Send us Fan Mail Chronic Pruritus Workup & Treatment Pearls (CPUO, Neuropathic Itch, Nemolizumab, JAKs) | The Derm Resident Contact: thedermresident.pod@gmail.com Dr. Jonny Hatch hosts Dr. Diego Da Silva, a chronic pruritus expert and host of Skin In the Game, to discuss a practical approach to itch. They outline an initial framework based on distribution (localized vs generalized), time course (with shorter duration and older age raising concern for malignancy), and morphology (primary lesions vs excoriations only). For localized itch without rash, they emphasize neuropathic etiologies (notalgia paresthetica, brachioradial pruritus, meralgia, dysesthesias), consider spine wear-and-tear, and discuss PT plus gabapentinoids and other neuromodulators. For generalized pruritus without rash, they review ROS for constitutional symptoms, recommend considering biopsy of “normal” itchy skin (e.g., CTCL, sarcoid), and suggest labs (CBC, CMP, TSH, A1C, SPEP/IFE, ferritin, vitamin D), chest X-ray, and BP testing/DIF. Treatment pearls include skincare, phototherapy, atopic-directed therapies (dupilumab, nemolizumab), JAK inhibitor counseling (noting shingles risk and “JAKne”), and empiric ivermectin for possible scabies; off-label options include low-dose naltrexone, dronabinol, and intranasal butorphanol, plus advice for residents to develop a niche and “declare” expertise. 00:00 Show Introduction 00:59 Why Itch Matters 01:26 Finding a Niche 04:44 First Steps in Pruritus 07:00 Localized Itch Workup 09:02 Neuropathic Itch Treatments 11:32 Generalized Itch Workup 14:32 Labs Imaging and Biopsy 17:54 Treating CPUO Like Atopy 21:49 Choosing First Biologic 22:27 Nemolizumab Itch Breakthrough 23:58 JAK Inhibitors Safety Reality 26:08 Managing Shingles And Jackne 28:05 Treating Jackne Options 28:54 Derms As Real Doctors 30:54 Low Dose Naltrexone Role 32:15 Scabies And Empiric Ivermectin 33:09 Off Label Itch Rescue Meds 35:42 Advice And Podcast Wrap Up This episode is sponsored by Mind the Skin, a patent-pending, steroid-free, patch system. Learn more at mindtheskinlabs.com. Use code TDRP26 at checkout for 20% off.