find menopause-educated clinicians, recognize quality care, and demand treatment that actually works. As Dr. Haver emphasizes throughout the episode, no woman should suffer unnecessarily when safe, effective options exist. Guest links: Mary Claire Wellness The ‘Pause Life Dr. Mary Claire Haver (Instagram) Dr. Mary Claire Haver (YouTube) Books “The New Menopause,” by Dr. Mary Claire Haver Other Resources The Menopause Society The Women’s Health Initiative Dr. Kelly Casperson Dr. Corinne Menn To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

    51 min
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About

Welcome to unPAUSED, the podcast where bold, unfiltered conversations take place about what it really takes for women to thrive in the second half of life. Every week, Dr. Mary Claire Haver, a board-certified Obstetrician-Gynecologist, Certified Menopause Practitioner, and #1 New York Times best-selling author, tackles the conversations women actually need to hear. Dr. Haver sits down with a variety of medical experts, CEOs, and risk-takers to discuss everything that matters, from hormones and identity to financial power, relationships, and the tools needed to build the life you want. unPAUSED is about reclaiming your healthspan—not just the number of years you live, but the number of years you live well. Tune in every Tuesday for new episodes of unPAUSED. Subscribe now so you don't miss it.

Information

  • Channel
    Audacy
  • Creator
    Audacy | Mary Claire Haver, MD
  • Years Active
    2025 - 2026
  • Episodes
    22
  • Rating
    Explicit
  • Copyright
    Copyright © Mary Claire Media, LLC. All rights reserved.
  • Show Website
    unPAUSED with Dr. Mary Claire Haver

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