Nicotine has not gone away. It has moved from cigarettes to vapes and pouches, and athletes and high performers now use it for focus, energy and calm. Dr. Jay Wiles used it that way too, until he noticed what it was doing to his nervous system. This episode follows nicotine from Native American ceremony to the cigarette rolling machine, the 1964 Surgeon General's report, the vaping wave and the pouch era. Then it goes inside the body. Nicotine is shaped enough like acetylcholine, one of your own neurotransmitters, to fit its receptors, and those receptors sit in the relay stations of both branches of the autonomic nervous system: the gas pedal and the brake. Jay walks through what the research shows nicotine does to heart rate, HRV, blood pressure, the baroreflex and sleep, why much of the calm it brings is relief from the withdrawal the last dose started, and what happens in the first week after quitting. Then he ran the test on himself. After three to four months without nicotine, he took a baseline, used one 6 mg pouch, sat still for 15 minutes and measured again. His resting heart rate went from 62 to 70 beats per minute. His HRV went from 84.6 to 65.9 milliseconds. That is one person and one dose, not a study. It is also not a score going the wrong way. It is what an acute stress response looks like in the data: a nervous system pushed toward the gas pedal while its owner sat in a chair and did nothing. The episode closes with what to do about it. If you do not use nicotine, do not start. If you do, delay the first dose, keep it away from the evening, keep the ritual and lose the drug, and, if you already track HRV, run the same experiment on yourself. Disclosure The readings in my experiment were taken with The Resilient Engine app, which is mine. Ohm is my company too, and I mention the Ohm Circle group at the end of the episode. Weigh what I say about either with that in mind. Nothing in this episode was paid for by anyone. This episode is education, not medical advice. Chapters 00:00 Why nicotine, and why now 02:14 My own nicotine story 04:16 A short history of nicotine 07:44 Vaping and the pouch boom 12:25 What nicotine is and how it works 17:06 Why nicotine feels calming 19:55 The gas and the brake 24:38 Blood pressure and the baroreflex 29:24 Pouches, heart rate and sleep 31:44 What happens when you quit 32:34 My one pouch experiment 35:30 What I recommend Run the experiment yourself I ran this right before recording, after three to four months without nicotine. It is written out so that anyone who already uses nicotine and tracks HRV can repeat it. If you do not use nicotine, this is not a reason to start. 1. Sit where you will stay for the whole test. Use the same device, in the same position, for every reading. 2. Take three two-minute readings and average them, for resting heart rate and for HRV. That is your baseline. 3. Use one pouch. I used 6 mg, which hit hard after months without one. If you already use nicotine, use your usual product and dose. 4. Stay seated for 15 minutes. Do not get up, move around or change anything else, or you are measuring the change in context rather than the nicotine. 5. Take three more two-minute readings and average them. My averages, measured with The Resilient Engine app: Resting heart rate: 62 beats per minute before, 70 after. Up 8. HRV: 84.6 milliseconds before, 65.9 after. Call it 85 to 66. Show notes, with every study: theresilientengine.com/media/nicotine HRV CV 101, episode 3: theresilientengine.com/media/hrv-cv The app: theresilientengine.com Dr. Jay T. Wiles is a clinical health and performance psychologist and the creator of Nervous System Resiliency Training.