Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (17)
  • Alternative Health
  • Weekly

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 1d ago ·  Bonus

    Practical Tips to Lower Histamine Levels Fast [Replay]

    Does your histamine bucket feel like it’s overflowing? In this replay of one of the Histamine Well Podcast’s fourth most popular episodes, Joanne explores her approach to managing histamine symptoms while investigating the underlying causes. If you’re navigating histamine intolerance and symptoms such as headaches, hives, bloating or disrupted sleep, this episode explores dietary strategies and supplement considerations to discuss with your practitioner. Joanne also explains why individual responses matter, particularly when supplements seem to make symptoms worse. In this episode, Joanne discusses: A low histamine diet as a short-term strategy while addressing underlying causes.DAO enzymes and their role in breaking down histamine in food.Supplement considerations, including quercetin, vitamin C and Saccharomyces boulardii.The connection between SIBO, histamine symptoms and dietary choices.Why constipation, digestion and gut motility deserve attention.Oxalate sensitivity and why further dietary restrictions need individual guidance.How oestrogen, progesterone and hormonal changes may influence symptoms.Methylation and why methylated B vitamins may not suit everyone.Whether you’re new to histamine intolerance or revisiting the foundations, this episode offers insight into Joanne’s clinical approach and questions to explore with your healthcare practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  2. Oct 14

    Q&A. When Should I Take L-Theanine?

    When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night? In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-theanine to support relaxation and explains how timing may differ depending on your symptoms. She also explores combining L-theanine with magnesium and the options she discusses when magnesium glycinate isn’t tolerated. In this episode, you’ll learn: How Joanne uses L-theanine for daytime anxiety and nervous system hyperarousal.When she considers taking it before bed for difficulty falling asleep.How she approaches L-theanine timing for waking during the night.The doses and supplement combinations discussed in her clinical approach.Why individual tolerance matters when choosing magnesium.If you’ve been wondering when to take L-theanine for anxiety or sleep, this quick episode explores the timing options Joanne considers in practice. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  3. Oct 12

    61. SIBO Case Study: Bloating, Constipation, IBS & Histamine

    Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture? In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions. The patient had experienced significant bloating, nausea, reflux, constipation and brain fog, with probiotics making her bloating worse. Despite seeing several practitioners, she had not been assessed for SIBO. Joanne shares the clues that prompted testing, why she prioritised a SIBO breath test over stool microbiome testing in this case, and how she introduced a SIBO low-histamine diet and personalised digestive support. At her first follow-up, the patient reported an 80% reduction in bloating, alongside improvements in nausea, reflux and heartburn. With constipation still an issue, Joanne explains the next adjustments to her care and why retesting remained part of the plan. In this episode, you’ll hear: The patient’s symptom history following food poisoning.Joanne’s reasoning behind targeted SIBO testing.How the methane-positive result informed her approach to constipation.The dietary changes and digestive support used initially.How Joanne adjusted the plan as symptoms improved.Her plans for follow-up, retesting and food reintroduction.Whether you’re experiencing ongoing gut symptoms or supporting patients in clinical practice, this episode offers a practical look at Joanne’s assessment and treatment decisions. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  4. Oct 7

    Q&A. Why Do I Feel Depressed On Calcium-D-Glucarate?

    Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration. In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement. If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  5. Oct 5

    60. The Gut and Immune System: The Histamine Connection

    Could your gut help explain why you’re reacting to foods you once tolerated? In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact. A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters. What you’ll learn: How the intestinal barrier and secretory IgA help protect your gut.Why microbial diversity, butyrate and immune tolerance matter.How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.How mast cells and certain gut bacteria produce histamine.Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.How stress, the nervous system, and gut motility can influence digestive symptoms.Why gut support needs to be personalised to your symptoms and tolerance.Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  6. Sep 30 ·  Bonus

    Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?

    A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one? In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating. In this episode: How food swaps on a low FODMAP diet may increase your sulfur or oxalate intakeSymptoms Joanne suggests watching for alongside bloatingWhy the migrating motor complex may matter when bloating persistsWhy a SIBO test can help clarify what may be going on✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  7. Sep 28

    59. Circadian Rhythm: How Your Body Clock Affects Sleep, Hormones, Gut Health & Histamine

    In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night. Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to support a more consistent rhythm, including morning daylight, time outdoors during the day and a darker evening routine. In this episode, you’ll learn: What circadian rhythm is and why it matters beyond sleepHow light and darkness influence cortisol and melatoninWhy meal timing may matter for digestion and gut motilityHow histamine activity follows a daily patternSimple ways to support your body clock within your routineIf you’re navigating histamine intolerance, sleep difficulties, hormone concerns or persistent gut symptoms, this conversation offers another piece of the picture to discuss with your healthcare practitioner. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

  8. Sep 23 ·  Bonus

    Q&A. Why Do I Feel Sick from Taking N-Acetylcysteine?

    NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it. In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects. You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introduction or different approach may be needed. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

See All (83)

5
out of 5
17 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

Information

You Might Also Like