In this solo Q&A episode of Trying with Dr. Sasha Hakman, Dr. Sasha answers listener questions across fertility, IVF, embryo transfer, hormone health, pregnancy, exercise, and reproductive genetics. From adenomyosis treatment before embryo transfer and ways to support a short luteal phase to whole genome sequencing, balanced translocations, IVF in your 40s, male factor infertility, and exercise during treatment, Dr. Sasha breaks down what the evidence tells us, where the research is still limited, and why fertility care often needs to be highly individualized. As always, this episode is for general education and is not personal medical advice. In this episode, we cover: ➜ Adenomyosis, why it can affect implantation, and when Depo Lupron and letrozole may be considered before embryo transfer ➜ Using Inito to track FSH, LH, estrogen, and progesterone, confirm ovulation, and potentially identify a luteal phase defect ➜ Whole genome sequencing of embryos, polygenic risk scores, monogenic conditions, Juniper Genomics, Orchid, Nucleus, and the limitations of embryo genetic testing ➜ Persistent chronic endometritis after doxycycline, when additional antibiotics may be needed, and where EMMA/ALICE testing may have a role ➜ Resistance training, powerlifting, pelvic floor health, urinary incontinence, prolapse, and what researcher Margie Davenport's work suggests about exercise in pregnancy ➜ Balanced translocations, genetic counseling, untested embryos, embryo biopsy and re-freezing, and how maternal age can influence decisions around PGT ➜ Vaginal estrogen and the vaginal microbiome, Evvy testing, and using progesterone supplementation to support a short luteal phase ➜ Reproductive immunology after miscarriage or failed embryo transfer, plus when a rheumatologist or reproductive immunologist may be helpful ➜ ICSI for male factor infertility, high AMH, reproductive urology, varicoceles, hypothalamic amenorrhea, restoring ovulation, and trying to conceive after losing your period ➜ Fertility and IVF in your 40s, including the realities of egg quality, ovarian reserve, repeated IVF cycles, and when donor eggs may enter the conversation ➜ Pregnancy symptoms that deserve evaluation, including ocular migraines, shortness of breath, severe fatigue, low ferritin, and iron deficiency ➜ IVF add-ons including Neupogen, hCG washes, steroids, IV intralipids, and uterine PRP, and why limited evidence does not always stop patients with recurrent implantation failure from considering them ➜ Luteal phase ovarian stimulation, estrogen and testosterone priming, diminished ovarian reserve, follicle synchronization, and individualized stimulation protocols ➜ Exercise during ovarian stimulation and after frozen embryo transfer, plus microdose Lupron protocols, FSH stimulation, hCG triggers, and OHSS risk CHAPTERS 00:00 Solo Q&A and a reminder about general medical advice01:00 Adenomyosis treatment before transfer and tracking ovulation with Inito08:03 Whole genome sequencing, embryo genetics and chronic endometritis13:55 Resistance training, pelvic floor health, balanced translocations and untested embryos20:44 Vaginal estrogen, the microbiome and lengthening the luteal phase23:44 Reproductive immunology, ICSI and male factor infertility27:29 Hypothalamic amenorrhea and trying for another baby in your 40s30:34 Migraines in pregnancy, iron deficiency and IVF success in the mid to late 40s35:22 Neupogen, IVF add-ons and luteal phase stimulation39:06 Exercise during IVF and after embryo transfer, plus microdose Lupron protocols Episodes and experts mentioned: Whole genome sequencing with Juniper Genomics CEO Jeremy Greco IVF medications Follow Dr. Sasha! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingpod YouTube: @sashahakmanmd Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter for updates, Q&A answers and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every week. If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Thank you to our sponsors! Head to AquaTru.com now and get 20% off your purifier using promocode DRSASHA Go to Rula.com/ DRSASHA for quality therapy that’s covered by insurance. Head over to Superpower.com and use code DRSASHA for $50 off. After you sign up, they’ll ask you how you heard about Superpower, tell them Trying sent you to support the show. Learn more about your ad choices. Visit megaphone.fm/adchoices