Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Joanne Kennedy
  • 5.0 (16)
  • ALTERNATIVE HEALTH
  • UPDATED WEEKLY

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

  1. 1D AGO

    35. Understanding MARCoNS and Its Impact on Inflammation, Histamine, and Chronic Symptoms

    In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms. Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, anxiety, poor detoxification, and heightened inflammatory responses, especially in individuals who don’t improve despite targeted gut or histamine protocols. This episode walks listeners through how MARCoNS are identified, with a focus on nasal swab testing, and outlines evidence-informed treatment strategies, including biofilm disruptors, targeted herbal antimicrobials, and supportive therapies designed to reduce bacterial load and calm immune activation. Whether you’re a health practitioner working with complex chronic cases or an individual struggling with ongoing symptoms that don’t fully resolve, this episode provides practical insight into MARCoNS as a hidden driver of inflammation and histamine dysregulation. In This Episode, You’ll Learn: What MARCoNS are and how they impact the immune systemWhy MARCoNS are linked to chronic inflammation and histamine-related symptomsCommon signs and symptoms associated with MARCoNS colonizationHow nasal swab testing is used to identify MARCoNSTreatment approaches including biofilm disruptors and targeted antimicrobialsJoanne discusses laboratories that provide MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci) nasal swab testing, commonly used in clinical practice to identify bacterial colonisation linked to chronic inflammation, histamine-related symptoms, and mould-associated illness. Nutripath (Australia): https://nutripath.com.au/Microbiology Dx (USA): https://www.microbiologydx.com/ ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    10 min

  2. FEB 2

    34. Vitamin B12 Explained: Forms, Methylation, Homocysteine & Absorption

    In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health. Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is often overlooked, how genetic variations can impact B12 utilization, and why choosing the correct form of B12 supplementation is essential for optimal outcomes. Joanne and James also examine the different forms of Vitamin B12—including methylcobalamin, hydroxocobalamin, adenosylcobalamin, and cyanocobalamin—discussing how each functions in the body and when one may be more appropriate than another.  The conversation highlights common signs and symptoms of B12 deficiency, from fatigue and brain fog to neurological and mood-related concerns, and offers practical, evidence-informed strategies for assessing and supporting B12 status. This episode is especially valuable for health practitioners, functional medicine clinicians, and individuals seeking a deeper understanding of how Vitamin B12, genetics, and methylation intersect to influence long-term health. In This Episode, You’ll Learn: Why Vitamin B12 is essential for methylation, detoxification, and neurological healthThe different forms of Vitamin B12 and how they work in the bodyCommon and often-missed symptoms of Vitamin B12 deficiencyHow B12 supports homocysteine regulation and cardiovascular healthHow to choose the right B12 supplementation based on individual needsThe connection between genetics, methylation pathways, and B12 metabolism ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    48 min

  3. JAN 26

    33. Over-Methylation Explained: COMT, Estrogen, Mood & Inflammation

    In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation. This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react badly to methylated B vitamins, and how over-methylation can drive symptoms such as anxiety, irritability, insomnia, nervous system overload, and chronic inflammation. Joanne also introduces the Mood Sense test as a real-time tool for assessing methylation status, helping practitioners and individuals move away from guesswork and toward personalized, symptom-aware support. With insights inspired by James Bradshaw, this episode is essential listening for anyone navigating estrogen-related symptoms, mood instability, or complex supplement reactions. What you’ll learn in this episode: Why over-methylation is becoming more common, especially in womenHow COMT enzyme activity influences mood, stress tolerance, and neurotransmitterThe connection between estrogen dominance and over-methylationCommon emotional and inflammatory symptoms linked to over-methylationWhy methylated supplements can worsen symptoms for some peopleHow the Mood Sense test can help assess methylation status in real timeKey considerations for supporting estrogen balance and calming the nervous system✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    11 min

  4. JAN 12

    32. Hormone Replacement Therapy in Perimenopause: Interview with Rachel Schaefer

    Are your hormones out of balance? In this episode of The Histamine Well Podcast, Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine, to demystify perimenopause and the role of Hormone Replacement Therapy (HRT) in supporting women’s health. They explore what actually happens during hormone fluctuations in perimenopause, how to recognize estrogen dominance, and the benefits and risks of estrogen, progesterone, and testosterone therapy. Rachel shares practical insights on how personalized care, detailed hormone testing, and integrative medicine can help women navigate this transitional stage with confidence. You’ll learn how early intervention with the right HRT protocol can improve energy, mood, sleep, and long-term wellbeing—plus how to avoid common pitfalls with synthetic hormones, patches, and oral estrogen. Whether you’re just entering perimenopause or already considering HRT, this episode offers a clear, empowering look at how to restore hormonal harmony and thrive through midlife. Learn more about Rachel’s integrative approach to hormone health and women’s wellbeing: Website: https://www.ginkgointegrativemedicine.com/ Instagram: @ginkgointegrative🧪 Rachel’s Recommended Annual Serum Lab Panel (Age 40+) Done fasting, ideally once per year. Tracks hormonal shifts & key biomarkers: CBC w/ diff · Ferritin, TIBC, Iron sat · CMP · GGT · SHBG · DHEA-S · Free & Total Testosterone · Estradiol LC/MS (Cycle Day 2–3) · FSH (Day 2–3) · LH · Progesterone LC/MS (Day 20–21) · Homocysteine · MMA · HSCRP · Insulin · HbA1c · ApoB · Lp(a) · TSH · Free T4 · Free T3 · rT3 · TPO antibodies · ANA · Vitamin D Additional testing based on the case: DUTCH · Tiny Health GI Pro · Mira · 3x4 Genetics · Total Tox Burden · DEXA · OATS · Mood Sense 💡 At-Home Hormone Tracking — Listener Discount Rachel checked in with Mira, a home-based hormone urine testing device, to offer a special 20% off discount for listeners of The Histamine Well Podcast. 🔸 Public Discount Code: 2GINGKO20 🔸 Mira Website: www.miracare.com ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    1h 14m

  5. 11/10/2025

    31. How to Protect Your Home from Mold and EMF Exposure with Building Biologist Jo Lia

    Is your home secretly affecting your health? In this episode of The Histamine Well Podcast, Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnetic fields (EMF), and poor indoor air quality. Jo shares her journey into building biology and explains how unseen environmental factors—like hidden mold spores or constant EMF exposure—can impact your immune system, mood, and energy levels. Together, they break down what you can do to make your home a truly healthy space, from proper mold testing and remediation to simple steps that minimize EMF radiation in your daily life. If you’ve struggled with chronic inflammation, fatigue, allergies, or unexplained symptoms, this episode will help you connect the dots between your home environment and your health. What You’ll Learn: How to identify the early signs of mold in your homeThe truth about EMFs and how they affect your healthSimple ways to reduce EMF exposure from Wi-Fi and devicesWhat to do if you suspect mold contamination — and how to remediate safelyWhy modern airtight homes can worsen indoor air qualityHow to improve ventilation and maintain clean indoor airHow to find and work with a certified Building BiologistPractical tips for creating a toxin-free, health-supportive living environment Connect with Jo Lia: 🌿 Website: https://www.notoxrox.com/ 📸 Instagram: @notoxrox 📘 Facebook: facebook.com/notoxrox Australian Society of Building Biologists: https://www.asbb.org.au/ ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    1h 1m

  6. 10/27/2025

    30. Hydrogen Sulfide SIBO Explained: Symptoms, Testing & Treatments with Rosaria Nithart

    In this episode of The Histamine Well Podcast,  Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood forms of Small Intestinal Bacterial Overgrowth (SIBO). Together, they break down how Hydrogen Sulfide SIBO differs from hydrogen- and methane-dominant SIBO, exploring the unique bacteria and biochemical pathways involved. Rosaria shares her step-by-step naturopathic framework for identifying, testing, and treating Hydrogen Sulfide SIBO naturally. The conversation also dives deep into the role of sulfur metabolism, oxalates, and molybdenum in managing symptoms and restoring gut balance. Listeners will learn: The root causes and drivers behind Hydrogen Sulfide SIBOHow to identify key symptoms and understand testing limitationsThe connection between sulfur, oxalates, and bacterial imbalancesPractical treatment strategies that support gut healing without extreme dietsHow Hydrogen Sulfide SIBO links to UTIs, histamine intolerance, and detox pathwaysWhether you’re a practitioner seeking deeper clinical insights or a patient navigating chronic gut issues, this episode offers a clear, actionable approach to understanding and managing Hydrogen Sulfide SIBO naturally.  Connect with Rosaria Nithart: Website: rosarianithart.com | rosarianithart.itFacebook: facebook.com/rosaria.nithartInstagram: @rosarianithartnaturopatheBreath Tests for Hydrogen, Methane & Hydrogen Sulfide: Trio Smart (USA / Canada)– Trio-Smart® — The only 3-Gas SIBO Breath Test: https://www.triosmartbreath.com/Nordic Labs (Europe) – https://nordiclabs.com/EProduct.aspxInvivo Healthcare (UK): https://invivohealthcare.com/Teletest (Spain): https://www.teletest.es/ | https://www.facebook.com/teletest/✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    39 min

  7. 10/13/2025

    29. Healing Chronic Illness Through Nervous System Regulation with Jacqui Raadschelders

    In this episode of The Histamine Well Podcast, Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness. You’ll learn how the limbic system, vagus nerve, neuroplasticity, and brain retraining techniques play a vital role in recovery from conditions influenced by trauma, mold exposure, and stress. Jacqui shares her journey from traditional physiotherapy to a holistic, trauma-informed approach—highlighting the impact of emotions, beliefs, and environment on healing. Key topics include: Fight, flight, and freeze responsesThe role of the limbic system in chronic illnessPractical vagus nerve toning exercisesEmotional regulation and belief system shiftsBrain retraining for long-term resilienceTailored strategies to regulate and recalibrate the nervous systemWhether you’re a practitioner, student, or someone navigating chronic illness, this conversation offers practical tools and evidence-based insights for restoring balance and supporting your nervous system health. Enrol in the Regulate Your Nervous System online program and receive 10% off with the code JOANNE10. This program is for anyone navigating chronic illness, burnout, stress or persistent symptoms who’s ready to understand their body in a new way. Enrol here  ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    47 min

  8. 09/29/2025

    28. Oxalates, Adrenal Fatigue & Blood Sugar Imbalance: Tracy’s Journey to Healing

    In this episode of The Histamine Well Podcast, Joanne is joined by colleague Melanie and patient Tracy, who shares her powerful story of navigating the challenges of oxalates, histamine intolerance, adrenal fatigue, and blood sugar imbalances. Tracy’s journey highlights the complex relationship between oxalates, adrenal and blood sugar imbalances, and oxalate dumping symptoms. With support from Melanie, she has worked through paradoxical reactions to magnesium and B6, learned strategies for managing sulfur metabolism, and discovered the importance of patience and persistence in recovery. Melanie provides expert insights into identifying oxalate issues, tailoring dietary strategies, and supporting detoxification pathways. Together, the conversation emphasizes the importance of professional guidance, careful supplementation, and tracking progress when addressing oxalates. Whether you’re a practitioner seeking functional medicine insights or someone personally struggling with oxalates, histamine intolerance, or methylation challenges, this episode offers practical advice and encouragement to support your healing journey. What You’ll Learn in This Episode How oxalates affect adrenal health and blood sugar balanceWhat to know about oxalate dumping symptoms and how to manage themThe role of sulfur metabolism and detox pathways in oxalate sensitivityWhy do some people experience paradoxical reactions to magnesium and B6Dietary and lifestyle strategies for long-term oxalate managementThe link between oxalates, histamine levels, and methylationWhy professional support is crucial for navigating complex health issues Why This Episode Matters Oxalates are often overlooked in discussions about chronic health, but they can play a major role in gut health, nutrient absorption, adrenal function, and histamine intolerance. Tracy’s story shows how challenging—but also how rewarding—it can be to address these issues with the right support and strategies. If you’ve been struggling with fatigue, blood sugar swings, or unexplained reactions to supplements, this conversation offers valuable guidance. ✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!

    1h 9m
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5
out of 5
16 Ratings

About

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.

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