Send us Fan Mail Atopic Dermatitis High-Yield Review: Etymology, Diagnosis, Pathogenesis, Cytokines, Microbiome, Distribution, and Mimickers | The Derm Resident Email us: thedermresident.pod@gmail.com Hosts Dr. Jonny Hatch and Dr. Deven Curtis review high-yield atopic dermatitis (AD), covering its 1923 “atopos” etymology, clinical definition, and the atopic march (AD/food allergy in infancy, asthma in childhood, allergic rhinoconjunctivitis in adolescence). They outline AAD diagnostic criteria: pruritus, classic age-specific morphology/distribution, and chronicity, plus intrinsic (IgE-associated) vs non–IgE AD. Pathogenesis is framed as barrier dysfunction, immune dysregulation, and microbiome alteration, highlighting filaggrin’s role, transepidermal water loss, increased skin pH, and unchecked kallikrein proteases; Netherton syndrome (SPINK5/LEKTI) is discussed. They review Th2→Th1 evolution, key cytokines (IL-4/13 targeted by dupilumab; IL-13-only agents; IL-31 “itch cytokine” and nemolizumab), Staph aureus colonization and impetiginization, age-based distribution patterns, site variants and stigmata (Denny-Morgan lines, white dermatographism, keratosis pilaris, ichthyosis vulgaris), complications (ocular disease, eczema herpeticum with IV acyclovir on boards), quality-of-life impact, biopsy rationale (spongiotic dermatitis, rule out mycosis fungoides), and common mimickers and differentials including seb derm, scabies, contact dermatitis, immunodeficiencies, hypereosinophilia causes, nummular dermatitis, SCC in situ, dyshidrotic eczema, and asteatotic eczema. 00:00 Welcome and Topic Setup 00:31 Atopic Derm Name Origin 01:59 What It Is and Atopic March 04:41 Diagnosis Criteria Essentials 06:13 IgE Types and Core Pathogenesis 08:32 Barrier Breakdown and Filaggrin 13:02 Proteases and Netherton Syndrome 15:11 TH2 to TH1 Cytokine Shift 18:09 Dupilumab IL4 IL13 Explained 21:24 IL31 The Itch Cytokine 23:57 Staph Aureus and Microbiome 27:10 Age Based Distribution Infants 27:53 Age Based Distribution 29:32 Site Specific Variants 31:18 Head Neck Dupixent 31:58 Atopic Stigmata Signs 34:24 Ichthyosis And KP 36:09 Ocular Complications 37:55 Eczema Herpeticum Urgency 40:07 Quality Of Life Burden 42:27 When To Biopsy 45:18 Mimickers And Immunodeficiency 49:31 Eosinophilia Differential 50:22 Rapid Fire Dermatitis 53:25 Episode Wrap Up