Less of You: Life on Semaglutide & Tirzepatide

The Axis
The Axis
  • 4.5 (19)
  • Nutrition
  • Updated Biweekly

Eva + Kami are two old-ish moms confronting our reasons for being obese while losing weight on semaglutide and tirzepatide, and roasting our past selves. Sarcasm is our happy place. Follow us on Instagram @lessofyoupodcast.  After a friend (who is a plastic surgeon) talked Eva into starting semaglutide in February of 2023, she lost 70 pounds in 14 months, alternating between long stretches of being stalled at the same weight and consistent but slow weight loss.  Chasing a lifelong dream to being considered just overweight and not obese by the BMI calculator, after 14 months Eva switched to tirzepatide to try and reach a goal that still seems just out of reach.   A prolific eater of her feelings, Kami was tired of being uncomfortable and when she heard through a mutual friend how semaglutide had changed Eva’s life, she found a trusted medical weight loss provider and took the first step.  As Kami starts her life on semaglutide, Eva adjusts to a world with less food noise and figures out how to let go of the crippling negative self-talk.  On each episode, we connect on how our lives are changing in real time as semaglutide and tirzepatide help us be smaller people, and try to answer the bigger question for ourselves:  When there’s less of you, what is left?

  1. 1d ago

    Do I look better yet?

    Three weeks after her Halo resurfacing, Eva decides to take the opportunity to have a Junera laser treatment, a new technology that treats the skin from within to tighten the face and neck from the inside.  On the morning before heading to Dr. Jennifer Walden’s office in Austin, she took her before photos seriously: the 6:43 AM bathroom pictures, the long-stoplight car selfie video, the in-office clinical photos.  Then two pills, a grid drawn on her face, almost falling while putting on socks, nitrous held by Jenny (“Feels like high school, huh?”), and a new perspective on what a great surgeon looks like and what it means to be a patient. Swelling peaks at 72 hours, and by day 10 the befores and afters look glorious. The great reveal comes next week. Kami has her own procedure brewing. After 14 years of sleep apnea, an insurance company demanding a sleep study from a clinic on the other side of the country, and a scope that couldn’t even get up one nostril — 80% closed on one side, 90% on the other — scheduled for in Indianapolis booked her for turbinate reduction and balloon sinuplasty, with a real shot at ditching the CPAP for good. Questions answered by this episode What is the Junera laser and how does it work?Does Junera laser skin tightening hurt?What kind of sedation is used for minimally invasive laser procedures?How long does swelling last after a Junera treatment?Can you tighten loose neck skin after major weight loss without a facelift?What is balloon sinuplasty?What are turbinates and why do they stay swollen?Does losing weight cure sleep apnea?Can fixing a blocked nose get you off a CPAP machine?Follow us on Instagram: @lessofyoupodcast Save 10% through our partner EpixNxt with code LESSOFYOU10. Co-hosts: Eva Sheie & Kami Gamlem Assistant Producer: Mary Ellen Clarkson Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis.

  2. Aug 14

    Replacing The Microwave (Also Known As The Micro-Wah-Vay)

    After an important discussion about the microwave (also known as the micro-wah-vay), we theorize that GLP-1s are basically commoditized now.  Meanwhile, to fix the microwave door, Eva's husband drove actual screws through it (that’s not how microwaves work) and we get an update on Kami's small claims case against her former broker. Eva considers an unexpected opportunity to get her very loose turkey neck skin fixed with the new Junera laser, which was at the top of the wish list someday, and now that day is next Monday. Kami reports back on her first EpixNxt order and walks through the whole thing: a thorough intake form, telemedicine approval, and a tracking number in under a day — coming in around $125 a month, less than the $170–$300 the local compounding pharmacies quoted. Questions answered by this episode Why are compounded GLP-1 medications getting cheaper?How do online tirzepatide prices compare to a local compounding pharmacy?If I've been off a GLP-1 for months, how should I restart my dose?What is the Junera laser and can it tighten loose neck skin after weight loss?Is loose skin on the neck caused by weight loss or genetics?Follow us on Instagram: @lessofyoupodcast Save 10% through our partner EpixNxt with code LESSOFYOU10. Co-hosts: Eva Sheie & Kami Gamlem Assistant Producer: Mary Ellen Clarkson Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis.

  3. Aug 7

    I Did Halo Laser Resurfacing On My Way to a Dance Recital

    After Eva went in for Halo laser resurfacing with a friend (who happens to be one of the best in the world), she walked out looking horrifying (according to the 8 year old) then drove straight to a dance recital tearing a cooling mask in half and swapping it between cheeks. She’s back with the whole before-and-after saga: the time-lapse, the nitrous oxide she thought she wouldn’t need, a wicked fever-blister flare, and ten full seconds of obsessing over her jawline. An opportunity to do Junera came up — a thin, spaghetti-like fiber laser that works under the skin to melt a little fat and tighten the jaw and neck, which happens August 10. Kami placed her first EpixNxt order for tirzepatide, coupon code and all, with an unboxing and an honest weigh-in coming next week. Eva weighs a switch from her compounded progesterone pill to the injectable version, and the two compare notes on why injections beat pills and how gummies and chewable magnesium became dessert. Eva’s kids head to a brand-new school with nine kids per class after a rough kindergarten year, and Kami’s daughter starts the high-ability track — plus a Barbie convention where Eva met the woman who designed Barbie’s clothes for three decades, still holding court in her 90s on a scooter. Kami signs off with a cliffhanger about her lawsuit. Questions answered by this episode What is recovery from a Halo laser resurfacing actually like, day by day?Why do laser providers offer nitrous oxide during a resurfacing treatment?Can a laser skin treatment trigger a cold sore or fever-blister flare?What is Junera, and how does a subdermal laser tighten the jaw and neck?What is it like to be a training or model patient for a new aesthetic device?How does ordering weight-loss medication like tirzepatide through EpixNxt work?Can you switch from a compounded progesterone pill to injectable progesterone?Why do some people end up preferring injections over pills for hormones and GLP-1s?Follow us on Instagram: @lessofyoupodcast Save 10% on weight-loss meds and peptides through our partner EpixNxt with code LESSOFYOU10. Co-hosts: Eva Sheie & Kami Gamlem Assistant Producer: Mary Ellen Clarkson Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis.

  4. Jul 31

    We're Back, and We Found a Cheaper Way to Get Your Meds

    After an accidental three-and-a-half-month hiatus, we are back with updates and committing to every week. We catch up on  kids, summer camps, GLP-1 dosing and pricing, HRT and perimenopause, peptides, and one genuinely scary night at the tennis court. Eva shares what she learned digging into the GLP-1 market, from the shell-website pharmacies to the discovery that most of them source from the same distributor, and how she finally found an affordable telehealth source she trusts that also ships fast and costs a fraction of what she used to pay. Kami shares how backing off her dose and starting HRT collided with perimenopause rage, and why she's rebuilding her plan around her budget instead of the scale. A heat-stroke scare at Sunday-night tennis turns into a talk about not eating all day to lose weight, a running debate about how much protein a person can actually stomach, and the usual detour through their kids, from cupcake camp to a very memorable definition of "making love." Help us keep this podcast going! When you order your weight loss meds or peptides through our partner at EpixNXT, we get a few dollars and you get 10% off with the code LESSOFYOU10 at epixNXT.com   Get your meds and support the show: epixNXT.com  (use our code LESSOFYOU10 for 10% off) Less of You is a candid, funny, no-filter conversation between friends about weight loss, GLP-1 medications, aging, and everything that comes with trying to take care of yourself in real life. Follow us on Instagram @lessofyoupodcast Are you confronting the same challenges and have a story to tell? Share it on the Skinny Shot Stories podcast at skinnyshotstories.com If you're a doctor and would like to learn more about sponsoring this or any of our cosmetic surgery and weight loss podcasts, go to lessofyou.com Less of You is a production of The Axis: theaxis.io

  5. Mar 27

    Why you shouldn’t go off meds

    Kami goes off her GLP-1, stops her thyroid meds, and gains back 25 lbs. After 3 months of Eva being angry for no reason, it turns out she just needs hormones. Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.  Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io. To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.  Follow us on Instagram @lessofyoupodcast  Co-hosts: Eva Sheie & Kami Gamlem Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis

  6. Jan 9

    The Dryer Shrunk My Jeans

    Kami runs out of weight loss meds during the holidays, gains 10 pounds, and blames the dryer for shrinking her clothes. Eva overschedules everything, battles inconsistent clothing sizes at fancy events, and gets unsolicited body size comments at work. Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.  Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io. To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.  Follow us on Instagram @lessofyoupodcast  Co-hosts: Eva Sheie & Kami Gamlem Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis

  7. 11/14/2025

    I took a 4 week break from semaglutide and here’s what happened

    Eva gets ghosted in the middle of an important situation and spirals for a day. Kami stops her meds and finds out what it feels like to be hungry again after two years. Check out Murderland: Crime and Bloodlust in the Time of Serial Killers Shop Shapermint Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.  Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io. To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.  Follow us on Instagram @lessofyoupodcast  Co-hosts: Eva Sheie & Kami Gamlem Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart Engineering: Victoria Cheng Theme music: Old Grump, Smartface Less of You is a production of The Axis  This episode includes AI-generated content.

  8. 10/03/2025

    You Want Fries With That?

    After sewing a quilt on the floor, Kami’s back goes out. After kicking a dumbbell, her foot goes out too. New compounded meds including glycine and B12 make a noticeable dent in Eva’s persistent body aches. A 3-week pause in medication to get a tooth pulled has a surprising effect.  We deconstruct our instincts to soften bad news by bribing our children with treats like McDonald’s. Listen to the new addiction & recovery podcast My Last Relapse Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese while losing weight on semaglutide and roasting our past selves. Sarcasm is our happy place.  Are you confronting the same challenges? We’d love to hear your story. Send an email to podcasts@theaxis.io. To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at lessofyou.com To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, request more info at theaxis.io.  Follow us on Instagram @lessofyoupodcast  Co-hosts: Eva Sheie & Kami Gamlem Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart Engineering: Spencer Clarkson Theme music: Old Grump, Smartface Less of You is a production of The Axis

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Eva + Kami are two old-ish moms confronting our reasons for being obese while losing weight on semaglutide and tirzepatide, and roasting our past selves. Sarcasm is our happy place. Follow us on Instagram @lessofyoupodcast.  After a friend (who is a plastic surgeon) talked Eva into starting semaglutide in February of 2023, she lost 70 pounds in 14 months, alternating between long stretches of being stalled at the same weight and consistent but slow weight loss.  Chasing a lifelong dream to being considered just overweight and not obese by the BMI calculator, after 14 months Eva switched to tirzepatide to try and reach a goal that still seems just out of reach.   A prolific eater of her feelings, Kami was tired of being uncomfortable and when she heard through a mutual friend how semaglutide had changed Eva’s life, she found a trusted medical weight loss provider and took the first step.  As Kami starts her life on semaglutide, Eva adjusts to a world with less food noise and figures out how to let go of the crippling negative self-talk.  On each episode, we connect on how our lives are changing in real time as semaglutide and tirzepatide help us be smaller people, and try to answer the bigger question for ourselves:  When there’s less of you, what is left?

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