The Orange Pill Podcast

KGK Science
  • 0.0 (0)
  • NUTRITION
  • UPDATED WEEKLY

The Orange Pill Podcast 🎙️ Your go-to source for the latest in the dietary supplement and natural health product industry! Brought to you by KGK Science, a global leader in clinical research and regulatory consulting, this podcast delivers: ✔️ Breaking industry news and trends ✔️ Educational insights and practical takeaways ✔️ Discussions on cutting-edge research ✔️ Landmark cases and notable events shaping the field Join us as we bridge the gap between science, regulation, and everyday impact.

  1. 1D AGO

    Episode 90- The Invisible Crisis in Your Pantry: The Ultra-Processed Takeover No One Warned You About

    Ultra-processed foods now make up over half of the average adult’s calories and nearly 60% of children’s diets. They look harmless. They’re marketed as “natural.” Some even carry health halos. But behind the packaging lies a system built on loopholes, engineered starches, and thousands of additives the FDA may never have formally reviewed. In Episode 90 of the Orange Pill Podcast, we unpack the growing bipartisan alarm around ultraprocessed foods - from the controversial GRAS loophole to the striking alliance between Robert F. Kennedy Jr. and former FDA Commissioner Dr. David Kessler under the “Make America Healthy Again” banner. This isn’t about fear. It’s about understanding how policy, processing, and profit reshaped the modern pantry. Because the real question isn’t just what are we eating? It’s who decided it was safe in the first place?

    31 min

  2. 6D AGO

    Episode 89- Beyond the Burner: 5 Surprising Ways Science Is Reinventing Your Food’s Protein

    High heat built the modern food system. But it may also be limiting it. In Episode 89, we explore how Novel Food Processing (NFP) technologies are transforming protein at the molecular level, unlocking better texture, higher bioavailability, improved digestibility, and cleaner labels without sacrificing safety. From electricity-powered milk processing to ultra-high pressure seafood engineering, this episode breaks down how food science is moving beyond the burner and into the future. If you work in food innovation, functional ingredients, protein R&D, or regulatory strategy, this one changes how you think about what’s possible.

    34 min

  3. FEB 10

    Episode 88- How a New Bill Shuts the Door on Secret Food Safety Deals

    What if many of the ingredients in your food were never reviewed by the FDA? In Episode 88 of the Orange Pill Podcast, we break down the newly introduced GRAS Oversight and Transparency Act (February 3, 2026); a bill that aims to close one of the most controversial loopholes in U.S. food regulation. For decades, the “Generally Recognized as Safe” (GRAS) framework has allowed companies to self-determine ingredient safety without notifying the FDA, leaving regulators and consumers in the dark. This episode unpacks how that system works, why it matters, and how this new legislation could permanently reshape food ingredient oversight. From legacy ingredients approved decades ago, to a new interagency GRAS Review Board with real enforcement authority, we explore what this bill means for manufacturers, regulators, and the future of food transparency.

    31 min

  4. FEB 5

    Episode 87- The Hidden Cost of “Safe” Sweets: How Erythritol May Be Quietly Compromising Your Brain’s Security

    Erythritol has earned a near-perfect reputation in the clean-eating world. It’s natural, calorie-free, keto-friendly, and widely considered one of the safest sugar substitutes on the market. But new research from the University of Colorado suggests that this confidence may be dangerously misplaced. In Episode 87 of the Orange Pill Podcast, we unpack a startling new study from the DeSouza laboratory that shows how erythritol may quietly compromise the blood-brain barrier (BBB), the brain’s most critical line of defense against toxins, inflammation, and vascular injury. This episode breaks down: • How erythritol triggers a 75% surge in oxidative stress inside brain endothelial cells • Why the body’s antioxidant defenses can’t keep up • How nitric oxide suppression and endothelin-1 elevation promote dangerous vessel constriction • Why erythritol may disable the brain’s natural “clot-buster” response • And most critically, why these effects occur at blood concentrations reached after a single serving This isn’t a story about extreme overconsumption. It’s about everyday exposure hiding behind a “natural” label. If you consume sugar-free snacks, energy drinks, or keto products, this episode is essential listening.

    30 min

  5. FEB 3

    Episode 86- When Supplements Become Drugs: What FDA’s BIMO Program Is Really Policing

    Many wellness and nutraceutical companies believe that calling a product a dietary supplement creates a regulatory safe zone. FDA enforcement actions tell a very different story. In Episode 86 of the Orange Pill Podcast, we break down the FDA’s Bioresearch Monitoring (BIMO) Program and analyze recent FDA Warning Letters that caught sponsors, CROs, and IRBs completely off guard. This episode explains a hard regulatory truth: the FDA does not regulate labels - it regulates intent. We explore three critical lessons drawn directly from enforcement actions involving U.S.-based clinical trials: • Why study design, not product category, determines whether something is legally a drug • How enrolling diseased subjects instantly converts a “supplement study” into a drug trial • Why skipping an IND isn’t a paperwork error but a serious safety and data integrity failure • How validated clinical instruments can unintentionally trigger drug classification • The role CROs and IRBs play and where accountability ultimately falls If your clinical trial measures disease outcomes, targets pathology, or recruits diagnosed populations, the FDA will treat it as a drug study, regardless of what’s on the bottle. This episode is essential listening for sponsors, CROs, regulatory teams, and anyone designing human research in the supplement space.

    52 min

  6. JAN 29

    Episode 85- The GLP-1 Hack in Your Grocery Cart: Why #Fibermaxxing Is Replacing the Protein Obsession

    For years, protein dominated the wellness conversation. Shakes, bars, and macro tracking became the gold standard of “healthy.” But a new movement is rapidly reshaping nutrition culture  and it isn’t coming from gyms or supplement brands. It’s coming from the gut. In Episode 85 of the Orange Pill Podcast, we unpack the science behind #Fibermaxxing - the viral trend shifting attention from protein obsession to microbiome-driven health. This episode explores why fiber has suddenly become the internet’s most powerful nutrient and how it connects directly to the decade’s most talked-about pharmaceutical target: GLP-1. We break down: • How fiber naturally stimulates GLP-1 -  the hormone behind fullness, glucose control, and metabolic regulation • Why the U.S. is facing a hidden fiber deficiency crisis • The biological risks of jumping from low fiber to extreme fiber overnight • The overlooked science of soluble vs. insoluble fiber and fermentation • How ultra-processed “fiber-added” foods differ from whole-food fiber sources • And a practical, microbiome-safe way to increase intake without digestive fallout Fibermaxxing isn’t a hack. It’s a return to biological fundamentals.

    37 min

  7. JAN 27

    Episode 84- Inside FDA’s 2026 Food Overhaul: The End of the Chemical Loophole

    For decades, America’s food system operated in a gray zone where chemicals could quietly enter the supply chain, nutrition guidance lagged behind chronic disease, and safety was often reactive rather than preventive. That era is ending. In Episode 84 of the Orange Pill Podcast, we unpack the FDA’s newly solidified Human Foods Program (HFP) and its sweeping 2026 agenda, a regulatory blueprint that signals one of the most aggressive transformations in food policy in modern history. This episode explores how the FDA is shifting from a watchdog to an architect of national health, built around three core pillars: Food Chemical Safety, Nutrition, and Microbiological Food Safety. We dive into what’s actually coming in 2026, including: • The dismantling of the GRAS loophole and the rise of mandatory pre-market chemical transparency • The targeted review of controversial additives like phthalates, BHA, BHT, and parabens • The phase-out of petroleum-based food dyes in favor of plant-derived colors • New front-of-package nutrition labeling designed to influence real-time consumer behavior • FDA’s expansion into microplastics, heavy metals, and PFAS oversight • The modernization of infant formula standards under Operation Stork Speed • And the federal effort to formally define “ultra-processed foods” This is not incremental regulation. It is a structural reset of the relationship between government, industry, and the grocery shelf.

    30 min

  8. JAN 22

    Episode 83- Inside the FDA’s Cosmetics Overhaul: What MoCRA Is Really Changing

    For nearly a century, U.S. cosmetic regulation remained largely unchanged. That era officially ended with the passage of the Modernization of Cosmetics Regulation Act (MoCRA), and now, the FDA is racing to catch up. In Episode 83 of the Orange Pill Podcast, we unpack five major regulatory developments that signal a fundamental shift in how cosmetics are tested, labeled, and enforced in the United States. Drawing from recent FDA actions and the Fall 2024 Unified Agenda, this episode explores: • The FDA’s long-awaited move to mandate asbestos testing in talc products • Why the agency is using a broader mineral definition to future-proof safety • How fragrance “trade secrets” are ending with allergen disclosure rules • The delayed but historic push toward a formaldehyde ban in hair products • How the 2025 administrative transition has triggered a widespread regulatory freeze impacting MoCRA timelines We discuss what these shifts mean for brands, manufacturers, regulatory teams, and consumers, and why companies should already be preparing their quality systems, documentation, and compliance strategies. This episode isn’t just about beauty. It’s about accountability, transparency, and the future of consumer protection.

    27 min
See All (90)

About

The Orange Pill Podcast 🎙️ Your go-to source for the latest in the dietary supplement and natural health product industry! Brought to you by KGK Science, a global leader in clinical research and regulatory consulting, this podcast delivers: ✔️ Breaking industry news and trends ✔️ Educational insights and practical takeaways ✔️ Discussions on cutting-edge research ✔️ Landmark cases and notable events shaping the field Join us as we bridge the gap between science, regulation, and everyday impact.

Information

  • Creator
    KGK Science
  • Years Active
    2025 - 2026
  • Episodes
    90
  • Rating
    Clean
  • Copyright
    Copyright ©2025 KGK Science. All rights reserved.
  • Show Website
    The Orange Pill Podcast