Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz
  • 4.8 (119)
  • Health & Fitness
  • Updated Weekly

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

  1. 6d ago

    Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms

    Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctors were never taught to test for. Dr. Tania Dempsey, MD, trained in internal medicine at Johns Hopkins before leaving conventional practice to focus on mast cell activation syndrome, a condition she believes explains far more chronic illness in women than most doctors realize. She's the founder of The AIM Center for Personalized Medicine and helped found the International Society for Mast Cell Activation Syndromes, where she now serves as treasurer. This isn't some rare, fringe diagnosis. Dr. Dempsey estimates it may affect as many as one in five people, and in women it hides behind a long list of other labels, PMOS, endometriosis, hypermobility, unexplained heavy periods, that rarely get connected back to the same root. Optimize your sleep with the Eight Sleep Pod. Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community This conversation explores The overreaction inside your immune system that never fully resets Why PMOS and mast cell activation almost always show up together The natural blood thinner behind unusually heavy periods Where treatment actually starts, from vitamin D to advanced IV therapy Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr. Tania Dempsey: Instagram: https://www.instagram.com/drtaniadempseymd/ LinkedIn: https://www.linkedin.com/in/taniadempsey/ Website: https://drtaniadempsey.com/ YouTube: https://www.youtube.com/@DrTaniaDempsey #longevity #womenslongevity #mastcellactivationsyndrome #mcas #pmos #histamineintolerance #endometriosis #womenshealth #chronicillness #rootcausemedicine #hormonehealth #inflammation

  2. Aug 27

    Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease

    Pregnancy has long been treated as a season to slow down and play it safe. The data tells a different story, and it starts with a number most women were taught to fear. Dr. Margie Davenport, PhD, is an exercise physiologist and professor at the University of Alberta who has spent over a decade studying how the body moves through pregnancy, postpartum, and the years before. What stayed with me most: a pregnancy complication isn't just a pregnancy problem. It's information about a woman's future heart health that most of us are never told to pay attention to. Track your hormones at home with Mira.  Get 25% off Mira kits at https://www.miracare.com/ with code “KAYLA” Support cellular health with Solaray Spermidine, featuring 3.3 mg of spermidine from rice germ extract: https://solaray.com/products/spermidine   Use the code “KAYLABARNES” at checkout for 30% off your order. This conversation explores Why the “stay under 140 beats per minute” rule taught to pregnant women for decades was already outdated before most of us ever heard it What Dr. Davenport's lab is learning by tracking a baby's heart rate and blood flow in real time during heavy lifting and high intensity training Why gestational diabetes, preeclampsia, and gestational hypertension are now considered a risk factor for future heart disease as strong as smoking Why the “high risk at 35” label given to so many pregnancies is based on outdated data rather than a woman's actual health Why almost no strength exercise, including deadlifts and heavy squats, has been shown to need to be avoided in a low risk pregnancy Why the standard advice to wait six weeks and then resume normal activity after birth has little evidence behind it How staying active after birth is tied to a real reduction in postpartum depression and noticeably better sleep quality, even when total sleep doesn't change Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Margie: Instagram: https://www.instagram.com/drmargiedavenport/ LinkedIn: https://www.linkedin.com/in/margie-davenport-b3095825/  X: https://x.com/ExercisePreg  Website: https://www.ksr.ualberta.ca/exerciseandpregnancy/index.php #womenshealth #gestationaldiabetes #preeclampsia #pelvicfloor #diastasisrecti #fertility #cardiovascularhealth #strengthtraining #hiit#longevity #womenslongevity #pregnancyexercise #exerciseinpregnancy #postpartumrecovery #prenatalfitness

  3. Aug 20

    Dr. Gabrielle Lyon, DO: Muscle as the Organ of Longevity, Protein Mistakes, and the Truth About Menopause Muscle Loss

    Muscle is not just something you build in the gym. Dr. Gabrielle Lyon has spent her career arguing it's the organ that actually determines how well you age, and almost none of us have been taught to think about it that way. Dr. Gabrielle Lyon, DO, is the founder of Muscle-Centric Medicine and the New York Times bestselling author of Forever Strong. She's spent over two decades studying muscle as the most overlooked organ in medicine. The line that stuck with me most: she believes we're on track to trade an obesity epidemic for a sarcopenia epidemic, and most people won't see it coming until it's already happened. It's the kind of prediction I can't stop turning over, especially knowing how many women are on these medications right now without anyone telling them how to protect their muscles while they're on them.  Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member This conversation explores: Why muscle, not weight, decides how you age Why most women are not eating enough protein The protein habit most people get backwards Why menopause doesn't have to mean muscle loss What GLP1 users need to know to protect muscle Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Gabrielle Lyon:YouTube: https://www.youtube.com/@DrGabrielleLyon Instagram: https://www.instagram.com/drgabriellelyon/ X: https://x.com/drgabriellelyon Website: https://drgabriellelyon.com/ #longevity #musclecentricmedicine #muscle #proteinintake #strengthtraining #womenslongevity #sarcopenia #menopause #perimenopause #womenshealth #hormonereplacement #longevityoptimization #biohacking #GLP1

  4. Aug 6

    Dr. Christin Glorioso, MD, PhD: The Alzheimer's Blood Test, How to Cut Your Dementia Risk by 30%, and Why Women Are at Higher Risk

    Brain aging does not start when memory loss shows up. It starts around age 25, decades before anyone notices anything is different. By the time a symptom appears, the window for the highest-leverage prevention has usually already closed. Today I'm talking with Dr. Christin Glorioso, an MD and PhD who has spent her career studying Alzheimer's, partly because of her own family history and partly because she carries the ApoE4 gene herself. She has since used her own brain scans, blood work, and lifestyle changes to lower her own brain age, and she's built a company around helping other people do the same. This conversation covers what actually causes Alzheimer's versus what we got wrong for decades, why the brain can grow back the same way muscle does, and why a ten minute daily habit has better evidence behind it than any drug currently on the market. We also get into hormone therapy, cholesterol, the ketogenic diet, and why women are so consistently underserved on all three. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Christin Glorioso, MD, PhD LinkedIn: https://www.linkedin.com/in/christin-glorioso-md-phd-39627719/  Website: https://www.neuroagetx.com/ #BrainHealth #AlzheimersPrevention #DementiaPrevention #BrainAging #Neuroscience #CognitiveHealth #HRT #Perimenopause #Menopause #Cholesterol #Nootropics

  5. Jul 31

    Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

    Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it. Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease.  What makes this conversation different from most gut health discussions is the level of scientific rigor behind it. This is not wellness theory. This is published research, clinical data, and a decade of actually building the science from the ground up. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member In this conversation we explore: How your gut produces its own GLP-1 naturally and why synthetic versions may blunt that system over time Why Akkermansia is elevated in centenarians and depleted across virtually every chronic disease The fiber gap: 95% of people are under-threshold and it is driving metabolic and colon health decline What early antibiotic use does to the microbiome and how to rebuild at any age Why soap may be fueling the allergy and asthma epidemic by stripping the skin's protective barrier How butyrate links gut health, colon cancer risk, and natural GLP-1 production Why most probiotics on Amazon do not contain what the label claims Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr Coleen Instagram: https://www.instagram.com/drcolleencutcliffe/ Pendulum Life Instagram: https://www.instagram.com/pendulumlifeco/ Website: https://pendulumlife.com/

  6. Jul 2

    Dr. Elizabeth Yurth, MD: Muscle Building in Midlife, Joint Regeneration, Peptide Protocols, and Why Osteoarthritis Is Not Wear and Tear

    Dr. Elizabeth Yurth, co-founder of Boulder Longevity Institute, is one of the rare physicians who spent 30 years in orthopedic and sports medicine before pivoting to longevity and regenerative medicine. This episode covers joint health in women, osteoarthritis, bone density, peptides, perimenopause, hormones, mitochondrial health, and the regenerative protocols most women have never been offered. What she found after decades of patching people together: we have been thinking about joint disease completely wrong. Osteoarthritis is not a wear and tear condition. It is a metabolic disease driven by mitochondrial dysfunction, hormonal decline, and chronic low-grade inflammation, and it can be prevented, slowed, and in many cases reversed if you start addressing it at the root. Most women wait until something breaks before paying attention. By then, the damage has been building for years. The interventions that actually work are available now. They are just not in the standard conversation. Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/checkout/become-a-member In this conversation we explore: Why osteoarthritis is not a wear and tear disease and what the research actually shows How progesterone protects your ligaments, tendons, and bone (and why estrogen gets all the credit) Why birth control creates the perfect storm for joint and ligament injury Why mitochondrial dysfunction is at the root of joint disease, muscle loss, and brain decline and why you have to repair before you rev Hip fractures carry a 25% mortality rate in women, and most have never had a DEXA scan Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Elizabeth Yurth: Website: https://boulderlongevity.com/  Instagram: https://www.instagram.com/dryurth/ YouTube: https://www.youtube.com/@dryurth  #longevity #womenslongevity #peptides #jointhealth #bonedensity #musclebuilding #mitochondria #regenerativemedicine #perimenopause #womenshealth #biohacking #osteoarthritis #hormones #longevityoptimization

  7. Jun 25

    Dr. Wendy Troxel, PhD: Insomnia, Sleep Apnea, Perimenopause Sleep, and the Treatment That Outperforms Every Medication

    Sleep is not just something women need more of. It is something women struggle with in ways that are fundamentally different from men and almost nobody explains why. Dr. Wendy Troxel, PhD is one of the most respected sleep scientists in the world. Her research has shaped sleep policy in the US military. Her book, Sharing the Covers, is one of the most practical and science-backed guides to partnered sleep available. She is the rare researcher who can speak to the biology of sleep, the hormonal shifts of perimenopause, and what is actually happening in your bedroom, all in the same conversation. This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides.  Use the code KAYLA20 for 20% off. https://zenbasil.com/shopzenbasil/zenbasilseedbag Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community In this conversation: Why women are twice as likely to have insomnia as men What the new sleep duration research actually says (and why the magic number is not the point) How relationship quality affects women's sleep and long-term health differently than men's Why perimenopause is a perfect storm for sleep disruption The 5 things that most reliably improve sleep quality Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Connect with Dr Wendy: Instagram: https://www.instagram.com/drwendytroxel/  Website: https://www.drwendytroxel.com/ LinkedIn: https://www.linkedin.com/in/dr-wendy-troxel   Shownotes: Society of Behavioral Sleep Medicine: https://www.behavioralsleep.org Dr. Wendy Troxel's TEDx Talk: https://youtu.be/G0Zj_InJ4BQ?si=4-p3Iac2gItHlxtX

  8. Jun 18

    Dr. Sharon Horesh Bergquist, MD: Hormetic Stress, Women’s Resilience, and the 5 Stressors That Support Longevity

    Avoiding stress at all costs may actually be making you less resilient. In this episode, Dr. Sharon Horesh Bergquist reframes stress as one of the body’s most overlooked tools for longevity. The right kind of challenge can activate repair, strengthen resilience, improve metabolic health, and help the body adapt in ways that support healthier aging over time. Rather than trying to eliminate stress completely, she explains how to use it more intelligently. At the center of the conversation are five key stressors the body appears designed to benefit from when they’re used well: plant phytochemicals, exercise, heat and cold exposure, time-restricted eating, and purpose-driven psychological stress.  Sharon also explains why recovery matters and why too little stress can be just as harmful as too much, and how mindset changes the biology of the stress response. A study of 29,000 people found that believing stress is harmful raised the risk of dying by 43%, while viewing it as not harmful lowered that risk by 17%.  Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women. https://kayla-barnes-lentz.circle.so/female-longevity-community This episode is sponsored by Zen Basil. Their certified edible basil seeds are designed for human nutrition, deliver 15g of fiber per serving, and are batch-tested for glyphosate and over 400 pesticides. Use the code KAYLA20 for 20% off. https://zenbasil.com/shopzenbasil/zenbasilseedbag In This Conversation: Why the right kind of stress can improve longevity The 5 hormetic stressors that help the body adapt Why recovery matters just as much as challenge Heat, cold, exercise, fasting, and plant compounds through a longevity lens Why modern comfort may be making us less resilient How mindset and purpose change the biology of stress Connect with Kayla: Instagram: https://www.instagram.com/kaylabarnes/ TikTok: https://www.tiktok.com/@femalelongevity Twitter:https://x.com/femalelongevity Website:https://www.kaylabarnes.com/ Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054 Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227 Follow Her Female Protocol: https://www.protocol.kaylabarnes.com Learn more about Dr. Sharon: Instagram: https://www.instagram.com/thegoodstressdoctor/ LinkedIn: https://www.linkedin.com/in/thegoodstressdoctor/ Website: https://drsharonbergquist.com/ Order Her Book - The Stress Paradox: https://drsharonbergquist.com/the-stress-paradox Top 10 Health & Longevity Tests By Dr. Sharon: https://dr-sharon-bergquist.kit.com/ten-tests

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4.8
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Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

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