Longevity.Technology UNLOCKED

Longevity.Technology

Longevity.Technology UNLOCKED brings together science, business, and human potential to explore the frontier of longer, healthier living. 🎙 Mondays: In-depth conversations with scientists, founders, investors, operators, and elite performers shaping the longevity ecosystem. 🧠 Fridays: A sharp weekly round-up of the biggest stories, trends, and insights from across the longevity space. If you’re curious about the future of health, performance, and lifespan, this is where it gets UNLOCKED.

  1. 2d ago

    Sam Altman's $1.8B Longevity Company, CRISPR & AI Health | Longevity News Roundup — Week 22, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: https://partners.fatty15.com/UNLOCKED ---------- In this week’s Longevity News Roundup, Phil Newman and Nina Patrick examine FDA-cleared sleep diagnostics, safer CRISPR therapies, longevity clinic accountability, Retro Biosciences’ valuation, and AI-driven preventative healthcare. Sunrise received FDA clearance for Sunrise Air, a rechargeable at-home sleep apnea diagnostic using a chin sensor for multi-night testing. The device tracks airflow, oxygen, pulse, and snoring while targeting underdiagnosis linked to cardiovascular and cognitive decline.Insilico and Human Longevity have announced a multimillion-dollar collaboration to build what they describe as the industry’s first large-scale AI foundation model dedicated to longevity science. Daewoong Pharmaceutical acquired Turn Biotechnologies’ partial reprogramming assets, including its ERA mRNA platform. The deal gives longevity-focused age reversal IP a new clinical and regulatory pathway.Scribe Therapeutics presented preclinical ELXR CRISPR data showing 18-month cholesterol reduction in primates through epigenetic PCSK9 silencing. The platform reduced off-target activity by up to 100-fold without permanently altering DNA.At the Milan Longevity Summit 2026 they explored how longevity clinics are moving from wellness branding toward evidence-based preventative medicine. Clinics are increasingly being pressured to prove outcomes through validated biomarkers and longitudinal patient data.Retro Biosciences reached a $1.8 billion valuation while advancing an Alzheimer’s drug into human trials. Retro’s approach focuses on boosting a natural cellular process called autophagy, essentially the body’s built-in recycling program. ---------- News & References: Retro Bio’s $1.8b moment: Hopes up as Alzheimer’s trial advances → https://longevity.technology/news/retro-bios-1-8b-moment-hopes-up-as-alzheimers-trial-advances/Longevity clinics face their proving ground → https://longevity.technology/news/longevity-clinics-face-their-proving-ground/Sunrise receives FDA clearance for rechargeable at-home sleep test → https://longevity.technology/news/sunrise-receives-fda-clearance-for-rechargeable-at-home-sleep-test/Daewoong acquires Turn Bio age-reversal assets → https://longevity.technology/news/daewoong-acquires-turn-bio-age-reversal-assets/Scribe Therapeutics debuts CRISPR platforms for cholesterol treatment → https://longevity.technology/news/scribe-therapeutics-debuts-crispr-platforms-for-cholesterol-treatment/Insilico and Human Longevity eye to predict disease early with AI → https://longevity.technology/news/insilico-and-human-longevity-eye-to-predict-disease-early-with-ai/

    24 min

  2. 6d ago

    This Wearable Tracks the Female Cycle in Real Time

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: fatty15.com/UNLOCKED ---------- Guests: Jenny Duan Co-Founder and CEO of Clair Health LinkedIn: https://www.linkedin.com/in/jennysduan/ Website: https://wearclair.com/ Abhinav Agarwal Co-Founder and CTO of Clair Health LinkedIn: https://www.linkedin.com/in/agarwalaabhinav/ Website: https://wearclair.com/ ---------- What if women’s hormones were tracked like heart rate, continuously and contextually, not through annual snapshots? Phil Newman and Dr. Nina Patrick sit down with Jenny Duan, CEO of Clair, and Abhinav Argawal, CTO, to explore how a jewelry-inspired wrist wearable uses multi-sensor biosignals to infer estrogen and progesterone in real time across daily life. They explain how signals such as skin temperature, HRV, sweat response, intracellular and extracellular current shifts, and more than 100 derived biomarkers are combined through sensor fusion to model hormone trajectories that update throughout the day. From forecasting an athlete’s rate of perceived exertion days before training to identifying progesterone patterns associated with PCOS and endometriosis risk, these examples show what continuous data reveals that snapshot testing cannot. The discussion also uncovers how this level of visibility allows the female cycle to be understood as nine distinct sub-phases rather than the traditional four. They also discuss how lifestyle context, such as sleep, hydration, stress, and schedule, is integrated into the model to avoid contradictions between device feedback and lived experience. Early beta studies across PCOS, endometriosis, and perimenopause cohorts are already informing how this data can support fertility planning and symptom awareness. In this episode, you’ll learn: Why the female cycle can be divided into nine hormone sub-phasesHow 230 biomarkers are refined into 100 inputs for hormone modelingHow athletes can adjust hydration and nutrition before exertion spikesHow progesterone trends may signal risk patterns for PCOS and endometriosisWhy fertility and perimenopause represent 60% of early pre-orders If you want to understand how continuous hormone visibility reshapes female health decisions across life stages, this episode connects biosensing, AI modeling, and practical insights for longevity. Subscribe for weekly episodes that explore longevity science, preventative medicine, and the systems shaping how we live longer and better.

    31 min

  3. May 22

    GLP‑1 Gene Therapy: A One‑Time Fix for Obesity & Diabetes? | Longevity News Roundup — Week 21, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: https://partners.fatty15.com/UNLOCKED ---------- In this week’s Longevity News Roundup, Phil Newman and Dr. Nina Patrick examine pancreatic cancer immunotherapy, GLP-1 gene therapy, immune system rebuilding, cardiovascular plaque reversal and microbiome medicine. MatterBio filed its first IND application for Lm-LLO-TT, an engineered Listeria-based therapy targeting pancreatic ductal adenocarcinoma. Pending FDA clearance, the company plans a Phase 1/2a study evaluating safety, dosing and early efficacy in advanced pancreatic cancer patients resistant to conventional immunotherapy.Fractyl Health received European approval to begin a first-in-human Phase 1/2 trial of RJVA-001, GLP-1 gene therapy for obesity and type 2 diabetes. The therapy uses endoscopic ultrasound-guided pancreatic delivery to program beta cells to produce GLP-1 in response to meals rather than relying on repeated injections.Ossium Health presented clinical trial data showing successful engraftment using cryopreserved bone marrow collected from deceased organ donors. Researchers believe the banking platform could eventually simplify bone marrow transplantation logistics and expand future immune system renewal applications.Cyclarity shared new progress on therapies targeting 7-ketocholesterol, an oxidized cholesterol molecule linked to plaque instability and chronic arterial inflammation. Rather than slowing plaque growth, the company aims to physically remove toxic cholesterol deposits already embedded within blood vessel walls.Microbiotica reported positive Phase 1b MELODY-1 trial data for MB097, a microbiome therapy containing nine bacterial strains combined with KEYTRUDA in advanced melanoma patients. The therapy showed successful gut engraftment and encouraging signals that microbiome modulation may help overcome immunotherapy resistance.The episode also explored health equity in longevity medicine with Poonam Desai ahead of The Longevity Show. Discussions focused on sex-specific medicine, unequal access to longevity care and the risks of building precision health systems around biased clinical data. ---------- News & References: ‘Rebuilding the human immune system is possible’ → https://longevity.technology/news/rebuilding-the-human-immune-system-is-possible/Fractyl Health to begin EU trials for one-time weight loss gene therapy → https://longevity.technology/news/fractyl-health-to-begin-eu-trials-for-one-time-weight-loss-gene-therapy/Matter Bio takes pancreatic therapy to clinic → https://longevity.technology/news/matter-bio-takes-pancreatic-therapy-to-clinic/New data suggests plaque damage can be cleared → https://longevity.technology/news/new-data-suggests-plaque-damage-can-be-cleared/Microbiome medicine moves past wellness into clinics → https://longevity.technology/news/microbiome-medicine-moves-past-wellness-into-clinics/‘Equity in longevity is the entire ballgame’ → https://longevity.technology/news/equity-in-longevity-is-the-entire-ballgame/

    23 min

  4. May 18

    Valter Longo: Can Short Fasting Cycles Regenerate the Body?

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: fatty15.com/UNLOCKED ---------- Guests: Valter Longo Professor and Director at USC Longevity Institute Instagram: https://www.instagram.com/prof_valterlongo/ Website: https://valterlongo.com/ ---------- What if a five-day diet could reset metabolism, regenerate tissue, and challenge decades of nutrition dogma? Phil Newman and Dr. Nina Patrick sit down with Valter Longo, USC Longevity Institute researcher and architect of the fasting mimicking diet, to explore how short, periodic fasting cycles may interact with aging biology, insulin signaling, and tissue regeneration. Together they break down how the fasting mimicking diet differs from water fasting and simple calorie restriction, and why its plant based, low protein, low sugar, and high fat composition is designed to maintain protection while still triggering nutrient sensing pathways. Longo explains how in clinical and preclinical data, repeated cycles have shown improvements in insulin resistance, reductions in diabetes medication use by 60 to 70% in some cohorts, and measurable shifts in metabolic biomarkers compared to Mediterranean diet controls. The conversation also explores mechanistic findings, including autophagy activation peaking around day five in human studies, stem cell associated regeneration signals, and embryonic like gene expression patterns observed in multiple organ systems. In animal models, these cycles have been associated with pancreatic regeneration, kidney repair after induced damage, and normalization of cholesterol and glucose regulation. In this episode, you’ll learn: Autophagy activation and peak biological signaling observed around day five in human fasting mimicking protocols Clinical trials in diabetes showing 60 to 70% reduction in medication use within one year in some populationsAnimal studies showing reversal of severe metabolic dysfunction with monthly fasting mimicking cyclesProtein restriction and mTOR IGF-1 signaling pathways repeatedly linked with lifespan extension across multiple speciesRisk discussion around prolonged fasting triggering energy conserving metabolic adaptation states If you want to understand how structured fasting protocols may interact with aging pathways, metabolic disease, and regenerative biology, this episode connects clinical evidence with evolutionary and mechanistic frameworks shaping modern longevity science. Subscribe for weekly episodes exploring longevity science, preventative medicine, and the systems shaping human healthspan.

    1h 3m

  5. May 15

    Can Longevity Disrupt Hospitals From Within? — Longevity News Roundup — Week 20, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: https://partners.fatty15.com/UNLOCKED ---------- In this week’s Longevity News Roundup, Phil Newman and Nina Patrick examine GLP-1 drugs in progressive MS, Executive Health as a gateway to longevity care, AI-assisted skin regeneration, lab-grown red blood cells, and convergence in aging biomarkers. Neuraly’s NLY01 dosed its first Phase 2 patient with progressive MS in the 120-person, 96-week TAGMS trial. Instead of tracking relapse rates, researchers will use MRI-measured brain atrophy as the primary endpoint to determine whether the GLP-1 receptor agonist can slow neurodegeneration after inflammation is controlled.Biograph’s six-hour executive assessment compresses what they describe as three months of diagnostics into a single visit. Advanced imaging, biomarker panels, cardiac testing, biological age metrics, and cancer screening are bundled into one experience followed by a personalized action plan. ROKIT Healthcare presented one to two-year follow-up data showing sensory restoration, minimal scarring, functional recovery, and zero cancer recurrence after AI-assisted autologous skin reconstruction. The platform uses a patient’s own fat-derived cells combined with AI-guided bioprinting to recreate tissue that behaves like original skin. Hospitals are recognizing that prevention-focused longevity care could erode revenue from late-stage cardiometabolic and surgical interventions. At the same time, they already possess the imaging, labs, multidisciplinary teams, and care coordination required to deliver structured midlife risk assessment programs.Scarlet Therapeutics raised $4 million in seed funding after demonstrating that lab-grown red blood cells survive in circulation as long as donor-derived cells. The company is developing applications that include universal transfusion supply, therapeutic carrier cells, and engineered red blood cells designed for enhanced biological function. Steve Horvath argues that apparent biomarker chaos is narrowing toward a smaller set of aging measures that consistently predict mortality, disease risk, and functional decline. This convergence is critical for trials, clinics, and employer programs that need reliable endpoints to justify prevention strategies. ---------- News & References: GLP-1 drug enters trial for progressive multiple sclerosis → https://longevity.technology/news/glp-1-drug-enters-trial-for-progressive-multiple-sclerosis/Executive Health program condenses three months of testing into six hours → https://longevity.technology/news/executive-health-program-condenses-three-months-of-testing-into-six-hours/AI regenerative medicine targets skin recovery → https://longevity.technology/news/ai-regenerative-medicine-targets-skin-recovery/Hospitals confront longevity’s quiet disruption → https://longevity.technology/news/hospitals-confront-longevitys-quiet-disruption/Scarlet raises $4m as lab-grown blood matches donor cell survival → https://longevity.technology/news/scarlet-raises-4m-as-lab-grown-blood-matches-donor-cell-survival/‘We are not at consensus but we are at convergence’ → https://longevity.technology/news/we-are-not-at-consensus-but-we-are-at-convergence/

    21 min

  6. May 11

    Can You Reverse Cognitive Decline?

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: fatty15.com/UNLOCKED ---------- Guests: Dr Henry Mahncke CEO of BrainHQ from Posit Science Instagram: https://www.instagram.com/brainhq_app/ Website: https://www.brainhq.com/ Dr Majid Fotuhi Johns Hopkins Professor and Author of The Invincible Brain Instagram: https://www.instagram.com/dr_fotuhi/ Website: https://drfotuhi.com/ ---------- What if cognitive decline is not a fixed trajectory but a reversible biological state shaped by how we train the brain? In this episode of Longevity Technology Unlocked, Dr. Nina Patrick and Phil Newman are joined by Dr. Henry Mahncke, CEO of Posit Science, and Dr. Majid Fotuhi, Johns Hopkins affiliated neurologist and author of The Invincible Brain. The discussion explores a shift in neuroscience thinking, from viewing cognitive aging as inevitable decline to seeing it as a modifiable process driven by neuroplasticity, attention, and lifestyle. They break down why dementia and cognitive decline are increasingly being reframed as outcomes influenced by multiple modifiable systems. Dr. Mahncke explains how decades of brain plasticity research, including early cochlear implant studies, helped establish that the adult brain remains capable of change. Dr. Fotuhi adds a clinical framework built around five pillars of brain health, combining cognitive training with exercise, sleep, diet, and stress control as a unified intervention strategy for cognitive resilience. Across both perspectives, the emphasis is on adaptive, challenging training that continuously engages attention and processing speed as a driver of broad brain plasticity rather than isolated cognitive skills. In this episode, you’ll learn: How speed-based cognitive training is linked to long-term reductions in dementia riskWhy attention and processing speed are central drivers of neuroplasticityHow structured 12-week programs can improve memory and cognitive performanceThe role of lifestyle pillars like sleep, exercise, and diet in brain resilienceWhy mindset and perceived cognitive limits may influence brain adaptation If you want to understand how neuroplasticity reshapes aging trajectories, this episode connects clinical neuroscience with real-world interventions for brain healthspan. Subscribe for weekly episodes that explore longevity science, preventative medicine, and the systems shaping how we live longer and better.

    1h 7m

  7. May 8

    The Future of Longevity Medicine — Longevity News Roundup — Week 19, 2026

    Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn ---------- Sponsor: Fatty15 Fatty15 is a science-backed, patented, award-winning supplement with pure C15:0 that strengthens cell membranes and supports healthy aging at the cellular level. Benefits include deeper sleep, calmer mood, improved energy, and overall wellbeing. Click the link below to learn more and use code UNLOCKED for 15% off the 90-day Starter Kit. Link: https://partners.fatty15.com/UNLOCKED ---------- In this week’s Longevity News Roundup, Phil Newman and Nina Patrick examine multi-target Alzheimer's therapy, sugar glycation in aging, personalized CRISPR for Parkinson's, Longevity.Technology partnerships, FDA real-time trials, and peptide platforms. Longevity.Technology partners with AND Capital Ventures to combine DLT intelligence platform with funding for healthspan startups. It maps hallmarks, biomarkers, and revenue trajectories to scale longevity firms from data to investment. This scaffolds the ecosystem like oncology, signaling maturation into an asset class.Annovis Bio's Buntanetap oral pill reduces production of multiple neurotoxic proteins like amyloid, tau, and alpha-synuclein by targeting mRNA translation machinery. This upstream approach outperforms single-target amyloid drugs, offering a practical pill over infusions.Estée Lauder research reveals sugar-induced glycation in skin cells triggers inflammation, senescence, and elasticity loss beyond collagen stiffening. Published in International Journal of Molecular Sciences, it links metabolic sugar exposure to systemic aging in vessels and organs. Scribe Therapeutics' CRISPR platform, with STX-1150 data, advances personalized gene editing for Parkinson's, repairing genetic defects in neurons for dopamine restoration. Precise delivery shows strong safety and efficiency signals.FDA pilots real-time cloud-based trials with AstraZeneca and Amgen, streaming data for faster safety signals and approvals. Aimed at accelerating development, it suits longevity's slow endpoints via validated biomarkers like frailty indices. LifespanningRX launches clinician-guided peptide programs for clinics, handling prescriptions, compounding, and shipping amid RFK Jr.-era FDA easing. With $500K funding, it taps recovery and longevity stacks demand via compliant platforms. Raises standards but risks hype without outcome tracking. ---------- News & References: Longevity.Technology and AND Capital Ventures launch partnership → https://longevity.technology/news/longevity-technology-and-and-capital-ventures-launch-partnership/ Buntanetap gains ground in new Alzheimer’s trial results → https://longevity.technology/news/buntanetap-gains-ground-in-new-alzheimers-trial-results/Sugar’s hidden role in skin aging revealed → https://longevity.technology/news/sugars-hidden-role-in-skin-aging-revealed/LifespanningRx launches partner program for peptide therapy → https://longevity.technology/news/lifespanningrx-launches-partner-program-for-peptide-therapy/FDA’s real-time trial push could transform medicine – if they work → https://longevity.technology/news/fdas-real-time-trial-push-could-transform-medicine-if-they-work/Scribe highlights CRISPR advances and STX-1150 data at ASGCT, EAS → https://longevity.technology/news/scribe-highlights-crispr-advances-and-stx-1150-data-at-asgct-eas/

    23 min

  8. May 4

    Glycans, Inflammation & Biological Age: A New Lens on Longevity

    Find Nina Patrick here: https://qrco.de/bgXpKn ---------- Sponsor: GlycanAge Inflammaging drives CVD, metabolic disorders, and accelerated aging, but clinicians still lack reliable tools to measure, intervene, and track it in practice. GlycanAge brings together leading experts to close that gap with practical frameworks for assessing immune aging in real-world clinical settings. Register via the link below and join the one-day event to learn how to measure immune aging and apply it to preventive and longevity care. Date: June 20 2026 | Location: Hotel Dubrovnik Palace, Croatia Link: https://glycanage.com/inflammaging-in-clinical-practice ---------- Guests: Nikolina Lauc CEO & Co-Founder of GlycanAge LinkedIn: https://www.linkedin.com/in/nikolinalauc/ Website: https://glycanage.com/ ---------- What if glycans—the neglected sugars on immune proteins—reveal inflammation and biological age more accurately than DNA methylation or CRP? Phil Newman and Dr. Nina Patrick sit down with Nikolina Lauc, CEO and co-founder of GlycanAge, to explore how these biomarkers integrate genetics, epigenetics, and environment for superior aging insights. Together they explain glycan shifts predicting cardiovascular events better than standard markers, with 300,000+ samples showing changes up to 10 years before diabetes. From perimenopause accelerating biological age by nine years (or decades in months for some) to moderate exercise yielding 10 years younger profiles versus pros matching sedentary inflammation, these reveal immune-driven aging realities. Contrasting epigenetic clocks' 10% variability (five-year swings same-day), glycans stay stable within one year. They also discuss hormone replacement reversing effects, fasting dropping profiles in days despite 21-day half-life, overtraining myths, and psychology like PTSD adding 15 years immune age—pushing immune resilience scores over raw age. In this episode, you’ll learn: Glycans predict CV risk/mortality across 350+ papers, outperforming CRPPerimenopause doubles aging rate; estrogen reverses 9-year spikeOver-exercisers match sedentary inflammation; moderates gain 10 yearsFasting alters glycans in days vs 21-day half-lifeStress/divorce adds decades; PTSD shortens expectancy 15-20 yearsGlycans enable modifiable risk scores for hospitals like Northwestern If you want to understand why inflammation may be the true driver of aging, this episode connects large-scale glycan data with real-world clinical implications for prevention and longevity. Subscribe for weekly episodes that explore longevity science, preventative medicine, and the systems shaping how we live longer and better. ---------- Hosts: Phil Newman: https://qrco.de/bgXpNY Nina Patrick: ⁠⁠https://qrco.de/bgXpKn

    53 min
See All (43)

Trailer

Ratings & Reviews

5
out of 5
3 Ratings

About

Longevity.Technology UNLOCKED brings together science, business, and human potential to explore the frontier of longer, healthier living. 🎙 Mondays: In-depth conversations with scientists, founders, investors, operators, and elite performers shaping the longevity ecosystem. 🧠 Fridays: A sharp weekly round-up of the biggest stories, trends, and insights from across the longevity space. If you’re curious about the future of health, performance, and lifespan, this is where it gets UNLOCKED.

Information

You Might Also Like