Optimization Academy with Dr. Greg Jones

Dr. Greg Jones
  • 4.7 (12)
  • HEALTH & FITNESS
  • UPDATED BIWEEKLY

Welcome to the Optimization Academy Podcast! Here I will be interviewing some of my favorite innovators in the health care industry and beyond. We will be sharing tips and information on how to become the most powerful version of yourself using naturopathic and integrative medicine, fitness, nutrition, and more. Together we will give you the tools to be informed and empowered! Dr. Greg Jones is Naturopathic Physician, Navy Vet, Reformed Engineer, and Grumpy Dog Dad. His mission in medicine is to shift the conversation away from "sick" care to true healthiness and wellness.

  1. 3D AGO

    83. Peptides, Mitochondria, and Personalized Healing with Dr. Kathleen O’Neil Smith

    True wellness isn’t about chasing symptoms—it’s about understanding the internal communication systems that allow the body to repair, adapt, and thrive. In this episode, Dr. Greg Jones is joined by Dr. Kathleen O’Neil-Smith, a Harvard-trained physician and pioneer in peptide therapy, to explore how peptides, mitochondria, and personalized medicine work together to support resilient, long-term health. As a founding board member of the International Peptide Society, Dr. Kathleen explains how small signaling proteins orchestrate large-scale healing by influencing cellular communication, inflammation, metabolic efficiency, and recovery. The conversation highlights why mitochondrial health sits at the foundation of longevity and how modern medicine often overlooks the body’s innate capacity to heal. Moving beyond trends and surface-level protocols, Dr. Kathleen shares how peptide therapy integrates with hormones, gut health, nervous system balance, and lifestyle to create durable clinical outcomes. They also discuss why one-size-fits-all medicine consistently fails patients, and how clinicians can think more strategically about restoring resilience rather than suppressing symptoms. 📌 About Dr. Kathleen O’Neil-Smith Dr. Kathleen O’Neil-Smith is a Harvard-trained physician who graduated magna cum laude from Boston University School of Medicine. She completed advanced postgraduate training in pathology at Massachusetts General Hospital and internal medicine at Brigham and Women’s Hospital. An elite athlete and lifelong national team rower with a background in exercise physiology, Dr. O’Neil-Smith bridges high-performance science and clinical medicine. She is a founding board member of the International Peptide Society and the American Academy of Stem Cell Physicians, and a recognized global authority on peptide therapy, GLP-1s, exosomes, and regenerative medicine. Formerly the Medical Director at the TB12 Wellness Center, she is known for her patient-centered approach and ability to translate complex science into practical clinical care. She currently leads Treat Wellness in Boston, providing personalized, evidence-based medicine to elite performers and patients worldwide. 📌Learn more about Dr. Kathleen O’Neil-Smith Website: https://www.treatwellness.bostonInstagram: https://www.instagram.com/treatwellnessFacebook: Treat Wellness – Prima Klasse 📌Connect with Dr. Greg Jones YouTube: https://www.youtube.com/@DrJonesNMDTVInstagram: @doctorjones_doctorjonesEnovative Wellness Center: https://enovativewellness.com/Book Dr. Jones to speak at your next event: https://www.drjonesnmd.com/ 🔗 Want to learn more? Check these resources: • NIH – National Institute of General Medical Sciences (Cellular Signaling, Mitochondria, Systems Biology):https://www.nigms.nih.gov • International Peptide Society (Clinical & Educational Authority):https://peptidesociety.org 🔬 Chapters Welcome & Introduction to Dr. Kathleen O’Neil-Smith (00:00 - 01:29) The Philosophy of Patient Rapport and Trust (01:29 - 02:27) From Harvard to Peptide Pioneer (02:27 - 16:06) Mitochondria and the Foundation of Longevity (16:06 - 20:54) Hormones, Peptides, and Systemic Synergy (20:54 - 23:25) Understanding Peptides Beyond Collagen (23:25 - 30:23) The Gut-Brain Axis and Whole-Body Healing (30:23 - 33:05) Inflammation as a Root Cause of Disease (33:05 - 37:44) Mindset, Spirit, and Physical Recovery (37:44 - 41:17) Why One-Size-Fits-All Medicine Fails (41:17 - 46:16) Clinical Entry Points for Peptide Therapy (46:16 - 51:18) The Future of Regenerative Medicine (51:18 - 55:04) Practical Steps to Improve Health Span (55:04 - 01:00:25) The International Peptide Society’s Mission (01:00:25 - 01:04:02) Navigating Misinformation in Wellness (01:04:02 - 01:07:55) Closing Thoughts and Where to Connect (01:07:55 - 01:10:55)

    1h 11m

  2. MAR 5

    Peptide Law Update: FDA Changes and Protecting Your Practice

    The legal landscape for peptide therapy is changing. In this episode, Dr. Greg Jones talks with healthcare attorney Jeff Cohen about recent regulatory updates and their implications for providers. Jeff explains the risks of using "Research Use Only" products in a clinical setting and how to properly verify your suppliers' quality and safety.  You will learn why it is important to focus on education rather than promotion on your website and how to improve your informed consent process to protect your license. Jeff also discusses the goals of the new American Peptide Association in setting industry standards. This conversation provides clear steps for clinic owners and practitioners to stay compliant while using compounded medications. 📌 Jeff L. Cohen, Esq. Jeff L. Cohen, Esq., is a Board Certified Specialist in Health Law and the founder of the Florida Healthcare Law Firm. Prior to founding the firm, Mr. Cohen was in-house counsel for the Florida Medical Association and served for 13 years as a partner at a respected law firm in South Florida. He is equally knowledgeable about contract law, corporate and employment law, and all of the specific laws and compliance regulations that relate to healthcare entities, including Stark, Anti-Kickback, fraud and abuse, and HIPAA. An AV-rated attorney, he has developed a reputation for providing exceptional legal services and ethical counsel. With over 35 years of experience, Mr. Cohen is a member of the American Health Lawyers Association, the Doctor’s Advisory Network of the American Medical Association, and the American Society for Medical Association Counsel. He is also a member of the Florida Hospital Association and a certified arbitrator with the American Health Lawyers Association (AHLA). Throughout his career, he has been recognized as a leader in his field, being named "Best Health Care Attorney" and consistently selected by his peers for the Florida Legal Elite. 🔗 Learn more about Jeff L. Cohen, Esq. LinkedIn: www.linkedin.com/in/jeff-cohen-42847413 Website: https://floridahealthcarelawfirm.com Instagram: www.instagram.com/flhealthcarelawfirm Connect with Dr. Greg Jones Instagram: @doctorjones_doctorjones  Enovative Wellness Center: https://enovativewellness.com/  🔬 Timestamps Introduction to Jeff's Journey in Healthcare Law (00:00 - 02:29) The Shift from Traditional Medicine to Wellness (02:29 - 08:06) The Impact of Regulatory Changes on Peptides (08:06 - 12:12) Understanding Category One and Two Products (12:12 - 16:02) The Black Market of Peptides and Its Implications (16:02 - 17:02) Research-Only Peptides: Risks and Realities (17:02 - 24:25) The Role of Professional Use-Only Products (24:25 - 27:09) Auditioning Suppliers: Ensuring Quality and Safety (27:09 - 29:13) The Future of Compounded Peptides and Regulatory Landscape (29:13 - 31:44) Navigating Compound Pharmacy Regulations (31:44 - 36:01) The Impact of the SAFE Act in Indiana (36:01 - 38:24) The Irony of GLP Shortages and Regulations (38:24 - 41:28) Customizing Informed Consent in Peptide Therapy (41:28 - 45:22) Website Risks for Clinics (45:22 - 52:12) Handling Cease and Desist Letters (52:12 - 55:24) The Role of the American Peptide Association (55:24 - 01:01:04)

    1h 1m

  3. FEB 24

    82. Ozone Amplified: Navigating the Benefits of EBOO

    In this episode, Dr. Greg Jones welcomes back Kim Look to explore the cutting-edge landscape of EBOO (Extracorporeal Blood Oxygenation and Ozonation). While many are familiar with traditional ozone therapy, EBOO represents a significant evolution, enabling the treatment of much larger volumes of blood through a sophisticated filtration and gas exchange system. Kim breaks down the "same but different" mechanics of EBOO compared to standard Major Autohemotherapy (MAH), explaining how the therapy acts as a "bio-detox" rather than just a mechanical filter. They discuss the controversial "waste cup" often seen on social media, the crucial role of Ultraviolet Blood Irradiation (UBI), and why EBOO is becoming a powerful tool for navigating long-haul symptoms, Lyme disease, and general longevity. Finally, Kim shares essential safety protocols, including the specific nutritional prep required to prevent blood sugar crashes during treatment. Whether you’re a patient looking to improve skin health at a cellular level or a provider interested in the evolving field of regenerative aesthetics, this episode offers a science-backed, practical framework for understanding what truly drives skin regeneration and longevity. 📌 Kim Look Kim Look brings over 16 years of experience in functional, regenerative, and integrative medicine, with a specialized focus on EBOO, ozone therapy, and Ultraviolet Blood Irradiation Therapy. Her expertise also spans advanced IV therapies, human cellular tissue products, peptides, and hormone replacement. In 2022, Kim was part of an elite team that conducted R&D for the modern USA-based EBOO device, personally writing the medical protocols that established a new standard for the therapy worldwide. As the founder of the Ozone Training Academy, she has trained over 1,300 medical professionals and overseen thousands of procedures to ensure safety and efficacy in regenerative care. Today, she continues to treat patients daily at Ridgeline Longevity and Aesthetics in Idaho, combining deep clinical insight with cutting-edge techniques to help patients achieve optimal wellness. 🔗 Learn more about Kim Look Website: https://eboomedical.com/about/ LinkedIn: www.linkedin.com/in/kim-look-74026658 Connect with Dr. Greg Jones Instagram: @doctorjones_doctorjones  Enovative Wellness Center: https://enovativewellness.com/  🔬 Timestamps Welcome & Episode Introduction (00:00 - 02:44) Kim Look’s Journey: From Paramedic to Regenerative Medicine (02:44 - 05:20) Understanding EBOO: Extracorporeal Blood Oxygenation and Ozonation (05:20 - 06:57) The Difference Between Standard Ozone and EBOO (06:57 - 08:52) How Bio-Stimulation Works for Skin Health (08:52 - 16:11) How EBOO Clears Environmental Toxins and Debris (16:11 - 20:42) Real-World Patient Results and Case Studies (20:42 - 23:05) The Importance of Standardized Protocols in Regenerative Medicine (23:05 - 25:33) Bridging the Gap Between Aesthetics and Longevity (25:33 - 26:30) The Role of Ultraviolet Blood Irradiation (UBI) (26:30 - 33:54) Addressing Systemic Inflammation and Its Effect on Aging (33:54 - 40:12) Exosomes and Cellular Messengers in Aesthetics (40:12 - 40:48) Combining IV Therapy with Aesthetic Procedures (40:48 - 46:08) Skin Quality Reflects Internal Organ Health (46:08 - 56:27) The Future of Non-Surgical Rejuvenation (56:27 - 01:01:25) Training the Next Generation of Medical Providers (01:01:25 - 01:04:11) Final Actionable Guidance & Closing Thoughts (01:04:11 - 01:04:30)

    1h 4m

  4. FEB 15

    3 POWERFUL Peptides To Heal Your Gut

    Leaky gut is a major driver of inflammation, autoimmune issues, and chronic digestive symptoms. In this video, you’ll learn what leaky gut really is and how three powerful peptides—BPC-157, KPV, and Larazotide—can support gut repair, reduce inflammation, and strengthen the intestinal barrier. Perfect for anyone exploring advanced gut-healing tools.CHAPTERS00:00 What Leaky Gut Is and Why It Matters01:26 How Leaky Gut Leads to Systemic Inflammation02:06 Conditions Linked to Increased Intestinal Permeability02:43 Top 3 Peptides for Gut Repair Overview02:48 BPC-157: How It Heals & Repairs Gut Tissue04:03 Clinical Uses of BPC-157 for Gut Conditions04:09 KPV: Anti-Inflammatory Peptide for Gut Flares05:03 How KPV Helps Mast Cells, Histamine, and IBD05:28 Larazotide: Tight Junction Regulator Explained06:10 How Larazotide Reduces Food Sensitivity & Immune Activation06:56 When to Use Each Peptide Clinically07:34 Final Thoughts & Next Steps for Gut HealingConnect with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/ 📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ ____________________________The information provided in this video is solely for educational and informational purposes. It is not intended to provide medical advice or to diagnose, treat, cure, or manage any health condition. Viewing this content does not establish or imply a doctor–patient relationship. You should not rely on this content as a substitute for consultation with a licensed healthcare professional regarding your own specific medical questions or health concerns. Always seek the advice of your physician or other qualified healthcare provider before starting, stopping, or changing any medication, supplement, treatment, or lifestyle program. Never disregard professional medical advice or delay seeking it because of something you have seen in this video. If you believe you may be experiencing a medical emergency, call 911 or your local emergency number immediately.

    8 min

  5. FEB 10

    81. Beyond the DNA Test: How Genomics Redefines Your Heart and Brain Health with Dr. Sharon Hausman-Cohen

    In this episode, Dr. Greg Jones sits down with Dr. Sharon Hausman-Cohen, Chief Medical Officer of IntelliXX DNA, to explore how medical genomics is transforming the way we understand heart disease, brain health, inflammation, and metabolism. Most people think genetics stops at traits like eye color or ancestry. Genomics goes much deeper—analyzing how thousands of genes interact to influence cardiovascular risk, cognitive function, clotting tendencies, nutrient metabolism, and chronic inflammation. Dr. Hausman-Cohen explains why many direct-to-consumer DNA tests fall short, how incomplete interpretation can mislead patients, and why clinician-guided genomic analysis allows for truly personalized care. The conversation also dives into inflammation, methylation, homocysteine, cholesterol myths, caffeine metabolism, mitochondrial health, and women’s unique clotting risks. Whether you’re trying to reduce your risk of heart disease, improve mental clarity, or understand how your biology responds to diet, supplements, and medications—this episode offers a science-based roadmap for precision health. 📌 About Dr. Sharon Hausman-Cohen Dr. Sharon Hausman-Cohen has spent over a decade using genomics to deliver personalized medicine. Recognizing that complexity and misinformation were major barriers, she helped develop IntelliXX DNA™, a clinician-focused, evidence-based genomic interpretation platform. She earned both her Master’s and MD from Harvard Medical School, is board-certified in Family Medicine, a Fellow of the American Board of Integrative and Holistic Medicine, and holds additional board certification in Integrative Medicine. She has practiced full-spectrum and integrative medicine for over 20 years and is a nationally sought-after educator on genomics and precision medicine. 📌Learn more about Dr. Hausman-Cohen Website: https://www.intellxxdna.com  LinkedIn: https://www.linkedin.com/in/sharon-h-26185718/  📌 Connect with Dr. Greg Jones YouTube: https://www.youtube.com/@DrGregJonesNMDInstagram: @doctorjones_doctorjonesBecome a Patient: https://enovativewellness.com/ Book Dr. Jones to speak at your next event: https://www.drjonesnmd.com/  🔗 Want to learn more? Check these resources: • NIH – Genetics & Precision Medicine:https://www.genome.gov/health/Genomics-and-Medicine • American Heart Association – Cardiovascular Health & Genetics:https://www.heart.org • CDC – Genomics & Precision Health:https://www.cdc.gov/genomics 🔬 Chapters Introduction to genomics & personalized medicine (00:00 - 02:51) The evolution of IntelliXX DNA (02:51 - 06:01) Genetics vs. medical genomics (06:01 - 10:06) Limits of direct-to-consumer DNA tests (10:06 - 15:44) Genomics & cardiovascular disease risk (15:44 - 21:38) Inflammation and chronic disease (21:38 - 25:40) Applying genomic data in practice (25:40 - 30:31) Thrombotic risk & clotting genes (30:31 - 32:31) Women’s health & clotting risk (32:31 - 34:13) Rethinking cholesterol (34:13 - 38:03) Caffeine metabolism & heart health (38:03 - 41:22) Homocysteine & methylation (41:22 - 46:32) Obesity, metabolism & genetics (46:32 - 53:05) Empowering patients through data (53:05 - 54:50) Mitochondria & cognitive health (54:50 - 58:59)

    1h 3m

  6. JAN 30

    5 POWERFUL MOTS-c Benefits for Mitochondria, Performance & Aging

    Dr. Jones dives into the world of MOTS-C, explaining its potential to enhance metabolic health. He highlights its role in peptide therapy to optimize healing and promote fat loss. This biohacking approach could be a key to longevity science and overall health.CHAPTERS00:00 What MOTS-c Is & Why It’s Unique00:37 How MOTS-c Works in the Cell01:12 Mitochondrial Benefits & Energy Support02:18 Key Benefits: Energy, Metabolism & Fat Loss03:33 MOTS-c for Longevity & Anti-Aging Pathways04:37 Performance, Recovery & Endurance Support05:08 Cognitive Support & Stress Resilience05:38 Why MOTS-c Is Popular in Longevity Protocols06:19 Clinical Uses: Fat Loss, Fatigue & Insulin Resistance06:36 How to Use MOTS-c Safely (Cycling & Dosing Principles)Connect with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/ 📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ ____________________________The information provided in this video is solely for educational and informational purposes. It is not intended to provide medical advice or to diagnose, treat, cure, or manage any health condition. Viewing this content does not establish or imply a doctor–patient relationship. You should not rely on this content as a substitute for consultation with a licensed healthcare professional regarding your own specific medical questions or health concerns. Always seek the advice of your physician or other qualified healthcare provider before starting, stopping, or changing any medication, supplement, treatment, or lifestyle program. Never disregard professional medical advice or delay seeking it because of something you have seen in this video. If you believe you may be experiencing a medical emergency, call 911 or your local emergency number immediately.

    8 min

  7. JAN 27

    80. Why PRP Fails (and How to Do It Right): Regenerative Orthopedics, Hormones & Healing

    Platelet-Rich Plasma (PRP) is everywhere—but why does it help some patients and completely fail for others? In this episode, Dr. Greg Jones sits down with Dr. Joe Albano, a nationally recognized expert in regenerative orthopedics, to break down why not all PRP is created equal. They explore the real reasons PRP fails, including missed diagnoses, incorrect platelet dosing, poor patient preparation, and inadequate after-care protocols. Dr. Albano explains the true order of regenerative treatments, from PRP to bone marrow–based therapies, and why age alone should never disqualify someone from regenerative care. The conversation also dives into overlooked but critical factors like hormone balance, peptides, nutrition, sleep, body weight, and why common interventions—such as steroid injections and statins—can quietly sabotage joint and tendon healing. This is a direct, science-based discussion for patients considering PRP, stem cell therapies, or regenerative injections—and for anyone who wants to avoid costly mistakes and understand what actually helps the body heal. 📌 About Dr. Joe Albano Dr. Joe Albano is a lifelong multisport athlete with experience in hockey, ultra-marathons, cycling, skiing, and endurance sports. He has served as a team physician for organizations including U.S. Speed Skating, U.S. Military Endurance Sports, and Real Salt Lake. Having personally undergone numerous procedures for his own sports injuries, Dr. Albano is deeply committed to non-surgical solutions for tendon, nerve, and cartilage injuries. He specializes in ultrasound-guided injections, PRP, and bone marrow aspiration, and regularly teaches national courses on regenerative techniques. His approach emphasizes whole-body optimization, addressing hormones, supplements, sleep, and lifestyle to maximize healing and long-term outcomes. 🔗 Learn more about Dr. Joe Albano Website: https://www.albanoclinic.com/ Instagram: https://www.instagram.com/drjoealbano TikTok: https://www.tiktok.com/@drjoealbano 🔗 Connect with Dr. Greg Jones Instagram: @doctorjones_doctorjonesEnovative Wellness Center: https://enovativewellness.com/Book Dr. Jones to speak at your next event:  https://www.drjonesnmd.com/ 🔬 Timestamps Dr. Albano’s background & episode overview (00:00 - 06:40) PRP vs bone marrow injections (28:11 - 31:06) Why patients say PRP “didn’t work” (35:40 - 36:23) When PRP isn’t strong enough (36:24 - 36:41) Diagnosis errors vs treatment failure (36:42 - 37:59) What PRP removes—and what shouldn’t be there (38:00 - 39:55) Platelet dose, blood cells & why PRP can hurt (39:56 - 42:33) Age myths in regenerative medicine (42:34 - 47:50) Questions every patient should ask a clinic (47:51 - 53:58) Sleep, nutrition & protein for healing (53:59 - 56:47) Hormones, weight, joint stress (56:48 - 62:23) Why PRP series outperform one-off injections (62:24 - 66:16) Testosterone, steroids & joint risks (66:17 - 71:53) Statins and tendon injury (71:54 - 76:40) Peptides, first steps & closing insights (76:41 - 01:30:52)

    1h 31m

  8. JAN 16

    The Incredible Impacts of GHK Copper (GHK CU) on Skin, Hair & Longevity

    Dr. Jones discusses using innovative therapies for patient healing, specifically noting benefits like reduced inflammation and boosted hair growth. He highlights the science behind GHK-Cu, especially its positive effects on skin care and collagen synthesis. Learn more about how GHK-Cu enhances skin.CHAPTERS00:00 Introduction to GHK Copper00:46 What Is GHK Copper and How It Works01:34 Skin Health and Anti-Aging Benefits02:15 Healing and Tissue Repair03:08 Hair Growth and Restoration03:42 Antioxidant and Anti-Inflammatory Effects04:17 Longevity and Gene Activation05:07 How GHK Copper Is Used Clinically06:16 Final Thoughts and TakeawayConnect with Dr. Greg JonesInstagram: @doctorjones_doctorjones Enovative Wellness Center: https://enovativewellness.com/ 📣 Subscribe + Follow: Don’t miss an episode! Subscribe and leave a review. 📺 YouTube: https://www.youtube.com/@DrJonesNMDTV 🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK?si=WhH4DW3oQw2k9qkfCtHZdQ ____________________________The information provided in this video is solely for educational and informational purposes. It is not intended to provide medical advice or to diagnose, treat, cure, or manage any health condition. Viewing this content does not establish or imply a doctor–patient relationship. You should not rely on this content as a substitute for consultation with a licensed healthcare professional regarding your own specific medical questions or health concerns. Always seek the advice of your physician or other qualified healthcare provider before starting, stopping, or changing any medication, supplement, treatment, or lifestyle program. Never disregard professional medical advice or delay seeking it because of something you have seen in this video. If you believe you may be experiencing a medical emergency, call 911 or your local emergency number immediately.

    7 min
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4.7
out of 5
12 Ratings

About

Welcome to the Optimization Academy Podcast! Here I will be interviewing some of my favorite innovators in the health care industry and beyond. We will be sharing tips and information on how to become the most powerful version of yourself using naturopathic and integrative medicine, fitness, nutrition, and more. Together we will give you the tools to be informed and empowered! Dr. Greg Jones is Naturopathic Physician, Navy Vet, Reformed Engineer, and Grumpy Dog Dad. His mission in medicine is to shift the conversation away from "sick" care to true healthiness and wellness.

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