The Functional Code Podcast

Dr. Jace Nybo, Dr. Addy Knutson

We are here to bring you knowledge and tools to help you better yourself. Dr. Jace Dr. Addy We are The Functional Podcast

  1. 2d ago

    The Colon Code: Fiber, Butyrate, and the Microbiome

    Your colon is not just a waste pipe. In episode 5 of our Organ Series, Dr. Jace and Dr. Addy explore the colon, fiber, short-chain fatty acids, butyrate, microbiome diversity, constipation, diarrhea, stool transit time, resistant starch, prebiotic foods, and the role your colon plays in immune function and whole-body health. The colon contains roughly 38 trillion bacteria, close to the number of human cells in the body. That means your microbiome is a major part of your biology — and what you feed it matters. This episode breaks down how the colon ferments fiber into short-chain fatty acids like butyrate, propionate, and acetate. Butyrate is the star of the episode because it acts as a major fuel source for colon cells and plays a role in immune signaling, gut barrier health, and communication with the brain. Dr. Jace and Dr. Addy also discuss why most Americans are under-consuming fiber, why diversity matters, how the 30-plant rule can support microbiome health, how hydration impacts stool movement, why squatting mechanics matter, and how transit time can reveal whether things are moving too quickly or too slowly. They also cover red meat, processed meat, carnivore diets, colon cancer risk, fecal microbiota transplant, stool testing, and when colon symptoms should be evaluated by a provider. In this episode, we cover: The colon as a fermentation chamberThe 38 trillion bacteria living in the colonFiber and microbiome diversityShort-chain fatty acids: butyrate, propionate, and acetateWhy butyrate matters for colon healthSoluble fiber, insoluble fiber, resistant starch, and prebioticsThe 30-plant ruleCooked and cooled rice, potatoes, legumes, and green bananasHydration and fiber intakeConstipation, diarrhea, and transit timeThe beet or sesame seed transit testSquatting mechanics and pelvic floor functionWhy suppressing the urge can create problemsPsyllium husk and stool consistencyDysbiosis and stool testingFecal microbiota transplantC. diff, ulcerative colitis, and microbiome restorationProcessed meat vs. unprocessed red meatCarnivore diets and microbiome diversityColon cancer screening and red flags Key takeaway:The colon is where fiber becomes fuel. A healthy colon depends on rhythm, hydration, movement, plant diversity, resistant starch, prebiotic foods, and a microbiome that is fed well enough to produce beneficial compounds like butyrate. The goal is not just better bowel movements. The goal is better microbiome function, better immune signaling, better gut barrier support, and better long-term colon health. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    30 min
  2. Jun 17

    The Small Intestine Code: Leaky Gut, SIBO, and the Gut-Brain Axis

    our small intestine does far more than digest food. In episode 4 of our Organ Series, Dr. Jace and Dr. Addy explore the small intestine, leaky gut, SIBO, absorption, intestinal permeability, the gut-brain axis, serotonin production, microbiome signaling, and how gut health can influence inflammation, mood, energy, and nutrient status. The small intestine is the body’s main absorption site. It helps absorb amino acids, carbohydrates, fats, vitamins A, D, E, and K, iron, calcium, magnesium, zinc, and more. But when the gut lining becomes compromised, larger particles, inflammatory compounds, and bacterial byproducts may pass through the intestinal barrier and contribute to systemic symptoms. This episode breaks down the small intestine as a “border” system. When the fence breaks, we may see leaky gut. When the bacteria overgrow, we may see SIBO. When the gut-brain signal gets noisy, we may see symptoms that extend beyond digestion — including anxiety, depression, mood swings, fatigue, and inflammation. Dr. Jace and Dr. Addy also discuss practical strategies to support the small intestine, including removing processed foods and excess sugar, using bone broth and collagen, adding fermented foods gradually, improving sleep, managing stress, supporting nasal breathing, using L-glutamine, digestive enzymes, zinc carnosine, and working with the right provider for testing when symptoms become more serious. In this episode, we cover: The small intestine as the body’s main absorption organWhy absorption matters for nutrient statusLeaky gut and intestinal permeabilityTight junctions and the gut barrierGlyphosate, pesticides, gluten, and gut lining irritationFood sensitivities and “allergic to everything” patternsSIBO and bacterial overgrowthThe gut-brain axisThe vagus nerve and gut-to-brain communicationSerotonin production in the gutMood, anxiety, depression, and microbiome signalingProcessed food, excess sugar, and dysbiosisBone broth, collagen, and gut lining supportFermented foods and microbiome diversityKimchi, microplastics, and future gut researchSleep and intestinal repairStress and intestinal permeabilityL-glutamine for gut barrier supportDigestive enzymes for meal supportZinc carnosine and mucosal repairTargeted probiotics and microbiome mappingSIBO breath testing and stool analysisRed flags that require medical evaluation Key takeaway:You can eat healthy and still be malnourished if your small intestine is not absorbing properly. The goal is not just to eat better. The goal is to absorb better, protect the gut barrier, reduce inflammatory triggers, support the microbiome, and improve the gut-brain communication system. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    36 min
  3. Jun 10

    The Stomach Code: Acid, Ulcers, and Digestion Explained I The Functional Code Podcast

    Your stomach is one of the most powerful chemical factories in the body. In episode 3 of our Organ Series, Dr. Jace and Dr. Addy break down the stomach: how stomach acid works, why acid is essential, how food gets broken down, why H. pylori matters, how ulcers form, and what happens when the stomach lining becomes inflamed. The doctors explain why stomach acid is not something to fear. It helps break down protein, activate pepsin, support B12, iron, calcium, and mineral absorption, kill pathogens, and signal the pancreas and gallbladder that food is coming. They also cover what happens when the stomach gets disrupted by H. pylori, low stomach acid, chronic NSAID use, long-term acid suppression, excessive alcohol, chronic stress, gastritis, ulcers, and poor digestive timing. This episode also explores practical tools and support strategies, including meal spacing, the migrating motor complex, intermittent fasting, herbal tea before meals, digestive bitters, stress reduction before eating, breathwork, zinc carnosine, mastic gum, DGL, fermented foods, betaine HCl, and when symptoms need medical evaluation. In this episode, we cover: Stomach acid and why it mattersThe stomach as a chemical factoryProtein digestion and pepsin activationB12, iron, calcium, and mineral absorptionThe pyloric valve and chyme productionH. pylori and stomach ulcersPPIs and long-term acid suppressionNSAIDs, gastritis, and stomach lining damageLow stomach acid and hypochlorhydriaWhen reflux may be misdiagnosed as an acid issueGastric ulcers vs. duodenal ulcersMeal spacing and the migrating motor complexIntermittent fasting and stomach recoveryDigestive bitters and GLP-1 signalingStress management and parasympathetic activationZinc carnosine and mucosal healingMastic gum and H. pylori researchDGL and stomach lining supportFermented foods and digestive healthBetaine HCl and low-acid theoryRed flags that require medical evaluation Key takeaway:Your stomach acid is not the enemy. It is one of the most important tools your body uses to digest food, absorb nutrients, kill pathogens, and protect the rest of the digestive tract. The goal is not simply to suppress acid. The goal is to understand why the stomach factory is irritated, inflamed, underproducing, overloaded, or disrupted in the first place. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    32 min
  4. Jun 3

    Why Acid Reflux Isn’t Just an Acid Problem I The Functional Code Podcast

    Why does reflux happen? In episode 2 of our Organ Series, Dr. Jace and Dr. Addy break down the esophagus, the lower esophageal sphincter, GERD, reflux, heartburn, PPIs, antacids, hiatal hernias, and the deeper mechanics of digestion. This episode explains the lower esophageal sphincter, or LES, as the “bouncer” at the bottom of the esophagus. Food should move down into the stomach, and the LES should close behind it. But when the LES opens too often, loses tone, or becomes overwhelmed by pressure, acid can move back up into the esophagus and create burning, irritation, and discomfort. The major reframe in this episode: GERD is not always just an acid problem. It is often a pressure problem. Dr. Jace and Dr. Addie discuss how obesity, central belly pressure, late meals, large portions, hiatal hernias, weak vagal tone, poor breathing patterns, and poor gastric mechanics can all contribute to reflux. They also cover practical tools that may help support reflux and digestion, including the 3-hour rule before bed, left-side sleeping, chewing more thoroughly, walking after meals, hydration timing, belly breathing, digestive bitters, apple cider vinegar, DGL, slippery elm, marshmallow root, nasal breathing, breathwork, and stress reduction. In this episode, we cover: The esophagus and lower esophageal sphincterThe LES as the “bouncer” of the stomachGERD, reflux, heartburn, and acid exposureWhy PPIs were not designed as a forever fixHow the diaphragm supports the LESHiatal hernias and reflux mechanicsWhy reflux is often a pressure problemCentral adiposity and belly pressureHow weight loss can improve reflux symptomsMeal timing and the 3-hour ruleLeft-side sleeping for nighttime refluxChewing, bloating, and swallowed airWalking after meals and gastric emptyingHydration timing around mealsBelly breathing and vagal toneDigestive bitters and GLP-1 signalingApple cider vinegar and low-acid theoryDGL, slippery elm, and marshmallow rootBreathwork, nasal breathing, and stress regulationWhen reflux symptoms need medical evaluation Key takeaway:The goal is not just to reduce acid. The goal is to improve the mechanics that keep acid where it belongs. If reflux is driven by pressure, timing, stress, weak LES tone, or poor digestion mechanics, then the solution has to go deeper than simply suppressing stomach acid. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    32 min
  5. May 27

    Secret Mouth Hacks Mouth and Tongue, Organ Series I The Functional Code Podcast

    Your mouth is more than teeth, gums, and breath. In this episode of The Functional Code, Dr. Jace and Dr. Addy begin a new 12-part organ series by exploring the mouth and tongue as the first “front door” of the body. They break down how the mouth functions as the beginning of digestion, an immune barrier, a microbiome, and a major indicator of whole-body health. This conversation covers the connection between poor oral hygiene and systemic inflammation, cardiovascular risk, diabetes, kidney disease, bleeding gums, dental infections, bad breath, and oral dysbiosis. The doctors also explore practical tools and trends, including tongue scraping, mouthwash, hydroxyapatite toothpaste, xylitol, oil pulling, oral probiotics, nasal breathing, mouth taping, hydration, saliva, nitrate-rich foods, and nicotine pouches. In this episode, we cover: The mouth as the first door of the body The oral microbiome and bacterial balance How poor oral hygiene may influence systemic health Bleeding gums and pathogen entry Bad breath and volatile sulfur compounds Mouthwash and its potential effect on nitrate-reducing bacteria Tongue scraping and tongue coating What tongue color may reveal Brushing, flossing, and longevity markers Nasal breathing, mouth taping, and dry mouth Saliva, hydration, and oral pH Nitrate-rich foods and nitric oxide production Hydroxyapatite toothpaste and enamel support Xylitol and cavity prevention Oil pulling and plaque reduction Oral probiotics and future microbiome testing Nicotine pouches, Zyns, and oral health concerns When to see a dentist or periodontist Key takeaway: Your mouth is not separate from the rest of your body. It is connected to your immune system, cardiovascular system, metabolism, digestion, inflammation, and microbiome. The goal is not just fresh breath or white teeth. The goal is a healthy oral ecosystem. Follow The Functional Code: Instagram: https://www.instagram.com/thefunctionalcode YouTube: https://www.youtube.com/@TheFunctionalCode Spotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlf Apple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    40 min
  6. May 20

    The Hidden Repair System: How Your Body Fights Back Against Aging I The Functional Code Podcast

    What if aging could be reset? In the final episode of this cellular aging series, Dr. Jace and Dr. Addie explore one of the most fascinating and disruptive areas in longevity science: Yamanaka factors, cellular reprogramming, gene therapy, and longevity escape velocity. This conversation starts with the Nobel Prize-winning discovery of Yamanaka factors — OCT4, SOX2, KLF4, and c-MYC — and how these biological tools may help reprogram cells back toward a younger state. From studies reversing blindness in mice and primates to early human clinical trials, this episode breaks down how close we may be to changing the way humans age. But this episode is not just about science. It also asks the bigger questions: What happens if humans begin living 150, 200, or even 300 years?What happens to retirement, careers, birth rates, wealth, family structure, and purpose?Will longer life create more meaning — or remove the urgency that gives life meaning?Will AI, robotics, Neuralink, and automation reshape what it means to work, contribute, and survive?And will society become more adaptable — or more fragile? In this episode, we cover: -Yamanaka factors and cellular reprogramming-The future of gene therapy and aging research-Longevity escape velocity-David Sinclair, Life Biosciences, Altos Labs, Retro Biosciences, NewLimit, and Rejuvenate Bio-The 109% lifespan mouse study-Stem cells, pluripotency, and cancer risk-The economic value of slowing aging-How longer lifespans could affect wealth and power-The future of jobs, retirement, and universal income-AI, Neuralink, cyborgs, and automation-Population growth, quality of life, and purpose-Why adaptability may be the most important skill of the future Key takeaway:The goal is not just to live longer. The goal is to be physically, mentally, and socially prepared for the future that longevity science may create. The best investment you can make right now is still yourself: your body, your mind, your relationships, your skills, your adaptability, and your purpose. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    38 min
  7. May 13

    Why We Age: The Hidden Cost of Repairing Your DNA I The Functional Code Podcast

    What’s actually breaking down inside your body as you age? In this episode of The Functional Code, Dr. Jace and Dr. Addie explore the biology of aging from the inside out — DNA damage, epigenetics, mitochondrial function, autophagy, senolytics, NAD+, stem cells, peptides, air quality, and the lifestyle factors that shape how your body repairs itself over time. Every cell in your body experiences thousands of DNA lesions per day, and your body repairs almost all of them. But the problem may not be the damage itself — it may be the cost of constantly repairing that damage. The doctors break down aging through powerful metaphors, including the “repair crew” analogy and the orchestra analogy, where your DNA is the sheet music and your epigenome is the conductor. As the conductor loses precision, the same genetic code can start producing different outcomes: wrinkles, arrhythmias, immune dysfunction, cognitive decline, and other signs of aging. They also explore the future of longevity science and ask a deeper question: If we can slow or reverse aging, should we? This episode covers: DNA damage and cellular repairEpigenetics and gene expressionWhy aging may be the cost of repairUV radiation, stress, alcohol, tobacco, and processed foodsMitochondrial dysfunction and cellular declineAutophagy, fasting, and exerciseNAD+, sirtuins, senolytics, and peptidesStem cells and regenerative medicineAir quality and environmental agingAI, culture, mental health, and the future of human healthWhy exercise, sleep, and nutrition still sit at the top of the longevity pyramid Key takeaway:The future of anti-aging medicine may be powerful, but the highest-value tools are still the fundamentals: exercise, sleep, nutrition, clean air, stress regulation, and doing hard things consistently. Follow The Functional Code:Instagram: https://www.instagram.com/thefunctionalcodeYouTube: https://www.youtube.com/@TheFunctionalCodeSpotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlfApple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 Disclaimer: This podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    39 min
  8. May 6

    THE CODE INSIDE YOU — How Your Cells Read, Rewrite, and Run Your Code I The Functional Code Podcast

    What if aging isn’t just a countdown — but a communication problem? In this episode of The Functional Code, Dr. Jace and Dr. Addy explore the code inside your body: DNA, epigenetics, cellular signaling, exosomes, stem cells, probiotics, microbiome communication, and the future of longevity medicine. They discuss how your cells communicate, why signal naturally declines with age, how emerging therapies may influence cellular behavior, and why the basics — sleep, movement, nutrition, strength training, and cardio — still remain the foundation for long-term health. This episode also touches on David Sinclair’s work, Yamanaka factors, gene therapy, exosome research, stem cell delivery, first-pass effect, and the difference between anti-aging hype and the direction medical research is actually moving. Episode: 119 🧠 KEY TAKEAWAY Your body is constantly reading, rewriting, and running biological code. The goal is not just to chase the newest therapy — it’s to build a body that can maintain better signal, better repair, and better adaptability over time. 🔗 FOLLOW THE FUNCTIONAL CODE 📸 Instagram: https://www.instagram.com/thefunctionalcode 🎥 YouTube: https://www.youtube.com/@TheFunctionalCode 🎙 Spotify: https://open.spotify.com/show/3aY5zkhwg5Rzk2q33cbIlf 🍎 Apple Podcasts: https://podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557 📣 SHARE THIS EPISODE Send this to someone interested in longevity, genetics, anti-aging, peptides, stem cells, exosomes, or the future of health. 👉 Because most people are chasing the wrong solution — when the real question is how your body communicates, adapts, and repairs. ⚠️ DISCLAIMER The content provided in this podcast is for informational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

    30 min

Ratings & Reviews

4.3
out of 5
3 Ratings

About

We are here to bring you knowledge and tools to help you better yourself. Dr. Jace Dr. Addy We are The Functional Podcast

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