Out of Patients with Matthew Zachary

Matthew Zachary Worldwide
Out of Patients with Matthew Zachary

Out of Patients with Matthew Zachary is the longest-running, independent healthcare podcast.  Since 2007, Matthew’s been calling out the hypocrisy, hubris, and hostage-taking baked into American healthcare—with a mic in one hand and a middle finger in the other.  What started as a pirate radio rebellion is now the most trusted, notorious, and unfiltered show in the game. Patients love it. Industry listens. And anyone who’s ever been gaslit by the system knows exactly where to turn to nod their heads in shared rage. Every episode delivers unsanitized stories, dark humor, policy takedowns, and angsty GenX truth bombs—told by the people living it, not spinning it. It’s the show you love about the healthcare you hate.

  1. The Bronx Bleeds Blue: Vanessa Ghigliotty vs. Everyone

    JUL 1

    The Bronx Bleeds Blue: Vanessa Ghigliotty vs. Everyone

    Episode Description: If you’ve ever wondered what happens when a Bronx-born pediatric nurse with stage 4 colon cancer survives, raises a kid, becomes a policy shark, and fights like hell for the ignored, meet Vanessa Ghigliotty. She’s not inspirational. She’s a bulldozer. We go way back—like pre-Stupid Cancer back—when there was no “young adult cancer movement,” just a handful of pissed-off survivors building something out of nothing. This episode is personal. Vanessa and I built the plane while flying it. She fought to be heard, showed up in chemo dragging her kid to IEP meetings, and never stopped screaming for the rest of us to get what we needed. We talk war stories, progress, side-eyeing advocacy fads, TikTok activism, gatekeeping, policy wins, and why being loud is still necessary. And yeah—she’s a damn good mom. Probably a better one than you. You’ll laugh. You’ll cry. You’ll want to scream into a pillow. Come for the nostalgia. Stay for the righteous anger and iced coffee. RELATED LINKS Vanessa on LinkedIn Colorectal Cancer Alliance: Vanessa’s Story ZenOnco Interview with Vanessa FEEDBACK Like this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.com. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    50 min
  2. Pediatric Engineering for the Rest of Us: Dr. Jamie Wells

    JUN 17

    Pediatric Engineering for the Rest of Us: Dr. Jamie Wells

    Dr. Jamie Wells is back—and this time, she brought a book. We cover everything from biomedical design screwups to the glorified billing software known as the EHR. Jamie's new book, A Clinical Lens on Pediatric Engineering, is a masterclass in what happens when you stop treating kids like small, drunk adults and start designing medicine around actual human factors. We talk about AI in pediatric radiology, why drug repurposing might save lives faster than biotech IPOs, and the absurdity of thinking one-size-fits-all in healthcare still works. Jamie’s a former physician, a health policy disruptor, a bioethicist, an MIT director, and a recovering adjunct professor. She’s also a unicorn. We dig into the wonk, throw shade at bad design, and channel our inner Lisa Simpsons. This one’s for anyone who ever wondered why kids’ hospitals feel like hell and why “make it taste like bubblegum” might be the most important clinical innovation of all time. You’ll laugh, you’ll learn, and you might get angry enough to fix something. RELATED LINKS Jamie Wells on LinkedIn Book: A Clinical Lens on Pediatric Engineering (Amazon) Book on Springer Drexel BioMed Profile Global Blockchain Business Council Jamie’s HuffPost Articles FEEDBACK Like this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    40 min
  3. Dr. Allyson Ocean Unfiltered: Science, Colons and Calling BS

    JUN 3

    Dr. Allyson Ocean Unfiltered: Science, Colons and Calling BS

    Allyson with a Y. Ocean with two Ls. And zero chill when it comes to changing the face of cancer care. Dr. Allyson Ocean has been quietly—loudly—at the center of every major cancer breakthrough, nonprofit board, and science-backed gut punch you didn’t know you needed to hear. In this episode, she joins me in-studio for a conversation two decades in the making. We talk twin life, genetics, mitochondrial disease, and why she skipped the Doublemint Twins commercial but still ended up as one of the most recognizable forces in oncology. We cover her nonprofit hits, from Michael’s Mission to Let's Win Pancreatic Cancer to launching the American Jewish Medical Association—yes, that’s a thing now. We get personal about compassion in medicine, burnout, bad food science, and microplastics in your blood. She also drops the kind of wisdom only someone with her résumé and sarcasm can. It's raw. It's real. It's the kind of conversation we should’ve had 20 years ago—but better late than never. RELATED LINKS: – Dr. Allyson Ocean on LinkedIn – Let's Win Pancreatic Cancer – NovoCure Leadership Page – Michael’s Mission – American Jewish Medical Association – The POLG Foundation – Cancer Buddy App (Bone Marrow and Cancer Foundation) – Dr. Ocean at OncLive FEEDBACK: Like this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.com. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    44 min
  4. [BONUS] No One Told Me: COVID and Cancer

    MAY 30 · BONUS

    [BONUS] No One Told Me: COVID and Cancer

    Sponsored by Invivyd, Inc. Nobody wants to hear about COVID-19 anymore. Especially not cancer patients. But if you’ve got a suppressed immune system thanks to chemo, radiation, stem cell transplants—or any of the other alphabet soup in your chart—then no, it’s not over. It never was. While everyone else is getting sweaty at music festivals, you’re still dodging a virus that could knock you flat. In this episode, Matthew Zachary and Matt Toresco say the quiet part out loud: many immunocompromised people may not even know they have options beyond vaccines. Why? Because the system doesn’t bother to tell them. So we’re doing it instead. We teamed up with Invivyd to help get the word out about tools other than vaccines that can help prevent COVID-19. We break down the why, the what, and the WTF of COVID-19 risk for cancer patients and why every oncologist should be talking about this. No fear-mongering. No sugarcoating. Just two guys with mics who’ve been through it and want to make sure you don’t get blindsided. It’s fast, funny, and furious—with actual facts. You’ve got more power than you think. Time to use it. RELATED LINKS Expand Their Options Invivyd Matt Toresco on LinkedIn Out of Patients podcast FEEDBACK Like this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.com. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    5 min
  5. Constellations and Cancer: A Storytelling Rebellion with Lisa Shufro

    MAY 27

    Constellations and Cancer: A Storytelling Rebellion with Lisa Shufro

    EPISODE DESCRIPTION Lisa Shufro is the storyteller’s storyteller. A musician turned innovation strategist, TEDMed curator, and unapologetic truth-teller, Lisa doesn’t just craft narratives—she engineers constellations out of chaos. We go way back to the early TEDMed days, where she taught doctors, scientists, and technocrats how not to bore an audience to death. In this episode, we talk about how storytelling in healthcare has been weaponized, misunderstood, misused, and still holds the power to change lives—if done right. Lisa challenges the idea that storytelling should be persuasive and instead argues it should be connective. We get into AI, the myth of objectivity, musical scars, Richard Simmons, the Vegas healthcare experiment, and the real reason your startup pitch is still trash. If you’ve ever been told to “just tell your story,” this episode is the permission slip to do it your way. With a bow, not a violin. RELATED LINKS Lisa Shufro’s Website LinkedIn Super Curious Archive Eight Principles for Storytelling in Innovation StoryCorps Interview Coursera Instructor Profile WhatMatters Project FEEDBACK Like this episode? Rate and review Out of Patients on your favorite podcast platform. For guest suggestions or sponsorship inquiries, email podcast@matthewzachary.com. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    40 min
4.9
out of 5
152 Ratings

About

Out of Patients with Matthew Zachary is the longest-running, independent healthcare podcast.  Since 2007, Matthew’s been calling out the hypocrisy, hubris, and hostage-taking baked into American healthcare—with a mic in one hand and a middle finger in the other.  What started as a pirate radio rebellion is now the most trusted, notorious, and unfiltered show in the game. Patients love it. Industry listens. And anyone who’s ever been gaslit by the system knows exactly where to turn to nod their heads in shared rage. Every episode delivers unsanitized stories, dark humor, policy takedowns, and angsty GenX truth bombs—told by the people living it, not spinning it. It’s the show you love about the healthcare you hate.

You Might Also Like

To listen to explicit episodes, sign in.

Stay up to date with this show

Sign in or sign up to follow shows, save episodes, and get the latest updates.

Select a country or region

Africa, Middle East, and India

Asia Pacific

Europe

Latin America and the Caribbean

The United States and Canada