Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (16)
  • ALTERNATIVE HEALTH
  • UPDATED WEEKLY

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 1D AGO · BONUS

    Q&A. What Type of Magnesium Should I Take?

    In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive.  ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    7 min

  2. 3D AGO

    37. Candida and Histamine: Why Fungal Overgrowth Keeps Coming Back

    In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms. She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break histamine down. You’ll learn why antifungals alone often fail, how gut “terrain” factors like low stomach acid, poor bile flow, digestive enzyme insufficiency, microbiome imbalance, mold exposure, and chronic stress allow fungal overgrowth to persist, and how SIBO and SIFO are connected through small intestinal pH imbalance. If you struggle with histamine intolerance, sugar cravings, brain fog after carbs, bloating, or recurrent candida, this episode explains the deeper root causes — and why nervous system regulation is essential for long-term healing. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    14 min

  3. FEB 25 · BONUS

    Q&A. Should I Be Taking Antihistamines Long Term?

    In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system.  ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    4 min

  4. FEB 23

    36. Less Is More: Why Over-Treating Mold & Food Intolerance Makes Things Worse

    In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure. After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares how targeted support using sulforaphane, digestive enzymes, and Epsom salt baths helped stabilize her system and gradually restore tolerance to food. Joanne explains the biochemical drivers behind mold-related illness, including sulfur metabolism, detoxification pathways, and nervous system load, and why aggressive protocols, heavy supplementation, and herbal overuse can often worsen symptoms in sensitive individuals. This conversation highlights the importance of gentle, well-timed interventions, practitioner guidance, and understanding the body’s capacity before pushing detoxification. Topics covered include: Severe food reactions and histamine intoleranceMold exposure and chronic illnessSulforaphane and detoxification supportSulfur metabolism and nervous system balanceWhy “less is more” in complex healing casesShow Notes:  🌐 Official Program Links 1. The Gupta Program – Brain Retraining This is the main site for the limbic retraining and neuroplasticity program designed to help calm the nervous system and support recovery from chronic and sensitivity-related conditions. 2. Irene Lyon – Somatic & Nervous System Work This is the official site for Irene Lyon, a nervous system expert who provides somatic-based exercises and education to help regulate the nervous system body-mind connection. 3. Cell‑Logic – G.E.M.M. Protocol for Patients This page explains the G.E.M.M. Protocol (Gut Ecology & Metabolic Modulation) — an approach focused on restoring cellular health and gut-immune balance. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    39 min

  5. FEB 18

    Q&A. If I have MTHFR Does it Mean I Can't Detox?

    In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities.  ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    6 min

  6. FEB 16

    35. Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms

    In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms. Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, anxiety, poor detoxification, and heightened inflammatory responses, especially in individuals who don’t improve despite targeted gut or histamine protocols. This episode walks listeners through how MARCoNS are identified, with a focus on nasal swab testing, and outlines evidence-informed treatment strategies, including biofilm disruptors, targeted herbal antimicrobials, and supportive therapies designed to reduce bacterial load and calm immune activation. Whether you’re a health practitioner working with complex chronic cases or an individual struggling with ongoing symptoms that don’t fully resolve, this episode provides practical insight into MARCoNS as a hidden driver of inflammation and histamine dysregulation. In This Episode, You’ll Learn: What MARCoNS are and how they impact the immune systemWhy MARCoNS are linked to chronic inflammation and histamine-related symptomsCommon signs and symptoms associated with MARCoNS colonizationHow nasal swab testing is used to identify MARCoNSTreatment approaches including biofilm disruptors and targeted antimicrobialsJoanne discusses laboratories that provide MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci) nasal swab testing, commonly used in clinical practice to identify bacterial colonisation linked to chronic inflammation, histamine-related symptoms, and mould-associated illness. Nutripath (Australia): https://nutripath.com.au/Microbiology Dx (USA): https://www.microbiologydx.com/ ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    10 min

  7. FEB 2

    34. Vitamin B12 Explained: Forms, Methylation, Homocysteine & Absorption

    In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health. Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is often overlooked, how genetic variations can impact B12 utilization, and why choosing the correct form of B12 supplementation is essential for optimal outcomes. Joanne and James also examine the different forms of Vitamin B12—including methylcobalamin, hydroxocobalamin, adenosylcobalamin, and cyanocobalamin—discussing how each functions in the body and when one may be more appropriate than another.  The conversation highlights common signs and symptoms of B12 deficiency, from fatigue and brain fog to neurological and mood-related concerns, and offers practical, evidence-informed strategies for assessing and supporting B12 status. This episode is especially valuable for health practitioners, functional medicine clinicians, and individuals seeking a deeper understanding of how Vitamin B12, genetics, and methylation intersect to influence long-term health. In This Episode, You’ll Learn: Why Vitamin B12 is essential for methylation, detoxification, and neurological healthThe different forms of Vitamin B12 and how they work in the bodyCommon and often-missed symptoms of Vitamin B12 deficiencyHow B12 supports homocysteine regulation and cardiovascular healthHow to choose the right B12 supplementation based on individual needsThe connection between genetics, methylation pathways, and B12 metabolism ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    48 min

  8. JAN 26

    33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation

    In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation. This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react badly to methylated B vitamins, and how over-methylation can drive symptoms such as anxiety, irritability, insomnia, nervous system overload, and chronic inflammation. Joanne also introduces the Mood Sense test as a real-time tool for assessing methylation status, helping practitioners and individuals move away from guesswork and toward personalized, symptom-aware support. With insights inspired by James Bradshaw, this episode is essential listening for anyone navigating estrogen-related symptoms, mood instability, or complex supplement reactions. What you’ll learn in this episode: Why over-methylation is becoming more common, especially in womenHow COMT enzyme activity influences mood, stress tolerance, and neurotransmitterThe connection between estrogen dominance and over-methylationCommon emotional and inflammatory symptoms linked to over-methylationWhy methylated supplements can worsen symptoms for some peopleHow the Mood Sense test can help assess methylation status in real timeKey considerations for supporting estrogen balance and calming the nervous system✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    11 min
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5
out of 5
16 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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