Dr. M's Women and Children First Podcast

Dr. Chris Magryta, "Dr. M"
  • 4.9 (76)
  • Medicine
  • Updated Biweekly

Providing listeners with cutting edge science based information for maternal and child health

  1. 16h ago

    Dr. M’s Women and Children First Podcast #114: Aimie Apigian, MD – Biology of Trauma

    Today's podcast guest is Dr. Aimie Apigian, a physician who has become one of the leading voices in helping us understand the biology of trauma. Dr. Aimie is double board-certified in Preventive Medicine and Addiction Medicine, with advanced training in biochemistry, public health, and functional medicine. She earned her medical degree from Loma Linda University, where her education also included behavioral health, child psychiatric therapy, play therapy, and addiction family counseling. Before medical school, she studied Cell and Molecular Biology at the University of Washington, where she worked in the laboratory of renowned cancer researcher Dr. Larry Loeb. She is the national bestselling author of The Biology of Trauma, featuring a foreword by Dr. Gabor Maté. The book has appeared on the USA TODAY Best-Selling Book List and has received multiple national book awards. What makes Dr. Aimie's work unique is her ability to bridge neuroscience, functional medicine, attachment science, and trauma therapy into a practical framework that explains how our bodies store survival patterns after stress and adversity. Rather than viewing trauma as simply a psychological experience, she teaches that it is a biological state—one that can be identified, measured, and, importantly, healed. She is the creator of the Biology of Trauma® framework, which integrates somatic therapies, parts work, nervous system regulation, and targeted biological interventions into a structured sequence designed to restore the body's innate capacity for healing. She is also the founder of Trauma Healing Accelerated™ and the host of the popular Biology of Trauma® Podcast, where she has educated thousands of clinicians and individuals around the world. Today, we're going to explore what trauma actually is from a biological perspective, how it influences immune function, metabolism, chronic disease, and childhood development, and perhaps most importantly, what it truly takes to move from surviving to thriving. Dr. M

    1 hr

  2. 6d ago

    Dr. M’s SPA Newsletter Volume 16 Issue 16 – Fake it Till You Make it

    Fake It Till You Make It? One of the most misunderstood pieces of advice in our culture is the phrase "fake it until you make it." At face value, it sounds dishonest. It sounds like pretending to be something you are not. It sounds like confidence without competence. But after nearly three decades in medicine, I have come to believe there is a deeper truth hiding inside that phrase. Most success in life is not built on pretending. It is built on being willing to step into situations where you are not yet fully prepared, knowing that growth happens only when you are slightly or deeply beyond your comfort zone. If I am being honest, much of my professional life has felt this way, and the depth vacillated based on the context. When I finished my pediatric residency at the University of Virginia, I was 29 years old and knew just enough to realize how much I did not know. Medical school and residency provide an enormous foundation, but they also expose you to the staggering volume of knowledge that exists in the world. And that volume has only skyrocketed in the past 30 years. The farther I traveled in medicine, the more I realized the horizon kept moving, often unattainable. One experience from those early years remains crystal clear, almost like a scar from a wound. I had been asked to give a lecture to the pediatric residents at UVA on electrolyte solutions and exercise physiology. I spent time preparing and thought I knew the material reasonably well. I walked into the room feeling confident. Then the questions started..... and a literature review. Enjoy, Dr. M

    15 min

  3. Jun 14

    Dr. M’s Women and Children First Podcast #113: Navaz Habib, DC – Vagal Action and Health

    Welcome back to Dr. M’s Women and Children First. Today, we are joined by one of the leading voices in the world of vagus nerve health, functional medicine, and autonomic nervous system regulation, Dr. Navaz Habib. Dr. Habib is a chiropractor, educator, international speaker, and author of the bestselling books *Activate Your Vagus Nerve* and *Upgrade Your Vagus Nerve*. His work has helped bring the science of the vagus nerve from the research world into practical clinical medicine, helping providers and patients better understand the powerful connection between the brain, immune system, gut, metabolism, and overall health. On today's episode, we take a pediatric lens to this fascinating topic. We explore how vagal tone influences inflammation, stress resilience, digestion, sleep, emotional regulation, and neurodevelopment. We discuss what happens when the autonomic nervous system becomes dysregulated, how chronic stress can shape a child's physiology, and why the vagus nerve may be one of the most important communication highways in the body. We'll also dive into practical strategies that families and clinicians can use to support vagal function, including breathing techniques, movement, nutrition, social connection, sleep, and other evidence-informed interventions that can help children build greater resilience in an increasingly stressful world. If you've ever wondered how the nervous system intersects with immune health, behavior, gut function, and chronic disease risk, this conversation is for you. Please join me in welcoming Dr. Navaz Habib. Dr. M

    1h 8m

  4. Jun 12

    Dr. M’s SPA Newsletter Volume 16 Issue 15 – Virus and Food

    Should You Feed A Viral Illness? This Nature news article discusses emerging evidence that eating may acutely enhance immune responsiveness, particularly through effects on T cells, the learning part of the adaptive immune system. The paper centers on the old saying “feed a cold, starve a fever,” suggesting there may actually be biologic truth behind at least the “feed a cold” half of the proverb. The article reviews a new study in mice and humans showing that T cells, key adaptive immune cells responsible for recognizing and attacking pathogens, behave differently depending on recent nutritional status. Researchers found that T cells from recently fed organisms proliferated more rapidly and mounted stronger activation responses compared with those from fasting states. In essence, nutrient availability appears to act as a metabolic “permission signal” for immune activation. .... Enjoy, Dr. M

    8 min

  5. Jun 7

    Dr. M’s SPA Newsletter Volume 16 Issue 14 – The Adult Chair

    The Adult Chair, the Adolescent Chair and the Child's Chair The Adult Chair by Michelle Chalfant is a practical framework for emotional maturity, self-awareness, and healing old patterns that unconsciously drive adult behavior. The central premise is that most people move through life reacting not from their grounded adult self, but from unresolved emotional states formed during childhood and adolescence. She organizes this idea into what she calls the “three chairs”: the Child Chair, the Adolescent Chair, and the Adult Chair. The Child Chair represents the emotional self formed in early childhood. This is the place of vulnerability, fear, shame, abandonment, loneliness, and unmet needs. When people react from this chair, they often feel helpless, emotionally flooded, overly dependent on validation, or afraid of rejection. Many adult relationship conflicts, according to Chalfant, are actually wounded children (in adult bodies) interacting with each other while wearing grown-up clothing and carrying iPhones. Same child like nervous system. Better accessories. Think of the statement: lipstick on a pig, you cannot dress up dysfunction and make it disappear. The Adolescent Chair reflects the defensive coping strategies people develop to protect the wounded child. This includes control, perfectionism, blame, avoidance, rebellion, people-pleasing, passive aggression, and emotional shutdown. The adolescent self seeks power and protection but often creates disconnection and conflict. Chalfant argues that many high-achieving adults unknowingly operate from this chair, appearing successful externally while internally driven by fear, insecurity, or the need for approval. The Adult Chair is the goal.... Enjoy, Dr. M

    10 min

  6. Jun 1

    Dr. M’s SPA Newsletter Volume 16 Issue 13 – Birth Order

    Birth Order Birth Order Is Biology, Not Birthright - so says a new paper in MedRxIV (Kramer et. al. 2026) Here is a short field guide to how sequence shapes the immune system, and maybe the brain in children. We’ve treated birth order like personality trivia. First-borns are “responsible.” Youngest are “free spirits.” Middle children… well, we forgot them. This paper suggests something more interesting: birth order is a biologic exposure. Not destiny. Not diagnosis. But signal. Across a very large dataset, the researchers mapped birth order against hundreds of diseases. The effects are small for any single child. But the pattern is consistent at a population level. Children are not born into identical biology, even within the same family. Each pregnancy changes the mother. Meaningfully. Immunologically. Successively. Each fetus inherits a slightly different environment. Epigenetics in full swing. It turns out that sequence matters. What Changes Across Pregnancies? Three levers move, quietly, predictably: 1) The Maternal Immune System Learns Pregnancy is not passive. It is negotiation. The first pregnancy = naïve immune system learning tolerance. Subsequent pregnancies = trained, adapted immune responses That training alters: cytokine tone, antibody profiles, placental signaling The fetus is downstream of all of it. 2) The Placenta Is Not a Copy-Paste Organ... Dr. M

    14 min

  7. May 22

    Dr. M’s Women and Children First Podcast #112: Mona Delahooke, PhD – Beyond Behaviors

    Today on Dr. M’s Women and Children First, we welcome one of the most important voices in modern child development and behavioral science, Mona Delahooke. Dr. Delahooke is a licensed clinical psychologist, internationally recognized speaker, and the author of groundbreaking books including Beyond Behaviors and Brain-Body Parenting. Her work challenges one of the deepest assumptions in modern parenting and education: that difficult behaviors are simply choices to be corrected. Instead, she invites us to ask a radically different question, what is the nervous system trying to communicate? This conversation sits right at the crossroads of neuroscience, attachment theory, polyvagal theory, developmental psychology, and the lived experience of parenting. In many ways, Mona’s work gives language to something clinicians and parents often feel intuitively but struggle to articulate: behavior is not merely compliance or defiance, behavior is biology expressed through the body. We explore how stress physiology, early attachment, sensory processing, trauma, neurodivergence, and autonomic nervous system states shape the way children interact with the world around them. We discuss why punishment-based models often fail vulnerable children, how “bad behavior” may actually represent adaptive survival responses, and why safety and connection are foundational to learning, resilience, and emotional regulation. For me personally, this conversation resonates deeply with the broader themes we often discuss on this podcast, the interaction between environment, physiology, immune health, metabolism, and neurodevelopment. Mona helps bridge the gap between cellular stress and relational stress, between body and mind, between physiology and behavior. If you’ve ever cared for a child with anxiety, ADHD, autism, sensory challenges, explosive behavior, school struggles, or chronic dysregulation, this episode offers both compassion and a fundamentally different framework. One that moves away from blame and toward curiosity. Away from control and toward connection. This is a conversation about seeing children more clearly. And perhaps, seeing ourselves more clearly too. Please enjoy this conversation with Dr. Mona Delahooke. Dr. M

    56 min

  8. May 17

    Dr. M’s SPA Newsletter Volume 16 Issue 12 – Creatine and Microbiomes

    Creatine and Microbiomes A new 2026 Cell Metabolism study explores a compelling and increasingly central idea in modern biology: the gut/brain/immune/metabolism axis is not just associative, it is mechanistic. Specifically, Dr. Lu and colleagues investigate how the gut microbiota can directly influence depressive behavior by reshaping systemic and neural metabolism. This is another in a long running list of papers describing the amazing work that bacterial commensal microbes do for us. In this case, our minds and moods. "Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression." "The brain, as an energy-intensive organ, relies on precise metabolic regulation to maintain synaptic plasticity, neurotransmitter synthesis, and stress response systems. Accumulating evidence implicates energy metabolism dysregulation as a hallmark of depression. Neuroimaging studies using positron emission tomography (PET) have identified marked glucose hypometabolism in the medial prefrontal cortex (mPFC) of patients with depression. Cerebral mitochondrial dysfunction and ATP imbalance have been mechanistically linked to depression progression. Notably, emerging studies emphasize the bidirectional interplay between peripheral metabolic signals and central energy regulation, which is fundamental to neural metabolism. Clinical observations such as fatigue, appetite dysregulation, and unexplained weight fluctuations in patients with depression further suggest systemic metabolic disturbances spanning peripheral organs and the CNS.." (Lu et. al. 2026) This is next-level medicine. Mental health can no longer be framed as a disorder of genetics, experience, or circumstance alone. This work opens a clearer window, showing how the microbiome participates as an active partner, shaping brain function through the metabolites it helps produce and deliver. Compounds like creatine are no longer just peripheral players. They become signals, fuel, structure, and information, bridging gut and brain, metabolism and behavior.... and more Enjoy, Dr. M

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