205 episodes

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Health & Fitness
    • 4.8 • 4.4K Ratings

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation

    Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation

     

    Katherine Eban is an award-winning investigative journalist who previously appeared on The Drive to discuss the widespread fraud in the generic drug industry. In this episode, she discusses the content of her recent Vanity Fair article, which examined the evidence for the theory that the COVID-19 pandemic resulted from a virus lab escape as opposed to a natural virus that came from an animal host. Katherine and Peter walk through the evidence for both theories as well as discuss the long and troubling history of dangerous lab leaks and safety concerns about the Wuhan Institute of Virology.  They also talk about the controversy surrounding gain-of-function research and its funding by the US government. Finally, they conclude with a discussion on the likelihood of definitively establishing the origins of the virus given the Chinese government’s lack of cooperation and highlight the fact that the many barriers to performing a full investigation may be the most troubling aspect of the controversy. This episode was originally recorded on July 6, 2021. 

     

    We discuss:
    An overview of the lab leak controversy [1:30]; The troubling history of lab leaks of dangerous pathogens [8:30]; The zoonotic transmission theory: did SARS2 come from a bat? [11:45]; The debate about gain-of-function (GoF) research [26:15]; Questions about US funding of GoF research in China [33:45]; The uncertain significance of the furin cleavage site [51:30]; Discerning what’s most important about both the zoonotic transmission and lab leak theories [1:01:15]; Barriers to a full investigation [1:19:15]; and More. Learn more: https://peterattiamd.com/
    Show notes page for this episode: https://peterattiamd.com/katherineeban2 
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    • 1 hr 39 min
    Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine

    Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being Wolverine

    Hugh Jackman is an award-winning actor and an overall fascinating and introspective individual. In this episode, Hugh reflects upon his acting career, including how he navigated many tough decisions that led to important professional turning points for him. Peter and Hugh have an intimate discussion related to handling professional criticism, self-identity, spirituality, raising kids, and the role that past trauma often plays in extremely driven individuals. Hugh gives the inside scoop on some of his most well-known character roles and explains how he finds the energy to consistently perform. Finally, they tie the conversation together with a discussion on the importance of physical and mental health and wellbeing.

    We discuss:

    Hugh’s voracious curiosity and early years of his acting career [2:15];
    Self-identity, overworking, and the importance of living well [9:15];
    Handling criticism and letting go of the desire to please everyone [18:30];
    Dismissing vitriol on social media, and the challenge of communicating science [28:15];
    Going with your gut and the value in finding the right partner [31:30];
    A hard decision that lead to a turning point in Hugh’s life [40:15];
    How driven personalities often develop from a place of trauma, and how to avoid going from productive to destructive [47:00];
    The effect of fame on Hugh’s family [58:45];
    How Hugh finds the energy to consistently perform, and the spiritual connection he feels when acting [1:07:15];
    Hugh’s experiences on the set of The Fountain and the meaning behind the film [1:26:30];
    The potential of imagination, the idea of a higher power, and thoughts on science vs. religion [1:33:45];
    The deep connection Hugh felt to Logan (his character in Wolverine) [1:41:45];
    Reflections on physical aging, emotional wellbeing, and longevity [1:55:15]; and
    More Learn more: https://peterattiamd.com/
    Show notes page for this episode: https://peterattiamd.com/HughJackman
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    • 2 hr 9 min
    Gary Taubes: Bad science and challenging the conventional wisdom of obesity

    Gary Taubes: Bad science and challenging the conventional wisdom of obesity

    Gary Taubes is an investigative science and health journalist and a best-selling author. In this podcast, Gary explains how he developed a healthy skepticism for science as he was transitioning from being a physics major to beginning as a science journalist. He talks about how he was particularly drawn to sussing out “pathologic science,” telling the stories behind his books on the discovery of the W and Z bosons and cold fusion, emphasizing the need for researchers to perform a thorough background analysis. Gary then describes how his work came to focus on public health, nutrition, and obesity. He provides a great historic overview of obesity research and provides his explanation for why the conventional wisdom today is incorrect.
    We discuss:


    Gary’s background in science and journalism, and developing a healthy skepticism for science [2:20];
    Gary’s boxing experience, and the challenge of appreciating behavioral risk [8:40];
    How Gary developed his writing skills, and what the best science writers do well [16:45];
    Example of how science can go wrong, and the story behind Gary’s first book, Nobel Dreams [25:15];
    Theoretical vs. experimental physicists: The important differentiation and the relationship between the two [36:00];
    Pathological science: research tainted by unconscious bias or subjective effects [40:30];
    Reflecting on the aftermath of writing Nobel Dreams and the legacy of Carlo Rubbia [49:45];
    Scientific fraud: The story of the cold fusion experiments at Georgia Tech and the subject of Gary’s book, Bad Science [53:45];
    Problems with epidemiology, history of the scientific method, and the conflict of public health science [1:09:00];
    Gary’s first foray into the bad science of nutrition [1:26:45];
    Research implicating insulin’s role in obesity, and the story behind what led to Gary’s book, Good Calories, Bad Calories [1:36:15]
    The history of obesity research, dietary fat, and fat metabolism [1:46:00]
    The evolving understanding of the role of fat metabolism in obesity and weight gain [1:55:15]
    Mutant mice experiments giving way to competing theories about obesity [2:04:00]
    How Gary thinks about the findings that do not support his alternative hypothesis about obesity [2:08:00]
    Challenges with addressing the obesity and diabetes epidemics, palatability and convenience of food, and other hypotheses [2:14:45];
    Challenging the energy balance hypothesis, and the difficulty of doing good nutrition studies [2:25:00]; and
    More.
    Learn more: https://peterattiamd.com/
    Show notes page for this episode: https://peterattiamd.com/GaryTaubes 
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    • 2 hr 36 min
    Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease

    Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease

    Dr. Patricia Corby is Associate Professor of Oral Medicine and Associate Dean of Translational Research at Penn Dental Medicine. Her work focuses on the importance of providing dental services alongside critical public healthcare services, like cancer treatment. In this episode, Pat provides an overview of dental anatomy, the importance of oral hygiene to overall health, and the association of poor oral health and systemic diseases like cancer and diabetes. She addresses tooth decay, oral hygiene in children, the utility of dental products, and ideal oral care regimens for different populations. She also discusses issues specific to immunocompromised patients and those with chronic illnesses as well as her own research with cancer patients undergoing radiation treatment.
     
    We discuss:
    Anatomy of teeth and the purpose of the dental pulp—a highly vascularized and innervated region of the tooth [3:00]; Types of teeth and the different purpose they serve [14:15]; Anatomy of the oral cavity, bacteria in the mouth, and what a healthy mouth looks like [18:10]; Pat’s study demonstrating the importance of flossing [23:00]; Detrimental effects of sugar and the importance of fluoride and oral hygiene [31:45]; Oral health challenges for cancer patients and immunocompromised people [39:45]; Pat’s current research on cancer patients undergoing radiation treatment and the oral health risks associated with human papilloma virus (HPV) [50:00]; Periodontal disease: caries and root canals [57:30]; The relationship between poor oral health and systemic health diseases [1:11:00]; Potential connection between oral hygiene and COVID-19 [1:17:45]; Dry mouth leading to oral infections and ways to prevent it [1:22:30]; What determines the appearance of teeth, methods of teeth whitening, and whether you should remove mercury fillings [1:27:30]; Importance of fluoride for preventing tooth decay, and dental care for children [1:32:45]; Useful dental products: floss, electrics toothbrushes, and more [1:39:15]; Ideal oral care regimens [1:47:30]; and More. Learn more: https://peterattiamd.com/
     
    Show notes page for this episode: https://peterattiamd.com/patriciacorby 
     
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    • 2 hr
    AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM 

    AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM 

    In this “Ask Me Anything” (AMA) episode, Peter and Bob dive deep into blood glucose and why it matters so much with respect to metabolic health and longevity. They explain the need to pay close attention to metrics like average blood glucose, glucose variability, and peak glucose numbers. Additionally, Peter explains why he encourages all his patients, even nondiabetics, to utilize a continuous glucose monitor (CGM) which gives important insights that traditional lab testing and metrics consistently miss.

    If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #24 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

     

    We discuss:
    The problem with traditional blood tests and metrics for determining metabolic health [1:10]; The superior insights from a continuous glucose monitor [6:15]; Why lower is better than higher: average glucose, glucose variability, and glucose peaks [12:00]; Deep dive into average blood glucose and the importance of having the lowest average blood glucose possible [14:45]; Deep dive into glucose variability and why less variability is better [33:15]; Example of how HbA1c and traditional measures could catch metabolic issues too late [41:45]; Postprandial dips in blood glucose as a predictor of subsequent hunger and energy intake [43:00]; Exploring the idea that the suppression of fatty acids is actually causing hunger rather than a low blood glucose [49:45]; Deep dive into peak glucose and why lower peaks is better [57:15]; What the best rodent models tell us about the impact of peak glucose levels [1:06:25]; Why Peter encourages all his patients to wear a CGM [1:14:30]; and More.

    Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/ama24/ 

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    • 17 min
    Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia

    Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia

    Amanda Grant Smith is a geriatric psychiatrist with decades of experience treating patients with dementia and Alzheimer's disease. In this episode, Amanda shares how she developed a passion for geriatric psychiatry as a means to support dementia patients. She explains how to recognize, define, and diagnose dementia—a process that still remains somewhat elusive. They also talk about the significance of ApoE genotype and compare the various forms of dementia including differentiating between Alzheimer’s disease and Lewy body dementia. They discuss the current landscape of clinical trials, the drug pipeline, and talk about a very promising monoclonal antibody directed at amyloid beta that has the potential to be a disease-modifying drug. They conclude with a discussion about how to define “healthy aging” and reflect on how understanding dementia can shape one’s life philosophy.
     

    We discuss:
    How Amanda developed a passion for geriatric psychiatry [3:15]; Defining and diagnosing dementia and Alzheimer’s disease [13:30]; Medical tests for dementia and their relationship to clinical symptoms [22:45]; The pathology of dementia, and the role of the tau and beta-amyloid protein in Alzheimer’s disease [33:15]; The significance of ApoE genotype, and differentiating Alzheimer’s disease from Lewy body dementia [43:15]; The evolution of Alzheimer’s disease prevention, care, and medications over the last 20 years [52:45]; Psychiatric support for dementia patients (and caregivers) with depression and anxiety [1:02:45]; Drug pipeline, clinical trials, and major challenges to overcome [1:13:45]; Redefining Alzheimer’s disease and designing effective trials [1:23:00]; The promise of monoclonal antibody treatments for Alzheimer’s disease [1:34:15]; How we should measure outcomes in dementia trials and define “healthy aging” [1:42:30]; How understanding dementia can reshape our life philosophy [1:53:45]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/AmandaSmith

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    • 2 hr 1 min

Customer Reviews

4.8 out of 5
4.4K Ratings

4.4K Ratings

mrskwillis! ,

HJ

Enjoyed the Hugh Jackman episode. Great format - liked learning more about Peter’s personal journey and loved the personal love stories with their partners.

s mn ,

A Master Class

Short of going back to school, you’d be hard pressed to find a more informative medical podcast. I routinely find myself going back to reference studies and data for the topic being discussed.

EricaBushwell ,

Awesome podcast!

Peter, host of the Peter Attia Drive podcast, highlights all aspects of medicine, wellness and more in this can’t miss podcast! The host and expert guests offer insightful advice and information that is helpful to anyone that listens!

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