The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin

    10h ago

    BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin

    Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing  Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  -Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive  Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world.    Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now.  You'll Learn:  Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen   Thank you to our sponsors!       - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE  - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE.  - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave      Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range  Resources:     • Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive  • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15     • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   00:00 – Trailer  01:34 – Dave Rabin Introduction  05:01 – Psychedelics and Psychiatry  08:35 – Psychedelic Safety and Dosing  14:53 – Serotonin Syndrome Warning  21:17 – Vagus Nerve and Safety  27:36 – Smartphones and Chronic Stress  34:18 – Defining Trauma  38:00 – Trauma and Epigenetics  40:23 – MDMA Cortisol Gene Repair  44:44 – Therapy vs. Medicine Alone  49:15 – FDA MDMA Rejection  55:35 – Ketamine Personal Experience  59:15 – Closing and Book Recommendation  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1h 1m
  2. The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher

    2d ago

    The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher

    Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap   Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to do about it. This episode covers the detection tool that finds 10 times more melanomas, the real truth about sunscreen chemicals, the biohacking peptide that can hide cancer on your skin, and the cheap anti-aging drug that most people have never tried.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Michael Christopher, a board-certified dermatologist and expert dermoscopist recognized for his work in early melanoma detection. Through consistent, evidence-based use of dermoscopy, he identifies between 150 and 215 melanomas annually, far exceeding national and state averages and exposing a critical gap in standard skin cancer screening. Dr. Christopher speaks regularly on prevention, early detection, and systemic failures in dermatology training across health, wellness, and longevity-focused media, and has made it his mission to change the standard of care before more people die from a cancer that is almost always curable when caught early.    Dave and Dr. Christopher break down why a standard skin exam with no additional tools is essentially a guess, how dermoscopy changes everything, and why most dermatologists who claim to use it actually cannot interpret what they see. They get into the real risk factors for rising melanoma rates, what sunscreen labels are not telling you, and how melanotan and other biohacking peptides interact with your skin cancer risk in ways that matter. They also cover tretinoin as one of the most evidence-backed anti-aging and skin optimization tools available, how red lighttherapy supports mitochondria function and skin rejuvenation, and what parents should know about protecting their kids' skin for long-term longevity  You'll Learn:  Why most dermatologists miss melanoma and what the detection gap actually looks like What dermoscopy is, how it works, and why you should ask for it by name How melanoma survival drops from 99% at stage one to 73% at stage three What the Prop 65 cancer warning on most pharmacy sunscreens actually means Why visible light can darken your skin even when you wear sunscreen How melanotan activates melanocortin receptors and why that may affect melanoma risk What Retin-A does to collagen, the epidermis, and long-term skin aging How AI is entering dermoscopy and where it still falls short The right concentration of tretinoin to start with and how to get through the adjustment period What parents should do now to protect their kids from melanoma later   Thank you to our sponsors!        -Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. -Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. -Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month -Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.   Keywords: Michael Christopher, Dr. Michael Christopher, melanoma detection, dermoscopy, dermatoscope, skin cancer screening, melanoma prevention, early melanoma detection, skin cancer biohacking, sunscreen toxins, Prop 65 sunscreen, mineral sunscreen, zinc oxide, titanium dioxide, melanotan, melanocortin, skin aging, anti-aging, tretinoin, Retin-A, retinol, skin rejuvenation, collagen, red light therapy, mitochondria, UV exposure, UVB light, skin cancer longevity, melanoma survival rate, squamous cell carcinoma, functional medicine, human performance, longevity, biohacking, supplements, skin optimization, dermoscopy AI, skin cancer AI, visible light tanning, omega-6 sunburn, astaxanthin, skin health, melanoma staging, skin exam, skin cancer prevention  Resources:     • Learn More About Dr. Christopher’s Work At: https://www.instagram.com/michael_christopher_md/  • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15     • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com     Timestamps:   0:00 – Trailer  1:41 – Guest Introduction  3:59 – Dermatoscope Explained  12:27 – Melanoma Rising: Why  16:57 – Melanotan & Sun Risk  21:14 – Melanoma & Longevity  22:31 – Stage 1 vs Stage 3  26:05 – Retin-A Deep Dive  38:53 – Loose Skin Solutions  41:26 – Kids' Skin Health  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    45 min
  3. Just 1 Gram Activates Your Deep Focus Switch (Take THIS)

    4d ago

    Just 1 Gram Activates Your Deep Focus Switch (Take THIS)

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/ Try Suppgrade Labs: https://shopsuppgradelabs.com/ Over the last 15 years, I’ve built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C. I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long. Thank you to our sponsors! -KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off -Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 00:00 – Trailer 00:21 – Focus Is Biology 01:53 – Brain Chemistry Explained 05:33 – Vitamin C Revealed 07:09 – How to Dose 08:18 – Absorption Barriers 09:31 – Optimize Uptake 10:00 – Oxidative Stress Problem 11:00 – Stack for Deeper Focus Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    12 min
  4. World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more...

    6d ago

    World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more...

    Semaglutide Slows Biological Aging  A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers.  Sources:  https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging   FDA Approves First New Sunscreen Ingredient in 20 Years  The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available.  Sources:  https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/   Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study  Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching.  Sources:  https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth   Caffeinated Chewing Gum and Exercise Performance  A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding.  Sources:  https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/   Vitamin A Overdoses Surge Nearly 40 Percent  Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt.  Sources:  https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount   World Cup 2026 and Mass Gathering Health Risk  With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer.  Sources:  https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself   This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.    New episodes every Tuesday, Thursday, Friday, and Sunday.    Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade    Thank you to our sponsors!   - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE    Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 – Intro  00:41 – Story 1: Ozempic Slows Aging Clocks  01:53 – Story 2: New Sunscreen Approved  03:12 – Story 3: DNA Sugar & Hair Regrowth  04:38 – Story 4: Caffeine Gum & Performance  06:13 – Story 5: Vitamin A Overdose Spike  07:59 – Story 6: World Cup & Immune Prep  09:34 – Outro  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    11 min
  5. Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi

    Jun 11

    Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi

    How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction  Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him.    Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. .    You'll Learn:  Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity   Thank you to our sponsors!       - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.  - Pique | Go to Piquelife.com/dave for 20% off.  - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance  Resources:     • Learn More About Dr. Fotuhi’s Work At: https://drfotuhi.com/  • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15     • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com       Timestamps:   00:00 – Trailer  00:59 – Intro  03:00 – Cannabis & Nicotine  04:15 – Understanding Alzheimer's  05:38 – Five Pillars Explained  07:55 – Best Cognitive Training  09:08 – Brain Size & Growth  12:36 – B12 & Lab Ranges  17:48 – Head-to-Toe Evaluation  24:17 – Sex & Brain Health  25:43 – Loneliness & Isolation  33:59 – ApoE4 Genetics  35:28 – Alzheimer's Declining  48:44 – Lithium & Brain  59:38 – VO2 Max & Fitness  1:06:42 – Psychedelics  1:09:38 – GLP-1s & Brain  1:12:38 – Closing & Action Steps  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1h 20m
  6. The Foods That Starve Cancer | William Li

    Jun 9

    The Foods That Starve Cancer | William Li

    Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health  Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science.    Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat.  You'll Learn:  What centenarian research reveals about immune function, gut health, and vascular resilience Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing How microplastics travel through your nose directly to your central nervous system What flow-mediated dilation and pulse wave velocity tell you about your true biological age Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy How to use biohacking tools to compound your health the same way you compound financial returns   Thank you to our sponsors!       - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.  - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out  - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order.  - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system  Resources:     • Learn More About Dr. Li’s Work At: https://drwilliamli.com  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15     • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/   • Upgrade Labs: https://upgradelabs.com        Timestamps:   00:00 – Trailer  02:33 – William's Background  06:21 – Food vs. Cancer Drugs  14:09 – Gene Therapy  23:50 – Centenarian Research  27:41 – Stress & the Vagus Nerve  37:31 – Vascular Health  42:34 – Microplastics  53:19 – Novel Biomarkers  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1h 3m
  7. I Drink Fat To Look Shredded (Lost 100lbs)

    Jun 7

    I Drink Fat To Look Shredded (Lost 100lbs)

    I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted. In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym. Thank you to our sponsors! Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 0:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – Closing Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    8 min
  8. Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer...

    Jun 5

    Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer...

    Pancreatic Cancer Halted by Virus Injection  Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field.  Sources:  https://www.newscientist.com    AI Chatbots and Teen Mental Health  A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it.  Sources:  https://www.nbcnews.com    GLP-1 Drugs Cut Breast Cancer Risk  Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now.  Sources:  https://www.pennmedicine.org    Putin's $26 Billion Longevity Program  The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program.  Sources:  https://www.wsj.com https://www.france24.com    Sauna vs. Cold Plunge  A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes.  Sources:  https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.    New episodes every Tuesday, Thursday, Friday, and Sunday.    Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade    Thank you to our sponsors!   - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today  - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE    Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Intro  00:42 – Pancreatic Cancer Halted by Virus Injection  01:44 – Teens & AI Therapy Chatbots  03:13 – GLP-1 Drugs Cut Breast Cancer Risk  04:30 – Russia's $26B Longevity Program  06:18 – Sauna vs. Cold Plunge  09:10 – Closing  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    10 min
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About

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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