Join host Phil Plisky, PT, DSc, ATC, CSCS, as he sits down with Dr. Julie Mulcahy, PT, DPT, Director of MSK at Omada Health, to navigate the rapidly evolving intersection of metabolic health and rehabilitation. Together, they explore how GLP-1 medications—now used by 1 in 8 U.S. adults—are redefining chronic disease management and altering muscle physiology. You will discover how to adapt your screening and exercise prescriptions to protect lean muscle mass, manage medication-induced fatigue or GI side effects, and ensure patients don’t trade vital physical power for lost pounds. Tune in to learn how to lead the way in interprofessional collaboration and build sustainable, long-term functional habits that last far beyond the prescription. Learning Outcomes Analyze the evidence around the physiologic and systemic effects of GLP-1 receptor agonists and the resulting necessity for shifts in contemporary rehabilitation practiceApply evidence-based, practical strategies to actionably address musculoskeletal risks, energy limitations, and exercise prescription adjustments across the escalation, maintenance, and discontinuation phases of GLP-1 therapySolve patient case scenarios involving screening, patient education, and interprofessional collaboration to optimize long-term health outcomes for patients with obesity or diabetes utilizing GLP-1 agonists Timestamps (00:00:00) Welcome(00:00:00) Introduction to the episode and guest(00:02:24) Guest introduction: Dr. Julie Mulcahy(00:03:24) Importance of discussing GLP-1 in rehab(00:04:53) How GLP-1 medications work(00:07:05) Clinical considerations: muscle mass and tissue health(00:11:27) Screening questions for patients on GLP-1(00:16:33) Exercise recommendations and functional training(00:22:20) Impact of GLP-1 on tissue healing and bone health(00:27:50) Loading strategies and resistance training(00:30:46) Research findings on GLP-1 benefits(00:32:39) Integrating GLP-1 management into clinical practice(00:36:15) Managing patients in hospital and post-discharge(00:38:18) Nutrition, protein intake, and muscle preservation(00:47:05) Case study: patient with weight loss and musculoskeletal issues(00:50:24) Long-term strategies for maintaining health(00:53:11) Red flags and red flag screening(00:59:36) Addressing misconceptions about body composition and muscle gain(01:00:49) Education and patient engagement(01:01:26) Potential for rehab to complement GLP-1 therapy(01:02:40) Inappropriate use and ethical considerations(01:04:45) Resources and further education opportunities(01:05:14) Three important takeaways(01:11:51) Closing remarks and contact information Rehab and Performance Lab is brought to you by Medbridge. If you’d like to earn continuing education credit for listening to this episode and access bonus takeaway handouts, log in to your Medbridge account and navigate to the course where you’ll find accreditation details. If applicable, complete the post-course assessment and survey to be eligible for credit. The takeaway handout on Medbridge gives you the key points mentioned in this episode, along with additional resources you can implement into your practice right away. To hear more episodes of Rehab and Performance Lab, visit https://www.medbridge.com/rehab-and-performance-lab If you’d like to subscribe to Medbridge, visit https://www.medbridge.com/pricing/