105 episodes

The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach.

We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more.

We give you accurate, unbiased information so you can choose the peptides that suit YOU best.

In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most.

About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics.

She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.

The Peptide Podcast The Peptide Queen

    • Health & Fitness
    • 4.4 • 39 Ratings

The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach.

We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more.

We give you accurate, unbiased information so you can choose the peptides that suit YOU best.

In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most.

About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics.

She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.

    Does Semaglutide Cause NAION?

    Does Semaglutide Cause NAION?

    In a recent study published in JAMA Ophthalmology, researchers explored a possible link between the medication semaglutide and a rare type of eye stroke called non-arteritic anterior ischemic optic neuropathy (NAION). In this podcast, we’ll explain what this means and why it's important.
    What is NAION?
    NAION is a condition that affects the optic nerve, leading to sudden vision loss in one eye. It's considered a rare eye stroke and is not related to artery disease.
    What is Semaglutide?
    Semaglutide is a medication used to help manage blood sugar levels in people with type 2 diabetes and is also prescribed for weight loss. It works by increasing insulin secretion in response to meals, which helps regulate blood sugar levels. Semaglutide also helps reduce appetite and increase feelings of satiety, leading to lower calorie intake. It slows the emptying of the stomach, prolonging the feeling of fullness after eating.
    The Study's Findings
    The researchers discovered a link between semaglutide and NAION. However, it's important to note that this is just a link. It doesn't prove that semaglutide causes NAION. Showing a connection is only the first step, and proving causation is much more challenging.
    Possible Explanations
    Rapid Changes in the Body: When someone starts taking semaglutide, their body undergoes quick cardiovascular and metabolic changes. These changes could trigger NAION, rather than the medication itself being the direct cause.
    Common Risk Factors: People who take semaglutide often have conditions like high blood pressure, obstructive sleep apnea, or diabetes. These conditions already put them at higher risk for NAION. Semaglutide might just be a common factor among these patients, rather than the cause of their eye issues.
    Study Limitations
    The authors note that since their institution specializes in eye conditions, they are more likely to encounter higher numbers of NAION cases. This may limit the generalizability of their findings to other settings.
    Additionally, the study's records indicate only whether a medication was dispensed to a patient, not whether it was actually taken as prescribed. This distinction is important for accurately assessing the medication's impact. 
    Furthermore, due to NAION's rarity, the analysis included only a small number of cases, which can complicate the interpretation of statistical results.
    What Does This All Mean?
    Scientists need to conduct further studies to determine if semaglutide directly causes NAION or if other factors are at play. And they should be conducted in a larger and more diverse population.
    Expert Picks:
    If you’d like to listen about the benefits of semaglutide, check out the following podcasts:
    Long-Term Health Benefits of Semaglutide for Weight Loss 
    How GLP-1 Agonists Like Semaglutide Fight Inflammation
    The Use of GLP-1 Agonists in Post-Heart Attack Care
    Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week!
    We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. 
    Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.

    • 3 min
    How Do GLP-1 Agonists Affect Metabolism?

    How Do GLP-1 Agonists Affect Metabolism?

    What is Metabolism? Metabolism refers to the biochemical processes in which our bodies convert food and drink into energy. This energy is then used to fuel bodily functions such as breathing, circulating blood, and repairing cells. 
    Metabolism is divided into two categories:
    Catabolism: Catabolism is the set of metabolic pathways that break down molecules into smaller units to release energy. It involves the breakdown of complex molecules such as carbohydrates, fats, and proteins into simpler ones like glucose, fatty acids, and amino acids. This breakdown process releases energy, which is captured in the form of adenosine triphosphate (ATP), the primary energy carrier in cells. In simple terms, catabolism is the breakdown of molecules to obtain energy. 
    Anabolism: Anabolism is the set of metabolic pathways that construct molecules from smaller units. These biosynthetic processes require energy, which is often derived from ATP produced during catabolic reactions. Anabolism is responsible for the growth and repair of tissues, the storage of energy, and the production of molecules necessary for cellular functions. In simple terms, anabolism is the synthesis of compounds needed by the cells.
    How Does Metabolism Maintain Weight? Our body weight is determined by the balance between the calories we consume and the calories we expend. Metabolism plays an important role in this balance:
    Basal Metabolic Rate (BMR): This is the amount of energy expended while at rest. It accounts for about 60-80% of daily calorie expenditure and includes the energy required for vital functions like breathing and keeping the heart beating.
    Thermic Effect of Food (TEF): This is the energy required for digestion, absorption, and removal of ingested nutrients. It accounts for about 10% of daily energy expenditure.
    Physical Activity: This includes all movements, from exercise to daily activities like walking or cleaning. It can vary greatly among individuals and is the most variable component of our energy expenditure.
    What Happens to Our Metabolism When We Lose Weight? When we lose weight, several changes occur in our metabolism:
    Reduction in BMR:
    Loss of Lean Body Mass: During weight loss, especially if it’s rapid or involves severe calorie restriction, some of the weight loss can be from lean muscle mass. Since muscle tissue is more metabolically active than fat tissue, a decrease in muscle mass leads to a reduction in BMR.
    Smaller Body Size: A smaller body requires fewer calories to maintain. As you lose weight, your body mass decreases, and thus the energy required to sustain basic bodily functions also decreases.
    Adaptive Thermogenesis:
    Metabolic Adaptation: The body responds to caloric restriction and weight loss by becoming more energy-efficient. This means that for a given level of activity, the body will burn fewer calories. This adaptive thermogenesis is believed to be a survival mechanism developed during periods of food scarcity in human history.
    Decreased Energy Expenditure from Physical Activity:
    Reduced Body Mass: When you weigh less, the energy cost of physical activities decreases. For instance, walking or running requires less energy if you are lighter.
    Why Steady Weight Loss is Better than Rapid Weight Loss Steady, gradual weight loss is generally considered more effective and sustainable than rapid weight loss for several reasons we just mentioned:
    Preservation of Lean Muscle Mass: Slow weight loss helps preserve lean muscle mass, which is crucial for maintaining a higher metabolic rate.
    Sustainable Habits: Gradual weight loss encourages the development of healthy, sustainable habits rather than quick fixes that are difficult to maintain.
    Also, keep in mind that rapid weight loss can lead to nutrient deficiencies, as it often involves restrictive diets that may lack essential nutrients. This can cause deficiencies that may impact overall health, energy levels, immune function, a

    • 9 min
    Best Foods While on a GLP-1

    Best Foods While on a GLP-1

    When embarking on a weight loss journey, it's important to be aware that losing weight can sometimes result in the loss of muscle mass along with fat. This unintended muscle loss can lead to decreased strength, slower metabolism, a less toned appearance, or extra skin. 
    To counteract this, it's essential to incorporate foods that support muscle maintenance and growth into your diet. Consuming adequate protein, healthy fats, and nutrient-dense carbohydrates can help preserve muscle mass, ensuring that your weight loss is both healthy and sustainable.
    In this podcast, we’ll discuss what foods are best to help maintain muscle mass while taking a GLP-1 agonist like semaglutide or tirzepatide.
    How does weight loss affect muscle mass?
    Weight loss can affect muscle mass in several ways, depending on how the weight loss is achieved:
    Caloric Deficit: Weight loss typically requires a caloric deficit, meaning you consume fewer calories than your body needs to maintain its current weight. If the deficit is too large or if protein intake is insufficient, the body may start to break down muscle tissue for energy, leading to a loss of muscle mass.
    Exercise: Incorporating strength training or resistance exercises during weight loss can help preserve and even build muscle mass. Conversely, focusing solely on cardio without any form of resistance training may lead to a higher proportion of muscle loss.
    Protein Intake: As we mentioned, adequate protein intake is important for preserving muscle mass during weight loss. Protein provides the necessary building blocks (amino acids) for muscle repair and growth. Insufficient protein can lead to muscle catabolism, where muscle tissue is broken down.
    Rate of Weight Loss: Rapid weight loss often results in a higher percentage of muscle loss compared to slower, more gradual weight loss. A slower rate of weight loss allows the body to better preserve muscle tissue while losing fat.
    To minimize muscle loss during weight loss, it's important to:
    Include resistance training in your exercise routine
    Consume adequate protein
    Avoid excessively large caloric deficits
    Aim for a gradual and sustainable rate of weight loss
    What foods help maintain muscle mass while losing weight on a GLP-1?
    Remember that this discussion doesn’t include all foods that can help support muscle maintenance and growth but it’s a good start.
    Chicken breast: It’s high in quality protein (22 grams per serving) and leucine. Chicken breast is also low in calories, which can help you lose weight. Try removing the chicken skin to help lower the amount of saturated fat.
    Fish (Salmon, Tuna): Fish is a great source of protein and omega-3 fatty acids, which have anti-inflammatory effects and support muscle recovery. Studies also show that omega-3 fatty acids can help reduce muscle soreness. One serving of salmon provides about 20 grams of protein while one serving of fresh tuna provides about 28 grams of protein.
    Eggs: A complete protein source that contains all essential amino acids, as well as vitamins and minerals like vitamin D and leucine (amino acid), which support muscle function. Eggs are often called the “perfect protein”. One large hard-boiled egg provides about 6 grams of protein.
    Greek Yogurt: High in protein and often lower in sugar than regular yogurt, Greek yogurt also provides probiotics that support digestive health. Like eggs, Greek yogurt provides all essential amino acids. 
    Pro tip: Keep in mind that Greek yogurt is better than plain yogurt as it provides nearly double the amount of protein (17 grams per serving) that plain yogurt provides in the same portion size. If you’re watching carbohydrate intake, Greek yogurt has about half as much as regular yogurt. Also, plain Greek yogurt is better than flavored Greek yogurt. This is because flavored yogurt has added sugar. 
    Low-fat cottage cheese (2% milk fat): Another dairy product high in protein and also

    • 8 min
    Digestion and the Impact of GLP-1 Agonists

    Digestion and the Impact of GLP-1 Agonists

    Digestion is a complex process that involves breaking down food into nutrients that the body can absorb and use. For a healthy person, the time it takes to digest meals and snacks can vary based on the type and composition of the food consumed. Keep in mind the digestive process varies significantly between healthy individuals and those with digestive disorders. While healthy individuals typically digest meals within a predictable timeframe, digestive disorders can cause delays or speed up this process. 
    Keep in mind that GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) influence digestion by slowing gastric emptying and regulating appetite, which can be beneficial for weight loss and diabetes management but may pose challenges for those with certain digestive conditions. 
    In this podcast, we’ll discuss how digestion is impacted by digestive orders and how GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound) affect digestion.
    The Digestive Process Explained Starting in the Mouth: The digestive process begins in the mouth when you chew food. Chewing breaks down food into smaller particles, and saliva, which contains an enzyme that starts the digestion of starches, moistens the food, making it easier to move along the gastrointestinal (GI) tract.
    Moving to the Esophagus: When you swallow, food travels down the esophagus. Here, peristalsis—rhythmic contractions—automatically propel the food forward. At the lower end of the esophagus, a circular muscle called the lower esophageal sphincter (LES) relaxes to allow food to pass into the stomach and then closes to prevent stomach acid from flowing back into the esophagus.
    Stomach Function: Once food reaches the stomach, muscles in the stomach wall mix it with stomach acid and enzymes, creating digestive juices that break the food down into a liquid mixture called chyme.
    The Small Intestine: In the small intestine, food mixes with digestive juices from the pancreas, liver, and gallbladder. The walls of the small intestine then absorb nutrients into the bloodstream before peristalsis moves the remaining mixture forward.
    Large Intestine Function: Undigested food, fluids, and damaged cells from the GI tract's lining enter the large intestine or colon. Here, water is absorbed, transforming the waste material from liquid to stool. Peristalsis then moves the stool into the rectum, where it is stored until it is expelled during a bowel movement.
    Typical Digestion Times:
    Liquids: Water and other clear fluids pass through the stomach quickly, usually within 20-30 minutes.
    Simple Carbohydrates: Foods like fruit, white bread, and sugary snacks are typically digested within 30-60 minutes.
    Complex Carbohydrates: Whole grains, quinoa, vegetables, and legumes take longer, around 2-3 hours.
    Proteins: Meat, dairy, and other high-protein foods generally take 3-4 hours to digest.
    Fats: Fatty foods such as nuts, cheese, and fried foods are the slowest to digest, often taking up to 6 hours or more.
    On average, the entire digestive process, from ingestion to elimination, can take about 24-72 hours in healthy individuals.
    Digestion in Individuals with Digestive Disorders Digestive disorders can significantly alter the time it takes for food to move through the digestive system. Conditions such as gastroparesis, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) can disrupt normal digestive function.
    Gastroparesis: This condition, often caused by diabetes or other underlying issues, slows stomach emptying. Symptoms include nausea, vomiting, and bloating. In gastroparesis, digestion can be severely delayed, with food remaining in the stomach for prolonged periods, sometimes up to several hours longer than normal.
    Irritable Bowel Syndrome (IBS): IBS can cause both accelerated and delayed digestion, depending on whether diarrhea-predominant (IBS-D) or constipation-predominant (IBS-C) symptoms are present. IBS-D can lead

    • 10 min
    Resistance Training to improve Peptide Performance

    Resistance Training to improve Peptide Performance

    Did you know that you don't need a gym to enjoy the benefits of resistance training? You can do it right in the comfort of your home with no gym equipment, and it's fantastic for your overall health and heart health. Regular resistance training can improve your blood pressure, blood sugar, blood lipids, and body composition. It's especially helpful for older adults and those with a higher risk of heart problems (e.g., high blood pressure or cholesterol, diabetes, excess weight, current or former smokers, or a family history of heart disease).
    In this podcast, we’ll discuss simple home workouts that you can do to help your overall health.
    What is resistance training?
    Resistance training, also known as strength training, involves exercises that improve muscular strength and endurance. This form of exercise typically uses resistance in the form of weights, resistance bands, or body weight to work specific muscle groups. By repeatedly challenging muscles, resistance training enhances their ability to generate force and sustain physical activity.
    Benefits of Resistance Training Cardiovascular and Overall Health While resistance training primarily targets muscle strength and endurance, it also offers substantial cardiovascular benefits. Regular resistance training can:
    Improve heart health by reducing blood pressure and cholesterol levels.
    Help keep your arteries flexible and improves blood vessel function while lowering inflammation levels that typically lead to atherosclerosis (clogged arteries).
    Keep in mind that while you may not notice these cardiovascular effects, you may experience noticeable improvements in your sleep and mood. 
    Weight Loss and Muscle Mass Resistance training is a powerful tool for weight loss and muscle mass maintenance. But how?
    Increased Metabolism: Building muscle boosts your resting metabolic rate, meaning you burn more calories even at rest.
    Fat Loss: While you may not see immediate weight loss, resistance training can help you lose fat and gain lean muscle, leading to a healthier body composition. 
    Muscle Preservation: During weight loss, preserving muscle mass is crucial. When people lose weight, they usually lose fat along with muscle mass. Given the popularity of GLP-1 agonists like semaglutide (Wegovy) and tirzepatide (Zepbound), it’s important to know that muscle wasting is a possible side effect of these medications. Resistance training ensures that most of the weight lost comes from fat, not muscle.
    Keep in mind: Resistance training also promotes better body mechanics and posture, reducing the risk of injury and improving balance and coordination.
    How to Get Started with Resistance Training Getting started with resistance training can be intimidating, especially if you already don’t exercise or have mobility limitations due to arthritis, neurological conditions like multiple sclerosis, or obesity. 
    You can always join a gym and meet with a personal trainer but we all know this is both costly and time-consuming. While in-person classes or training sessions might be motivating and fun, there is always the option of trying resistance training at home, on your own. You can find free exercise videos on YouTube or personal fitness blogs. 
    Set Clear Goals: Determine what you want to achieve, whether it’s building muscle, losing or maintaining weight, or improving overall health.
    Start with a Plan: Create a balanced workout plan that includes all major muscle groups (e.g., chest, shoulders, upper back, back and front of arms and legs, stomach, and lower back).
    Learn Proper Technique: Proper form is important to prevent injuries. Consider working with a trainer initially or using reputable online resources. 
    Start Light: To master the exercises, begin with lighter weights, then gradually increase the resistance as you become more comfortable and stronger. Start with shorter, lower-intensity sessions to help your body readjust and minimize the ri

    • 6 min
    The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation

    The Role of Glucagon-Like Peptide 1 (GLP-1) in Reducing Inflammation

    Glucagon-like peptide 1 (GLP-1) is a hormone primarily known for its role in regulating blood sugar levels through its effects on insulin secretion and appetite control. However, recent research has shown another significant function of GLP-1: its ability to reduce inflammation. This opens new avenues for therapeutic interventions in various inflammatory conditions and chronic diseases.
    In this podcast, we’ll discuss GLP-1’s role in reducing inflammation and how it may help you.
    What is GLP-1?
    GLP-1 is an incretin hormone produced by intestinal L-cells in response to food intake. It enhances insulin secretion from the pancreas in a glucose-dependent manner. 
    Here's how glucose-dependent insulin secretion works:
    Increase in Blood Glucose Levels: After you eat, carbohydrates in your food are broken down into glucose, which is absorbed into your bloodstream, raising your blood sugar levels.
    Release of GLP-1: In response to the rising blood glucose levels, your intestines release a hormone called GLP-1 (Glucagon-Like Peptide 1).
    Stimulation of the Pancreas: GLP-1 travels through your bloodstream to your pancreas, where it stimulates the beta cells in the pancreas to release insulin.
    Insulin Release: The insulin is then released into your bloodstream. Insulin acts like a key, allowing glucose to enter your cells so it can be used for energy.
    Glucose-Dependent Nature: The important part is that this whole process depends on the presence of glucose. If your blood glucose levels are not high, GLP-1 will not signal your pancreas to release insulin. This prevents your blood sugar from dropping too low, which could cause hypoglycemia (dangerously low blood sugar levels).
    GLP-1 also slows gastric emptying and reduces appetite, which collectively help manage postprandial blood glucose levels. GLP-1 exerts its effects by binding to the GLP-1 receptor (GLP-1R), which is expressed in multiple tissues, including the pancreas, brain, heart, and immune cells.
    The Link Between GLP-1 and Inflammation
    Inflammation is a complex response to harmful stimuli such as pathogens, damaged cells, or irritants. Chronic inflammation contributes to many diseases, including cardiovascular diseases, diabetes, and neurodegenerative disorders. 
    How does GLP-1 reduce inflammation?
    Modulation of Immune Cells: GLP-1 influences various immune cells, including macrophages, T cells, and dendritic cells. It has been observed to shift macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, reducing the secretion of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. This shift plays a crucial role in dampening the inflammatory response.
    Inhibition of Nuclear Factor-kappa B (NF-κB) Pathway: NF-κB is a transcription factor that regulates the expression of genes involved in inflammation. Activation of GLP-1R has been shown to inhibit the NF-κB pathway, thereby reducing the transcription of pro-inflammatory genes. This inhibition helps in lowering the levels of inflammatory mediators in the body.
    Reduction of Oxidative Stress: GLP-1 reduces oxidative stress by increasing the expression of antioxidant enzymes. Oxidative stress is a significant driver of inflammation, and by mitigating it, GLP-1 helps in lowering the inflammatory burden. This is particularly beneficial in conditions like atherosclerosis and diabetes, where oxidative stress is a major pathogenic factor.
    Cardiovascular Protection: Chronic inflammation is a well-known risk factor for cardiovascular diseases. GLP-1 and its analogs have been shown to improve endothelial function, reduce vascular inflammation, and protect against atherosclerosis. These effects are mediated through the reduction of inflammatory cytokines and oxidative stress, as well as the improvement of lipid profiles.
    Neuroprotection: Neuroinflammation is a critical component of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. GLP-1 analogs ha

    • 6 min

Customer Reviews

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39 Ratings

39 Ratings

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A podcast that is short and gets directly to the point with valuable information

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Dr. Nikki is so knowledgeable! Pretty much has answers to all my curiosities and questions.

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Best podcast

Love this podcast! Thanks for the information! Very informative!

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