Night Science Itai Yanai & Martin Lercher

John Mattick is Professor of RNA Biology at the University of New South Wales in Sydney, Australia. For decades, he has been on a mission to show that the large portions of the human genome that many scientists consider useless "junk" instead have important regulatory functions. In this episode, he tells us that his creative process involves always seeing things from different perspectives – something he learned as a teenager listening to the debates of his mother and her sisters. He reveals how publishing a manifesto can supercharge your research. We discuss how science lurches from paradigm to paradigm, and how the current best guess, if untestable at the time, can become accepted wisdom. And he tells us that he advises his graduate students that it's very hard to be creative when you're still in the fog of ignorance, but that they should always look for the things that don't make sense to them - sometimes that's a clue to something worth chasing.

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Peter J. Ratcliffe shared the 2019 Nobel Prize in Physiology or Medicine for his work on oxygen sensing in animal cells. He directs research institutes in London and Oxford. In this episode, he reveals the interplay between dissociation – daydreaming – and interaction with colleagues as a major source of his scientific creativity. He emphasizes that to make an important discovery, you must define your own question, even as everyone – from colleagues to editors and funders – will try to convince you otherwise. We discuss how too much planning can make you unhappy, and how everyone overestimates the information transfer in lectures and presentations. 

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Christina Curtis is a Professor of Medicine and the Director of Artificial Intelligence and Cancer Genomics at Stanford University’s Cancer Institute. Among her many achievements is the conception of the “Big Bang Theory” of tumor biology. In this episode, she tells us how not being biased by assumptions of what we know has been very helpful in her research. We talk about how her background in statistical genetics has shaped her cancer research. We also discuss how the despair of not understanding is a phase that occurs in almost any research project, and we discuss the use of generative AI in the creative scientific process. 

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Daniel Dennett, Professor at Tufts University, may be the most important living philosopher, tackling the biggest questions around: what is consciousness, do we have free will, how does evolutionary adaptation occur? In this episode, Dan tells us about some of his ‘intuition pumps’ - tools that are as indispensable for thinking as hammers and saws are for carpentry. We discuss how creativity really is just a bag of tricks, what Descartes‘ biggest mistake was, and how to ‘jump out of the system‘ to make creative leaps. Dan tells us about how magic tricks can teach us about thinking, and how an irrational fear of the intentional stance can slow us down. And Dan assures us that when we scientists wonder what is the right way to phrase a research question, we‘re really doing philosophy. 

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Howard Stone is a Professor of Engineering at Princeton. His research explores how fluid dynamics can help to understand diverse systems, from bacterial biofilms to the earth’s interior.  In this episode, Howard explains how a lot of important, low-hanging fruit are at the interface between disciplines. Howard is most creative when he debates phenomena at a blackboard together with a collaborator. A trick he likes to use is to identify related problems in isolated disciplines, helping him to unravel underlying mechanisms. And he warns against being too conservative – taking things in textbooks for granted. 

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Prisca Liberali is a senior group leader at the Friedrich Miescher Institute for Biomedical Research in Switzerland. In this episode, Prisca tells us how her creative thinking thrives on recursive thinking – going deeper and deeper into a problem from different angles. Prisca also deliberately uses carefully chosen conferences to discuss and to develop ongoing projects. As much as her lab’s creativity is an inextricable part of the process, she admits that at the core it’s a lonely job. What eases leadership in the lab is learning who you are: which tasks you find easy and which tasks require excessive energy – and then sharing that information with your team members.

For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .