The Longevity Show with Dr. Hillary Lin

Hillary Lin, MD
  • 5.0 (3)
  • HEALTH & FITNESS
  • UPDATED DAILY

The Longevity Show with Dr. Hillary Lin breaks down complex medical concepts into easy-to-understand, actionable advice. We explore cutting-edge topics in preventative medicine, nutrition, metabolic health, exercise, and mental wellness - all aimed at helping you live a longer, healthier life.

  1. APR 17

    The Modern Lipid Playbook Part 2: THE TESTING — Why Your Lipid Panel Isn't Enough

    🚨 2026 ACC/AHA Dyslipidemia Guidelines just dropped — the first update in 8 years. Eleven specialty societies declared ApoB and Lp(a) standard of care. The standard lipid panel is officially not enough.My patient "David" did everything right for 25 years. His LDL was in the 40s — below even the NEW aggressive target. His stress test was normal. But his Lp(a), a genetic risk marker no one had ever checked, was nearly 3x the danger threshold. His CAC score: 1,522. His widowmaker artery: 75-99% blocked. Weeks later, he needed an emergent stent.His wife? Same household. CAC: zero. His brother? CAC: 2,700.In this episode, I break down every blood test and imaging test for heart disease — what each one measures, what it misses, and why CCTA (coronary CT angiography) with AI should be first-line imaging for anyone at risk.📋 WHAT YOU'LL LEARN:• Why LDL-C is a calculated estimate from a 1972 equation — and why it misses 1 in 5 patients• ApoB — the $15 test now in the formal clinical risk algorithm• Lp(a) — the genetic marker every adult should know (universal screening recommended)• Why "passing a stress test" may be the most dangerous false reassurance in cardiology• CAC scores — useful but completely blind to the plaque most likely to kill you• CCTA + AI — how it cut heart attacks 41% in SCOT-HEART (sustained at 10 years)• CPT 75577 — AI plaque analysis is now covered by Medicare (effective Jan 2026)• A tiered testing playbook with real costs and insurance tips• How to talk to your doctor when they won't order the right testsChapters: 00:00 25 Years on a Statin — and Still Missed00:27 The 2026 Guidelines Changed the Standard01:56 The Standard Lipid Panel’s 1972 Flaw06:38 ApoB and Lp(a): The Two Tests That Change the Story13:24 The Truth About Advanced Panels, HDL, & Triglycerides16:30 The Metabolic Fire: Fasting Insulin & hs-CRP20:18 Why “Passing a Stress Test” Creates Dangerous False Reassurance27:19 The CAC Score: Useful, but Blind to Soft Plaque33:30 CCTA & AI: The New Gold Standard for Plaque Detection42:15 Insurance Coverage, Microvascular Disease, and Who Gets Missed46:29 The Tiered Testing Hierarchy & Your Personal Playbook

    50 min

  2. APR 7

    The Toxic Wellness Myths Aging You Faster (Cycle Syncing, Plastics & Noise) with Non-Toxic City Girl

    Think the smog outside your city window is the biggest threat to your longevity? Think again. The air inside your kitchen—and the noise from your street—are likely doing significantly more damage to your cellular health.In this episode of The Longevity Show, I sit down in the Tribeca studio with Jiyeon, the brilliant mind behind NonToxicCityGirl. We cut through the noise of the modern wellness industry to discuss what actually moves the needle for your health and what is just an expensive distraction.We dive deep into "rational biohacking," why the traditional medical system is structurally broken, and how agentic AI is about to change how we advocate for our own health. We also dismantle popular wellness myths (like cycle syncing), uncover the real reasons behind generational fertility decline, and share practical protocols for detoxing your daily routine—from "house burping" and navigating the microplastics in your takeout, to the surprising longevity benefits of walking on a treadmill desk.If you want to protect your metabolic health and take agency over your own longevity, this episode is your blueprint. Hit subscribe so you never miss an update, and share this with a friend who needs to cut through the wellness noise!*Chapters:*00:49 Demographics of Longevity and Health Trends03:03 Rational Biohacking vs. Reckless Experimentation06:49 The Role of AI in Personal Health Research20:03 The 17-Year Gap & The Broken Business of Healthcare25:41 Navigating Health Advice with AI & Critical Thinking36:12 Non-Toxic Living: Pollution, Plastics, and Forever Chemicals47:20 The Ultimate Longevity Tool: Daily Movement51:24 The Global Fertility Crisis & Reproductive Optionality01:08:28 Urban Longevity vs. Modern Hustle Culture01:13:14 Diet, Body Recomposition, & Chronic Inflammation01:21:53 Metabolic Health, Mitochondria, & Wellness Myths

    1h 33m

  3. MAR 10

    The $500M Performance Myth: What Tom Brady’s Chef Actually Fed Him

    We’re told that elite physical longevity requires a $500 million contract and a 24/7 medical team, but that is a myth. The food that fuels world-class performance isn't about extreme restriction or magic supplements—it’s about understanding systemic inflammation, eliminating hidden toxins, and utilizing the power of local, whole foods. Traditional culinary arts prioritize taste and presentation over sustenance. Allen Campbell flipped that model. After completely transforming his own health through sobriety and dietary elimination, he went from high-end restaurant kitchens to engineering the precise, anti-inflammatory diet that helped Tom Brady play in the NFL until age 45. In this episode, we dismantle the myths surrounding the TB12 Method, explain the true danger of industrial seed oils in restaurant food, and reveal why bio-individuality matters more than following any celebrity diet. We also dive deep into advanced body recomposition macros, the reality of organic sourcing (and the "Dirty Dozen"), and the high-performance nutritional habits you need to build a longer, healthier life. Topics Covered 𝗧𝗵𝗲 𝗖𝘂𝗹𝗶𝗻𝗮𝗿𝘆 𝗣𝗶𝘃𝗼𝘁: Why traditional restaurant food prioritizes art over healthspan, and how to shift your mindset toward sustenance.𝗧𝗵𝗲 𝗦𝗲𝗲𝗱 𝗢𝗶𝗹 𝗘𝗽𝗶𝗱𝗲𝗺𝗶𝗰: Understanding why cheap, polyunsaturated restaurant oils are the real culprits behind your brain fog and systemic inflammation.𝗗𝗲𝗰𝗼𝗻𝘀𝘁𝗿𝘂𝗰𝘁𝗶𝗻𝗴 𝗧𝗕𝟭𝟮: The truth about nightshades (tomatoes, eggplants), and why Tom Brady's highly specific restrictions shouldn't necessarily be your own.𝗖𝘂𝘀𝘁𝗼𝗺𝗶𝘇𝗶𝗻𝗴 𝗠𝗮𝗰𝗿𝗼𝘀 𝗳𝗼𝗿 𝗥𝗲𝗰𝗼𝗺𝗽: How precision software is scaling bespoke nutrition to optimize protein, fat, and fiber ratios for individual body types.𝗡𝗮𝘃𝗶𝗴𝗮𝘁𝗶𝗻𝗴 𝗣𝗲𝘀𝘁𝗶𝗰𝗶𝗱𝗲𝘀: The realities of Glyphosate, the "Dirty Dozen" vs. the "Clean Fifteen," and a simple mental framework for when you absolutely must buy organic.𝗧𝗵𝗲 𝗙𝘂𝘁𝘂𝗿𝗲 𝗼𝗳 𝗙𝗼𝗼𝗱 𝗦𝘂𝗽𝗽𝗹𝘆: The challenges of sourcing organic ingredients at scale and the emerging promise of vertical, indoor farming.Newsletter: https://www.hillarylinmd.com/subscribeInstagram:   / hillarylinmd  Twitter/X:   / hillarylinmd  CareCore (For Clinicians): https://carecore.io About Allen Campbell: Allen Campbell is a renowned personal chef, entrepreneur, and culinary innovator dedicated to the intersection of high-performance nutrition and longevity. He is best known as the former private chef for Tom Brady and Gisele Bündchen, and the co-author of the New York Times bestseller, The TB12 Method. Today, he is the founder of AC Kitchen, a service delivering highly customized, anti-inflammatory meal plans, and the co-founder of Nuda, a pioneering keto-friendly almond pasta brand. Website: https://allencampbell.com/ Instagram:   / chefallencampbell   X: https://x.com/chefalcampbell Chapters 02:59 Personalized Nutrition Philosophy 07:05 Customizing Nutrition at Scale 10:54 Inflammatory Triggers & The TB12 Myth 22:25 Life as a Chef: Passion vs. Business 27:37 Sourcing Organic & Clinical Diet Protocols 35:29 Protein Sourcing & Caloric Realities 42:51 Nutritional Investing & Self-Worth 46:10 Nutrition Trends and Their Impact About the Show: The Longevity Show with Dr. Hillary Lin takes complex medical research and distills it into practical, easy-to-understand advice for living a longer, healthier life. Covering everything from preventative medicine and metabolic health to the latest breakthroughs in nutrition, exercise, and mental wellness, Dr. Lin gives you the tools you need to thrive. ABOUT DR. HILLARY LIN: Dr. Hillary Lin is a Stanford-trained physician and the Co-Founder/CEO of CareCore. She explores the cutting edge of longevity medicine, metabolic health, and mental resilience, translating complex science into actionable protocols for a longer, healthier life.

    58 min

  4. FEB 21

    The Oral Longevity Blind Spot: Detecting the Silent Killer in Your Mouth

    You probably track your sleep, HRV, and blood work, yet the second-largest microbiome in your body is quietly driving systemic aging. In fact, 57 major systemic diseases—including Alzheimer's, cardiovascular disease, and autoimmune conditions—are directly linked to oral inflammation. Traditional dentistry waits for symptoms—cavities, bleeding gums, or severe pain—before treating the problem. Dr. Jonathan Levine argues this is like waiting for a massive heart attack before ever checking your cholesterol. In this episode, we dismantle the 1840 "Grand Rebuke" that dangerously separated dentistry from medicine. We explain why standard basic cleanings fail to detect early pathogenic risk and why the equivalent of a preventative full-body scan for your mouth—AI-enabled 3D Mouth Mapping—is the only way to truly visualize your risk. We also dive deep into advanced longevity protocols, including airway expansion for deep sleep, point-of-care salivary omics, and the high-performance oral hygiene regimen you need to adopt immediately. Topics Covered: • The Failure of the "Gold Standard": Why standard 2D x-rays and basic cleanings completely miss dangerous pathogens. • Leaky Gums & Systemic Disease: Understanding how the P. gingivalis bacteria travels from your mouth to build arterial plaque and drive Alzheimer's. • Advanced Imaging: How 3D Mouth Mapping and AI visualize hidden airway obstructions and structural breakdown. • Protocols for Prevention: The role of pH-raising rinses, tongue scraping, and why you must throw out alcohol-based mouthwashes. • Airway Health & Sleep: The connection between mouth breathing, nitric oxide depletion, and how structural jaw expansion can cure disrupted sleep. • The Nuance of Fluoride: Protecting your enamel without neurotoxic risks through dose-specific applications. About Dr. Jonathan Levine: Dr. Jonathan Levine is a preventative prosthodontist, clinical innovator, and pioneer in oral-systemic health based in New York City. He is the inventor of GLO Science technology and the co-founder of Smile House, the Center for Dental Longevity. He has dedicated his 35-year career to bridging the gap between medicine and dentistry, utilizing advanced diagnostics to detect and stop systemic inflammatory diseases at their source. Website: https://www.drjonathanlevine.com/ Instagram:   / drjonlevine   JBL New York City: @jblnewyorkcity Smile House Tribeca: @smilehousetribeca GLO Science: @gloscience GLO Science Pro: @glosciencepro GLO Good Foundation: @glogoodfoundation Chapters 00:00 The Overlooked Role of Oral Health in Longevity 03:10 Rebuilding the Dental Care Model 06:19 The Center for Dental Longevity & Smile House 11:14 The Oral-Systemic Connection 14:33 Integrating Dentistry with Overall Health 20:07 The Tech-Enabled Dental Exam 22:28 Airway Health, Nitric Oxide, & Sleep 29:51 The Future of Salivary Diagnostics 31:12 Mission Work in Dental Deserts 34:06 High-Performance Oral Protocols 36:48 The Role of Fluoride in Dental Health 39:17 Epigenetics vs. Genetics in Decay 46:04 Top Takeaways for Oral Longevity

    49 min

  5. FEB 12

    The Heart Attack You Won't See Coming (Even With 'Good' Stats).

    50% of people who die of a heart attack have zero prior symptoms. They have no chest pain, no shortness of breath, and often, "normal" cholesterol on a standard panel. In Part 1 of 𝘛𝘩𝘦 𝘔𝘰𝘥𝘦𝘳𝘯 𝘓𝘪𝘱𝘪𝘥 𝘗𝘭𝘢𝘺𝘣𝘰𝘰𝘬, I break down why the standard of care is failing to detect the world's #1 killer until it’s too late. I share the science on why atherosclerosis is actually a pediatric disease, the "cumulative exposure" math that proves early prevention is 3x more effective, and the specific blood markers you need to look at instead of just LDL-C. 📩 𝐆𝐞𝐭 𝐖𝐞𝐞𝐤𝐥𝐲 𝐋𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲 𝐔𝐩𝐝𝐚𝐭𝐞𝐬: https://www.hillarylinmd.com/subscribe 𝐎𝐍 𝐓𝐇𝐈𝐒 𝐄𝐏𝐈𝐒𝐎𝐃𝐄: We dismantle the "plumbing" model of heart disease and replace it with the latest science on lipidology and longevity. • 𝐓𝐡𝐞 "𝐒𝐢𝐥𝐞𝐧𝐭" 𝐊𝐢𝐥𝐥𝐞𝐫: Why your body is evolutionarily designed to hide heart disease from you. • 𝐓𝐡𝐞 𝐏𝐞𝐝𝐢𝐚𝐭𝐫𝐢𝐜 𝐄𝐯𝐢𝐝𝐞𝐧𝐜𝐞: Autopsy data showing plaque in 20-year-olds (Korean War & PDAY studies). • 𝐓𝐡𝐞 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦: How ApoB particles get trapped in the artery wall (The "Response to Retention" model). • 𝐓𝐡𝐞 𝐌𝐚𝐭𝐡 𝐨𝐟 𝐑𝐢𝐬𝐤: Why "Cholesterol-Years" matter more than your current numbers. • 𝐋𝐢𝐟𝐞𝐬𝐭𝐲𝐥𝐞 𝐅𝐚𝐜𝐭𝐨𝐫𝐬: How sleep debt and stress physically damage your endothelium. 𝐂𝐇𝐀𝐏𝐓𝐄𝐑𝐒: 01:47 One Disease, Three Addresses: Heart Attack, Stroke, and Aneurysm 03:09 The Pediatric Bombshell: This Is a Childhood Disease 09:14 The Mechanism: What's Actually Happening Inside Your Arteries 15:20 The Math of Cumulative Exposure: Why When You Start Matters More Than What You Do 22:17 The Evolutionary Paradox: Why Our Bodies Betray Us 27:41 The Invisible Damage: What's Happening While You Feel Fine 32:27 The Information War: Why You’re Confused 41:12 What This Means For You: The Stakes, The Opportunity

    43 min

  6. JAN 17

    Stop Cooking With These: A Longevity Physician’s Guide to Seed Oils & Saturated Fat

    We’ve been told the same story for 50 years: "Saturated fat is bad, vegetable oil is heart-healthy." But if that’s true, why are we in a global energy crisis of chronic fatigue and metabolic stalling? As a longevity physician, I look at the body like an engineer looks at a high-performance machine. When the engine stalls, I don't blame the driver—I look at the fuel. In this masterclass, we dismantle the "Fat Wars" with clinical nuance. I explain why the Seed Oil debate is often missing the most dangerous variable: Oxidation. We explore the "Two-Hit Theory" of heart disease, how unstable fats create "zombie" membranes in your mitochondria, and why your Air Fryer might be an oxidation accelerator. Most importantly, I provide a practical kitchen protocol to help you rebuild your biology from the cell membrane out. In this episode, we cover: • The Two-Hit Theory: Why LDL volume is only half the problem (and why oxidation is the match that lights the fire). • The Membrane Theory: How Linoleic Acid creates "fragile" cells that leak toxic waste (4-HNE) into your brain. • The Migraine Connection: New NIH data on how specific oils chemically activate your pain receptors (TRPV1). • The Smoke Point Lie: Why "high smoke point" oils can still rot your DNA. • The Official Protocol: My Tier 1, 2, and 3 hierarchy for the longevity-focused kitchen. Chapters 00:00 The Energy Crisis Within Us 01:47 The Two-Hit Theory: Why "Healthy" Oils May Be Driving Heart Disease 04:34 Cellular Sabotage: How Unstable Fats Break Mitochondria & Trigger Pain 07:54 Cooking Myths Debunked: Smoke Points, Olive Oil, & Air Fryer Risks 09:50 The Return of Solid Fats: Why Tallow Wins & Crisco Kills 11:37 The Official Protocol: Tier 1, 2, and 3 Oils for Your Kitchen ✨ Get 5 Easy Longevity Tips & Dr. Hillary Lin's Weekly Newsletter for Free: https://www.hillarylinmd.com/subscribe About the Show: The Longevity Show with Dr. Hillary Lin takes complex medical research and distills it into practical, easy-to-understand advice for living a longer, healthier life. Covering everything from preventative medicine and metabolic health to the latest breakthroughs in nutrition, exercise, and mental wellness, Dr. Lin gives you the tools you need to thrive. About Dr. Hillary Lin and Care Core Dr. Hillary Lin is a Stanford MD and CEO/Co-founder of Care Core, a platform helping clinicians launch personalized longevity practices powered by evidence-based protocols and AI-driven tools. Follow for insights on transforming care delivery through precision medicine. Connect with Dr. Hillary Lin: Instagram: https://www.instagram.com/hillarylinmd Facebook: https://www.facebook.com/hillarylinmd X: https://twitter.com/hillarylinmd TikTok: https://www.tiktok.com/@hillarylinmd Disclaimer: This podcast is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. No doctor-patient relationship is formed. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Use of this information is at your own risk.

    14 min

  7. 12/30/2025

    “Normal” Labs but Still Exhausted? Mitochondrial Series (Pt 1): Mitophagy + 4-Step Protocol

    If you’re sleeping well, eating clean, exercising—and still exhausted—this may be an engine problem, not a fuel problem.This is Part 1 of my Mitochondrial Health Series, where I start with the foundation: mitophagy—your body’s ability to clear damaged mitochondria.In longevity medicine, I call this mitophagy failure: damaged mitochondria (“zombie batteries”) stop producing clean energy and leak signals that can trigger inflammation, brain fog, and that 2 p.m. crash.In this video, I break down:• Why zombie mitochondria can keep you stuck in “sickness behavior”• The key biology: PINK1 + Parkin (how your cells tag and remove broken mitochondria)• My 4-step energy protocol: 14–16 hr overnight fasting, Zone 2 cardio, heat (sauna/hot bath), and urolithin A + spermidine• The NAD+ trap: why NMN/NR can backfire if you “fuel” before you “clean”Chapters: 00:00 The "Zombie Battery" Cause of Fatigue 01:54 Why Your Cells Think They Are Dying04:43 The Cleanup Crew: PINK1 & Parkin07:02 Protocol 1: The "Janitor" Fast (AMPK vs. mTOR)08:44 Protocol 2: Why HIIT Might Be Making You Tired09:59 Protocol 3: Heat Shock Proteins & Sauna11:30 Protocol 4: Supplements (Urolithin A, Spermidine) & The NAD+ Mistake15:18 Summary: The 4-Step Energy Protocol

    16 min

  8. 12/20/2025

    The "Normal" Cholesterol Myth: Detecting the Widowmaker Before It Strikes

    Heart disease is still the #1 killer worldwide, yet 50-75% of people who suffer a heart attack have "normal" cholesterol levels.Traditional cardiology waits for symptoms—chest pain, shortness of breath, or cardiac arrest—before treating the problem. Dr. John Osborne, MD, PhD, argues this is like waiting for Stage 4 cancer before ordering a screening.In this episode, we dismantle "20th Century Cardiology." We explain why standard EKGs and stress tests fail to detect early plaque and why the "Cardiac Colonoscopy"—AI-enabled CCTA—is the only way to truly visualize your risk. We also dive deep into advanced reversal protocols, including the use of Colchicine for inflammation, the "Keto Paradox," and the genetic biomarkers (Lp(a) and ApoB) that you need to request immediately.*Topics Covered:*• The Failure of "Gold Standards": Why stress tests miss 30-40% of dangerous blockages.• Soft Plaque vs. Hard Plaque: Understanding the difference between stable calcium and the "lava" that causes sudden death.• Advanced Imaging: How AI CCTA visualizes the vessel wall (the "donut") rather than just the hole.• Protocols for Reversal: The role of Colchicine, PCSK9 inhibitors, and statins in shrinking plaque.• The Keto Paradox: Can you have healthy arteries with high cholesterol?• Genetics: Why everyone needs to test for Lipoprotein(a) once in their life.About Dr. John Osborne:Dr. John Osborne is a Preventative Cardiologist and Lipidologist based in Dallas. He holds an MD and PhD in cardiovascular physiology and founded State of the Heart Cardiology. He is the Co-Founder and Chief Medical Officer of Clear Cardio, pioneering the use of AI in cardiac imaging to detect and reverse heart disease before it becomes fatal. Chapters: 00:00 Introduction to Heart Disease and Its Impact 04:46 Why Your "Normal" Cardiology Workup Is Useless 13:08 The Cardiac Colonoscopy: AI Imaging vs. Blind Blood Work 16:24 Cardiac CT + AI: The 20-Second Scan That Changes Everything 31:08 The Blood Tests That Actually Matter 36:36 Cholesterol vs. Sticky Vessels: The Two-Factor Model  40:45 The Debate on Diets: Cholesterol and Inflammation 44:13 Reversing Heart Disease: Colchicine, Statins, and New Protocols 54:14 Exploring Stem Cell Therapy in Cardiology 57:00 The Future of Preventative Cardiology

    1 hr
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5
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3 Ratings

About

The Longevity Show with Dr. Hillary Lin breaks down complex medical concepts into easy-to-understand, actionable advice. We explore cutting-edge topics in preventative medicine, nutrition, metabolic health, exercise, and mental wellness - all aimed at helping you live a longer, healthier life.

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