This Evidence Based Reviews in Surgery (EBRS) webinar was filmed May 2025. This webinar was moderated by Dr. Alison Laws and Dr. Kerollos Wanis, and featured panelists Dr. Stephanie Wong, Dr. Sarah Knowles and Dr. Rebecca Warburton. In this EBRS webinar, we discussed Axillary Surgery in Breast Cancer--Primary Results of the INSEMA Trial (Reimer et al., 2024) & Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes (Gentilini et al., 2023). Links: Gentilini, O. D., Botteri, E., Sangalli, C., Galimberti, V., Porpiglia, M., Agresti, R., Luini, A., Viale, G., Cassano, E., Peradze, N., Toesca, A., Massari, G., Sacchini, V., Munzone, E., Leonardi, M. C., Cattadori, F., Di Micco, R., Esposito, E., Sgarella, A., Cattaneo, S., … SOUND Trial Group (2023). Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes: The SOUND Randomized Clinical Trial. JAMA oncology, 9(11), 1557–1564. https://doi.org/10.1001/jamaoncol.2023.3759Reimer, T., Stachs, A., Veselinovic, K., Kühn, T., Heil, J., Polata, S., Marmé, F., Müller, T., Hildebrandt, G., Krug, D., Ataseven, B., Reitsamer, R., Ruth, S., Denkert, C., Bekes, I., Zahm, D. M., Thill, M., Golatta, M., Holtschmidt, J., Knauer, M., … Gerber, B. (2025). Axillary Surgery in Breast Cancer – Primary Results of the INSEMA Trial. The New England journal of medicine, 392(11), 1051–1064. https://doi.org/10.1056/NEJMoa2412063