Join Stacy of Real Everything and Dr. Sarah of The Paleo Mom as they bust myths and answer your questions about a nontoxic lifestyle, nutrient-dense diet, Autoimmune Protocol, and parenting.
Episode 455: Covid-19 Vaccines - Real World Data and Updated Vaccine Studies
Welcome to episode 455 of The Whole View! This week, Stacy and Sarah discuss the data from updated vaccine studies in terms of what we knew in previous episodes.
If you enjoy the show, please review it on iTunes!
The Whole View, Episode 455: Covid-19 Vaccines - Real World Data and Updated Vaccine Studies
Welcome back to episode 455! (0:28)
This is the next part in a series of shows where Sarah and Stacy discuss the science behind the Covid-19 vaccines.
Sarah and Stacy will be discussing updated vaccine studies from previous episodes. So be sure to check those out before jumping right in:
In episode #440, we examined the history of vaccines, the very real statistics on vaccine-induced injury, and the advances that led to mRNA vaccine technology, along with the inherent advantages of this platform.
Episode #441 looked at the safety and efficacy data from the phase 2/3 clinical trials for both the Pfizer/BioNTech and the Moderna covid-19 vaccines, including subgroup analysis.
In episodes #443 & #444, we answered listener FAQ, including concerns about adverse events including autoimmune disease, fertility, antibody-enhanced infection, the current state of evidence regarding safety concerns for pregnancy and children. We addressed common myths circulating on the internet.
And last week, on episode 454, we looked at how adenovirus vaccines work and the safety and efficacy data from the phase 2/3 clinical trials for both the Johnson & Johnson & Janssen and the AstraZeneca/Oxford University vaccines, including a deep dive into immune thrombotic thrombocytopenia (what the news is reporting as a rare type of blood clot).
All five episodes took a data-driven approach, presenting the science and facts with context, detail, nuance, integrity, compassion, and as objectively as possible.
Stacy reminds listeners that she and Sarah are not medical professionals or here to tell anyone what to do. Their only goal is to pass along the science to allow you to make an informed decision that works best for you.
Personal Experiences with Covid & Vaccination
Sarah and Stacy first share their personal experiences with Covid-19. (7:01)
As many may remember, Stacy got Covid in April of last year and is one of the estimated 10% that end up with "long hauler" Covid.
She shares how that's impacted her life for the last year and techniques she's utilized to cope with it, such as focusing on nutrient density and getting enough sleep.
Stacy also took the first vaccine appointment she gets, which was for Moderna. She talks a bit about the mild side effects she experienced. And how the vaccine has actually shown treatment benefits to people, like Stacy, that have developed long-hauler symptoms.
Sarah, on the other hand, was lucky enough to avoid getting infected with Covid. She and her family have lived relatively isolated for the past year. And she is looking very forward to seeing people outside of her immediate family again.
She managed to book a vaccine appointment that was a cancellation. So she had about 3 hours' notice to get there and had no idea which vaccine she was getting. Although, she would have taken whichever they had available.
She shares what side effects she experienced after vaccination, which were a little more on the moderate side than many.
Stacy notes that one of the things she appreciates in previous Covid shows was that Sarah looked into the possibility of adverse side effects.
She notes, however, that if the audience doesn't hear about any of those adverse effects in this show, Stacy and Sarah aren't ignoring them. It's because they covered them in other shows.
Updated Vaccine Studies on mRNA Vaccines
Last week, Sarah talked about how the mRNA vaccines slightly altered the spike protein to maintain its prefusion conformation. (24:35)
She erroneously said postfusion. And, this makes sense since we want the i
Episode 454: J&J and AstraZeneca Covid-19 Vaccines
The Whole View, Episode 454: J&J and AstraZeneca Covid-19 Vaccines
Welcome back to episode 454! (0:28)
This is the next part in a series of shows where Sarah and Stacy discuss the science behind the Covid-19 vaccines.
They strive to present you with all the information available to make an informed decision about whether receiving the vaccine is right for you.
Sarah plans to go through the show with the assumption that listeners have background/base knowledge about vaccines and how they work.
So if you have not yet listened to the previous shows in this series, Sarah highly recommends you do before listening to this episode.
Previous Covid-19 Shows
In episode #440, Sarah and Stacy examined the history of vaccines and the very real statistics on vaccine-induced injury. They also looked at the advances that led to mRNA vaccine technology and the inherent advantages of this platform.
Episode #441 explored the safety and efficacy data from the phase 2/3 clinical trials for both the Pfizer/BioNTech and the Moderna covid-19 vaccines.
In episodes #443 & #444, Sarah and Stacy answered listener FAQ. This included concerns about adverse events, including autoimmune disease, fertility, and antibody-enhanced infection. They also examined safety concerns for pregnancy and children and addressed common myths circulating on the internet.
Stacy and Sarah took a data-driven approach for all four episodes, presenting the science and facts with context, detail, nuance, integrity, compassion, and as objectively as possible.
Fact vs. Opinion on The Whole View
Stacy underlines that they are not here to convince you of a certain mindset or push a vaccine agenda in this show.
Although Stacy and Sarah may share their personal opinions on vaccines, they remind the audience that their opinions are just that - opinions. And what's right for them might not be right for you.
They strive to take this same scientific approach today and next week with the J&J and AstraZeneca Covid-19 vaccines. (Yes! You're getting two more vaccine shows!)
Stacy also reminds listeners of Sarah's credentials and that she had a Ph.D. in research science. Like the other shows, they will address the rumors, concerns, and myths.
It's critical to walk through the facts first. And remember- facts don't have opinions. Stacy and Sarah's primary agenda is to give the data for you to interpret for yourself.
Adenovirus Vector Vaccines
J&J and AstraZeneca Covid-19 vaccines are both DNA vaccines that use an adenovirus vector. The concept is similar to the mRNA vaccines but not wholly the same. (5:20)
Sarah reminds the audience that to make proteins, DNA is first transcribed into mRNA, which is then translated into protein.
So, both J&J and AstraZeneca vaccines deliver instructions to make the full-length covid-19 spike protein.
Only slightly different from the instructions for the mRNA vaccines, which have a couple of mutations to stabilize the tertiary structure into what's called the postfusion conformation and the transmembrane anchor added
Both adenovirus vaccines encode full-length spike protein without the postfusion conformation stabilization mutations (say that 5 times fast!) but still add the membrane anchor.
Sarah recommends this source for more information.
So, these work similarly to the Pfizer/BioNTech and Moderna mRNA vaccines.
However, J&J and AstraZeneca Covid-19 vaccines require two steps to make the spike protein instead of one. They also require a special delivery agent to get into the cell nucleus. That's where adenoviruses kick in!
Adenovirus Vectors Research
There are about 50 years of research on adenovirus vectors as DNA delivery vectors. (8:48)
Adenoviruses are basically common cold viruses that can cause illnesses ranging from cold-like symptoms to bronchitis, gastroenteritis, and conjunctivitis.
They are non-enveloped DNA viruses that can't alte
Episode 453: Should We Eat Breakfast Before 8:30am?
The Whole View, Episode 453: Should We Eat Breakfast Before 8:30am?
Welcome back to episode 453! (0:28)
Stacy reminds listeners that science is an evolutionary process and, like life, things are constantly changing and growing.
The Whole View has years of shows that may contain outdated science. Both Stacy and Sarah feel it's important to bring some of these episodes back to the forefront and re-examine how science has changed.
So in honor of revisiting some of our favorite shows with the updated science, Sarah decided to start with re-examining the science behind eating (or not eating) breakfast before 8:30am.
See Episode 381: Is Breakfast the Most Important Meal of the Day? for more notes from the last episode!
Stacy reminds listeners that when you go through long periods of not eating (intermittently fasting), it signals to your body that it's time to rest. This can mess with your circadian rhythm. (58:26)
Studies link eating breakfast can lower stress levels, help manage mental health, and improve physical health.
Stacy also reminds listeners that coffee doesn't count as breakfast and can actually inflame stomach issues.
You can also spread out breakfast throughout the morning "breakfast" window by eating a series of small things.
Endocrinology Conference: Breakfast Before 8:30am
The study was designed to look at restricted feeding, comparing shorter windows to loger windows. (1:04:20)
Previous studies have found that time-restricted eating, which consolidates eating to a shortened time frame each day, has consistently demonstrated improved metabolic health.
But research shows that an early time-restricted feeding window is better:
TPV Podcast Episode 386: Intermittent Fasting
Intermittent Fasting: Secret to Weight Loss or Dangerous Fad?
Researchers analyzed data from 10,575 adults who participated in the National Health and Nutrition Examination Survey.
They divided participants into three groups depending on the total duration of food intake: less than 10 hours, 10-13 hours, and more than 13 hours per day.
Then, they created six subgroups based on eating duration start time (before or after 8:30 am).
They analyzed this data to determine if eating duration and timing were associated with fasting blood sugar levels and estimated insulin resistance.
Fasting blood sugar levels did not differ significantly among eating interval groups.
Insulin resistance was higher with shorter eating interval duration but lower across all groups with an eating start time before 8:30am.
What they discovered instead was that eating breakfast early reduced insulin resistance, and feeding window didn't matter.
Is Breakfast the Most Important Meal of the Day?
Is Breakfast The Most Important Meal of the Day? New Science Has Answers!
People who start eating before 8:30 am had lower blood sugar levels and less insulin resistance. This could reduce the risk of developing type 2 diabetes.
Sarah surmises that it makes sense from a cortisol vs. insulin perspective!
Breakfast & Cortisol
Stress, breakfast cereal consumption, and cortisol: recent research has shown that regular breakfast cereal consumption is associated with lower stress levels and reports of better physical and mental health.
The present study examined this issue using an objective indicator of stress, salivary cortisol.
Results showed that stress was associated with higher cortisol levels, and daily consumption of breakfast cereal was associated with lower cortisol levels.
Meal Timing Regulates the Human Circadian System and affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial.
Another study showed female breakfast-skippers display a disrupted cortisol rhythm and elevated blood pressure.
Not to mention, chronic stress is associated with indicators of diet quality in habitual breakfast ski
Episode 452: New Science on Soaking or Activating Nuts
Welcome to episode 452 of The Whole View! This week, Stacy and Sarah look back at soaking or activating nuts and reflect on how data has impacted previous science.
If you enjoy the show, please review it on iTunes!
The Whole View, Episode 452: New Science on Soaking or Activating Nuts
Welcome back to episode 452! (0:28)
Facts are facts; science is science, and no matter how we felt about it before might change if we are open to hearing new information.
Sarah adds that there was science available in previous shows that allowed us to infer some of these things. As more data has become available in the past year, we see that it's actually not the case.
Episode 188, Paleo-Friendly Bread:
Episode 413: The Gut Health Benefits of Nuts
Stacy reminds listeners that this isn't a one-size-fits-all concept. To make sure the science on this show, which is specific to soaking or activating nuts, isn't extrapolated into different areas.
We have a question from listener Vanessa:
I'm interested in getting nuts and seeds back into my diet but am wary due to my autoimmunity.
I've read all the articles I can find on the subject on your website (even your dehydrator article) and ran a search. Still, there is no mention of soaking (and dehydrating) nuts and seeds to break down the enzyme inhibitors that cause digestive issues. Some nuts give me a stomach ache and bloating (I've experimented here and there with low Fodmap nuts), and I have also purchased activated nuts (that have already been soaked and dehydrated). I seem to get on fine with the activated nuts, but if you don't mention this process in your articles, is this not something you advocate? Thanks - Vanessa
Summarization of Nut Benefits
20 grams of tree nuts per day shows substantially reduced risk (think 20-70%) of cardiovascular disease, cancer, neurodegenerative disease, kidney disease, diabetes, infections, and mortality from respiratory disease. (3:05)
Even three 1-ounce servings per week can lower all-cause mortality risk by a whopping 39%. This means that eating nuts regularly improves health, but they can potentially extend lifespan.
Nut consumption is also known to decrease inflammation markers, including some endothelial markers (called adhesion molecules).
There's emerging evidence of beneficial effects on oxidative stress, vascular reactivity, and hypertension.
Numerous studies show that people who regularly eat nuts tend to have more favorable blood lipid profiles.
One meta-analysis of 25 clinical studies showed that nut consumption had a dose-response cholesterol-lowering effect.
Interventional studies consistently show that increasing nut intake has a cholesterol-lowering effect, even in the context of healthy diets.
Plenty of research suggests that, despite their energy density, nuts and seeds don't contribute to weight gain, and they may even protect against obesity and diabetes.
The health benefits of nut and seed consumption can be attributed to their nutritional content, rich in antioxidant vitamins, essential minerals, dietary fiber.
They also include L-arginine, polyphenols, and some nuts that contain high levels of heart-healthy monounsaturated fats and the omega-3 fatty acid α-linolenic acid.
We went into detail in Episode 413: The Gut Health Benefits of Nuts.
The Health benefits of nut consumption do not continue to increase beyond about 20 grams per day.
And there's some evidence that consuming large amounts of nuts daily can increase disease risk (at least for stroke).
That means we get benefits with about a palmful of nuts and seeds per day, but that eating more than that won't do us any favors (and may potentially undermine our health).
Why Aren't They AIP?
Tree nuts are among the most allergenic foods, with true allergies (meaning the body produces IgE antibodies against proteins in nuts) estimated at about 1% of the total po
Episode 451: ConspiraSEA: Is Sustainable Seafood Impossible?
Welcome to episode 451 of The Whole View! This week, Stacy and Sarah address the health benefits, the question of sustainable seafood and Seaspiracy as a whole.
If you enjoy the show, please review it on iTunes!
The Whole View, Episode 451: ConspiraSEA: Is Sustainable Seafood Impossible?
Welcome back to episode 451! (0:28)
Stacy and Sarah have received many questions on Netflix new documentary, Seaspiracy.
Stacy took almost eight pages of notes, while Sarah has also prepared many sea-related puns for you.
First off, the name ConspiraSEA was right there, and she totally feels they missed the boat (ha!) on that one.
Stacy also mentions they gathered thirteen pages between them to ensure you are provided with as much information as possible and not just Stacy and Sarah's opinions.
The message the show tries to deliver is the opposite of this show's top recommendations.
Stacy could tell within minutes that the filmmakers had an agenda. She and Sarah plan to review the science-based facts from the claims made in the film.
The goal is to help listeners navigate safe, sustainable seafood because despite what the film attempts to present, seaweed and plant-based options do not compare to the health benefits.
So Stacy and Sarah want to dive right in. (Get it?)
Benefits of Seafood
It's important to emphasize what we'd be missing out on if the premise that sustainable fishing is impossible is true. (4: 01)
Eating more seafood can reduce cardiovascular disease and prevent obesity and diabetes.
High amounts of vitamins, minerals, carotenoids, fats, and protein all contribute to these benefits. (Intro to Nutrivore)
Fish is a great source of vitamins B1, B2, B3, B6, B9, B12 and E, zinc, phosphorus, magnesium, iron, copper, potassium and selenium. Oily, cold-water fish provide substantial amounts of vitamin A and vitamin D as well.
Fish with bones remaining (such as canned salmon and sardines) are the best dietary sources of calcium in the food supply. Marine fish are an excellent dietary source of iodine.
High Selenium Content
protect against some cancers,
enhance bone health,
maintain thyroid health,
reduce the risk of infection,
assist in DNA production, and
protect the body from free radical damage
Omega-3 Fats EPA and DHA
lower blood pressure,
protect against some cancers (including breast),
increase insulin sensitivity, and
improve endothelial function
Improves gut microbiome composition
Or any fish with a similar salmon-pink or orange color also contains the antioxidant carotenoid astaxanthin.
helps reduce LDL oxidation
boosts HDL levels, and
protects against skin damage.
Fish protein is the BEST!
Also supports a healthy, diverse gut microbiome (in addition to omega-3s) - better than any other protein source: beef, pork, chicken, soy, casein, and pea. (11:20)
Many fish benefits are mediated via protein, and fish protein is easy to digest.
In a meta-analysis of five prospective cohort studies, lean whitefish's high consumption reduced the risk of stroke by 19% (which was even more than fatty fish intake, which reduced stroke risk by 12%).
A study of Swedish women shows that three servings of lean fish per week reduced the risk of stroke by 33% compared to zero servings per week.
In Norwegian men, weekly lean fish consumption (including whitefish) was associated with a lower risk of metabolic syndrome, lower triglyceride levels, and higher HDL cholesterol.
Likewise, a randomized crossover trial found that simply adding 100 grams per day of whitefish (Namibia hake) to the diet significantly lowered waist circumference, diastolic blood pressure, and LDL levels!
And another trial found that eating 150 grams of cod per week caused significantly greater weight loss in young overweight adults than a same-calorie diet without seafood.
Episode 450: Spices on the AIP? What’s In, What's Out, and Why.
The Whole View, Episode 450: Spices on the AIP? What’s In, What's Out, and Why.
Welcome back to episode 450! (0:28)
Stacy and Sarah both have sensitivities to nightshades due to inflammation-driven health issues.
Nightshades are common trigger foods and can be super problematic to autoimmune diseases and chronic illnesses as well.
This is because the immune system is already in overdrive. Adding an immune stimulant (such as nightshades) to the equation can cause symptom flare-ups.
The logic that goes into the autoimmune protocol requires a little bit of reasoning about how best to apply it to your day-to-day choices.
When writing her book on AIP, Sarah's research really focused on how the immune system works and how it intersects with nutrients, lifestyle, hormones, etc.
Understanding how foods can be problematic for some people is never irrelevant. Even if you're perfectly healthy, the science behind AIP can be applied to optimize diet and troubleshoot any future health issues.
In this episode, Stacy and Sarah plan to do a deep dive into what herbs and spices are awesome when on AIP, which are considered early reintroductions, and which ones are best avoided until the very end of the healing process.
For more references, please see:
When Do We Re-Do the Elimination Phase of the AIP?
Can Food Intolerances Be Fixed?
Food Allergy, Sensitivity, and Intolerance: What’s the Difference?
What Do I Do After a Bad Reaction?
This episode was inspired by this listener question from Jeff. (10:30)
I'm a chef of 20 years and as most of us in the hospitality industry have experienced, things are not good. During my temporary retirement I've decided to help out a family who has started an AIP diet. I haven't cooked specifically for a person who has said they are specifically AIP, but I have had plenty of experience with similar dietary needs. It will no doubt be a challenge, but it will be a fantastic learning experience and chance to change a persons experience while on their path to recovery.
In my journey I'm looking for ways to infuse the flavors which I like to use in ways that will be in line with the protocol. My inquiry has to do mainly with flavor infusion. Take for example a brine for pork. I use products like whole black peppercorn, whole coriander seed, mustard seed, etc. to add layers of flavor to the brine. Is the main issue with these spices the pieces of the seeds? Are the extracted oils also off limits? My main concern is around spices. I would venture to believe that nightshade oils are the problem (i.e. dried chilies, capsicum, etc).
Stacy reflects on how much she enjoy's Jeff looking at it from a chemistry perspective in the cooking.
Alternatively, people who find out they can't eat raw tomatoes might discover they can have cooked ones as they reintroduce foods back into their diet.
It's very bioindivideal, meaning Stacy and Sarah can't answer what foods will affect you and why. AIP is a way to isolate triggers for you personally to optimize your health.
Overall Philosophy Spices on the AIP
Sarah believes the most helpful place to start is taking a step back and looking at herbs and spices in general. (13:30)
The autoimmune protocol first tries to flood the body with nutrients- both essential and nonessential. Sarah references this show for more information on nutrient toxicity.
Another thing AIP tries to do is remove inflammatory properties from the diet. Herbs are derived from the leaves of fragrant plants and sometimes flowers.
They are safe to use whole, fresh or dried. It's actually very beneficial to include them since the same phytonutrients that provide the flavor tend to be awesome antioxidants and anti-inflammatory.
Other properties they often have are anti-cancer, liver protective, neuroprotective, and more. See our Essential Oil show for more on extracts,
Looking for science based facts for healthier living? Look no further!
This podcast is full of so much information on so many topics that go into living the best and most healthful lifestyle. The science data shared is not only informative, but thorough and it is shared by two hosts that have great personalities and fit well together.
Real life science based nutrition
Excellent content, very science based. Love hearing explanations of hormones & body reactions to food. Love hearing about the recipes & real life people living an autoimmune paleo lifestyle. Love it!
I’ve listened to this podcast for years, and over that time period, it has completely reshaped my mindset towards health and nutrition. I didn’t come to in to listening to it with a previous health condition, but my mindset towards nutrition specifically was not healthy and not well informed. I feel smarter after every episode with actionable, science based (non-biased) steps to improve my health, wellness, and overall life. I feel better equipped to make decisions that will set my health and my family’s health up for long term success. I get excited for the next topic every week and frequently share episodes with friends and family. I love that the hosts weigh in on current events with what the science says and also update us when new research is published on a topic previous covered. This is hands down my favorite podcast!