Solving the Puzzle with Dr. Datis Kharrazian

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.  His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

  1. 2D AGO

    Episode 84: Exploring Oxidative Stress, GST Genes, and Hormonal Detox Strategies

    In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance. Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions.  Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Identifying high hydrogen peroxide symptoms 03:06 Addressing brain fog and fatigue 08:11 Combating jet lag with supplements 12:01 Understanding hormone breakdown genetics 13:36 Finasteride side effects and solutions 19:18 Importance of Selenium and Zinc 21:10 Initial treatment and Dutch test results 25:50 Podcast resources and disclaimers 26:53 End of the episode reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    27 min

  2. APR 14

    Episode 83: The Functional Anatomy of Pain

    In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception. We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Understanding types of pain 04:57 How mood affects pain perception 08:02 Why visceral pain feels external 12:04 How pain signals are amplified 15:58 How pain is blocked 19:44 How the brain processes pain 22:12 Understanding central pain syndromes 26:01 Explaining brain pathways for pain 30:06 Podcast outro and resources 31:09 Closing message and reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    31 min

  3. APR 7

    Episode 82: Micronutrient Deficiency Signs

    Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps impacting mood, energy, and neurological health. Whether you're a practitioner seeking a sharper clinical eye or simply want to optimize your well-being, this episode supplies you with insights and tools to decode your body's signals and restore balance. Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Signs of vitamin A deficiency 06:21 Vitamin E and K deficiencies 07:30 Fermented foods and vitamin K 10:48 Understanding methylation and B vitamins 16:42 Effects of vitamin B6 on sleep 18:25 Signs and symptoms of B12 deficiency 23:37 Identifying causes of muscle cramps 25:57 Recognizing magnesium deficiency signs 30:20 Signs of potassium and zinc issues 31:28 Wrapping up and resources offered Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    33 min

  4. APR 1

    Episode 81: How Skin Reveals Deeper Health Issues and Nutritional Imbalances

    In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from dryness and discoloration to eczema, rosacea, and more. Whether you're a practitioner or someone interested in optimizing your own health, this episode bridges complex science and practical tips you can apply today.  Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Skin health and nutritional basics 03:56 Vitamin A and bruising 07:41 Eating healthy fats and fish 12:14 Identifying allergies and histamine response 15:07 Using food sensitivity tests 19:14 Testing for sensitivities and allergies 21:16 Food sensitivities and sweating 25:26 Talking about severe jaundice 27:59 Health effects of silver supplements 30:30 Closing and resources for listeners Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    32 min

  5. MAR 29

    Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully

    In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special emphasis on autoimmunity. Join us as Dr. Booth shares how discovering autoimmune markers in her own and her daughter’s bloodwork inspired a deep dive into strategies for managing and calming autoimmune conditions. We explore the evolution of her clinical approach, the challenges of educating and supporting patients, and the power of group care and community in fostering healing.  Dr. Darla Booth, DC, AFMC specializes in helping patients with complex health issues identify their root cause, improve symptoms, and stack habits to optimize their health with functional medicine protocols. Her care complements the support patients receive through Western medicine; taking a big picture approach to health through lab work analysis, lifestyle adjustments, and nutritional support. Chiropractic and other conservative, natural care options for adults and children are Dr. Booth's specialties. She is skilled in nutritional counseling for food allergies, cranial therapy, TMJ treatment, and more. To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Discovering autoimmunity in bloodwork 03:56 Launching an autoimmune program 07:08 Starting group coaching sessions 11:56 Helping clients rebuild health 13:20 Addressing leaky gut in autoimmune 19:00 Understanding digestion and gut health 21:52 Creating a treatment plan 23:58 Small shifts for immune health 26:47 Prioritizing health and wellness choices 29:43 How food impacts your body 33:57 Functional medicine's credibility and impact 37:18 Using RUPA and Fullscript 39:48 Resources for practitioners and individuals Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    41 min

  6. MAR 24

    Episode 79: Nutrition Focused Physical Assessment with Dr. Liz Lipski

    In this episode, Dr. Liz Lipski, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-focused physical assessment. Dr. Lipski explains how simple observations like cracks in a friend’s tongue over dinner or dark circles under a child’s eyes, can become powerful clues in solving chronic and complex health puzzles. She emphasizes the importance of integrating physical assessments with patient history, lifestyle intake forms, and lab data, demonstrating how even a five-minute exam can shape the entire care plan. Through case stories and practical examples, Dr. Lipski illustrates the vital role nutrition professionals play in the healthcare team, and why rediscovering hands-on assessment is a key to better outcomes in our modern, often rushed medical world.  Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "Nutrition-Focused Physical Assessment" 03:37 "Body Clues and Nutrition Insights" 09:48 "Chronic Health Needs Lifestyle Focus" 12:28 "Nutrition's Power in Healing" 17:21 "Riboflavin for Odor Relief" 19:05 "First Impressions Matter" 22:47 Cooking, Nutrition, and Self-Care 26:08 "Functional Medicine Training Hub" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    27 min

  7. MAR 17

    Episode 78: How Mitochondrial Dysfunction Drives Fatigue, Depression, and Chronic Pain Syndromes

    In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optimizing basic factors like sleep, movement, and stable blood sugar isn’t just “wellness” advice, but can actually be game changers for patients struggling with conditions such as leaky gut, Hashimoto’s, fibromyalgia, or neuropathic pain. Datis Kharrazian unpacks the science behind mitochondrial bioenergetics and reveals how even the tiniest steps, like improving circadian rhythm or addressing subtle nutritional imbalances can help untangle the complex web of chronic illness. You’ll also learn about the connection between mitochondrial dysfunction, increased pain sensitivity, and how negative neuroplasticity can turn temporary pain into a lasting syndrome. Whether you’re a practitioner, a patient, or someone passionate about functional medicine, this episode will empower you to look beyond protocols and focus on the underlying mechanisms that drive recovery. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Circadian Rhythm Improves Recovery 09:38 Mitochondria, Calcium, and Chronic Pain 10:46 Chronic Pain Linked to ER Stress 15:42 Mitochondrial Health Relieves Chronic Pain 17:34 "Fibromyalgia Mechanisms and Pain Reduction" 21:41 "Functional Medicine Training Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    23 min

  8. MAR 11

    Episode 77: The Root Causes of Chronic Fatigue and Pain Syndromes

    In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue and pain syndromes. If you've ever wondered why fatigue and pain are such stubborn and complex complaints, or why so many patients feel stuck despite having normal lab results, this conversation is for you. Dr. Kharrazian explores the critical role of cellular energy production—specifically mitochondrial bioenergetics—in recovery from injury and in managing conditions like fibromyalgia and chronic fatigue syndrome. He breaks down how disruptions in energy pathways can cascade into mood issues, pain syndromes, and overall decreased resilience, and explains why simply treating symptoms isn’t enough. This episode also underscores the importance of going beyond a “one-solution” mindset, urging practitioners to delve deeper into the mechanisms that affect their patients’ energy levels.  Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "Understanding Fatigue and Bioenergetics" 04:58 "ATP: Key to Energy and Health" 08:00 "Optimizing Energy and Resilience" 11:34 Mitochondria and Fatigue Factors 15:57 Anemia and Energy Function Insights 17:48 Mitochondria: Origins and Clinical Relevance 20:56 "Inherited vs. Acquired Mitochondrial Issues" 23:50 Mitochondrial Function and Enzymes 27:31 "Functional Medicine & Health Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    29 min
See All (84)

4.9
out of 5
99 Ratings

About

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.  His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Information

You Might Also Like