The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
  • 4.6 (7K)
  • Health & Fitness
  • Updated Daily

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. 1d ago

    Every Way to Melt Visceral Fat FAST In 14 Minutes

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction. If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off. You'll Learn: Why protein burns 20–30% of its own calories just to digest — and how that "thermic effect" makes it the most powerful diet lever for cutting visceral fatWhy short, intense workouts (as little as 10–20 minutes a week) beat long cardio sessions for triggering fat-burning hormonesHow cold exposure activates brown fat to burn visceral fat as fuel, and why consistency matters more than intensityWhy resistance training is one of the most effective tools for long-term fat loss, not just muscle-buildingHow poor sleep tanks growth hormone by up to 70% a night and drives up cortisol, both of which directly promote visceral fat storageWhy chronic stress is the single biggest driver of visceral fat, and how it creates a self-reinforcing loop that resists diet and exercise alone Thank you to our sponsors! Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighViome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Timestamps: 00:00 — Introduction & Calorie Myth 01:27 — Power of Protein 02:37 — Cut Sugar & Carbs 03:48 — HIIT for Fat Loss 05:44 — Cold Exposure 06:32 — Resistance Training 08:22 — Sleep & Growth Hormone 10:30 — Stress & Cortisol 13:39 — Breaking the Fat Loop Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Every Way to Melt Visceral Fat FAST In 14 Minutes

  2. 3d ago

    Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more

    Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion  Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness.  Sources:  https://www.bloomberg.com/news/articles/2026-09-22/ozempic-maker-novo-looks-to-target-hair-loss-in-consumer-push  https://www.novonordisk.com/investors/capital-markets-day-2026.html  https://www.irishexaminer.com/business/companies/arid-41914219.html  ~~~ Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency  A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth.  Sources:  https://doi.org/10.1177/21532176261486979  https://www.sciencedaily.com/releases/2026/09/260923035926.htm  https://pharmaceutical-journal.com/article/news/children-taking-glp-1s-can-be-at-risk-of-nutritional-deficiencies-study-finds  ~~~ Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health  Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites.  Sources:  https://www.nature.com/articles/s44220-025-00468-6  https://health.au.dk/en/display/artikel/the-stomachs-brain-is-more-in-sync-with-the-mind-during-mental-distress  https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html  ~~~ Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk  A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods.  Sources:  https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203  https://link.springer.com/article/10.1186/s12916-026-05132-z  https://www.escardio.org/news/press/press-releases/common-food-preservatives-linked-to-high-blood-pressure-and-heart-disease/  ~~~ Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats  A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives.  Sources:  https://www.nature.com/articles/s41598-017-05051-3  https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/  This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026  Thank you to our sponsors!   - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.  - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 — Intro  00:18 — Novo Nordisk & Hair Loss  02:52 — GLP-1s & Kids' Nutrition  05:08 — Stomach-Brain Sync  07:49 — Preservatives & Heart Risk  10:53 — Taurine & Stress Resilience  13:28 — Outro  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more

  3. 4d ago

    The Best Singular Hack To Change EVERYTHING About Your Life

    Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive. Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study:  Social connections are really good for you. Loneliness kills.It’s the quality of your close relationships that matters.Good close relationships don’t just protect your body, they protect your brain. Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like: how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)what social fitness is and how to practice it. (Yes, it’s a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.) You'll Learn: Why loneliness physically harms your body — affecting your brain, immune function, sleep, and pain sensitivityThe likely mechanism behind why relationships improve health: how a good listener helps regulate your stress responseWhat "social fitness" is and why relationships wither from neglect, even without conflictThe four attachment styles and why knowing yours matters before committing to a relationshipWhy intergenerational friendships may be one of the most underused tools for personal growth and happiness Resources:     • Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it.  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Timestamps: 00:00 — Introduction & the Study 04:43 — What Makes a Good Life 08:47 — How Relationships Heal 13:44 — Happiness: Nature vs Nurture 17:59 — Measuring Happiness 23:56 — Life Stages & Happiness 35:34 — Social Fitness 44:30 — Energizing Relationships 56:14 — Attachment & Childhood 1:05:04 — Casual Friends & Legacy Thank you to our sponsors!       - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.  - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Best Singular Hack To Change EVERYTHING About Your Life

  4. 6d ago

    15g Every Morning for Anti-Aging Mitochondria

    Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity  Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off.  Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity?  Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author of Love Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these microscopic organisms have been studied for decades as unusually nutrient-dense foods.  Catharine explains the major differences between spirulina and chlorella, from how they are grown and processed to how she uses them for completely different purposes. Spirulina contains compounds including phycocyanin and superoxide dismutase that Catharine believes can support mitochondrial function, antioxidant defenses, cellular energy, and brain health, while chlorella is used primarily for binding and removing unwanted compounds such as heavy metals. They also discuss why water quality, sourcing, drying temperature, and processing can dramatically change the final product.  The conversation goes deep into mitochondrial biology, including the electron transport chain, ATP production, oxidative stress, free radicals, cytochrome c, superoxide dismutase, and the blue pigment phycocyanin. Dave connects these mechanisms to his own experience rebuilding mitochondrial function and explains why increasing cellular energy without adequate antioxidant defenses may create problems, particularly for people experimenting with advanced longevity interventions such as mitochondrial peptides.  Dave and Catharine also explore methylene blue, psychedelics, exercise, brain aging, environmental toxins, nutrient density, food quality, algae farming, sustainable agriculture, and why maintaining mitochondrial function may become increasingly important with age. Catharine, who turns 70 shortly after the recording, also shares the philosophy behind her first book and her belief that aging does not have to mean accepting declining energy and cognitive function.  This is essential listening for anyone interested in mitochondria, spirulina, chlorella, cellular energy, brain health, detoxification, oxidative stress, longevity, biohacking, nutrient density, methylene blue, peptides, and maintaining performance as you age.  You’ll Learn:  Why spirulina and chlorella work differently in the body How spirulina may support mitochondrial energy and antioxidant defenses Why chlorella is commonly used for heavy metal and toxin binding What phycocyanin and superoxide dismutase do inside cells How oxidative stress can disrupt mitochondrial energy production Why Dave cautions against pushing mitochondrial output without adequate cellular protection How algae may support brain health, longevity, and performance as you age   Dave Asprey is 4x NY Times Bestselling Author, Longevity Expert and Creator of the Biohacking Movement. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Catharine Arnston, ENERGYbits, spirulina, chlorella, algae, microalgae, mitochondrial health, mitochondria, cellular energy, ATP production, electron transport chain, oxidative stress, free radicals, superoxide dismutase, SOD, phycocyanin, brain health, detoxification, heavy metals, glyphosate, environmental toxins, methylene blue, MOTS-c, peptides, biohacking, longevity, healthy aging, nutrient density, antioxidant defense, sustainable food  Resources:     • Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off.  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)      Thank you to our sponsors!       - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.  - Our Place | Upgrade your kitchen with Our Place today. Visit fromourplace.com/DAVE and use code DAVE for 10% off sitewide.  - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.  Timestamps:   00:00 — Show Open  01:25 — Algae Origins & History  06:15 — Sourcing Quality Algae  09:15 — Nutrient Density Crisis  17:15 — Spirulina vs. Chlorella  22:30 — Algae Industry Applications  27:45 — Algae in Your Cells  33:20 — SOD & Brain Health  42:00 — Phycocyanin & Cancer  52:30 — Aging vs. Declining  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    15g Every Morning for Anti-Aging Mitochondria

  5. Sep 20

    I Wasted 10 Years Stuck With Brain Fog Until I Learned This

    Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/discount/davetube Try Suppgrade Labs: https://shopsuppgradelabs.com/ Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey If you're waking up exhausted, foggy, or inflamed and nothing seems to fix it, the answer might be hiding in your walls. This deep dive walks through how toxic mold and mycotoxins settle into your brain, nerves, and mitochondria, how to properly test your home and body for exposure, and the exact order of operations, environment first, then detox, that actually leads to recovery. Drawing from his own diagnosis with mold-related brain damage, the creator breaks down everything from HVAC contamination to binders and glutathione so you can finally stop chasing symptoms and address the real source. Thank you to our sponsors! Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighNeuronic | Go to www.neuronic.online Code DAVE for $100 offiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Timestamps: 00:00 — Mold Toxins and My Story 02:14 — How Mycotoxins Damage Cells 04:09 — Three Sources of Mold 05:35 — Track Symptoms by Location 07:20 — Fix Environment Before Detox 08:53 — Mold Testing Methods 10:35 — Remediation and Moisture Control 12:47 — Belongings Can Recontaminate 14:45 — Why Recovery Varies 17:23 — Detox Protocol and Binders Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    I Wasted 10 Years Stuck With Brain Fog Until I Learned This

  6. Sep 18

    Teal Swan - Beyond the Veil of Ego, AI & Wisdom

    Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species? These are just a few of the big questions you’ll tackle in this enlightening and esoteric episode re-run. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to reduce human suffering. After a challenging upbringing, Teal emerged with a unique ability to talk about psychology, shadow work, and the nature of our world.  Teal shares the unusual and special way she sees the world. We talk about her ESP powers, how to identify a narcissist, and her favorite dimensions. We also get into the divine masculine vs. the divine feminine, the nature of ego, and how to build trust in the world and others.  00:00 — Trailer 00:18 — Intro 6:12 — Understanding Narcissism 13:20 — AI and Spiritual Perception 19:30 — Birth Trauma and Memory 28:00 — Art and Different Realities 35:22 — The Nature of Ego 42:50 — Divine Masculine and Feminine 50:00 — Hormones and Hope 54:05 — Synchronization Workshops 1:00:29 — Outro Sponsors Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighEMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources: • Learn More About Teal's Work At: https://tealswan.com/about-teal/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Teal Swan - Beyond the Veil of Ego, AI & Wisdom

  7. Sep 17

    How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP!

    Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity  Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function.  **Visit https://memoryair.com/ and use code DAVE15 for 15% off. ** Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world’s most cited scientists, to explore why smell may be one of the most overlooked tools for brain health and longevity.  Dr. Leon explains why the olfactory system has unusually direct access to the brain’s memory and emotional centers, why smell often declines alongside memory after age 60, and why reduced olfactory function has been associated with Alzheimer’s disease, cognitive decline, depression, and increased all-cause mortality. They also discuss how COVID, chronic congestion, pollution, stress, and aging can impair smell without people realizing it.  The conversation dives into olfactory enrichment, including research showing major improvements in memory when older adults were exposed to multiple scents during sleep. Dr. Leon explains why novelty matters, how nighttime scent exposure may increase deep sleep and reduce nightmares, and why olfactory stimulation is being studied in dementia, PTSD, depression, and autism. Dave also explores connections between smell, GLP-1 drugs, exercise, rapamycin, spermidine, oxytocin, hormones, mitochondrial function, and other longevity interventions.  This is essential listening for anyone interested in memory, sleep, Alzheimer’s prevention, brain aging, smell training, dementia, PTSD, autism, longevity, neuroplasticity, biohacking, and protecting cognitive function as you age.  You’ll Learn:  -Why your sense of smell often declines alongside memory  -How smell connects directly to the brain’s memory and emotional centers  -Why poor olfactory function is associated with Alzheimer’s risk and mortality  -How chronic congestion may affect memory and brain health  -What COVID-related smell loss may mean for long-term cognitive health  -How olfactory enrichment can stimulate memory centers while you sleep  -Why one study reported a 226% improvement in memory in healthy older adults  -How scent exposure may increase deep sleep and reduce nightmares  -Why novelty and rotating scents appear to matter for neuroplasticity  -How smell training is being studied in dementia, depression, PTSD, and autism  -Why several longevity interventions are also associated with improved olfaction  -How GLP-1 drugs may affect smell, food enjoyment, memory, and emotion  -Why professional wine tasters may offer clues about protecting the aging brain    Thank you to our sponsors!          - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off  - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.  - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.comDAVE and using code DAVE at checkout.  - LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.    Keywords: Michael Leon, smell training, olfactory enrichment, sense of smell, memory improvement, brain aging, Alzheimer’s disease, dementia, deep sleep, nightmares, PTSD, autism, depression, COVID smell loss, olfactory system, neuroplasticity, MemoryAir, essential oils, cognitive decline, all-cause mortality, GLP-1, rapamycin, spermidine, oxytocin, longevity, brain health, sleep optimization, memory loss, olfactory stimulation    Resources:     • Visit https://memoryair.com/ and use code DAVE15 for 15% off.  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)      Timestamps:   00:00 — Smell and Your Brain  01:25 — Intro  06:52 — Why Smell Goes Unnoticed  10:59 — Making MemoryAir  15:46 — Smell and Dementia  20:00 — Smell Predicts Lifespan  25:32 — Testing Your Sense of Smell  28:33 — Autism and Olfactory Therapy  36:23 — Biohacking Your Nose  42:50 — GLP-1 and Olfaction  45:55 — PTSD, Nightmares, and Sleep  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP!

  8. Sep 16

    Josh Duhamel on Nootropics, Peptides, and Testosterone at 53

    **Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!** At 53, Josh Duhamel says he feels better than he did in his 30s.  Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age.  Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools.  The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance.  This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity.  You'll Learn:  Why Josh started testosterone therapy in his early 40s How TRT changed his energy, strength, joints, and motivation Why testosterone levels should be individualized How injectable, oral, and topical testosterone differ Why peptide sourcing matters How GLP-1s can affect muscle and body composition What Josh has tried for hair loss Why brain performance became a major concern for him Which nootropics come up for memory, focus, and mental stamina Why becoming a father later in life changed how Josh thinks about longevity How breathwork, psychedelics, and spirituality fit into the conversation  Thank you to our sponsors!       - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY.  - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.  - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save.  - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality  Resources:     • Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.     • Danger Coffee: https://dangercoffee.com/discount/davetube  • My Daily Supplements: SuppGrade Labs (15% Off)      • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)      Timestamps:   00:00 – Trailer  01:15 – Intro  07:16 – Alcohol & Hangover Hacks  13:24 – Spirituality & Health  19:36 – Hormone Therapy for Women  24:45 – Inside Gatlan's Model  30:35 – Potty Training Secrets  38:39 – North Dakota & Fargo  43:57 – Hollywood's Beauty Secrets  50:19 – Acting Career & Longevity  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    Josh Duhamel on Nootropics, Peptides, and Testosterone at 53
See All (1.6K)

Hosts & Guests

4.6
out of 5
6,980 Ratings

About

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

Information

More From Integrity Network

You Might Also Like