Nick Norwitz MD PhD - Metabolic Health & Longevity

Nick Norwitz MD PhD
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MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where he majored in cell biology and biochemistry. He earned his PhD in Human Metabolism from the University of Oxford and completed his MD at Harvard Medical School.During his training, a personal battle with inflammatory bowel disease ignited a deep passion for metabolic health and a mission to empower others on their individual health journeys. Nick has since become a leading voice in the metabolic health space, best known for the intellectual rigor and clarity of his educational content, which reaches millions worldwide. He also authors a best-selling newsletter at StayCuriousMetabolism.com.Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.Links:Newsletter: https://staycuriousmetabolism.comInstagram: https://www.instagram.com/nicknorwitz/My Website: https://www.nicknorwitz.comTwitter: https://twitter.com/nicknorwitzLinkedIn: https://www.linkedin.com/in/nicknorwitz/ Unofficial fan audio feed — not affiliated with or endorsed by the original creator. All content belongs to its respective owner.

  1. 12h ago

    Allulose: Nature's Sweet Ozempic?

    Link: https://pubmed.ncbi.nlm.nih.gov/29317623/Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1 Learn more about your ad choices. Visit megaphone.fm/adchoices

    Allulose: Nature's Sweet Ozempic?

  2. 1d ago

    How a $1 Trillion Drug Got It Wrong

    For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2 For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueStatins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.Chapters0:00 – Intro: Statins as a Misunderstood Tool1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease3:43 – Imaging Beats LDL and ApoB for Risk Stratification4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?5:33 – Reviewing the Pros and Cons of Statins6:43 – Paper 3, Statins Harm Mitochondria and Muscles7:55 – Paper 4, Statins Slash GLP-1 Levels9:00 – The Essential Social Dynamics of Statins You Need to Know11:15 – Conclusion, The Right Tool for the Right Job#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

    How a $1 Trillion Drug Got It Wrong

  3. 2d ago

    Oreo Statin Data LEAK!

    Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=200:12: Data “leak”0:50: Who am I? (For those who don’t know me)1:54: Lean Mass Hyper-Responders2:56: What (design and hypothesis)5:15: Why am I doing this?7:13 – 9:40: “How” (Lipid Energy Model)Other details and Final commentsLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

    Oreo Statin Data LEAK!

  4. 2d ago

    The Coolest Fiber Paper and Biggest Keto Lie!

    Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSWinnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Inulin Video: https://youtu.be/blNLHsww_Qs Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBAIn this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.Chapters:0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD1:40 – The Coolest Fiber Paper Ever!21:19 – Probiotic That Binds Plastics22:52 – Keto Mouse Myths: A Shady Study Skews the Truth30:01 – Andrew Reflects on his Diary of a CEO Appearance 43:01 – Do Credentials Teach Curiosity, or Crush Them?#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch Learn more about your ad choices. Visit megaphone.fm/adchoices

    The Coolest Fiber Paper and Biggest Keto Lie!

  5. 3d ago

    Oreo Joe Rogan!

    JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwvOreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1XOreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices

    Oreo Joe Rogan!

  6. 4d ago

    The New Skinny on Lp(a)

    For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior VideosLp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.Genes are not destiny. Metabolic health changes the story.Chapters0:00 – I Have Lp(a)… Oh No!1:47 – New Study on Waist-to-Hip Ratio and Lp(a)2:47 – High Lp(a) But Low WHR… Low Risk!3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs!5:45 – Your Waist-to-Hip Ratio Goals7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?10:11 – Teasing the Protocol… See More at StayCurious Metabolism11:00 – Summarizing Key Points#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

    The New Skinny on Lp(a)

  7. 5d ago

    Nuanced Response to Peter Attia about LDL on Keto

    Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTYLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

    Nuanced Response to Peter Attia about LDL on Keto

  8. 5d ago

    Belly Fat is Destroying Your Mental Health

    For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices

    Belly Fat is Destroying Your Mental Health
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About

MD, Harvard | PhD, Oxford | Motto: StayCurious | Thanks for Learning with Me!About: Dr. Nick Norwitz graduated valedictorian from Dartmouth College, where he majored in cell biology and biochemistry. He earned his PhD in Human Metabolism from the University of Oxford and completed his MD at Harvard Medical School.During his training, a personal battle with inflammatory bowel disease ignited a deep passion for metabolic health and a mission to empower others on their individual health journeys. Nick has since become a leading voice in the metabolic health space, best known for the intellectual rigor and clarity of his educational content, which reaches millions worldwide. He also authors a best-selling newsletter at StayCuriousMetabolism.com.Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.Links:Newsletter: https://staycuriousmetabolism.comInstagram: https://www.instagram.com/nicknorwitz/My Website: https://www.nicknorwitz.comTwitter: https://twitter.com/nicknorwitzLinkedIn: https://www.linkedin.com/in/nicknorwitz/ Unofficial fan audio feed — not affiliated with or endorsed by the original creator. All content belongs to its respective owner.

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