Episode SummaryThis episode explores groundbreaking research from 2023 to 2026 that is transforming our understanding of female fertility and ovarian aging. Hosted by Aimee Raupp, a seasoned fertility expert, it covers inflammation, AMH, insulin resistance, NAD+, light exposure, stress, and oral health, offering practical insights for women seeking to optimize their reproductive health. Keywordsfemale fertility, ovarian aging, inflammation, AMH, insulin resistance, NAD plus, fertility research, reproductive health, stress, oral health Key Topics * Chronic inflammation and its effect on egg quality * The role of AMH and inflammation in fertility * Insulin resistance as a driver of IVF success * NAD+ levels and mitochondrial health in eggs * Impact of light exposure and circadian rhythms on ovaries * Stress and ovarian reserve decline * Oral inflammation and systemic reproductive effects * Practical steps to improve the ovarian environment Sound Bites * “Inflammation ages your tissues faster than your birthday” * “Low AMH reflects inflammation, not just egg count” * “NMN and resveratrol fuel mitochondrial health” Chapters00:00 Introduction to New Fertility Research02:25 Chronic Inflammation and Female Fertility06:37 Peritoneal Endometriosis and AMH Levels10:44 Insulin Resistance and IVF Outcomes15:21 NAD+ and Cellular Energy in Eggs20:31 Light Exposure and Ovarian Function21:25 Stress and Its Impact on Ovarian Reserve23:45 Oral Inflammation and Reproductive Health 10 Things You Can Do With This Research * Get your inflammation markers checked — hs-CRP, homocysteine. * Look at your gut — a major driver of the inflammaging pattern. * Stop fearing a low AMH number by itself; it’s a data point, not a verdict. * Prioritize protein and fiber at breakfast to support insulin sensitivity. * Move your body after meals — even a 10-minute walk helps glucose regulation. * Get morning sunlight within the first hour of waking. * Put your phone away 30–60 minutes before bed. * Build in real nervous system downtime — acupuncture, breathwork, meditation, nature walks. * Don’t skip your dental checkups. * Work with someone who looks at your whole picture — gut, blood sugar, inflammation, sleep, stress. Perfection doesn’t equal pregnancy. It’s consistency and frequency that moves the needle. ClosingEgg quality isn’t a fixed countdown. It’s shaped by inflammation, metabolic health, mitochondrial energy, circadian rhythm, and nervous system regulation. Age is a modifier, not a mandate. Before you go: there’s exciting new endometriosis research I haven’t covered yet — that’s coming as its own dedicated episode soon. If endo might be part of your story, ask your doctor about a pelvic MRI or 3D sonohysterogram in the meantime. Ready to work on this? Head to aimeeraupp.com and book a coaching call. Grab the revised edition of Yes, You Can Get Pregnant — it has the full lab panel, the nutrition breakdown, and every protocol I referenced today. And follow me on Substack, Instagram, and right here on the podcast for more research like this every week. Research Citations * Ameho & Klutstein — “The effect of chronic inflammation on female fertility,” Reproduction, 2025. PMID: 39932461 * [Authors incl. AW Horne] — AMH decreased in superficial peritoneal endometriosis with elevated inflammatory profile, University of Edinburgh, Reproduction and Fertility, 2026 (venous blood n=105, peritoneal fluid n=38). DOI: 10.1530/RAF-25-0127 * Bai et al. — Insulin resistance and IVF outcomes, Human Fertility, 2025 (cohort n=1,193). PMID: 40684365 * NAD+ gene expression and human oocyte quality, single-oocyte RNA-seq (n=46), JARG, 2025. DOI: 10.1007/s10815-025-03720-1 * Ying et al. — Circadian rhythm disruption and ovarian follicular development, EBioMedicine, 2026. PMID: 41797048 * Jiang et al. — Chronic stress and meiotic arrest/ovarian reserve decline, Frontiers in Endocrinology, 2023. PMID: 37720535 * Kles et al. — Chronic oral inflammation impairs female reproduction, Journal of Dental Research, 2026. DOI: 10.1177/00220345251412768 Note: only studies #2 (Edinburgh AMH) and #3 (Bai IVF cohort) are direct human clinical data; the rest are animal/rodent models or ex vivo human tissue. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit aimeeraupp.substack.com/subscribe