The Stem Cell Podcast

The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

  1. 1d ago

    Ep. 328: “Modeling Human Microenvironments” Featuring Dr. Abdullah Khan

    Guest: Dr. Abdullah Khan is an Associate Professor of Tissue Engineering at the University of Oxford and a Group Leader at the MRC Weatherall Institute of Molecular Medicine. He discusses how his lab engineers complex human tissue models to study the cellular interactions that drive development, aging, and disease. He also explores how multi-organoid systems can model interactions between tissues such as the bone marrow and heart, and how these platforms could advance disease modeling, drug discovery, and preclinical research. Featured Products and Resources: Get a free wallchart on the derivation and applications of hPSCs. Subscribe to ESC & iPSC News to receive all of the latest research, news, jobs, and events in ESC & iPSC research. The Stem Cell Science Round Up Rescuing hPSC Differentiation – A chemical chromatin restoration approach reverses differentiation defects in human pluripotent stem cells, restoring their ability to generate diverse cell types and brain organoids. A Tumor Organoid Atlas – Patient-derived tumor organoids reveal cancer-specific gene dependencies and therapeutic vulnerabilities, providing a resource for advancing precision oncology. Mapping New Cancer Vulnerabilities – CRISPR screening of organoids and spheroids expands the Cancer Dependency Map, revealing cancer vulnerabilities and molecular subtypes missed by traditional cell lines. Building Better Cancer Models – A large collection of next-generation cancer models captures much of the genetic and epigenetic diversity of patient tumors, creating a resource for studying cancer biology and treatment response. Modeling Heart Valve Disease – Human iPSC-derived valve assembloid models heart valve development and reveals how mechanical forces and fluid flow shape valve formation and disease. Heart Valves in the Lab – Stem cell-derived 3D heart valve tissues recapitulate key features of valve maturation and provide a human platform for studying inflammation and calcific valve disease. Photo Reference: Courtesy of Dr. Abdullah Khan. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  2. Aug 5

    Ep. 327: “The iPSC Revolution” Featuring Dr. Shinya Yamanaka

    Guest: Nobel Laureate Dr. Shinya Yamanaka is the Director Emeritus of the Center for iPS Cell Research and Application (CiRA), President of the CiRA Foundation, Professor at Kyoto University, and Senior Investigator at the Gladstone Institutes. 20 years after the discovery of iPSCs, he discusses how his lab is advancing iPSC therapies toward the clinic while continuing to investigate the basic mechanisms underlying pluripotency, stem cell biology, and translation initiation. He also shares his vision for the future of regenerative medicine, the ethical challenges posed by emerging stem cell technologies, and the opportunities created by combining iPSC with advances such as CRISPR and organoids. Featured Products and Resources: Get a free wallchart on the directed differentiation of hPSCs. Subscribe to STEMCELL Sceince News to stay current with the latest research and news in the fields of immunology and cell biology. The Stem Cell Science Round Up Elephant iPS Cells – Researchers have generated the first induced pluripotent stem cells from Asian elephants, providing a new platform for conservation and disease research. Epigenetic Cell Counter – Intestinal stem cells use an epigenetic division-counting mechanism to precisely control cell fate decisions during tissue maintenance. Reversing Bone Marrow Aging – Long-term vitamin C supplementation partially reverses age-related changes in primate bone marrow and hematopoietic stem cell function. Human Heart Atlas – A comprehensive atlas of human cardiac organoids reveals how signaling molecules regulate heart function and identifies pathways linked to heart failure. Photo Reference: Courtesy of Dr. Shinya Yamanaka. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

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A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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