Peptide of The Week

JD Denham and Will Haas
  • 4.6 (127)
  • Health & Fitness
  • Updated Weekly

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.

  1. 2d ago

    Peptide Q&A #58 – Shelf Life, Drug Test, HGH vs IGF-1 LR3 & Carnivore Diet

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover building muscle at 13.5% body fat, running carnivore diet on "R", St. John's Wort interactions, peptides for a marathon at 53, the mitochondrial stack sequenced properly, and whether IGF-1 LR3 and HGH can be run together. Chapters: 00:00 – Intro & Holiday Weekend Recap 00:39 – Shark Stories & Ocean Safety Talk 07:35 – School, Coaching & Warrior Maker Updates 08:18 – Q&A: Muscle Gain & a Shredded Stomach (Age 43) 15:11 – Q&A: R & Fat Digestion on Carnivore 20:59 – Q&A: St. John's Wort & Peptide Interactions 24:39 – Q&A: KPV for Connective Tissue Disease 27:42 – Q&A: Low Energy on Tirzepatide & AOD (Age 38) 36:05 – Q&A: How Long Do Unmixed Peptides Last? 38:36 – Q&A: Do Peptides Show Up on Drug Tests? 40:35 – Q&A: Stacking HGH, CJC/Ipa & IGF-1 LR3 47:36 – Q&A: Marathon Training Stack After Major Weight Loss 51:40 – Q&A: Sequencing Mitochondrial Peptides for Energy (Age 55) 56:53 – Outro & New Hyperbaric Chamber Announcement We cover: • Building Muscle at 13.5% Body Fat as a Woman: Why eating more not less is the answer, why AOD should come out, and why 5-Amino-1-MQ, SLU-PP-332, and Tesamorelin-Ipa are the right additions • Carnivore Diet on "R" with Ulcerative Colitis: Why high fat plus slow gastric emptying causes the problem, why small frequent meals fix it, and why a little fiber and 50 grams of carbs around training goes a long way • St. John's Wort & "R" Interactions: Why R is broken down by protein enzymes not the liver's CYP450 system, why St. John's Wort is notorious for drug interactions, and why milk thistle, TUDCA, and glutathione are better liver support • Mixed Connective Tissue Disease & KPV: Why oral BPC and KPV are generally safe to add, and why coming off a biologic requires a knowledgeable doctor not a podcast • Low Energy on Tirzepatide at 133 Pounds: Why under-eating protein is the most likely culprit, why tracking macros is more powerful than any peptide, and why NAD, SS-31, MOTS-C, and methylated B12 are the right energy stack • Lyophilized Peptide Shelf Life The Real Answer: Why unmixed peptides last up to two years in a cool dark place, why freezing creates moisture risk, and why the crisper drawer in a small fridge is all you need • Do Peptides Show Up on a 5-Panel Drug Test: Why no standard workplace panel tests for peptides and why only high-level professional sports testing would even attempt it • HGH vs IGF-1 LR3 — Can You Stack Both: Why CJC-Ipa is redundant once you're on HGH, when combining HGH and IGF-1 LR3 adds benefit vs. risk, and why MK-677 may be the smarter muscle-building add-on • Marathon Prep Stack at 53 Down 87 Pounds: Why Wolverine is non-negotiable at this age and mileage, why Cardarine and SLU-PP-332 are the endurance game changers, and why adding HGH now gives it time to work before December • Mitochondrial Stack for a 55-Year-Old Working at 2:30 AM: Why SS-31 comes first for at least two weeks, when to layer in MOTS-C, why NAD timing doesn't matter, and why Dihexa, magnesium glycinate, and glycine round out the protocol You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Peptide Of The Week Website: https://peptideoftheweekpod.com Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

  2. 5d ago

    Peptide of the Week: ARA-290 & 5-Amino-1MQ – Nerve Pain & Fat Burning

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas get back to basics and break down two compounds people have been asking about. ARA-290 for nerve pain and neuropathy, and 5-Amino-1MQ for fat burning and metabolic optimization. Two very different compounds with very different objectives. Chapters: 00:00 – Intro & Show Plugs 02:37 – New Podcast Format Announcement 03:28 – ARA-290: Redefining Nerve Pain & Repair 05:09 – Nerve Injury Stories: Sciatica & Back Surgery 08:03 – How ARA-290 Works: Macrophage Reprogramming 13:15 – Dosing Protocols & Cost 15:47 – Nerve Pain, Surgery & Long-Term Nerve Damage 17:39 – Tips: Timing, Sleep, Nutrition & Exercise 22:23 – Side Effects, Safety & What to Stack With 24:59 – Compound #2: 5-Amino-1MQ for Fat Burning 27:32 – Real User Results & Fat Loss Data 30:00 – Dosing: Oral vs. Injectable & Cycle Length 33:16 – Zone 2 Cardio & Maximizing Fat Burn 37:37 – Stacking with GLP-1s & Breaking Plateaus 40:49 – Outro, Feedback & Next Episode Preview We cover: 🧠 ARA-290 — Nerve Repair and Neuropathic Pain – First discovered and researched in the early 2000s, still experimental but with human trials – Selectively binds to the Tissue Protective Receptor (TPR) on immune cells, nerve cells, and metabolic tissues – Reprograms macrophages from pro-inflammatory to anti-inflammatory, actually healing the nerve instead of masking pain – Used for small fiber neuropathy, sarcoidosis, autoimmune nerve conditions, diabetic neuropathy, and post-viral recovery including long COVID – Unlike painkillers, effects continue AFTER you stop taking it because it is healing the nerve, not just covering the pain Real-world reports: – Burning pain dropped from a 7 out of 10 to a 2 out of 10 within 3 weeks in diabetic neuropathy patients – Mood lift and mental calm reported within 4 days (not the main intention but consistently reported) – Nerve fiber density measurably increases over days to weeks – Effects often persist 3 to 6 months post-cycle What to stack with: – BPC-157 and TB-500, NAD+, alpha lipoic acid, methylcobalamin, and B vitamins What to avoid: – NSAIDs and corticosteroids will blunt the effects – Alcohol, high sugar, ultra-processed food, and chronic sleep deprivation all work against nerve healing 🔥 5-Amino-1MQ — The Fat Burning Compound – Not a peptide, technically a small molecule compound. First developed around 2014 – Blocks NNMT (Nicotinamide N-Methyltransferase), which is massively upregulated in obese fat tissue and actively drives fat storage – Blocking NNMT shifts your metabolism to burn fat instead of store it, essentially injecting keto without the diet – Also replenishes NAD+ levels that have been depleted with age – In animal studies: obese mice lost 7 to 9% of fat with no loss of lean muscle while eating the same amount of food – Adds an additional 7 to 9% fat loss on top of GLP-1 results because it works on a completely different pathway Who it is for: – Anyone on a GLP-1 who has plateaued, this will relight the fire – People with insulin resistance or pre-diabetes, it increases insulin sensitivity – Already lean people looking to get even leaner and enhance body composition – People with metabolic syndrome or NAD+ depletion Best stacks: GLP-1 (especially R), MOTS-C, NMN, NAD+, L-Carnitine, Alpha Lipoic Acid, CoQ10 Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Peptide Of The Week Website: https://peptideoftheweekpod.com/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

  3. Sep 3

    Peptide Q&A #57 – Peptide Math, TRT & Thick Blood, HDL on Testosterone & Hair Loss

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover managing high hematocrit on TRT, why HDL drops on testosterone, navigating peptide social media censorship, peptide dosing math broken down simply, hair loss and DHT blockers, and protocols for insulin resistance and PCOS. Chapters: 00:00 – Intro & School Platform Update 01:20 – Coaching Program Update & New Coaches 03:48 – Website Launch & Losing Social Media Channels 04:40 – Personal Life & Family Updates 07:13 – Upcoming Hawaii Trip 08:52 – Teaching Discipline: The Jax Story 12:23 – Q&A: Managing High Hematocrit on TRT 21:33 – Q&A: Insulin Resistance & Weight Loss 28:24 – Q&A: Peptide Dosing Math Explained 36:41 – Q&A: Navigating Social Media & Regulation 44:29 – Q&A: Low HDL on TRT 49:06 – Q&A: Adjusting Your Stack After Reaching Goal Weight 58:35 – Q&A: Hair Loss & DHT Blockers on TRT 1:07:24 – Q&A: Microplastics in Backwater Vials 1:10:14 – Q&A: PCOS, ACL Recovery & Building Muscle & Outro We cover: • High Hematocrit & Thick Blood on TRT: Why testosterone shuts off your body's governor on red blood cell production, why dehydration skews the reading, and why donating blood twice a year is the single best fix • Insulin Resistance & Slow Fat Loss in Women: Why cardio is making it worse, why 40 grams of protein right when you wake up matters, and why walking 10 minutes after every meal may do more than any peptide • Peptide Dosing Math Explained Simply: A live walkthrough of how to calculate exact milligrams per unit for GHK-CU, KPV, MOTS-C, C-Max, and "R" so nothing gets wasted • Navigating Social Media Censorship as a Peptide Educator: Why JD's YouTube got pulled for a 10-minute fasting post, why algorithms are replacing human judgment, and why School and owned platforms are the only safe play • Going Down on "R" After Reaching Goal Weight: Why 5 migs every two weeks makes no sense given the half-life, why 2-3x weekly dosing works better, and when to swap Tesamorelin for 2 IU of HGH • Low HDL on TRT — What Actually Helps: Why niacin has been proven not to work, why aromatase inhibitors make it worse, and why mono-unsaturated fats and fasting are the real levers • Hair Loss, DHT, Finasteride & Dutasteride: Why you're going to lose your hair if your family did regardless, why DHT blockers tank libido and mood, and Will's strategy of microdosing for 3 days to reset without the side effects • Plastic vs. Glass Bacteriostatic Water Vials: Why benzyl alcohol pulls microplastics from plastic vials over time and why glass is the cleaner long-term choice • 32-Year-Old Female with PCOS & ACL Tear: Why Tesamorelin-Ipa blend is the right starting point, why "R" at 500 mcg is virtually nothing, and why protein immediately after waking is non-negotiable 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

  4. Aug 31

    Peptide of the Week: What's Really in Your Water – With Dani Carroll

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with Dani Carroll, a holistic health coach with 17 years of experience, Ayurvedic specialist, and yoga teacher. This one is not about peptides. It is about the thing most of us completely overlook that could be undermining everything else we do. Water. Chapters: 00:00 – Intro & Meeting Dani Carroll 01:05 – Dani's Autoimmune Story & Failed Treatments 07:00 – Discovering the Water That Changed Everything 11:11 – First Results: Brain Fog, Joint Pain & Skin 13:00 – Testing It on Her Skeptical Parents 17:56 – Why Isn't Anyone Talking About Water? 19:17 – The Truth About Tap & Bottled Water 25:44 – How Bottled Water Degrades in Transit 27:47 – RO & Distilled Water: The Mineral Problem 29:46 – Understanding pH & the Alkaline Water Scam 34:06 – JD's GERD & Gut Health Case Study 41:19 – Chlorine, Showers & Skin Absorption 50:04 – How the Machine's Settings & Hydrogen Water Work 1:14:04 – Checking Your Own Tap Water (EWG Database) 1:21:13 – Five Rules for Drinking Water & Outro We cover: 💧 Dani's story – Autoimmune disease surfaced at 16, misdiagnosed with rheumatoid arthritis, full body joint pain and monthly skin peeling episodes – Spent years going through every elimination diet, raw vegan, autoimmune paleo, nothing lasted beyond 90 days – Gut microbiome destroyed by antibiotics prescribed by doctors who never addressed the root cause – Discovered structured alkaline water during postpartum depression, within 45 days her skin stopped peeling for the first time in years – 90 days in she was glowing. Her father lost weight, eliminated gout, and cleared acid reflux within months 🧬 Why water matters more than food – You can survive 40 days without food. You die in 3 days without water. Yet nobody talks about water quality – Tap water contains chlorine, fluoride, heavy metals, pharmaceuticals, forever chemicals, pesticides, and herbicides – The chemicals in tap water are often added to protect aging city pipes, not to clean your water – Water softeners add salt or potassium to protect your pipes, they are not designed to be consumed – RO filtered water strips all minerals. Drinking it long term leaches minerals from your bones, causing bone density loss and eventually osteoporosis – Plastic bottled water is dead water that sits in your stomach, does not absorb properly, and leaches microplastics 🚿 Your shower is a bigger problem than you think – You absorb approximately one liter of water through your skin during a 10 to 15 minute hot shower – Pores open in hot water, you inhale chlorine vapor, and your body absorbs it all The 7 pH settings explained: – 2.5 pH (hypochlorous acid): kills E. coli, MRSA, and bacteria. Use to sanitize meat, surfaces, and as mouthwash – 11.5 pH (strong alkaline): veggie wash, makeup remover, skin treatment, poison ivy compress, eczema protocol. Neutralizes pesticides and herbicides which are designed to be water resistant – 6.0 pH (beauty water): matches your skin and hair pH of 6.4. Use to wash your face and hair, works as a leave-in conditioner without stripping natural oils – 7.0 pH (neutral): neutral rinse water for cooking and final food rinse – 8.5, 9.0, 9.5 pH: drinking water levels depending on your health goals and tolerance Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Dani Carroll: Instagram: https://www.instagram.com/rawsomeyoga/ TikTok: https://www.tiktok.com/@rawsomeyoga Join The Community: https://www.skool.com/peptideoftheweekcommunity

  5. Aug 27

    Peptide Q&A #56 – SS-31 Deep Dive, Fertility on TRT & Building Muscle

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover why SS-31 has been a game changer for JD, how to properly sequence the mitochondrial stack, NAD reactions and replacements, when to come off R, building muscle at 12% body fat, fertility protocols while on TRT, and whether you really need to plan your protocols a year in advance. Chapters: 00:00 – Intro & Personal Health Updates 03:06 – SS-31 & Finding the Right Protocol 06:04 – Disneyland Trip & Kids' Sports Talk 13:48 – Warrior Makers Coaching Program Launch 18:37 – School Platform Updates & Podcast Feedback 21:58 – Q&A: Sleep, Hormones & Energy for a Busy Mum 34:15 – Q&A: Major Weight Loss & a Bad NAD Reaction 39:07 – Q&A: Peptide Storage & Condensation 41:50 – Q&A: SS-31, MOTS-C & NAD Sequencing 49:31 – Q&A: Coming Off Retatrutide's Maintenance Dose 55:22 – Q&A: TRT & Fertility Protocols 1:08:14 – Q&A: Gut Health Flare-Up & Peptide Pause 1:14:53 – Q&A: Runner Wanting Muscle Over Fat Loss 1:21:14 – Q&A: Building a Smart Annual Peptide Plan 1:29:13 – Outro & Coaching Call Details We cover: • Why JD Is Feeling the Best He Has in Years: Why higher-dose SS-31 gets the credit, why less compounds often means feeling better, and why starting with two compounds and adding slowly is the smarter approach • NAD Allergy What to Do Instead: Why reactions to NAD may come from the compound itself not just contamination, why SS-31 at five-plus megs is the closest alternative, and why blood work and hormone optimization should come first at 35 • Peptide Storage and Condensation on Vials: Why condensation on the outside of a vial does not mean moisture got inside, and why a dedicated mini fridge beats any canister solution • Mitochondrial Stack SS-31, MOTS-C and NAD Sequenced Properly: Why SS-31 plugs the holes before MOTS-C revs the engine, why quarterly month-long SS-31 cycles make sense, and why NAD can run anytime regardless • 42-Year-Old Australian Female Should You Come Off R: Why she probably doesn't need it at all, why 5-Amino-1-MQ and SLU-PP-332 are the right replacements, and why discipline is a better long-term tool than any GLP • Fertility Protocol at 33 While Trying for a Baby: Why TRT doesn't have to stop, why HCG and Kisspeptin together improve fertility odds, and why Enclomiphene is the smarter choice over standard Clomid • Building Muscle at 12% Body Fat and Running 60-70 Miles a Week: Why all that running is burning off the muscle she's trying to build, why cutting back to HIIT and lifting heavy is the real answer, and why low-dose testosterone may matter more than any IGF-1 • Total T of 420 at 43 Is It Time for TRT: Why 420 with low energy is answer enough, why TRT will change his life, and why planning protocols a full year out is overrated for most people • How to Build a Smart Annual Protocol Without Overcomplicating It: Why JD and Will plan four months at a time, why trying too many compounds at once tells you nothing, and why the gateway compounds R and BPC are always the right starting point 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Follow us on social media: JD's Instagram: https://www.instagram.com/jddenhamofficial/ Will's Instagram: https://www.instagram.com/williamthaas/ Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

  6. Aug 24

    Peptide of the Week: HRT, Peptides & Longevity With Dr. Ksenia

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down virtually with Dr. Ksenia, known as Dr. K, a functional medicine doctor based in Miami who specializes in hormone replacement therapy, peptides, and weight loss. This one is packed with real clinical insight, especially for the ladies. Chapters: 00:00 – Intro & Welcoming Dr. K 01:34 – Her Specialties: HRT, Peptides & Weight Loss 02:34 – Why Hormones Are Crashing in Young Men 05:57 – Why Doctors Skip Free Testosterone Testing 08:38 – Sleep, Food & Exercise: The Real Fix 09:48 – Women's Hormone Symptoms & Menopause Myths 14:07 – Finding Your Testosterone "Sweet Spot" 19:00 – Cream vs. Injection & What "Normal" Really Means 25:30 – Retatrutide vs. Tirzepatide for Inflammation 27:21 – Peptides for Athletes & Why BPC Is Banned 31:09 – Overhyped Peptides: MOTS-c, SS-31 & IGF-1 LR3 39:41 – The Ideal Longevity Stack & Real Healing Stories 49:42 – Muscle as the Foundation of Healthy Aging 54:53 – Fasting, Gut Health & Psychedelics 1:04:40 – Fertility Q&A, Dr. K's Personal Stack & Outro We cover: 🧬 Why hormones are crashing in young people – Post-COVID, many men saw testosterone drop significantly, viral illness and vaccines both suspected but no confirmed research yet – Athletes with concussion histories frequently present with low testosterone due to trauma-induced endocrine dysfunction – Excess body fat aromatizes testosterone into estrogen, tanking levels even in young men – Free testosterone is the most important marker, not total, and most insurance doctors never run it – A 12-minute appointment cannot solve a hormone problem, personalized medicine is the only answer 🦋 Women and hormones, the orchestra – Women are not one hormone, they are estrogen, progesterone, testosterone, DHEA, and cortisol all working together – Low estrogen symptoms: hot flashes, night sweats, mood swings – Low progesterone symptoms: inability to stay asleep, anxiety, restlessness – Low testosterone symptoms: zero libido, no motivation, no desire to train – SSRIs are being prescribed for menopausal symptoms instead of hormones, which kills libido and solves nothing – Menopause raises cholesterol because the liver keeps making it to synthesize hormones that are no longer being produced. Giving statins instead of hormones is the wrong answer – Dr. K injects herself with 2 to 3mg of testosterone twice weekly and felt dramatically better within three weeks 💉 Testosterone for women – Injectable testosterone at 10 to 15mg is well within normal female range and will not cause masculinization – Creams work but require a higher concentration to hit therapeutic dose – Compounded injectable estrogen (estrogen cypionate) is an option now that patch shortages are happening – Pellets are not recommended by Dr. K, injectables or creams only – Always monitor labs and adjust based on individual response 🔬 SS-31 vs MOTS-c, setting the record straight – MOTS-c does not create more mitochondria, it reroutes energy. Dr. K has reviewed 80% of MOTS-c studies and finds no evidence it makes more mitochondria – SS-31 stabilizes cardiolipin in the mitochondrial membrane, which is how ATP production is stabilized. This is the real deal – Every person over 40 should consider SS-31 for longevity Follow us on social media: Will's Instagram: https://www.instagram.com/williamthaas/ Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/ Follow Dr. K: Instagram: https://www.instagram.com/dr.kseniamiami/ About Dr. K: https://kseniapetrushkina.com/ Join The Community: https://www.skool.com/peptideoftheweekcommunity

  7. Aug 20

    Peptide Q&A #55 – Peptide Sensitivity, COA Verification, Cortisol & Sleep & Insulin Resistance

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas are joined by peptide consultant Michael Vandal for a deep dive into peptide sensitivity reactions, how to spot a fake Janoshik COA, fixing cortisol and sleep, insulin resistance on secretagogues, and how to bulk while staying on R. Chapters: 00:00 – Intro & How Michael Joined the Team 03:36 – Warrior Maker Coaching Program Launch 07:49 – More Than Fitness: Business & Community 08:28 – Personal Life Updates 10:28 – Q&A Begins 11:14 – Q&A: Peptide Hypersensitivity & Histamine Reactions 18:30 – Q&A: Adding Tessa to a Hyrox Athlete's Stack 23:13 – Q&A: How to Verify a Janoshik COA 26:10 – Q&A: High Estrogen & R Plateau (Age 57) 38:19 – Q&A: Cortisol, Water Retention & Sleep Fixes 48:12 – Q&A: Muscle Maintenance After Cancer Surgery 55:01 – Q&A: Do Collagen Peptides Actually Work? 58:52 – Q&A: Insulin Resistance & GLP Stacking 1:05:45 – Q&A: R Dosing for Bulking 1:13:06 – Q&A: Losing the Last 15 Pounds 1:17:10 – Outro & Coaching Program Reminder We cover: • Severe Peptide Sensitivity to CJC and Wolverine: Why blended peptides use a binding ingredient that some people are genuinely allergic to, why single peptides are the right next step, and why sourcing should be questioned first • How to Verify a Janoshik COA and Spot Fakes: Why the unique code at the bottom is everything, how to verify it on Janoshik's site, and why photoshopped COAs always crop out that code • 44-Year-Old HYROX Athlete — Add Tesamorelin or Go Straight to HGH: Why HGH wins at 44, why SLU-PP-332 helps endurance and nutrient partitioning, and why bumping Wolverine to at least 1 mig daily matters for athletes • High Estrogen on TRT with No Symptoms: Why 1067 total T explains the elevated estrogen, why the three symptoms to watch for are the real indicator, and why an AI is not needed without symptoms • Cortisol, Water Retention and Wrecked Sleep — Non-DSIP Solutions: The glycine, ashwagandha, magnesium glycinate and slow-release melatonin protocol that fixed JD's sleep, why Selank beats Semax for cortisol, and why Epithalon helps reset circadian rhythm • Collagen Peptides — Do They Actually Work: Why powdered collagen supplements produce modest results at best and why BPC, TB-500 and GHK-CU are the real collagen peptides worth taking • 53-Year-Old Female Post-Gastrectomy and Mastectomy: Why HGH and secretagogues are off the table, why SS-31 plus MOTS-C are the right longevity tools, and why creatine is non-negotiable for muscle preservation • Insulin Resistance on Secretagogues: Why growth hormone peptides blunt insulin sensitivity over time, why pulling the secretagogue is the first move, and why an endocrinologist should be in the picture • Bulking While on R: Why dropping to 1.5 migs every five days keeps food noise at bay while allowing enough appetite to eat for muscle, and why protein per pound of body weight is the only number that matters • 27-Year-Old Down 80 Pounds — Last 15 to Lose: Why adding muscle is the only way to raise metabolism enough to drop the final pounds and why SLU-PP-332, 5-Amino-1-MQ and MOTS-C hit fat from three different angles 📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results. You're a warrior. Act like one. Join The Community: https://www.skool.com/peptideresearchinstitute/about Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

  8. Aug 17

    Peptide of the Week: Blood Work, Gut Health & Gear – With Dr. Scott Collie

    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk. Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with their personal functional medicine doctor and longtime friend, Dr. Scott Collie, for a deep dive into blood work, cardiovascular health, gut health, thyroid, and what actually matters when you are running gear or peptides. Chapters: 00:00 – Intro: Dr. Scott & Talking Real Food (Italy Recap)  05:29 – The Truth About "Running Gear"  06:15 – TRT vs. Steroid Cycles Explained  10:22 – Why Bloodwork Timing Matters On vs. Off Cycle  12:58 – Blood Sugar, Insulin & GLP-1s  17:45 – Kidney, Liver & Iron Health Markers  22:25 – Understanding Cholesterol: LDL, HDL & VLDL  27:31 – Thyroid Health & Hashimoto's  30:06 – Homocysteine & Methylation  35:13 – Rapid Weight Loss & Gallbladder Risks  39:16 – Inflammatory Markers & Heart Damage Warning Signs  46:02 – Top Supplements & Peptides for Cycle Support  53:41 – Cycle Timing & When to Test Blood  1:01:51 – Hydration & Final Thoughts  1:06:07 – Outro & Where to Find Dr. Scott We cover: 🩺What functional medicine actually looks at – Standard doctor panels are a snapshot, not a full picture – Dr. Scott runs up to 75 markers including cardiovascular, inflammatory, kidney, thyroid, and gut markers – Most insurance doctors stop at LDL and HDL, missing the full story completely – You need particle size, not just cholesterol weight, to understand your true cardiovascular risk 🫀 Cardiovascular markers that matter – APOB: umbrella marker for all arteriosclerotic particles including VLDL, LDL, and IDL – Particle size is critical: anabolic steroids shift particles to small dense LDL, the type that sticks and clogs arteries – Myeloperoxidase and LP-PLA2: direct markers of vascular inflammation most doctors never run – Triglycerides plus elevated liver enzymes (AST/ALT) almost always means fatty liver, no ultrasound needed – Fibrinogen: a clotting protein made by the liver, high fibrinogen plus high insulin plus high triglycerides is a walking time bomb, especially for steroid users – CRP (C-Reactive Protein): one of the best inflammatory markers available, if it is high something serious is going on 🧬Homocysteine, the underrated killer – Homocysteine scars the inside of your arteries so plaque particles can park and stick – Now being studied as an Alzheimer's marker as well – Dr. Scott wants it at 7 or below, many people are at 9 to 50 – Fix: methylate with B6, B12, and methyl folate, simple and cheap – TRT alone will elevate homocysteine, so methylating is a must for anyone on testosterone ⚖️Retatrutide and rapid fat loss, what to watch – Losing fat very fast can back up bile flow and cause gallstones, not kidney stones – Check alkaline phosphatase and GGT before starting Reta if there is any gallbladder history – Signs of gallbladder issues: bloating, belching, pain under right rib cage, high-fat meal distress, floating stools – Floating poop is not a good sign, it means fat is not being absorbed properly – Blood sugar, triglycerides, and inflammatory markers improve dramatically and quickly on Reta 🩸Blood work timing for gear users – Best time to test: before the cycle starts, to establish your baseline – After the cycle ends: retest to confirm you returned to baseline – Mid-cycle testing will look alarming by design, be ready for that – If you do not know what different esters are, you are not ready to run gear Follow Dr. Scott Collie: Website: https://heydrscott.com/ Facebook: https://www.facebook.com/DrScottCollie/ Instagram: https://www.instagram.com/hey_dr_scott/ Join The Community: https://www.skool.com/peptideoftheweekcommunity Follow us: Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

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127 Ratings

About

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.

Information

  • Creator
    JD Denham and Will Haas
  • Years Active
    2025 - 2026
  • Episodes
    129
  • Rating
    Explicit
  • Copyright
    © JD Denham and Will Haas
  • Show Website
    Peptide of The Week

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