Building Lifelong Athletes

Jordan Rennicke, MD

The Building Lifelong Athletes Podcast has one simple goal... to help keep you active and healthy for life. Whether you are a competitive athlete, fitness enthusiast, or just a weekend warrior, this podcast will help you be at your best by delivering practical and actionable information. From cholesterol management to exercise programming, this podcast covers every topic any lifelong athlete needs to know about. Jordan Rennicke, MD is a dual board certified physician in Family and Sports Medicine, has worked with thousands of athletes from all walks of life, and has a passion for learning, teaching, and helping people achieve their goals.

  1. 13h ago

    S1: The Data That Proves LDL DOESN'T Cause Heart Disease

    In this episode, we explore the cholesterol counterculture and the evidence behind non-traditional lipidology. From the collapse of trust in dietary guidelines to the Lipid Energy Model, Lean Mass Hyper-Responders, and the Keto-CTA study, we examine whether sky-high LDL carries the same vascular risk in a metabolically healthy body.Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.  ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdfCHAPTERS:00:00 - Intro00:42 - The Collapse of Trust in Dietary Guidelines01:33 - Rediscovered Data: Sydney & Minnesota Diet Heart Studies02:41 - LDL Cholesterol and Mortality in Older Adults03:47 - The Thrombogenic Model of Atherosclerosis04:42 - Metabolic Context & The CAC Score Zero Paradox05:56 - The Low-Carb Keto Surge & Skyrocketing LDL07:26 - The Lean Mass Hyper-Responder (LMHR) Phenotype08:46 - The Lipid Energy Model & The Oreo Cookie Experiment10:56 - The Keto-CTA Study: High LDL vs Plaque Burden12:52 - Individualizing Risk & The N=1 ApproachSELECTED REFERENCES:Ramsden et al. (2016): https://doi.org/10.1136/bmj.i1246Ravnskov et al. (2016): https://doi.org/10.1136/bmjopen-2015-010401Mortensen et al. (2022): https://doi.org/10.1001/jamanetworkopen.2021.48139Feldman, Norowitz, Soto-Mota et al. (2022): https://doi.org/10.3390/metabo12050460Norowitz et al. (2024): https://doi.org/10.3390/metabo14010073Budoff, Norowitz et al. (2024): https://doi.org/10.1016/j.jacadv.2024.101109*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  2. Oct 20

    S1: The Data That Proves LDL Causes Heart Disease

    In this episode, I try to cut through the noise of the cholesterol debate and walk through 150 years of vascular science. From ancient mummies to modern genetics, we examine how lipidology reached its consensus, the response-to-retention hypothesis, why ApoB particle count matters more than LDL cholesterol mass, and what landmark clinical trials reveal about cardiovascular risk.Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdfCHAPTERS:00:31 - The Ideological War in Lipidology01:30 - Is Heart Disease a Modern Industrial Illness?03:39 - The History of Atherosclerosis04:31 - Early Rabbit Experiments & The Discovery of Foam Cells06:13 - Post-War Heart Epidemic & The Framingham Study07:53 - Disproving the Threshold Theory: MRFIT & Observational Data09:18 - The Response-to-Retention Hypothesis Explained12:30 - Mendelian Randomization: Nature's Lifelong Clinical Trial16:04 - ApoB vs. LDL-C: Counting Particles vs. Cargo17:18 - Statin & Non-Statin Randomized Controlled Trials20:30 - The Scientific Consensus on ApoB and Cardiovascular RiskSELECTED REFERENCES:Thompson et al. (2013): https://doi.org/10.1016/S0140-6736(13)60598-XKannel et al. (1961): https://doi.org/10.7326/0003-4819-55-1-33Stamler et al. (1986): https://doi.org/10.1001/jama.1986.03380200061022Williams & Tabas (1995): https://doi.org/10.1161/01.ATV.15.5.551Cohen et al. (2006): https://doi.org/10.1056/NEJMoa054013Voight et al. (2012): https://doi.org/10.1016/S0140-6736(12)60312-2Richardson et al. (2020): https://doi.org/10.1371/journal.pmed.1003062Scandinavian Simvastatin Survival Study Group (1994): https://doi.org/10.1016/S0140-6736(94)90566-5Cannon et al. (2015): https://doi.org/10.1056/NEJMoa1410489Sabatine et al. (2017): https://doi.org/10.1056/NEJMoa1615664 Schwartz et al. (2018): https://www.nejm.org/doi/full/10.1056/NEJMoa1801174Nissen et al. (2023): https://doi.org/10.1056/NEJMoa2215024*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  3. Oct 13

    S1: Ancel Keys and His (in)famous legacy

    Was Ancel Keys a visionary pioneer of preventive cardiology or the villain who triggered our metabolic health crisis? In this episode, I pull back the curtain on the real science, the controversial 1953 graph, hidden trial data, and sugar industry influence. We explore where Keys was decades ahead of his time, where his model failed, and what his legacy teaches us about navigating scientific dogma in clinical practice today.Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.  ➡ Download Here: https://www.jrennickemd.com/necessaryninepdfCHAPTERS:00:00 - Intro00:35 - The Ancel Keys Debate01:14 - Wartime Physiology, K-Rations & Starvation02:34 - The Lipid Hypothesis & The Keys Equation04:04 - The 1953 6-Country Graph Controversy07:24 - The Seven Countries Study & Mediterranean Diet08:54 - Minnesota Coronary Experiment & Publication Bias10:10 - Sugar vs. Fat & Sugar Industry Influence11:37 - Trans Fats & The Flaw in the Fat Swap13:18 - Beyond Total Cholesterol: ApoB & Lipoproteins14:26 - Ancel Keys' Legacy & Lessons for Modern ScienceSELECTED REFERENCES:Seven Countries Study: Cardiovascular Disease in Seven Countries (Keys A, 1984): https://pubmed.ncbi.nlm.nih.gov/6739443/ Re-evaluation of the Traditional Diet-Heart Hypothesis: Minnesota Coronary Experiment (Ramsden et al., BMJ 2016): https://pubmed.ncbi.nlm.nih.gov/27071971/ Sugar Industry and Coronary Heart Disease Research: Historical Analysis (Kearns et al., JAMA Intern Med 2016): https://pubmed.ncbi.nlm.nih.gov/27617709/Disclaimer:This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat, or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  4. Oct 6

    S1: Lipidology 101

    In this episode, I break down the underlying science of cholesterol, lipoproteins, and heart disease. We'll cut through the online noise and examine how cholesterol actually moves through your bloodstream, why particle count (ApoB) matters more than total cholesterol weight, how statins and other medications work at the cellular level, and how plaque forms in atherosclerosis. Everything you need to understand lipidology 101. Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro00:42 - What Is Cholesterol & Where Does It Come From?01:25 - How Cholesterol Moves: The River Analogy02:10 - Lipoprotein Structure Explained02:55 - The Main Lipoproteins: Chylomicrons to HDL04:20 - Apolipoproteins: ApoA vs. ApoB05:35 - Why ApoB Is a Better Test Than LDL-C06:40 - APOC2, APOC3, and APOE Mechanics07:45 - Cellular Cholesterol Regulation & How Meds Work09:10 - The Real Science of Atherosclerosis & Plaque10:35 - LDL vs. ApoB Discordance11:50 - Lipoprotein(a): The Genetic Triple Threat13:00 - Conclusion Disclaimer:This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  5. May 19

    BLA 180: Choosing the right lipid lowering medication

    Welcome back to the trenches! In our final breakdown of the 2026 ACC/AHA lipid guidelines, we are unpacking the pharmacology toolbox. From statins and ezetimibe to PCSK9 inhibitors and the nuances of side effects like SAMS, I want to give you the practical, evidence-informed strategies we need for our patients. We are all just trying to navigate this together. Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro00:01:00 - Statin Mechanism of Action00:01:34 - Types of Statins and Intensities00:03:04 - Hydrophobic vs Hydrophilic Statins00:05:15 - Statins and Glycemic Control00:06:14 - Pleiotropic Effects of Statins00:07:12 - Statin Side Effects Overview00:08:36 - Ezetimibe as First-Line Add-On00:09:54 - Bempedoic Acid00:11:18 - PCSK9 Inhibitors00:13:16 - Inclisiran and siRNA Therapy00:14:26 - Bile Acid Sequestrants00:15:47 - The Rule of 6 and Combination Therapy00:17:16 - Statin-Associated Muscle Symptoms00:19:04 - CoQ10 Supplementation00:20:07 - Special Populations: Older Adults and Pregnancy00:21:20 - Liver Safety and Drug Interactions00:23:15 - Statins, Dementia, and Brain Fog00:24:23 - Statins and Diabetes Risk00:25:21 - Managing High Triglycerides00:27:06 - Conclusion and Summer Sabbatical SELECTED REFERENCES: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 *Disclaimer*This podcast is for entertainment, education, and informational purposes only.The topics discussed should not solely be used to diagnose, treat , or prevent any condition.The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  6. May 14

    BLA 179: How to Actually Use the New Lipid Guidelines (Part 3)

    In this episode, I'm breaking down sections 4.2.3 through 4.2.10 of the dense ACC/AHA dyslipidemia guidelines so you don't have to. We'll cut through the noise on the new PREVENT equations, risk enhancers, imaging, and algorithms for primary and secondary prevention. Let's get you equipped to handle these complex lipid management decisions in the clinic.Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.➡️ Download Here: https://www.jrennickemd.com/necessaryninepdfCHAPTERS:00:00 - Intro00:25 - Individualized Risk-Benefit Discussions02:24 - The New PREVENT ASCVD Equations Explained04:29 - Understanding New Risk Thresholds05:32 - The Math Behind the 3% Treatment Threshold09:28 - Risk Enhancers and Personalizing Risk11:21 - Reproductive Age Risk Markers12:15 - Polygenic Risk Scores13:12 - Selective Imaging: CAC and Coronary CT15:16 - Treating Incidental Plaque15:58 - The Core Primary Prevention Algorithm19:26 - Severe Hypercholesterolemia (LDL > 190)21:58 - Diabetes and Lipid Management23:15 - Residual Risk and Omega-3s23:37 - Secondary Prevention Targets26:46 - Special Populations: Children and Young Adults28:04 - Older Adults and Deprescribing28:54 - Pregnancy and Lactation29:55 - HIV, CKD, and Inflammatory Diseases31:14 - Heart Failure and Cancer Survivors32:05 - Managing Hypertriglyceridemia 34:18 - Lipoprotein(a) as a Risk EnhancerSELECTED REFERENCES:https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423*Disclaimer*This podcast is for entertainment, education, and informational purposes only.The topics discussed should not solely be used to diagnose, treat , or prevent any condition.The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

  7. May 5

    BLA 178: How To Treat Dyslipidemia With Lifestyle

    In this video, we break down the 2026 guidelines for lipid-lowering lifestyle treatments. From the minimalist vs. optimizer diet approach to exercise dosing and managing supplements, let's equip you with actionable tools for the primary care trenches. Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessaryninepdf CHAPTERS:00:00 - Intro01:36 - The Strategy of Primordial Prevention02:45 - The Dietary Shift: Minimalist vs. Optimizer04:56 - Titrating for Elevated Triglycerides06:23 - Weight Loss and Sick Fat07:31 - Physical Activity as the 5th Vital Sign08:27 - The Truth About Dietary Supplements10:15 - When to Consult a Registered Dietitian10:48 - The Comprehensive Impact & Takeaways SELECTED REFERENCES:https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423 *Disclaimer*This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

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About

The Building Lifelong Athletes Podcast has one simple goal... to help keep you active and healthy for life. Whether you are a competitive athlete, fitness enthusiast, or just a weekend warrior, this podcast will help you be at your best by delivering practical and actionable information. From cholesterol management to exercise programming, this podcast covers every topic any lifelong athlete needs to know about. Jordan Rennicke, MD is a dual board certified physician in Family and Sports Medicine, has worked with thousands of athletes from all walks of life, and has a passion for learning, teaching, and helping people achieve their goals.

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